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Cheol-Young Park  (Park CY) 28 Articles
Drug/Regimen
Safety and Effectiveness of Dulaglutide in the Treatment of Type 2 Diabetes Mellitus: A Korean Real-World Post-Marketing Study
Jeonghee Han, Woo Je Lee, Kyu Yeon Hur, Jae Hyoung Cho, Byung Wan Lee, Cheol-Young Park
Diabetes Metab J. 2024;48(3):418-428.   Published online February 2, 2024
DOI: https://doi.org/10.4093/dmj.2023.0030
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
To investigate the real-world safety and effectiveness of dulaglutide in Korean adults with type 2 diabetes mellitus (T2DM).
Methods
This was a real-world, prospective, non-interventional post-marketing safety study conducted from May 26, 2015 to May 25, 2021 at 85 Korean healthcare centers using electronic case data. Data on patients using dulaglutide 0.75 mg/0.5 mL or the dulaglutide 1.5 mg/0.5 mL single-use pens were collected and pooled. The primary objective was to report the frequency and proportion of adverse and serious adverse events that occurred. The secondary objective was to monitor the effectiveness of dulaglutide at 12 and 24 weeks by evaluating changes in glycosylated hemoglobin (HbA1c ), fasting plasma glucose, and body weight.
Results
Data were collected from 3,067 subjects, and 3,022 subjects who received ≥1 dose (of any strength) of dulaglutide were included in the safety analysis set (53% female, mean age 56 years; diabetes duration 11.2 years, mean HbA1c 8.8%). The number of adverse events reported was 819; of these, 68 (8.3%) were serious adverse events. One death was reported. Adverse events were mostly mild in severity; 60.81% of adverse events were considered related to dulaglutide. This study was completed by 72.73% (2,198/3,022) of subjects. At 12/24 weeks there were significant (P<0.0001) reductions from baseline in least-squares mean HbA1c (0.96%/0.95%), fasting blood glucose (26.24/24.43 mg/dL), and body weight (0.75/1.21 kg).
Conclusion
Dulaglutide was generally well tolerated and effective in real-world Korean individuals with T2DM. The results from this study contribute to the body of evidence for dulaglutide use in this population.
Drug Regimen
Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extension
Jun Sung Moon, Il Rae Park, Hae Jin Kim, Choon Hee Chung, Kyu Chang Won, Kyung Ah Han, Cheol-Young Park, Jong Chul Won, Dong Jun Kim, Gwan Pyo Koh, Eun Sook Kim, Jae Myung Yu, Eun-Gyoung Hong, Chang Beom Lee, Kun-Ho Yoon
Diabetes Metab J. 2023;47(6):808-817.   Published online September 26, 2023
DOI: https://doi.org/10.4093/dmj.2022.0387
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study investigates the long-term efficacy and safety of evogliptin add-on therapy in patients with inadequately controlled type 2 diabetes mellitus (T2DM) previously received dapagliflozin and metformin (DAPA/MET) combination.
Methods
In this multicenter randomized placebo-controlled phase 3 trial, patients with glycosylated hemoglobin (HbA1c) levels 7.0% to 10.5% (n=283) previously used DAPA 10 mg plus MET (≥1,000 mg) were randomly assigned to the evogliptin 5 mg once daily or placebo group (1:1). The primary endpoint was the difference in the HbA1c level from baseline at week 24, and exploratory endpoints included the efficacy and safety of evogliptin over 52 weeks (trial registration: ClinicalTrials.gov NCT04170998).
Results
Evogliptin add-on to DAPA/MET therapy was superior in HbA1c reduction compared to placebo at weeks 24 and 52 (least square [LS] mean difference, –0.65% and –0.55%; 95% confidence interval [CI], –0.79 to –0.51 and –0.71 to –0.39; P<0.0001). The proportion of patients achieving HbA1c <7% was higher in the triple combination group at week 52 (32.14% vs. 8.51% in placebo; odds ratio, 5.62; P<0.0001). Evogliptin significantly reduced the fasting glucose levels and mean daily glucose levels with improvement in homeostatic model assessment of β-cell function (LS mean difference, 9.04; 95% CI, 1.86 to 16.21; P=0.0138). Adverse events were similar between the groups, and no serious adverse drug reactions were reported in the evogliptin group.
Conclusion
Long-term triple combination with evogliptin added to DAPA/MET showed superior HbA1c reduction and glycemic control compared to placebo at 52 weeks and was well tolerated.
Guideline/Fact Sheet
Fatty Liver & Diabetes Statistics in Korea: Nationwide Data 2009 to 2017
Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park, on Behalf of Fatty Liver Research Group of the Korean Diabetes Association
Diabetes Metab J. 2023;47(3):347-355.   Published online March 29, 2023
DOI: https://doi.org/10.4093/dmj.2022.0444
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  • 6 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study investigated the changes of fatty liver disease prevalence in general Korean population.
Methods
This study analyzed data from the Korean National Health Insurance Service from 2009 to 2017 that included individuals aged 20 years or older who had undergone a medical health examination. Fatty liver disease was assessed using the fatty liver index (FLI). The disease severity was defined by FLI cutoff, ≥30 as moderate, and ≥60 as severe fatty liver disease.
Results
The prevalence of Korean adults aged 20 years or over with fatty liver disease (FLI ≥60) increased from 13.3% in 2009 to 15.5% in 2017 (P for trend <0.001). The increase in fatty liver disease prevalence was prominent in men (from 20.5% to 24.2%) and the young age (20 to 39 years) group (from 12.8% to 16.4%) (P for interaction <0.001). The prevalence of fatty liver disease was the highest in type 2 diabetes mellitus (T2DM, 29.6%) population compared to that of prediabetes or normoglycemia (10.0% and 21.8%) in 2017. The prevalence of fatty liver disease had statistically increased in individuals with T2DM and prediabetes (P for trend <0.001). Its prevalence increased more steeply in the young-aged population with T2DM, from 42.2% in 2009 to 60.1% in 2017. When applying a lower FLI cutoff (≥30) similar results were observed.
Conclusion
The prevalence of fatty liver disease in the Korean population has increased. Individuals who are young, male, and have T2DM are vulnerable to fatty liver disease.

Citations

Citations to this article as recorded by  
  • Longitudinal changes in fatty liver index are associated with risk of hepatocellular carcinoma: A nationwide cohort study in Korea
    Min Gu Kang, Chang Hun Lee, Chen Shen, Jong Seung Kim, Ji Hyun Park
    Journal of Hepatology.2024; 80(5): e216.     CrossRef
  • Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults
    Jin Hwa Kim, Young Sang Lyu, Mee Kyoung Kim, Sang Yong Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kyungdo Han, Hyuk‐Sang Kwon
    Diabetes, Obesity and Metabolism.2024; 26(1): 180.     CrossRef
  • Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study
    Eugene Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Yong-ho Lee, Seung Up Kim
    Metabolism.2024; 152: 155789.     CrossRef
  • Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    BMJ.2024; : e076388.     CrossRef
  • Hepatic Fibrosis and Cancer: The Silent Threats of Metabolic Syndrome
    Scott L. Friedman
    Diabetes & Metabolism Journal.2024; 48(2): 161.     CrossRef
  • Reply to G. Wang et al
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    Journal of Clinical Oncology.2023; 41(32): 5070.     CrossRef
  • The Role of the Fatty Liver Index (FLI) in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review
    Teodora Biciusca, Sorina Ionelia Stan, Mara Amalia Balteanu, Ramona Cioboata, Alice Elena Ghenea, Suzana Danoiu, Ana-Maria Bumbea, Viorel Biciusca
    Diagnostics.2023; 13(21): 3316.     CrossRef
  • Lean or Non-obese Nonalcoholic Fatty Liver Disease Patients: Are They Really Lean?
    Eugene Han, Yong-ho Lee
    Clinical and Molecular Hepatology.2023; 29(4): 980.     CrossRef
  • Approach to Fatty Liver Disease in Patients with Type 2 Diabetes
    Ji Cheol Bae
    The Journal of Korean Diabetes.2023; 24(3): 107.     CrossRef
Metabolic Risk/Epidemiology
Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study
Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
Diabetes Metab J. 2023;47(2):220-231.   Published online January 12, 2023
DOI: https://doi.org/10.4093/dmj.2021.0327
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  • 285 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We investigated whether metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with an elevated risk of all-cause and cardiovascular mortality using a large-scale health examination cohort.
Methods
A total of 394,835 subjects in the Kangbuk Samsung Health Study cohort were enrolled from 2002 to 2012. Participants were categorized by the presence of nonalcoholic fatty liver disease (NAFLD) and MAFLD as follows: normal subjects; patients with both NAFLD and MAFLD; patients with NAFLD only; and patients with MAFLD only. Cox proportional hazards models were used to analyze the risk of mortality.
Results
During a median 5.7 years of follow-up, 20.69% was patients with both NAFLD and MAFLD, 1.51% was patients with NAFLD only, and 4.29% was patients with MAFLD only. All-cause and cardiovascular death was higher in patients with MAFLD than those without MAFLD (P<0.001, respectively). In patients with MAFLD only, the hazard ratio (HR) of all-cause and cardiovascular death was 1.35 (95% confidence interval [CI], 1.13 to 1.60) and 1.90 (95% CI, 1.26 to 2.88) after adjusting for age, which lost its statistical significance by multivariable adjustments. Compared to patients with less than two components of metabolic dysfunction, patients with more than two components of metabolic dysfunction were a higher risk of cardiovascular death (HR, 2.05; 95% CI, 1.25 to 3.38) and only women with more than two components of metabolic dysfunction were a higher risk of all-cause death (HR, 1.44; 95% CI, 1.02 to 2.03).
Conclusion
MAFLD criteria could identify a high-risk group for all-cause and cardiovascular death.

Citations

Citations to this article as recorded by  
  • Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study
    Eugene Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Sang Hoon Ahn, Yong-ho Lee, Seung Up Kim
    Metabolism.2024; 152: 155789.     CrossRef
  • Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    BMJ.2024; : e076388.     CrossRef
  • Sex differences in mortality and liver‐related events in non‐alcoholic fatty liver disease: A systematic review and meta‐analysis
    Huimin Zhou, Haiyan Chen, Hanxiao Lu, Bo Wu, Shuo Zhang, Yuanlong Gu, Guangwen Zhou, Jie Xiang, Jun Yang
    Liver International.2024;[Epub]     CrossRef
  • Association between dietary carbohydrate to fiber ratio and metabolic dysfunction associated fatty liver disease in adults: evidence from the NHANES 2017–2020
    Zhenmin Liu, Taiyong Fang
    Journal of Health, Population and Nutrition.2024;[Epub]     CrossRef
  • Comparison of Outcomes Between Metabolic Dysfunction-Associated Fatty Liver Disease and Non-alcoholic Fatty Liver Disease: A Meta-Analysis
    Ghazala S Virk, Jaahnavi Vajje, Nausheen K Virk, Raam Mannam, Wajeeh Rehman, Naglaa G Ghobriel , Irfan-ud-din Mian, Muhammad Usama
    Cureus.2023;[Epub]     CrossRef
  • Trends in prevalence and all-cause mortality of metabolic dysfunction-associated fatty liver disease among adults in the past three decades: Results from the NHANES study
    Zhi-Qin Xie, Hong-Xia Li, Bing-Kun Wang, Zhao-Ming Yang, Zi-Yu Zhang, Wen-Liang Tan, Wen-Xin Li, Qing-Bin Wang, Lei Yang, Hong-Kai Zhuang, Chen-Wei Tang, Chang-Zhen Shang, Ya-Jin Chen
    European Journal of Internal Medicine.2023; 110: 62.     CrossRef
  • Comparing the Mortality Risk between Metabolic Dysfunction-Associated Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease
    Han Na Jung, Chang Hee Jung
    Diabetes & Metabolism Journal.2023; 47(2): 198.     CrossRef
  • Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis
    Hye Jin Chun, Eun Ran Kim, Minyoung Lee, Da Hyun Choi, Soo Hyun Kim, Eugene Shin, Jin-Hong Kim, Jin Won Cho, Dai Hoon Han, Bong-Soo Cha, Yong-ho Lee
    Metabolism.2023; 145: 155612.     CrossRef
  • Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes
    Karl Vaz, Daniel Clayton-Chubb, Ammar Majeed, John Lubel, David Simmons, William Kemp, Stuart K. Roberts
    Hepatology International.2023; 17(5): 1082.     CrossRef
  • Mitochondrial Quality Control: Its Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
    Soyeon Shin, Jaeyoung Kim, Ju Yeon Lee, Jun Kim, Chang-Myung Oh
    Journal of Obesity & Metabolic Syndrome.2023; 32(4): 289.     CrossRef
Drug/Regimen
A Real-World Study of Long-Term Safety and Efficacy of Lobeglitazone in Korean Patients with Type 2 Diabetes Mellitus
Bo-Yeon Kim, Hyuk-Sang Kwon, Suk Kyeong Kim, Jung-Hyun Noh, Cheol-Young Park, Hyeong-Kyu Park, Kee-Ho Song, Jong Chul Won, Jae Myung Yu, Mi Young Lee, Jae Hyuk Lee, Soo Lim, Sung Wan Chun, In-Kyung Jeong, Choon Hee Chung, Seung Jin Han, Hee-Seok Kim, Ju-Young Min, Sungrae Kim
Diabetes Metab J. 2022;46(6):855-865.   Published online March 8, 2022
DOI: https://doi.org/10.4093/dmj.2021.0264
  • 6,923 View
  • 298 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   
Background
Thiazolidinediones (TZDs) have been associated with various safety concerns including weight gain, bladder cancer, and congestive heart failure (CHF). This study evaluated the efficacy and safety of lobeglitazone, a novel TZD in patients with type 2 diabetes mellitus (T2DM) in real practice.
Methods
In this non-interventional, multi-center, retrospective, and observational study conducted at 15 tertiary or secondary referral hospitals in Korea, a total of 2,228 patients with T2DM who received lobeglitazone 0.5 mg for more than 1 year were enrolled.
Results
Overall adverse events (AEs) occurred in 381 patients (17.10%) including edema in 1.97% (n=44). Cerebrovascular and cardiovascular diseases were identified in 0.81% (n=18) and 0.81% (n=18), respectively. One case of CHF was reported as an AE. Edema occurred in 1.97% (n=44) of patients. Hypoglycemia occurred in 2.47% (n=55) of patients. Fracture occurred in 1.17% (n=26) of all patients. Lobeglitazone significantly decreased HbA1c level, resulting in a mean treatment difference of -1.05%± 1.35% (P<0.001), and decreased total cholesterol, triglyceride, and low-density lipoprotein cholesterol. However, it increased high-density lipoprotein cholesterol, regardless of statin administration. The patients who received lobeglitazone 0.5 mg showed an apparent reduction in glycosylated hemoglobin (HbA1c) from baseline during the first 6 months of treatment. The HbA1c levels remained stable between months 6 and 42.
Conclusion
Lobeglitazone has long-term safety profile, good glycemic-lowering effect and long-term durability of glycemic control in real-world clinical settings.

Citations

Citations to this article as recorded by  
  • Efficacy and safety of novel thiazolidinedione lobeglitazone for managing type-2 diabetes a meta-analysis
    Deep Dutta, Saptarshi Bhattacharya, Manoj Kumar, Priyankar K. Datta, Ritin Mohindra, Meha Sharma
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102697.     CrossRef
  • Efficacy and safety of lobeglitazone, a new Thiazolidinedione, as compared to the standard of care in type 2 diabetes mellitus: A systematic review and meta-analysis
    Shashank R. Joshi, Saibal Das, Suja Xaviar, Shambo Samrat Samajdar, Indranil Saha, Sougata Sarkar, Shatavisa Mukherjee, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102703.     CrossRef
  • Will lobeglitazone rival pioglitazone? A systematic review and critical appraisal
    Kalyan Kumar Gangopadhyay, Awadhesh Kumar Singh
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(4): 102747.     CrossRef
  • Lobeglitazone

    Reactions Weekly.2023; 1948(1): 262.     CrossRef
  • Lobeglitazone, a novel thiazolidinedione, for secondary prevention in patients with ischemic stroke: a nationwide nested case-control study
    Joonsang Yoo, Jimin Jeon, Minyoul Baik, Jinkwon Kim
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Lobeglitazone and Its Therapeutic Benefits: A Review
    Balamurugan M, Sarumathy S, Robinson R
    Cureus.2023;[Epub]     CrossRef
  • Oldies but Goodies: Thiazolidinedione as an Insulin Sensitizer with Cardioprotection
    Eun-Hee Cho
    Diabetes & Metabolism Journal.2022; 46(6): 827.     CrossRef
Metabolic Risk/Epidemiology
Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sungrae Kim
Diabetes Metab J. 2022;46(3):464-475.   Published online March 3, 2022
DOI: https://doi.org/10.4093/dmj.2021.0088
  • 7,256 View
  • 351 Download
  • 4 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We evaluated the achievement of low-density lipoprotein cholesterol (LDL-C) targets in patients with type 2 diabetes mellitus (T2DM) according to up-to-date Korean Diabetes Association (KDA), European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS), and American Diabetes Association (ADA) guidelines.
Methods
This retrospective cohort study collected electronic medical record data from patients with T2DM (≥20 years) managed by endocrinologists from 15 hospitals in Korea (January to December 2019). Patients were categorized according to guidelines to assess LDL-C target achievement. KDA (2019): Very High-I (atherosclerotic cardiovascular disease [ASCVD]) <70 mg/dL; Very High-II (target organ damage [TOD], or cardiovascular risk factors [CVRFs]) <70 mg/dL; high (others) <100 mg/dL. ESC/EAS (2019): Very High-I (ASCVD): <55 mg/dL; Very High-II (TOD or ≥3-CVRF) <55 mg/dL; high (diabetes ≥10 years without TOD plus any CVRF) <70 mg/dL; moderate (diabetes <10 years without CVRF) <100 mg/dL. ADA (2019): Very High-I (ASCVD); Very High-II (age ≥40+ TOD, or any CVRF), for high intensity statin or statin combined with ezetimibe.
Results
Among 2,000 T2DM patients (mean age 62.6 years; male 55.9%; mean glycosylated hemoglobin 7.2%) ASCVD prevalence was 24.7%. Of 1,455 (72.8%) patients treated with statins, 73.9% received monotherapy. According to KDA guidelines, LDL-C target achievement rates were 55.2% in Very High-I and 34.9% in Very High-II patients. With ESC/EAS guidelines, target attainment rates were 26.6% in Very High-I, 15.7% in Very High-II, and 25.9% in high risk patients. Based on ADA guidelines, most patients (78.9%) were very-high risk; however, only 15.5% received high-intensity statin or combination therapy.
Conclusion
According to current dyslipidemia management guidelines, LDL-C goal achievement remains suboptimal in Korean patients with T2DM.

Citations

Citations to this article as recorded by  
  • Risk factor control and cardiovascular events in patients with type 2 diabetes mellitus
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee, Hidetaka Hamasaki
    PLOS ONE.2024; 19(2): e0299035.     CrossRef
  • Distinct effects of rosuvastatin and rosuvastatin/ezetimibe on senescence markers of CD8+ T cells in patients with type 2 diabetes mellitus: a randomized controlled trial
    Sang-Hyeon Ju, Joung Youl Lim, Minchul Song, Ji Min Kim, Yea Eun Kang, Hyon-Seung Yi, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Monitoring Global Progress in Core Diabetes Control Metrics: Protocol for a Systematic Review of Prevalence (2015–2023)
    John McCaffrey, Samira Barbara Jabakhanji, Roopa Mehta, Steven James, Maisoon Mairghani, Dominika Bhatia, Hazel Ní Chonchubhair, Killian Walsh, Barbara Clyne, Edward W. Gregg
    HRB Open Research.2024; 7: 27.     CrossRef
  • Lipid Management in Korean People With Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
    Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
    Journal of Lipid and Atherosclerosis.2023; 12(1): 12.     CrossRef
  • Lipid Management in Korean People with Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
    Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
    Diabetes & Metabolism Journal.2023; 47(1): 1.     CrossRef
  • Management of Dyslipidemia in Patients with Diabetes Mellitus
    Kyung Ae Lee
    The Journal of Korean Diabetes.2023; 24(3): 111.     CrossRef
  • Association between carotid atherosclerosis and presence of intracranial atherosclerosis using three-dimensional high-resolution vessel wall magnetic resonance imaging in asymptomatic patients with type 2 diabetes
    Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, Geon-Ho Jahng, Soonchan Park, In-Kyung Jeong, Chang-Woo Ryu
    Diabetes Research and Clinical Practice.2022; 191: 110067.     CrossRef
Drug/Regimen
Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors
Sangmo Hong, Chang Hee Jung, Song Han, Cheol-Young Park
Diabetes Metab J. 2022;46(1):63-70.   Published online April 19, 2021
DOI: https://doi.org/10.4093/dmj.2020.0253
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Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
It is not known which type 2 diabetes mellitus (T2DM) patients would most benefit from dipeptidyl peptidase-4 (DPP-4) inhibitor treatment. We aimed to investigate the predictors of response to DPP-4 inhibitors considering degree of DPP-4 inhibition.
Methods
This study is a post hoc analysis of a 24-week, randomized, double-blind, phase III trial that compared the efficacy and safety of a DPP-4 inhibitor (gemigliptin vs. sitagliptin) in patients with T2DM. Subjects were classified into tertiles of T1 <65.26%, T2=65.26%–76.35%, and T3 ≥76.35% by DPP-4 inhibition. We analyzed the change from baseline in glycosylated hemoglobin (HbA1c) according to DPP-4 inhibition with multiple linear regression adjusting for age, ethnicity, body mass index, baseline HbA1c, and DPP-4 activity at baseline.
Results
The mean age was greater in the high tertile group compared with the low tertile group (T1: 49.8±8.3 vs. T2: 53.1±10.5 vs. T3: 55.3±9.5, P<0.001) of DPP-4 inhibition. Although HbA1c at baseline was not different among tertiles of DPP-4 inhibition (P=0.398), HbA1c after 24-week treatment was lower in the higher tertile compares to the lower tertile (T1: 7.30%±0.88% vs. T2: 7.12%±0.78% vs. T3: 7.00%±0.78%, P=0.021). In multiple regression analysis, DPP-4 enzyme inhibition rate was not a significant determent for HbA1c reduction due to age. In subgroup analysis by tertile of DPP-4 inhibition, age was the only significant predictor and only in the highest tertile (R2=0.281, B=–0.014, P=0.024).
Conclusion
This study showed that HbA1c reduction by DPP-4 inhibitor was associated with increasing age, and this association was linked with higher DPP-4 inhibition.
Technology/Device
Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
Sun Joon Moon, Inha Jung, Cheol-Young Park
Diabetes Metab J. 2021;45(6):813-839.   Published online November 22, 2021
DOI: https://doi.org/10.4093/dmj.2021.0177
  • 14,854 View
  • 818 Download
  • 31 Web of Science
  • 31 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Since Banting and Best isolated insulin in the 1920s, dramatic progress has been made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely injection to maintain optimal glycemic control are often challenging for T1DM patients and their families because they require frequent blood glucose checks. In recent years, technological advances in insulin pumps and continuous glucose monitoring systems have created paradigm shifts in T1DM care that are being extended to develop artificial pancreas systems (APSs). Numerous studies that demonstrate the superiority of glycemic control offered by APSs over those offered by conventional treatment are still being published, and rapid commercialization and use in actual practice have already begun. Given this rapid development, keeping up with the latest knowledge in an organized way is confusing for both patients and medical staff. Herein, we explore the history, clinical evidence, and current state of APSs, focusing on various development groups and the commercialization status. We also discuss APS development in groups outside the usual T1DM patients and the administration of adjunct agents, such as amylin analogues, in APSs.

Citations

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  • Integration of a Safety Module to Prevent Rebound Hypoglycemia in Closed-Loop Artificial Pancreas Systems
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    Martin Dodek, Eva Miklovičová
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Guideline/Fact Sheet
Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee, Korean Diabetes Association (KDA) Fatty Liver Research Group
Diabetes Metab J. 2020;44(3):382-401.   Published online May 11, 2020
DOI: https://doi.org/10.4093/dmj.2020.0010
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AbstractAbstract PDFPubReader   

This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic complications compared to those without NAFLD. With regards to the evaluation of patients with T2DM and NAFLD, ultrasonography-based stepwise approaches using noninvasive biomarker models such as fibrosis-4 or the NAFLD fibrosis score as well as imaging studies such as vibration-controlled transient elastography with controlled attenuation parameter or magnetic resonance imaging-proton density fat fraction are recommended. After the diagnosis of NAFLD, the stage of fibrosis needs to be assessed appropriately. For management, weight reduction achieved by lifestyle modification has proven beneficial and is recommended in combination with antidiabetic agent(s). Evidence that some antidiabetic agents improve NAFLD/NASH with fibrosis in patients with T2DM is emerging. However, there are currently no definite pharmacologic treatments for NAFLD in patients with T2DM. For specific cases, bariatric surgery may be an option if indicated.

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Corrigenda: Table Correction. Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee
Diabetes Metab J. 2019;43(5):731-731.   Published online October 24, 2019
DOI: https://doi.org/10.4093/dmj.2019.0188
Corrects: Diabetes Metab J 2019;43(1):31
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PDFPubReader   

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  • Association of statins with nonalcoholic fatty liver disease in patients with diabetes
    Raj Shah, Alexander Kong, Silvio De Melo, Moheb Boktor, Richard Henriquez, Amar Mandalia, Hrishikesh Samant, Carlos A. Alvarez, Ishak A. Mansi
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Clinical Diabetes & Therapeutics
Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment
Kyung-Soo Kim, Byung-Wan Lee, Yong Jin Kim, Dae Ho Lee, Bong-Soo Cha, Cheol-Young Park
Diabetes Metab J. 2019;43(2):127-143.   Published online April 15, 2019
DOI: https://doi.org/10.4093/dmj.2019.0034
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AbstractAbstract PDFPubReader   

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders that are often comorbid conditions. Among many proposed treatments, weight reduction is the only approved option for NAFLD to date. However, it is not easy to maintain weight loss by lifestyle modification alone; pharmacological treatments are helpful in this regard. Although many drugs have been investigated, pioglitazone could be a first-line therapy in patients with NAFLD and diabetes. Many more drugs are currently being developed and investigated, and it is likely that combination strategies will be used for future treatment of NAFLD and diabetes. Attention should be paid to the management of NAFLD and diabetes and efforts should be made to intervene early and individualize treatment of NAFLD in patients with diabetes.

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Complications
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee
Diabetes Metab J. 2019;43(1):31-45.   Published online December 17, 2018
DOI: https://doi.org/10.4093/dmj.2019.0011
Correction in: Diabetes Metab J 2019;43(5):731
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AbstractAbstract PDFPubReader   

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.

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Clinical Diabetes & Therapeutics
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes Metab J. 2018;42(2):93-100.   Published online April 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.93
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AbstractAbstract PDFPubReader   

Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide. On June 9, 2014, the NHIS signed a memorandum of understanding with the Korean Diabetes Association (KDA) to provide limited open access to its DB. By October 31, 2017, seven papers had been published through this collaborative research project. These studies were conducted to investigate the past and current status of type 2 diabetes mellitus and its complications and management in Korea. This review is a brief summary of the collaborative projects between the KDA and the NHIS over the last 3 years. According to the analysis, the national health check-up DB or claim DB were used, and the age category or study period were differentially applied.

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Clinical Care/Education
Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus
Sung-Ho Kim, Jung-Hwa Yoo, Woo Je Lee, Cheol-Young Park
Diabetes Metab J. 2016;40(5):339-353.   Published online September 12, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.339
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AbstractAbstract PDFPubReader   

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agent for the treatment of type 2 diabetes mellitus. They increase endogenous levels of incretin hormones, which stimulate glucose-dependent insulin secretion, decrease glucagon secretion, and contribute to reducing postprandial hyperglycemia. Although DPP-4 inhibitors have similar benefits, they can be differentiated in terms of their chemical structure, pharmacology, efficacy and safety profiles, and clinical considerations. Gemigliptin (brand name: Zemiglo), developed by LG Life Sciences, is a potent, selective, competitive, and long acting DPP-4 inhibitor. Various studies have shown that gemigliptin is an optimized DPP-4 inhibitor in terms of efficacy, safety, and patient compliance for treatment of type 2 diabetes mellitus. In this review, we summarize the characteristics of gemigliptin and discuss its potential benefits in clinical practice.

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Others
A Potential Issue with Screening Prediabetes or Diabetes Using Serum Glucose: A Delay in Diagnosis
Jun Goo Kang, Cheol-Young Park, Sung-Hee Ihm, Sung Woo Park
Diabetes Metab J. 2016;40(5):414-417.   Published online September 1, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.414
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AbstractAbstract PDFPubReader   

The aim of this study was to compare the fasting serum glucose level with the fasting plasma glucose level for diagnosing hyperglycemic states in real-life clinical situations. Additionally, we investigated a usual delay in sample processing and how such delays can impact the diagnosis of hyperglycemic states. Among 1,254 participants who had normoglycemia or impaired fasting glucose (IFG) assessed by the fasting serum glucose level, 20.9% were newly diagnosed with diabetes based on the plasma fasting glucose level. Of the participants with normoglycemia, 62.1% and 14.2% were newly diagnosed with IFG and diabetes, respectively, according to the plasma fasting glucose level. In our clinical laboratory for performing health examinations, the time delay from blood sampling to glycemic testing averaged 78±52 minutes. These findings show that the ordinary time delay for sample processing of the serum glucose for screening hyperglycemic states may be an important reason for these diagnoses to be underestimated in Korea.

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Comparison of the Usefulness of the Updated Homeostasis Model Assessment (HOMA2) with the Original HOMA1 in the Prediction of Type 2 Diabetes Mellitus in Koreans
Young Seok Song, You-Cheol Hwang, Hong-Yup Ahn, Cheol-Young Park
Diabetes Metab J. 2016;40(4):318-325.   Published online May 27, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.4.318
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AbstractAbstract PDFPubReader   
Background

The original homeostasis model assessment (HOMA1) and the updated HOMA model (HOMA2) have been used to evaluate insulin resistance (IR) and β-cell function, but little is known about the usefulness of HOMA2 for the prediction of diabetes in Koreans. The aim of this study was to demonstrate the usefulness of HOMA2 as a predictor of type 2 diabetes mellitus in Koreans without diabetes.

Methods

The study population consisted of 104,694 Koreans enrolled at a health checkup program and followed up from 2001 to 2012. Participants were divided into a normal glucose tolerance (NGT) group and a pre-diabetes group according to fasting glucose and glycosylated hemoglobin levels. Anthropometric and laboratory data were measured at the baseline checkup, and HOMA values were calculated at the baseline and follow-up checkups. The hazard ratios (HRs) of the HOMA1 and HOMA2 values and the prevalence of diabetes at follow-up were evaluated using a multivariable Cox proportional hazards model and Kaplan-Meier analysis.

Results

After adjusting for several diabetes risk factors, all of the HOMA values except 1/HOMA1-β and 1/HOMA2-β in the NGT group were significant predictors of the progression to diabetes. In the NGT group, there was no significant difference in HOMA1-IR (HR, 1.09; 95% confidence interval [CI], 1.04 to 1.14) and HOMA2-IR (HR, 1.11; 95% CI, 1.04 to 1.19). However, in the pre-diabetes group, 1/HOMA2-β was a more powerful marker (HR, 1.29; 95% CI, 1.26 to 1.31) than HOMA1-IR (HR, 1.23; 95% CI, 1.19 to 1.28) or 1/HOMA1-β (HR, 1.14; 95% CI, 1.12 to 1.16). In the non-diabetic group (NGT+pre-diabetes), 1/HOMA2-β was also a stronger predictor of diabetes (HR, 1.27; 95% CI, 1.25 to 1.29) than HOMA1-IR (HR, 1.14; 95% CI, 1.12 to 1.15) or 1/HOMA1-β (HR, 1.13; 95% CI, 1.11 to 1.14).

Conclusion

HOMA2 is more predictive than HOMA1 for the progression to diabetes in pre-diabetes or non-diabetic Koreans.

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Epidemiology
Glycosylated Hemoglobin Threshold for Predicting Diabetes and Prediabetes from the Fifth Korea National Health and Nutrition Examination Survey
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Cheol-Young Park, Chang Beom Lee, Sung-Hee Ihm
Diabetes Metab J. 2016;40(2):167-170.   Published online April 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.2.167
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AbstractAbstract PDFPubReader   

We aimed to estimate the threshold level of glycosylated hemoglobin (HbA1c) for the fasting plasma glucose of 100 and 126 mg/dL in the Korean adult population, using the 2011 Korea National Health and Nutrition Examination Survey. A total of 4,481 participants over 19 years of age without diabetic medications and conditions to influence the interpretation of HbA1c levels, such as anemia, renal insufficiency, liver cirrhosis, and cancers, were analyzed. A point-wise area under the receiver operating characteristic curve was used to estimate the optimal HbA1c cutoff value. A HbA1c threshold of 6.35% was optimal for predicting diabetes with a sensitivity of 86.9% and a specificity of 99.1%. Furthermore, the threshold of HbA1c was 5.65% for prediabetes, with a sensitivity of 69.3% and a specificity of 71%. Further prospective studies are needed to evaluate the HbA1c cutoff point for diagnosing prediabetes and diabetes in the Korean population.

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  • The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose
    Seyoung Kwon, Youngak Na
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Epidemiology
Changing Clinical Characteristics according to Insulin Resistance and Insulin Secretion in Newly Diagnosed Type 2 Diabetic Patients in Korea
Jang Won Son, Cheol-Young Park, Sungrae Kim, Han-Kyu Lee, Yil-Seob Lee
Diabetes Metab J. 2015;39(5):387-394.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.387
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AbstractAbstract PDFPubReader   
Background

The role of increased insulin resistance in the pathogenesis of type 2 diabetes has been emphasized in Asian populations. Thus, we evaluated the proportion of insulin resistance and the insulin secretory capacity in patients with early phase type 2 diabetes in Korea.

Methods

We performed a cross-sectional analysis of 1,314 drug-naive patients with newly diagnosed diabetes from primary care clinics nationwide. The homeostasis model assessment of insulin resistance (HOMA-IR) was used as an index to measure insulin resistance, which was defined as a HOMA-IR ≥2.5. Insulin secretory defects were classified based on fasting plasma C-peptide levels: severe (<1.1 ng/mL), moderate (1.1 to 1.7 ng/mL) and mild to non-insulin secretory defect (≥1.7 ng/mL).

Results

The mean body mass index (BMI) was 25.2 kg/m2; 77% of patients had BMIs >23.0 kg/m2. Up to 50% of patients had central obesity based on their waist circumference (≥90 cm in men and 85 cm in women), and 70.6% had metabolic syndrome. Overall, 59.5% of subjects had insulin resistance, and 20.2% demonstrated a moderate to severe insulin secretory defect. Among those with insulin resistance, a high proportion of subjects (79.0%) had a mild or no insulin secretory defect. Only 2.6% of the men and 1.9% of the women had both insulin resistance and a moderate to severe insulin secretory defect.

Conclusion

In this study, patients with early phase type 2 diabetes demonstrated increased insulin resistance, but preserved insulin secretion, with a high prevalence of obesity and metabolic syndrome.

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Maximal Fat Oxidation Rate during Exercise in Korean Women with Type 2 Diabetes Mellitus
Min Hwa Suk, Yeo-Jin Moon, Sung Woo Park, Cheol-Young Park, Yun A Shin
Diabetes Metab J. 2015;39(4):328-334.   Published online July 8, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.4.328
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AbstractAbstract PDFPubReader   
Background

The purpose of this study was to determine the appropriate exercise intensity associated with maximum fat oxidation, improvement of body composition, and metabolic status in Korean women with type 2 diabetes mellitus (T2DM).

Methods

The study included a T2DM group (12 women) and a control group (12 women). The groups were matched in age and body mass index. The subjects performed a graded exercise test on a cycle ergometer to measure their maximal fat oxidation (Fatmax). We also measured their body composition, metabolic profiles, and mitochondrial DNA (mtDNA).

Results

The exercise intensity for Fatmax was significantly lower in the T2DM group (34.19% maximal oxygen uptake [VO2 max]) than the control group (51.80% VO2 max). Additionally, the rate of fat oxidation during exercise (P<0.05) and mtDNA (P<0.05) were significantly lower in the T2DM group than the control group. The VO2 max level (P<0.001) and the insulin level (P<0.05) were positively correlated with the rate of fat oxidation.

Conclusion

The results of this study suggest lower exercise intensity that achieves Fatmax is recommended for improving fat oxidation and enhancing fitness levels in Korean women with T2DM. Our data could be useful when considering an exercise regimen to improve health and fitness.

Citations

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Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System
Sun Ok Song, Chang Hee Jung, Young Duk Song, Cheol-Young Park, Hyuk-Sang Kwon, Bong Soo Cha, Joong-Yeol Park, Ki-Up Lee, Kyung Soo Ko, Byung-Wan Lee
Diabetes Metab J. 2014;38(5):395-403.   Published online October 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.5.395
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AbstractAbstract PDFPubReader   
Background

The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access to the databases within the Korean Diabetes Association for the benefit of Korean subjects with diabetes. Here, we present the history, structure, contents, and way to use data procurement in the Korean National Health Insurance (NHI) system for the benefit of Korean researchers.

Methods

The NHIS in Korea is a single-payer program and is mandatory for all residents in Korea. The three main healthcare programs of the NHI, Medical Aid, and long-term care insurance (LTCI) provide 100% coverage for the Korean population. The NHIS in Korea has adopted a fee-for-service system to pay health providers. Researchers can obtain health information from the four databases of the insured that contain data on health insurance claims, health check-ups and LTCI.

Results

Metabolic disease as chronic disease is increasing with aging society. NHIS data is based on mandatory, serial population data, so, this might show the time course of disease and predict some disease progress, and also be used in primary and secondary prevention of disease after data mining.

Conclusion

The NHIS database represents the entire Korean population and can be used as a population-based database. The integrated information technology of the NHIS database makes it a world-leading population-based epidemiology and disease research platform.

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    Clinical Epidemiology.2023; Volume 15: 535.     CrossRef
  • Association of Waist Circumference with the Risk of Inflammatory Bowel Disease: a Nationwide Cohort Study of 10 Million Individuals in Korea
    Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
    Journal of Crohn's and Colitis.2023; 17(5): 681.     CrossRef
  • Lifestyle factors and long-term survival in patients with chronic non-cancer pain: a nationwide cohort study in South Korea
    Tak Kyu Oh, In-Ae Song
    Journal of Anesthesia.2023; 37(4): 522.     CrossRef
  • Long term renal outcome after hypertensive disease during pregnancy: a nationwide population-based study
    Kwang Hyun Lee, Ji Hye Bae, Jeesun Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Geum Joon Cho, Seung Mi Lee
    Obstetrics & Gynecology Science.2023; 66(3): 190.     CrossRef
  • Lower risk of depression after smoking cessation and alcohol abstinence in patients with gastric cancer who underwent gastrectomy: A population‐based, nationwide cohort study
    Bokyung Kim, Kyungdo Han, Hyunsoo Chung, Sang Gyun Kim, Soo‐Jeong Cho
    Cancer.2023; 129(18): 2893.     CrossRef
  • Acute Pancreatitis and the Risk of Dementia in Diabetes: A Nationwide Cohort Study Using Korean Healthcare Claims Database
    Woo Hyun Paik, Dong Kee Jang, Soyoung Cho, Jin Ho Choi, Min Kyu Kim, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Kyung-Do Han, Sang Hyub Lee
    Journal of Alzheimer's Disease.2023; 94(1): 205.     CrossRef
  • Application of big data in ophthalmology
    ZhiDa Soh, Ching-Yu Cheng
    Taiwan Journal of Ophthalmology.2023; 13(2): 123.     CrossRef
  • Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study
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  • Evaluating Reference Ages for Selecting Prosthesis Types for Heart Valve Replacement in Korea
    Sung Jun Park, You Jung Ok, Ho Jin Kim, Ye-Jee Kim, Seonok Kim, Jung-Min Ahn, Dae-Hee Kim, Jae-Sung Choi, Joon Bum Kim
    JAMA Network Open.2023; 6(5): e2314671.     CrossRef
  • Higher Non-High-Density Lipoprotein Cholesterol Was Higher Associated With Cardiovascular Disease Comparing Higher LDL-C in Nine Years Follow Up: Cohort Study
    Sangmo Hong, Kyungdo Han, Jung Hwan Park, Sung Hoon Yu, Chang Beom Lee, Dong Sun Kim
    Journal of Lipid and Atherosclerosis.2023; 12(2): 164.     CrossRef
  • Impact of Allergic Disease on the Risk of Mycobacterial Disease
    Taehee Kim, Hayoung Choi, Hyun Lee, Kyungdo Han, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
    The Journal of Allergy and Clinical Immunology: In Practice.2023; 11(9): 2830.     CrossRef
  • Trends in the Prevalence of Blindness and Correlation With Health Status in Korean Adults: A 10-Year Nationwide Population-Based Study
    Kyeong Ik Na, Won June Lee, Young Kook Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Association between regular physical activity and lower incidence of colorectal cancer in patients with diabetes mellitus: a nationwide cohort study
    Han Hee Lee, Kyu‐na Lee, Jin Su Kim, Dae Young Cheung, Hyuk‐Sang Kwon, Bo‐In Lee, Young‐Seok Cho, Soo‐Heon Park, Kyungdo Han, Jin Il Kim
    Colorectal Disease.2023; 25(8): 1588.     CrossRef
  • Bovine pericardial versus porcine bioprosthetic mitral valves: results from a Korean Nationwide Cohort Study
    Hong Rae Kim, Jino Park, Sung Jun Park, Ho Jin Kim, Seonok Kim, Ye-Jee Kim, Jung-Min Ahn, Dae-Hee Kim, Joon Bum Kim
    European Journal of Cardio-Thoracic Surgery.2023;[Epub]     CrossRef
  • Examining the factors associated with inpatients’ perception of overtreatment in Korea: a cross-sectional study
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  • Long-term clinical outcomes of tricuspid valve replacement using bovine versus porcine valves: a nationwide population-based study
    Suk Ho Sohn, Yoonjin Kang, Ji Seong Kim, Ho Young Hwang, Kyung Hwan Kim, Jae Woong Choi
    European Journal of Cardio-Thoracic Surgery.2023;[Epub]     CrossRef
  • Association of physical activity with total and cause-specific mortality in patients with diabetes: A nationwide population-based cohort study
    Inha Jung, Kyung-Do Han, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Diabetes Research and Clinical Practice.2023; 202: 110819.     CrossRef
  • The Association Between Institutional Case Volume of Hematopoietic Stem Cell Transplantation and Mortality
    Leerang Lim, Eun Jin Jang, Jun Woo Jo, Junghoon Shin, Hyobin Lee, Hannah Lee, Seung-Young Oh, Hyunjae Im, Ho Geol Ryu
    Transplantation Proceedings.2023; 55(7): 1715.     CrossRef
  • Association between periodontal disease status and risk of atrial fibrillation: a nationwide population-based cohort study
    Jung-Hyun Park, Hyungwoo Lee, Jin-Woo Kim, Tae-Jin Song
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  • Trends in the incidence and prevalence of dysphagia requiring medical attention among adults in South Korea, 2006–2016: A nationwide population study
    SuYeon Kwon, Seungwoo Cha, Junsik Kim, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim, Sina Azadnajafabad
    PLOS ONE.2023; 18(6): e0287512.     CrossRef
  • Socioeconomic Disparities in the Association Between All-Cause Mortality and Health Check-Up Participation Among Healthy Middle-Aged Workers: A Nationwide Study
    Byungyoon Yun, Juyeon Oh, Jaesung Choi, Laura S. Rozek, Heejoo Park, Juho Sim, Yangwook Kim, Jongmin Lee, Jin-Ha Yoon
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Association between smoking status and death from COVID-19 in South Korea: A nationwide cohort study
    Jae Woo Choi
    Tobacco Induced Diseases.2023; 21(July): 1.     CrossRef
  • A cohort study found a high risk of end-stage kidney disease associated with acromegaly
    Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
    Kidney International.2023; 104(4): 820.     CrossRef
  • Comparative cardiovascular outcomes in type 2 diabetes patients taking dapagliflozin versus empagliflozin: a nationwide population-based cohort study
    Jaehyun Lim, You-Jung Choi, Bong Sung Kim, Tae-Min Rhee, Hyun-Jung Lee, Kyung-Do Han, Jun-Bean Park, Jin Oh Na, Yong-Jin Kim, Heesun Lee, Hyung-Kwan Kim
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study
    Donghee Kwak, Seok-joo Moon, Jong Woong Park, Duk Hee Lee, Jung Il Lee
    Orthopaedic Journal of Sports Medicine.2023;[Epub]     CrossRef
  • Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea
    Seon Ha Baek, Jina Park, Sehoon Park, Mi-yeon Yu, Ji Eun Kim, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
    Kidney Research and Clinical Practice.2023; 42(4): 519.     CrossRef
  • Developing Operational Definitions Related toHelicobacter pyloriEradication Therapy
    Chan Hyuk Park, Sun-Young Jung, Ju Won Lee, Hyo-Joon Yang, Joon Sung Kim, Beom Jin Kim, Soo In Choi, Seung In Seo, Joongyub Lee, Jae Gyu Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Fracture Risk in Middle-Aged and Older Patients With Inflammatory Bowel Disease: A Korean Nationwide Population-Based Cohort Study
    Ji Min Lee, Kyungdo Han, Kang-Moon Lee, Jae-Seung Yun
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea
    Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Jae Won Hong, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
    European Journal of Endocrinology.2023; 189(2): 225.     CrossRef
  • Proton pump inhibitor use and the risk of metachronous gastric cancer after H. pylori eradication in patients who underwent endoscopic resection for gastric neoplasms: A population‐based cohort study
    Eun Jeong Gong, Hye‐Kyung Jung, Bora Lee, Jitaek Hong, Jong Wook Kim, Cheol Min Shin, Young Hoon Youn, Kwang Jae Lee
    Alimentary Pharmacology & Therapeutics.2023; 58(7): 668.     CrossRef
  • National Trends in Rotavirus Enteritis among Infants in South Korea, 2010–2021: A Nationwide Cohort
    Hyun Jee Lee, Yujin Choi, Jaeyu Park, Yong-Sung Choi, Dong Keon Yon, Do Hyun Kim
    Children.2023; 10(9): 1436.     CrossRef
  • Impact of Concomitant Use of Proton Pump Inhibitors and Clopidogrel on Recurrent Stroke and Myocardial Infarction
    Yong Kang Lee, Hyun Sun Lim, Youn I Choi, Eun Ju Choe, Seonji Kim, Seng Chan You, Kyung Joo Lee, Yerim Kim, Da Hee Park, Woon Geon Shin, Seung In Seo
    Pharmaceuticals.2023; 16(9): 1213.     CrossRef
  • Uric Acid and Risk of Cardiovascular Disease and Mortality: A Longitudinal Cohort Study
    Jae Young Kim, Changhwan Seo, Haeyong Pak, Hyunsun Lim, Tae Ik Chang
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Occupational characteristics and risk factors associated with endometriosis among Korean female workers
    Seunghyun Lee, Seung-Yeon Lee, Wanhyung Lee, Federico Romano
    PLOS ONE.2023; 18(10): e0292362.     CrossRef
  • Suicidal Thinking Among Patients With Spinal Conditions in South Korea: A Population-Based Cross-Sectional Study
    Tak Kyu Oh, Hye Yoon Park, In-Ae Song
    Psychiatry Investigation.2023; 20(9): 834.     CrossRef
  • Increased risk of venous and arterial thromboembolism in patients with colorectal cancer receiving cetuximab-based combination chemotherapy: A population-based study in Korea
    Ho-Young Yhim, Juhyun Lee, Kyoung Ha Kim, Sang-A Kim, Ji Yun Lee, Hun-Gyu Hwang, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang
    Thrombosis Research.2023; 231: 50.     CrossRef
  • Volatile Anesthetic Use Versus Total Intravenous Anesthesia for Patients Undergoing Heart Valve Surgery: A Nationwide Population-Based Study
    Jae-Woo Ju, Ho-Jin Lee, Karam Nam, Seungwook Kim, Hyunsook Hong, Seung Ho Yoo, Seohee Lee, Youn Joung Cho, Yunseok Jeon
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  • Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea
    Ga Hee Kim, Hyungchul Park, Kee Wook Jung, Min-Ju Kim, Ye-Jee Kim, Ji Min Lee, Bong Eun Lee, Yang Won Min, Jeong Hwan Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hyun Jin Kim
    Gut and Liver.2023; 17(6): 894.     CrossRef
  • Differential Impact of Obesity on the Risk of Diabetes Development in Two Age Groups: Analysis from the National Health Screening Program
    Tae Kyung Yoo, Kyung-Do Han, Yang-Hyun Kim, Ga Eun Nam, Sang Hyun Park, Eun-Jung Rhee, Won-Young Lee
    Diabetes & Metabolism Journal.2023; 47(6): 846.     CrossRef
  • Association between preoperative modifiable lifestyle factors and mortality after cancer surgery: a population-based cohort study in South Korea
    Tak Kyu Oh, In-Ae Song
    Annals of Surgical Treatment and Research.2023; 105(4): 179.     CrossRef
  • Classification of long-term clinical course of Parkinson’s disease using clustering algorithms on social support registry database
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    Journal of Big Data.2023;[Epub]     CrossRef
  • Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
    Hyungwoo Lee, Moo-Suk Park, Min Kyoung Kang, Tae-Jin Song
    Journal of Personalized Medicine.2023; 13(9): 1414.     CrossRef
  • Association of physical activity with the risk of Parkinson's disease in depressive disorder: A nationwide longitudinal cohort study
    Ji hyun An, Kyung-do Han, Jin-Hyung Jung, Hong Jin Jeon
    Journal of Psychiatric Research.2023; 167: 93.     CrossRef
  • Duration of dual-antiplatelet therapy after stent-assisted coil for unruptured intracranial aneurysm: A nationwide cohort study
    Minyoul Baik, Jimin Jeon, Seok-jae Heo, Joonsang Yoo, Jinkwon Kim
    International Journal of Stroke.2023;[Epub]     CrossRef
  • Effect of changes in the hearing aid subsidy on the prevalence of hearing loss in South Korea
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  • Preoperative Body Mass Index, Waist Circumference, and Mortality After Major Cancer Surgery: A Nationwide Cohort Study in Korea
    Tak Kyu Oh, In-Ae Song
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Characteristics and risk factors of suicide among people who attempted self-harm in South Korea: A longitudinal National Cohort Study in South Korea
    Hye Hyeon Kim, Jin Hyuk Lee, In Han Song, Yu Rang Park
    Psychiatry Research.2023; 330: 115613.     CrossRef
  • Association Between Premature Menopause and Cardiovascular Diseases and All‐Cause Mortality in Korean Women
    Gyu Bae Lee, Ga Eun Nam, Wonsock Kim, Byoungduck Han, Kyung Hwan Cho, Seon Mee Kim, Youn Seon Choi, Do Hoon Kim, Yong‐Gyu Park, Jin‐Hyung Jung, Kyungdo Han, Yang‐Hyun Kim
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • Risk of gastric cancer among long-term proton pump inhibitor users: a population-based cohort study
    Jong Wook Kim, Hye-Kyung Jung, Bora Lee, Cheol Min Shin, Eun Jeong Gong, Jitaek Hong, Young Hoon Youn, Kwang Jae Lee
    European Journal of Clinical Pharmacology.2023; 79(12): 1699.     CrossRef
  • Cancer Risk in Elderly Korean Patients with Neurodegenerative Disease and its relation to Type 2 Diabetes
    Hee-Cheol Kim, Ji-Hun Kim, Ho-Jun Lee, Yang-Tae Kim, Byeong-Churl Jang
    The Open Neurology Journal.2023;[Epub]     CrossRef
  • Performance of Cardiovascular Risk Prediction Models in Korean Patients With New‐Onset Rheumatoid Arthritis: National Cohort Study
    Jae Hyun Kim, Gaeun Lee, Jinseub Hwang, Ji‐Won Kim, Jin‐Won Kwon, Yun‐Kyoung Song
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • Impact of Propofol-based Total Intravenous Anesthesia Versus Inhalation Anesthesia on Long-term Survival After Cancer Surgery in a Nationwide Cohort
    Susie Yoon, Sun-Young Jung, Myo-Song Kim, Danbi Yoon, Younghae Cho, Yunseok Jeon
    Annals of Surgery.2023; 278(6): 1024.     CrossRef
  • Bovine pericardial versus porcine bioprosthetic aortic valves: A nationwide population-based cohort study in Korea
    Hong Rae Kim, Ho Jin Kim, Seonok Kim, Yejee Kim, Jung-Min Ahn, Joon Bum Kim, Dae-Hee Kim
    The Journal of Thoracic and Cardiovascular Surgery.2023;[Epub]     CrossRef
  • Decreased Risk of Knee Osteoarthritis with Taller Height in an East Asian Population: A Nationwide Cohort Study
    Dong Hwan Lee, Hwa Sung Lee, Soo Hyun Jang, Jun-Young Heu, Kyungdo Han, Se-Won Lee
    Journal of Clinical Medicine.2023; 13(1): 92.     CrossRef
  • Cost-effectiveness of the anti-vascular endothelial growth factor intravitreal injection and panretinal photocoagulation for patients with proliferative diabetic retinopathy in South Korea
    Hyeon-Jeong Lee, Songhee Cho, Jungeun Park, Yan Jin, Hyung Min Kim, Donghyun Jee
    BMC Health Services Research.2023;[Epub]     CrossRef
  • Prior Evaluation of Nutritional Status and Mortality in Patients with Sepsis in South Korea
    Tak Kyu Oh, In-Ae Song
    Nutrients.2023; 15(24): 5040.     CrossRef
  • Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
    Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
    Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
  • Cancer risks in patients with ankylosing spondylitis and the effects of biologic agents: a population-based study
    Sang-Yong Eom, Hyun-a Jang, Yo Han Im, Kyung-Hwa Choi, Ji Hyoun Kim
    Rheumatology.2023;[Epub]     CrossRef
  • Proton Pump Inhibitor Co-Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulants and a Prior History of Upper Gastrointestinal Tract Bleeding
    So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
    Cardiovascular Drugs and Therapy.2022; 36(4): 679.     CrossRef
  • Institutional case volume-incorporated mortality risk prediction model for cardiac surgery
    Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongnyeok Park, Ho Geol Ryu
    Asian Journal of Surgery.2022; 45(1): 189.     CrossRef
  • Does Surgical Ablation of Atrial Fibrillation Benefit Patients Undergoing Bioprosthetic Valve Replacement?
    Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
    Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906.     CrossRef
  • Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
    Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyunsun Lim, Jisoo Lee
    The Korean Journal of Internal Medicine.2022; 37(6): 1250.     CrossRef
  • Validation of Dynamic Aspartate‐to–Alanine Aminotransferase Ratio for Predicting Liver Disease Mortality
    In‐Ae Song, Eun Sun Jang, Tak Kyu Oh
    Hepatology Communications.2022; 6(4): 740.     CrossRef
  • Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
    Chan Joo Lee, Ji-Yeon Lee, Kyungdo Han, Da Hye Kim, Hanna Cho, Kwang Joon Kim, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee, Sungha Park
    Hypertension.2022; 79(1): 218.     CrossRef
  • Continuing regular physical activity and maintaining body weight have a synergistic interaction in improving survival: a population-based cohort study including 6.5 million people
    Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak
    European Journal of Preventive Cardiology.2022; 29(3): 547.     CrossRef
  • Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study
    Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
    Neurological Sciences.2022; 43(5): 3395.     CrossRef
  • Underutilisation of prophylactic G-CSF in breast cancer patients receiving adjuvant docetaxel/cyclophosphamide chemotherapy
    Minhee Ku, Nam Kyung Je
    Journal of Chemotherapy.2022; 34(8): 534.     CrossRef
  • Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
    Bum Sik Tae, Young Eun Yoon, Woong Na, Kyung Jin Oh, Sung Yul Park, Jae Young Park, Hong Sang Moon
    Investigative and Clinical Urology.2022; 63(1): 92.     CrossRef
  • Acromegaly and cardiovascular outcomes: a cohort study
    Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
    European Heart Journal.2022; 43(15): 1491.     CrossRef
  • Pericardial Versus Porcine Valves for Surgical Aortic Valve Replacement
    Hong Ju Shin, Wan Kee Kim, Jin Kyoung Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
    Korean Circulation Journal.2022; 52(2): 136.     CrossRef
  • Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
    Changil Choi, Jong Keun Kim, Kyungdo Han, Young Goo Lee, Jun Hyun Han
    Investigative and Clinical Urology.2022; 63(1): 63.     CrossRef
  • Comprehensive risk assessment for hospital-acquired pneumonia: sociodemographic, clinical, and hospital environmental factors associated with the incidence of hospital-acquired pneumonia
    Bo-Guen Kim, Minwoong Kang, Jihyun Lim, Jin Lee, Danbee Kang, Minjung Kim, Jinhee Kim, Hyejeong Park, Kyung Hoon Min, Juhee Cho, Kyeongman Jeon
    BMC Pulmonary Medicine.2022;[Epub]     CrossRef
  • Metabolic Disease Incidence After Allogeneic Stem Cell Transplantation: A Nationwide Korean Case-Control Study
    Jeonghoon Ha, See Hyun Park, Sung-Soo Park, Seunghoon Han
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(4): 943.     CrossRef
  • Development of eClaim system for private indemnity health insurance in South Korea: Compatibility and interoperability
    Sungchul Bae, Byoung-Kee Yi
    Health Informatics Journal.2022; 28(1): 146045822110710.     CrossRef
  • Incidence of Depression after Traumatic Brain Injury: A Nationwide Longitudinal Study of 2.2 Million Adults
    Yoonjeong Choi, Eun Young Kim, Jiyu Sun, Han-Kyoul Kim, Ye Seol Lee, Byung-Mo Oh, Hye Yoon Park, Ja-Ho Leigh
    Journal of Neurotrauma.2022; 39(5-6): 390.     CrossRef
  • Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
    Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
    Biomedicines.2022; 10(2): 303.     CrossRef
  • Clinical outcomes of early closure versus conservative strategy after diagnosis with atrial septal defect: a nationwide population-based cohort study
    Sun-Yang Min, Ji Sung Lee, Duk-Woo Park, Jong-Min Song
    European Journal of Cardio-Thoracic Surgery.2022;[Epub]     CrossRef
  • Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
    Gyeongsil Lee, Seulggie Choi, Yoosun Cho, Sang Min Park
    Clinical Nutrition Research.2022; 11(1): 32.     CrossRef
  • Long-term prognosis and causes of death among survivors after out-of-hospital cardiac arrest: A population-based longitudinal study
    Yongil Cho, Jaehoon Oh, Jeong-Hun Shin, Byung Sik Kim, Jin-Kyu Park, Jun Ho Lee, Jae Hwan Kim, Minae Park
    Resuscitation.2022; 173: 31.     CrossRef
  • Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study
    Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim, Kyungdo Han, Jin-hyung Jung, Do Hoon Kim, Joo-Hyun Park
    Scientific Reports.2022;[Epub]     CrossRef
  • Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
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    JAMA Network Open.2022; 5(2): e220262.     CrossRef
  • Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
    Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
    Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
  • Non-Alcoholic Fatty Liver Disease Defined by Fatty Liver Index and Incidence of Heart Failure in the Korean Population: A Nationwide Cohort Study
    Byoungduck Han, Gyu Bae Lee, Sun Young Yim, Kyung-Hwan Cho, Koh Eun Shin, Jung-Hwan Kim, Yong-Gyu Park, Kyung-Do Han, Yang-Hyun Kim
    Diagnostics.2022; 12(3): 663.     CrossRef
  • Contact with the health care system prior to suicide: A nationwide population-based analysis using linkage national death certificates and national health insurance data
    Eun Jee Park, Nam Ju Ji, Weon Young Lee
    Journal of Psychiatric Research.2022; 149: 226.     CrossRef
  • Association between asthma or chronic obstructive pulmonary disease and chronic otitis media
    Sung Kyun Kim, Seok Jin Hong, Dae Myoung Yoo, Chanyang Min, Hyo Geun Choi
    Scientific Reports.2022;[Epub]     CrossRef
  • Prognosis of pregnancy after breast cancer diagnosis according to the type of treatment: A population-based study in Korea by the SMARTSHIP group
    Soo Youn Bae, Jihyoun Lee, Ji Sung Lee, Jae Sun Yoon, Ku Sang Kim, Yoo Seok Kim, Zisun Kim, Jun Won Min, Eun-Jung Shim, Ilkyun Lee, Min Hyuk Lee, Sungmin Park
    The Breast.2022; 63: 46.     CrossRef
  • Fracture risk and impact of osteoporosis in patients with Parkinson’s disease: a nationwide database study
    Tae-lim Kim, Seong Jun Byun, Min Yong Seong, Byung-Mo Oh, Sang Jun Park, Han Gil Seo
    Journal of Bone and Mineral Metabolism.2022; 40(4): 602.     CrossRef
  • Risk prediction models incorporating institutional case volume for mortality after hip fracture surgery in the elderly
    Seokha Yoo, Eun Jin Jang, Junwoo Jo, Hannah Lee, Yoonbin Hwang, Ho Geol Ryu
    Archives of Orthopaedic and Trauma Surgery.2022; 143(5): 2307.     CrossRef
  • Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study
    Seung Hoon Kim, Yong-Moon Park, Kyungdo Han, Seung Hyun Ko, Shin Young Kim, So Hyang Song, Chi Hong Kim, Kyu Yeon Hur, Sung Kyoung Kim, Juan F. Orueta
    PLOS ONE.2022; 17(4): e0266262.     CrossRef
  • Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
    Young Bae Choi, Keon Hee Yoo
    Cancer Research and Treatment.2022; 54(2): 572.     CrossRef
  • The Effect of Alcohol Drinking on Metabolic Syndrome and Obesity in Koreans: Big Data Analysis
    Eun Jung Park, Hye Jung Shin, Sung Soo Kim, Ki Eun Kim, Sun Hyun Kim, Youl Ri Kim, Kyong Mee Chung, Kyung Do Han
    International Journal of Environmental Research and Public Health.2022; 19(9): 4949.     CrossRef
  • Prolonged or Transition to Metabolically Unhealthy Status, Regardless of Obesity Status, Is Associated with Higher Risk of Cardiovascular Disease Incidence and Mortality in Koreans
    Juhee Lee, So-Young Kwak, Dahyun Park, Ga-Eun Kim, Clara Yongjoo Park, Min-Jeong Shin
    Nutrients.2022; 14(8): 1644.     CrossRef
  • Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects
    Byung Kyu Park, Jeong Hun Seo, Jae Bock Chung, Jung Kyu Choi
    British Journal of Cancer.2022; 127(3): 549.     CrossRef
  • Cardiovascular Risk and Treatment Outcomes in Severe Hypercholesterolemia: A Nationwide Cohort Study
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    Journal of the American Heart Association.2022;[Epub]     CrossRef
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    Journal of Personalized Medicine.2022; 12(5): 691.     CrossRef
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    Frontiers in Neurology.2022;[Epub]     CrossRef
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    International Journal of Cancer.2022; 151(7): 1024.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Hepatology Communications.2022; 6(9): 2455.     CrossRef
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    Gastroenterology.2022; 163(3): 637.     CrossRef
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    BMC Medicine.2022;[Epub]     CrossRef
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    Gut and Liver.2022; 16(4): 555.     CrossRef
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    Yonsei Medical Journal.2022; 63(8): 774.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Journal of Personalized Medicine.2022; 12(8): 1260.     CrossRef
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    Journal of Cardiothoracic Surgery.2022;[Epub]     CrossRef
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    Hepatology Research.2022; 52(12): 975.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Frontiers in Medicine.2022;[Epub]     CrossRef
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    Clinical and Molecular Hepatology.2022; 28(4): 851.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Scientific Reports.2021;[Epub]     CrossRef
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  • Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study


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  • Trend of prevalence and incidence of systemic lupus erythematosus in South Korea, 2005 to 2015: a nationwide population-based study
    Eun Hui Bae, Sang Yeob Lim, Kyung-Do Han, Jin-Hyung Jung, Hong Sang Choi, Ha Yeon Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
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  • Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
    Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
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  • Metformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea
    Ji Hong You, Sun Ok Song, Min Jin Kang, Yoon Young Cho, Sun Wook Kim, Sung Hwan Suh, Sujin Lee, Yong-ho Lee, Byung-Wan Lee
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  • The association between hospital case volume and in-hospital and one-year mortality after hip fracture surgery
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  • Does Diabetes Increase the Risk of Contracting COVID-19? A Population-Based Study in Korea
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    Annals of Pediatric Endocrinology & Metabolism.2020; 25(4): 248.     CrossRef
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  • Maintenance of body weight is an important determinant for the risk of ischemic stroke: A nationwide population-based cohort study
    Jung-Hwan Cho, Eun-Jung Rhee, Se Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Soon-Jib Yoo, Yang-Hyun Kim, Won-Young Lee, Sabine Rohrmann
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  • Effect of Institutional Case Volume on In-Hospital and Long-Term Mortality in Critically Ill Patients Requiring Mechanical Ventilation for 48 Hours or More
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  • Effect of Institutional Case Volume on In-hospital Mortality After Living Donor Liver Transplantation: Analysis of 7073 Cases Between 2007 and 2016 in Korea
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  • Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study
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  • Incremental economic burden associated with exudative age-related macular degeneration: a population-based study
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  • Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study
    Seona Park, Jihye Kim, Jaeyoung Chun, Kyungdo Han, Hosim Soh, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
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  • Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population
    Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Hyejung Shin, Ha Yan Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
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  • Perioperative red blood cell transfusion and mortality following heart transplantation: A retrospective nationwide population‐based study between 2007 and 2016 in Korea
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  • The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Korean Nationwide Population-Based Study
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  • Association of body mass index with bladder cancer risk in men depends on abdominal obesity
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  • Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study
    Min Jung Ko, Ae Jeong Jo, Yun Jung Kim, Shin Hee Kang, Songhee Cho, Sang‐Ho Jo, Cheol‐Young Park, Sung‐Cheol Yun, Woo Je Lee, Duk‐Woo Park
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  • Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study
    Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-ho Lee
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  • Increased Risk of Osteoporotic Fracture in Postgastrectomy Gastric Cancer Survivors Compared With Matched Controls: A Nationwide Cohort Study in Korea
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  • Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study
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  • Long‐term clinical outcomes in patients with autoimmune hepatitis according to treatment response in Asian country
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  • Effectiveness and Safety of Direct Oral Anticoagulant for Secondary Prevention in Asians with Atrial Fibrillation
    Jiesuck Park, So-Ryoung Lee, Eue-Keun Choi, Soonil Kwon, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Sang-Bae Ko, Seil Oh, Gregory Y. H. Lip
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  • Optimal Rivaroxaban Dose in Asian Patients With Atrial Fibrillation and Normal or Mildly Impaired Renal Function
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  • Tobacco Smoking and Alcohol Consumption Are Related to Benign Parotid Tumor: A Nested Case-Control Study Using a National Health Screening Cohort
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  • Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-based Study in Korea
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  • The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study
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  • The risk of end-stage renal disease in systemic lupus erythematosus
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    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-Jung Choi, So-Ryoung Lee, Myung-Jin Cha, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y.H. Lip
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    Ho Won Kang, Seok-Joong Yun, Jae Il Chung, Hoon Choi, Jae Heon Kim, Ho Song Yu, Yun-Sok Ha, In-Chang Cho, Hyung Joon Kim, Hyun Chul Chung, Jun Sung Koh, Wun-Jae Kim, Jong-Hyock Park, Ji Youl Lee, So-Young Kim
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  • Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study
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  • Obstructive sleep apnea as a risk factor for incident end stage renal disease: a nationwide population-based cohort study from Korea
    Hong Sang Choi, Ha Yeon Kim, Kyung-Do Han, Jin-Hyung Jung, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
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  • Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
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  • The Effects after Implementing a Drug Utilization Review System on Contraindicated Drug use: A Systematic Review
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  • Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
    Minyoung Lee, Jiyu Sun, Minkyung Han, Yongin Cho, Ji-Yeon Lee, Chung Mo Nam, Eun Seok Kang
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  • Dose–response relationship between cigarette smoking and risk of ulcerative colitis: a nationwide population-based study
    Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
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  • Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population‐based propensity score matching study
    Bum Sik Tae, Byeong Jo Jeon, Hoon Choi, Jae Hyun Bae, Jae Young Park
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  • Adult lung transplantation case-volume and in-hospital and long-term mortality in Korea
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    E.H. Bae, S.Y. Lim, K.-D. Han, J.-Hy. Jung, H.S. Choi, C.S. Kim, S.K. Ma, SW Kim
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  • Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
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    Seung-Hwan Lee, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Kyungdo Han, Mee Kyoung Kim
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    Ki-Tae Hwang, Young Wook Ju, Young A Kim, Jongjin Kim, Sohee Oh, Jiwoong Jung, Young Jun Chai, In Sil Choi, So Won Oh
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  • Effect of Case Volume on Mortality After Pediatric Liver Transplantation in Korea
    Hannah Lee, Eun Jin Jang, Ga Hee Kim, Nam Joon Yi, Dal Ho Kim, Seokha Yoo, Hyung Sang Row, Chul-Woo Jung, Seung-Young Oh, Ho Geol Ryu
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  • Prescription Patterns and Burden of Pediatric Asthma in Korea
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  • Increased risk of coronary heart disease and stroke in lung cancer survivors: A Korean nationwide study of 20,458 patients
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    Journal of Clinical Medicine.2019; 8(1): 72.     CrossRef
  • Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri
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  • Factors influencing the incidence and treatment of intracranial aneurysm and subarachnoid hemorrhage: time trends and socioeconomic disparities under an universal healthcare system
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Anti-Obesity Drugs: A Review about Their Effects and Safety
Jun Goo Kang, Cheol-Young Park
Diabetes Metab J. 2012;36(1):13-25.   Published online February 17, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.1.13
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AbstractAbstract PDFPubReader   

The current recommendations for the treatment of obese people include increased physical activity and reduced calories intake. When the behavioral approach is not sufficient, a pharmacologic treatment is recommended. In past years, numerous drugs have been approved for the treatment of obesity; however, most of them have been withdrawn from the market because of their adverse effects. In fact, amphetamine, rimonabant and sibutramine licenses have been withdrawn due to an increased risk of psychiatric disorders and non-fatal myocardial infarction or stroke. Even if orlistat is not as effective as other drugs in reducing body weight, orlistat is presently the only available choice for the treatment of obesity because of its safety for cardiovascular events and positive effects on diabetic control. Hopefully, more effective and better tolerated anti-obesity drugs will be developed through an improved understanding of the multiple mechanisms and complex physiological systems targeting appetite.

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Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types
Mi-Ju Choi, Seung-Hyun Yoo, Kum-Rae Kim, Yoo-Mi Bae, Sun-Hee Ahn, Seong-Shin Kim, Seong-Ah Min, Jin-Sun Choi, Seung-Eun Lee, Yeo-Jin Moon, Eun Jung Rhee, Cheol-Young Park, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim
Diabetes Metab J. 2011;35(6):580-586.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.580
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AbstractAbstract PDFPubReader   
Background

Diabetes self-management education and reinforcement are important for effective management of the disease. We investigated the effectiveness of interactive small-group education on glycemic, blood pressure, and lipid levels.

Methods

For this study, 207 type 2 diabetes patients with suboptimal glycemic control (HbA1c levels >6.5%) were enrolled. The conventional education group received an existing education program from April to November in 2006, and the interactive education group received a new small-group education program from December 2006 to July 2007. The two groups were comparatively analyzed for changes in blood sugar, glycated hemoglobin, lipid, and blood pressure at baseline, 3, 6, and 12 months and the proportion of patients achieving target goals at 12 months.

Results

After 12 months of follow-up, HbA1c levels in the interactive education group were significantly lower than in the conventional education group (6.7% vs. 6.4%, P<0.001). Fasting and 2 hour postprandial glucose concentrations, total cholesterol, and low density lipoprotein cholesterol were significantly lower in the interactive education group than in the conventional education group. The proportion of patients that achieved target goals was significantly higher in the interactive education group.

Conclusion

The small-group educational method improved and re-established the existing group educational method. This finding suggests that the importance of education appears to be related to the method by which it is received rather than the education itself. Thus, the use of small-group educational methods to supplement existing educational methods established for diverse age levels should be considered in the future.

Citations

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  • The Effectiveness of Multidisciplinary Team-Based Education in the Management of Type 2 Diabetes
    Jong Ho Kim, Yun Jeong Nam, Won Jin Kim, Kyung Ah Lee, A Ran Baek, Jung Nam Park, Jin Mi Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim, Sang Soo Kim
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    Sang Yong Kim
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Retrospective Analysis on the Efficacy, Safety and Treatment Failure Group of Sitagliptin for Mean 10-Month Duration
Won Jun Kim, Cheol-Young Park, Eun Haeng Jeong, Jeong Youn Seo, Ji Soo Seol, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim
Diabetes Metab J. 2011;35(3):290-297.   Published online June 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.3.290
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AbstractAbstract PDFPubReader   
Background

To investigate the clinical results of sitagliptin (SITA) and the characteristics of the treatment failure group or of low responders to SITA.

Methods

A retrospective study of type 2 diabetic patients reviewed 99 cases, including 12 treatment failure cases, who stopped SITA because of worsening patients' condition, and 87 cases, who continued treatment over five visits (total 9.9±10.1 months) after receiving the prescription of SITA from December 2008 to June 2009. Subjects were classified as five groups administered SITA as an initial combination with metformin (MET), add-on to metformin or sulfonylurea, and switching from sulfonylurea or thiazolidinedione. The changes in HbA1c level from the first to last visit (ΔHbA1c) in treatment maintenance group were subanalyzed.

Results

The HbA1c level was significantly reduced in four groups, including initial coadministration of SITA with metformin (ΔHbA1c=-1.1%, P<0.001), add-on to MET (ΔHbA1c=-0.6%, P=0.017), add-on to sulfonylurea (ΔHbA1c=-0.5%, P<0.001), and switching from thiazolidinedione (ΔHbA1c=-0.3%, P=0.013). SITA was noninferior to sulfonlyurea (ΔHbA1c=-0.2%, P=0.63). There was no significant adverse effect. The treatment failure group had a longer diabeties duration (P=0.008), higher HbA1c (P=0.001) and fasting plasma glucose (P=0.003) compared to the maintenance group. Subanalysis on the tertiles of ΔHbA1c showed that low-response to SITA (tertile 1) was associated with a longer diabetes duration (P=0.009) and lower HbA1c (P<0.001).

Conclusion

SITA was effective and safe for use in Korean type 2 diabetic patients. However, its clinical responses and long-term benefit-harm profile is yet to be established.

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The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects
Eun-Jung Rhee, Ji-Hun Choi, Seung-Hyun Yoo, Ji-Cheol Bae, Won-Jun Kim, Eun-Suk Choi, Se Eun Park, Cheol-Young Park, Seok Won Park, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim, Won-Young Lee
Diabetes Metab J. 2011;35(2):138-148.   Published online April 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.2.138
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AbstractAbstract PDFPubReader   
Background

We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention.

Methods

From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weight×100. Subjects were divided into three groups according to weight change status in four years: weight loss (≤-5.0%), stable weight (-5.0 to 5.0%), weight gain (≥5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes.

Results

Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA β-cell function in four years was a negative predictor for glycemic progression.

Conclusion

Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects.

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The Association of Brachial-Ankle Pulse Wave Velocity with 30-Minute Post-Challenge Plasma Glucose Levels in Korean Adults with No History of Type 2 Diabetes
Eun-Suk Choi, Eun-Jung Rhee, Ji-Hoon Choi, Ji-Cheol Bae, Seung-Hyun Yoo, Won-Jun Kim, Se-Eun Park, Cheol-Young Park, Won-Young Lee, Yong-Kyun Cho, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim
Korean Diabetes J. 2010;34(5):287-293.   Published online October 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.5.287
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AbstractAbstract PDFPubReader   
Background

Acute postprandial hyperglycemia is an important affector for atherosclerosis in subjects with glucose intolerance. We analyzed the relationship of brachial-ankle pulse wave velocity (baPWV) with fasting and post-challenge plasma glucose levels according to different time points during oral glucose tolerance test (OGTT).

Methods

In 663 subjects with fasting hyperglycemia, 75 g OGTT were performed to confirm the glucose tolerant status, and fasting, post-challenge 30-minute and 120-minute glucose levels were measured. Anthropometric measurements were done, and fasting lipid profiles were measured. baPWV were measured in all subjects and the relationship between fasting, 30- and 120-minute post-challenge glucose levels and baPWV were analyzed.

Results

Among the participants, 62.9% were prediabetes and 31.7% were diabetes. Mean baPWV value was significantly higher in subjects with diabetes compared with prediabetes group. In bivariate correlation analyses, age, blood pressure, total cholesterol, low density lipoprotein cholesterol, 30-minute and 120-minute post-challenge glucose levels showed significant positive correlation with baPWV value. In multiple regression analysis, 30-minute post-challenge glucose level was a weak but significant determinant for mean baPWV value even after adjustment for other confounding variables.

Conclusions

Postprandial hyperglycemia, especially 30-minute glucose levels showed significant correlation with baPWV in subjects with fasting hyperglycemia. These results can imply the deleterious effect of acute hyperglycemic excursion on arterial stiffness in subjects with glucose intolerance.

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The Relationship of Adiponectin/Leptin Ratio with Homeostasis Model Assessment Insulin Resistance Index and Metabolic Syndrome in Apparently Healthy Korean Male Adults
Chan-Hee Jung, Eun-Jung Rhee, Ji-Hoon Choi, Ji-Cheol Bae, Seung-Hyun Yoo, Won-Jun Kim, Cheol-Young Park, Ji Oh Mok, Chul Hee Kim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim
Korean Diabetes J. 2010;34(4):237-243.   Published online August 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.4.237
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AbstractAbstract PDFPubReader   
Background

We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.

Methods

Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed.

Results

Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors.

Conclusion

A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.

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Letter: Effects of Rosiglitazone on Inflammation in Otsuka Long-Evans Tokushima Fatty Rats (Korean Diabetes J 2010;34:191-9)
Soo Jin Yang, Cheol-Young Park
Korean Diabetes J. 2010;34(4):261-262.   Published online August 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.4.261
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