Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Byung Yong Ahn  (Ahn BY) 1 Article
Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park
Diabetes Metab J. 2011;35(4):340-347.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.340
  • 4,248 View
  • 41 Download
  • 20 Crossref
AbstractAbstract PDFPubReader   
Background

Sulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ), one of the nuclear receptors. In this study, we investigated the effects of sulfonylurea on PPARγ transcriptional activity and on the glucose uptake via PPARγ.

Methods

Transcription reporter assays using Cos7 cells were performed to determine if specific sulfonylureas stimulate PPARγ transactivation. Glimepiride, gliquidone, and glipizide (1 to 500 µM) were used as treatment, and rosiglitazone at 1 and 10 µM was used as a control. The effects of sulfonylurea and rosiglitazone treatments on the transcriptional activity of endogenous PPARγ were observed. In addition, 3T3-L1 adipocytes were treated with rosiglitazone (10 µM), glimepiride (100 µM) or both to verify the effect of glimepiride on rosiglitazone-induced glucose uptake.

Results

Sulfonylureas, including glimepiride, gliquidone and glipizide, increased PPARγ transcriptional activity, gliquidone being the most potent PPARγ agonist. However, no additive effects were observed in the presence of rosiglitazone. When rosiglitazone was co-treated with glimepiride, PPARγ transcriptional activity and glucose uptake were reduced compared to those after treatment with rosiglitazone alone. This competitive effect of glimepiride was observed only at high concentrations that are not achieved with clinical doses.

Conclusion

Sulfonylureas like glimepiride, gliquidone and glipizide increased the transcriptional activity of PPARγ. Also, glimepiride was able to reduce the effect of rosiglitazone on PPARγ agonistic activity and glucose uptake. However, the competitive effect does not seem to occur at clinically feasible concentrations.

Citations

Citations to this article as recorded by  
  • Chitosan-Encapsulated Nano-selenium Targeting TCF7L2, PPARγ, and CAPN10 Genes in Diabetic Rats
    Omayma A. R. Abozaid, Sawsan M. El-Sonbaty, Neama M. A. Hamam, Moustafa A. Farrag, Ahmad S. Kodous
    Biological Trace Element Research.2023; 201(1): 306.     CrossRef
  • Insights from insulin resistance pathways: Therapeutic approaches against Alzheimer associated diabetes mellitus
    Ayesha Fauzi, Ewen Se Thoe, Tang Yin Quan, Adeline Chia Yoke Yin
    Journal of Diabetes and its Complications.2023; 37(11): 108629.     CrossRef
  • Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes
    Mika E. A. Berg, Jette-Britt Naams, Laura C. Hautala, Tuomas A. Tolvanen, Jari P. Ahonen, Sanna Lehtonen, Kristiina Wähälä
    ACS Omega.2020; 5(3): 1430.     CrossRef
  • Diabetic Theory in Anti-Alzheimer’s Drug Research and Development - Part 1: Therapeutic Potential of Antidiabetic Agents
    Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa
    Current Medicinal Chemistry.2020; 27(39): 6658.     CrossRef
  • Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats
    Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Vijayakumar Mayakrishnan, Arokiyaraj Selvaraj
    Biomedicine & Pharmacotherapy.2019; 112: 108688.     CrossRef
  • PPARγ Agonistic Activity of Sulphonylureas
    Debjani Banerjee, Harnovdeep Singh Bharaj, Moulinath Banerjee
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2019; 19(4): 467.     CrossRef
  • Glimepiride treatment in a patient with type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene
    Zhimin Huang, Juan Liu, Kaka Ng, Xuesi Wan, Lijuan Xu, Xiaoying He, Zhihong Liao, Yanbing Li
    Journal of Diabetes Investigation.2018; 9(5): 1075.     CrossRef
  • Arsenic, Cadmium, and Lead Like Troglitazone Trigger PPARγ-Dependent Poly (ADP-Ribose) Polymerase Expression and Subsequent Apoptosis in Rat Brain Astrocytes
    Rajesh Kushwaha, Juhi Mishra, Sachin Tripathi, Puneet Khare, Sanghamitra Bandyopadhyay
    Molecular Neurobiology.2018; 55(3): 2125.     CrossRef
  • Docosahexaenoic acid up‐regulates both PI3K/AKT‐dependent FABP7–PPARγ interaction and MKP3 that enhance GFAP in developing rat brain astrocytes
    Sachin Tripathi, Rajesh Kushwaha, Juhi Mishra, Manoj Kumar Gupta, Harish Kumar, Somali Sanyal, Dhirendra Singh, Sabyasachi Sanyal, Amogh Anant Sahasrabuddhe, Mohan Kamthan, Mohana Krishna Reddy Mudiam, Sanghamitra Bandyopadhyay
    Journal of Neurochemistry.2017; 140(1): 96.     CrossRef
  • Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes
    Krishna Adeshara, Rashmi Tupe
    Molecular Biology Reports.2016; 43(3): 195.     CrossRef
  • The therapeutic journey of pyridazinone
    Wasim Akhtar, M. Shaquiquzzaman, Mymoona Akhter, Garima Verma, Mohemmed Faraz Khan, M. Mumtaz Alam
    European Journal of Medicinal Chemistry.2016; 123: 256.     CrossRef
  • Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect
    Chetna Kharbanda, Mohammad Sarwar Alam, Hinna Hamid, Kalim Javed, Abhijeet Dhulap, Sameena Bano, Yakub Ali
    Bioorganic & Medicinal Chemistry Letters.2015; 25(20): 4601.     CrossRef
  • Method Development and Validation of Amlodipine, Gliquidone and Pioglitazone: Application in the Analysis of Human Serum
    Agha Zeeshan Mirza, M. Saeed Arayne, Najma Sultana
    Analytical Chemistry Letters.2014; 4(5-6): 302.     CrossRef
  • Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats
    Jian-Ting Ke, Mi Li, Shi-Qing Xu, Wen-Jian Zhang, Yong-Wei Jiang, Lan-yun Cheng, Li Chen, Jin-Ning Lou, Wei Wu
    Journal of Endocrinology.2014; 220(2): 129.     CrossRef
  • Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico
    Samuel E. Schriner, Steven Kuramada, Terry E. Lopez, Stephanie Truong, Andrew Pham, Mahtab Jafari
    Experimental Gerontology.2014; 60: 220.     CrossRef
  • Crif1 Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice
    Min Jeong Ryu, Soung Jung Kim, Yong Kyung Kim, Min Jeong Choi, Surendar Tadi, Min Hee Lee, Seong Eun Lee, Hyo Kyun Chung, Saet Byel Jung, Hyun-Jin Kim, Young Suk Jo, Koon Soon Kim, Sang-Hee Lee, Jin Man Kim, Gi Ryang Kweon, Ki Cheol Park, Jung Uee Lee, Yo
    PLoS Genetics.2013; 9(3): e1003356.     CrossRef
  • Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons
    Feiyang Liu, Yijin Wang, Ming Yan, Luyong Zhang, Tao Pang, Hong Liao
    Neuroscience Letters.2013; 557: 90.     CrossRef
  • Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis
    A. Cignarelli, F. Giorgino, R. Vettor
    Archives of Physiology and Biochemistry.2013; 119(4): 139.     CrossRef
  • Labisia pumilaUpregulates Peroxisome Proliferator-Activated Receptor Gamma Expression in Rat Adipose Tissues and 3T3-L1 Adipocytes
    Fazliana Mansor, Harvest F. Gu, Claes-Göran Östenson, Louise Mannerås-Holm, Elisabet Stener-Victorin, Wan Nazaimoon Wan Mohamud
    Advances in Pharmacological Sciences.2013; 2013: 1.     CrossRef
  • Protocol for effective differentiation of 3T3-L1 cells to adipocytes
    Katja Zebisch, Valerie Voigt, Martin Wabitsch, Matthias Brandsch
    Analytical Biochemistry.2012; 425(1): 88.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal