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Daein Choi  (Choi D) 1 Article
Cardiovascular Risk/Epidemiology
Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk
Jihoon Andrew Kim, Seulggie Choi, Daein Choi, Sang Min Park
Diabetes Metab J. 2020;44(2):307-315.   Published online November 1, 2019
DOI: https://doi.org/10.4093/dmj.2019.0002
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  • 8 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Whether depression before diagnosis of dyslipidemia is associated with higher cardiovascular disease (CVD) risk among newly diagnosed dyslipidemia patients is yet unclear.

Methods

The study population consisted of 72,235 newly diagnosed dyslipidemia patients during 2003 to 2012 from the National Health Insurance Service–Health Screening Cohort of South Korea. Newly diagnosed dyslipidemia patients were then detected for pre-existing depression within 3 years before dyslipidemia diagnosis. Starting from 2 years after the diagnosis date, patients were followed up for CVD until 2015. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated by Cox proportional hazards regression.

Results

Compared to dyslipidemia patients without depression, those with depression had higher risk for CVD (aHR, 1.24; 95% CI, 1.09 to 1.41). Similarly, pre-existing depression was associated with increased risk for stroke (aHR, 1.27; 95% CI, 1.06 to 1.53). The risk for CVD among depressed dyslipidemia patients for high (aHR, 1.42; 95% CI, 1.06 to 1.90), medium (aHR, 1.17; 95% CI, 0.91 to 1.52), and low (aHR, 1.25; 95% CI, 1.05 to 1.50) statin compliance patients tended to be increased compared to patients without pre-existing dyslipidemia. The risk-elevating effect of depression on CVD tended to be preserved regardless of subgroups of smoking, alcohol consumption, physical activity, and body mass index.

Conclusion

Dyslipidemia patients with pre-existing depression had increased risk for CVD. Future studies that determine CVD risk after management of depression among dyslipidemia patients are needed.

Citations

Citations to this article as recorded by  
  • Mediating effect of depression on the association between cardiovascular disease and the risk of all‐cause mortality: NHANES in 2005−2018
    Xinxin Ma, Huan Zhang, Yuan Tian, Yaping Wang, Ling Liu, Lei Wang
    Clinical Cardiology.2023; 46(11): 1380.     CrossRef
  • Associations of sleep duration, daytime napping, and snoring with depression in rural China: a cross-sectional study
    Xueyao Zhang, Guangxiao Li, Chuning Shi, Yingxian Sun
    BMC Public Health.2023;[Epub]     CrossRef
  • Association between socioeconomic inequality and the global prevalence of anxiety and depressive disorders: an ecological study
    Fatemeh Shahbazi, Marjan Shahbazi, Jalal Poorolajal
    General Psychiatry.2022; 35(3): e100735.     CrossRef
  • Impact of Alexithymia on the Lipid Profile in Major Depressed Individuals
    Camille Point, Benjamin Wacquier, Marjorie Dosogne, Mohammed Al Faker, Hadrien Willame, Gwenolé Loas, Matthieu Hein, Philip W. Wertz
    Journal of Lipids.2022; 2022: 1.     CrossRef
  • Association of Depression With Cardiovascular Diseases
    Zain I Warriach, Sruti Patel, Fatima Khan, Gerardo F Ferrer
    Cureus.2022;[Epub]     CrossRef
  • Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Metabolism.2022; 137: 155327.     CrossRef
  • Dyslipidemia prevalence and trends among adult mental disorder inpatients in Beijing, 2005–2018: A longitudinal observational study
    Fude Yang, Qiuyue Ma, Botao Ma, Wenzhan Jing, Jue Liu, Moning Guo, Juan Li, Zhiren Wang, Min Liu
    Asian Journal of Psychiatry.2021; 57: 102583.     CrossRef
  • Non-HDL cholesterol level and depression among Canadian elderly—a cross-sectional analysis of the baseline data from the CLSA
    Jian Liu, Surim Son, Mike Giancaterino, Chris P. Verschoor, Miya Narushima, David Moher
    FACETS.2020; 5(1): 1006.     CrossRef

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