- Basic Research
- Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
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Byung Soo Kong, Changhan Lee, Young Min Cho
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Diabetes Metab J. 2023;47(3):315-324. Published online February 24, 2023
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DOI: https://doi.org/10.4093/dmj.2022.0333
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 Abstract
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- Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.
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Citations
Citations to this article as recorded by  - Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
Satadeepa Kal, Sumana Mahata, Suborno Jati, Sushil K. Mahata
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Benyuan Zhang, Joon Young Chang, Min Hee Lee, Sang-Hyeon Ju, Hyon-Seung Yi, Minho Shong
Diabetes & Metabolism Journal.2024; 48(1): 1. CrossRef - Mitochondrial bioenergetics, metabolism, and beyond in pancreatic β-cells and diabetes
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Journal of Agricultural and Food Chemistry.2024; 72(38): 20944. CrossRef
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