Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Bum Joong Kim  (Kim BJ) 1 Article
Obesity and Metabolic Syndrome
Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice
Han-Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In-Sun Park, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2016;40(5):376-385.   Published online April 5, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.376
  • 7,512 View
  • 97 Download
  • 68 Web of Science
  • 129 Crossref
AbstractAbstract PDFPubReader   
Background

Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown.

Methods

Seven-week-old C57BL/6J mice were given normal chow or a methionine- and choline-deficient diet (MCDD) with or without various statins, fluvastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin (15 mg/kg/day), for 6 weeks. Histological lesions were analyzed by grading and staging systems of NASH. We also measured mitochondrial and peroxisomal FAO in the liver.

Results

Statin treatment prevented the development of MCDD-induced NASH. Both steatosis and inflammation or fibrosis grades were significantly improved by statins compared with MCDD-fed mice. Gene expression levels of peroxisomal proliferator-activated receptor α (PPARα) were decreased by MCDD and recovered by statin treatment. MCDD-induced suppression of mitochondrial and peroxisomal FAO was restored by statins. Each statin's effect on increasing FAO and improving NASH was independent on its effect of decreasing cholesterol levels.

Conclusion

Statins prevented NASH and increased mitochondrial and peroxisomal FAO via induction of PPARα. The ability to increase hepatic FAO is likely the major determinant of NASH prevention by statins. Improvement of peroxisomal function by statins may contribute to the prevention of NASH.

Citations

Citations to this article as recorded by  
  • Organelle stress and alterations in interorganelle crosstalk during liver fibrosis
    Saloni Sinha, Nora Hassan, Robert E. Schwartz
    Hepatology.2024; 79(2): 482.     CrossRef
  • Statin therapy: a potential adjuvant to immunotherapies in hepatocellular carcinoma
    Jiao Wang, Chengyu Liu, Ronghua Hu, Licheng Wu, Chuanzhou Li
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation
    Lan Yao, Xiang Zhu, Yunyi Shan, Liang Zhang, Jing Yao, Hui Xiong
    Small.2024;[Epub]     CrossRef
  • Exploration of the Key Genes Involved in Non-alcoholic Fatty Liver Disease and Possible MicroRNA Therapeutic Targets
    Ali Mahmoudi, Amin Jalili, Alexandra E. Butler, Seyed H. Aghaee-Bakhtiari, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Journal of Clinical and Experimental Hepatology.2024; 14(4): 101365.     CrossRef
  • Inflammation drives pathogenesis of early intestinal failure-associated liver disease
    Scott C. Fligor, Savas T. Tsikis, Thomas I. Hirsch, Ashish Jain, Liang Sun, Shira Rockowitz, Kathleen M. Gura, Mark Puder
    Scientific Reports.2024;[Epub]     CrossRef
  • A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
    Shiqin Zhang, Xiaoling Ren, Bingzheng Zhang, Tian Lan, Bing Liu
    Molecules.2024; 29(8): 1859.     CrossRef
  • Statins in Chronic Liver Disease: Review of the Literature and Future Role
    Nguyen Pham, Jihane N. Benhammou
    Seminars in Liver Disease.2024; 44(02): 191.     CrossRef
  • Team players in the pathogenesis of metabolic dysfunctions-associated steatotic liver disease: The basis of development of pharmacotherapy
    Shahid Habib
    World Journal of Gastrointestinal Pathophysiology.2024;[Epub]     CrossRef
  • Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review
    Gabriela Svobodová, Martin Horní, Eva Velecká, Iva Boušová
    Archives of Toxicology.2024;[Epub]     CrossRef
  • Effects of metformin and simvastatin treatment on ultrastructural features of liver macrophages in HFD mice
    Darko Ciric, Tamara Kravic-Stevovic, Vladimir Bumbasirevic, Sasa Petricevic, Sofija Jovanovic, Vladimir Trajkovic, Tamara Martinovic
    Ultrastructural Pathology.2023; 47(1): 1.     CrossRef
  • Statins for the Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis
    Weiwei Dai, Baohong Xu, Peng Li, Junhua Weng
    American Journal of Therapeutics.2023; 30(1): e17.     CrossRef
  • Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation
    José A. Inia, Geurt Stokman, Elsbet J. Pieterman, Martine C. Morrison, Aswin L. Menke, Lars Verschuren, Martien P. M. Caspers, Martin Giera, J. Wouter Jukema, Anita M. van den Hoek, Hans M. G. Princen
    International Journal of Molecular Sciences.2023; 24(9): 7818.     CrossRef
  • The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease
    Alexandra C. Finney, Sandeep Das, Dhananjay Kumar, M. Peyton McKinney, Bishuang Cai, Arif Yurdagul, Oren Rom
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
    Tomeka L. Suber, Stacy G. Wendell, Steven J. Mullett, Benjamin Zuchelkowski, William Bain, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Yingze Zhang, Faraaz Shah, Seyed Mehdi Nouraie, Janet S. Lee
    Respiratory Research.2023;[Epub]     CrossRef
  • Statins on nonalcoholic fatty liver disease: A systematic review and meta-analysis of 14 RCTs
    Haiyan Zhou, Maeda Toshiyoshi,, Wenli Zhao, Ye Zhao, Yan Zhao,
    Medicine.2023; 102(26): e33981.     CrossRef
  • Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes
    Erica M. Weekman, Sherika N. Johnson, Colin B. Rogers, Tiffany L. Sudduth, Kevin Xie, Qi Qiao, David W. Fardo, Teodoro Bottiglieri, Donna M. Wilcock
    Journal of Neuroinflammation.2023;[Epub]     CrossRef
  • Crosstalk between Lipids and Non-Alcoholic Fatty Liver Disease
    Divyavani Gowda, Chandra Shekhar, Siddabasave Gowda B. Gowda, Yifan Chen, Shu-Ping Hui
    Livers.2023; 3(4): 687.     CrossRef
  • Empagliflozin: Potential Protective Effects on Hepatocytes and Liver Outcomes in Streptozotocin -Diabetic Rats.
    Alia Khwaldeh, Nour Al-Sawalha, Shefa' Aljabali, Ziad Shraideh, Sokiyna Ababneh, Roba Bdeir
    Biomedical and Pharmacology Journal.2023; 16(4): 2123.     CrossRef
  • Is there a role of lipid-lowering therapies in the management of fatty liver disease?
    Ismini Tzanaki, Aris P Agouridis, Michael S Kostapanos
    World Journal of Hepatology.2022; 14(1): 119.     CrossRef
  • Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice
    Yanxiong Huo, Guoping Zhao, Jinwang Li, Ran Wang, Fazheng Ren, Yixuan Li, Xiaoyu Wang
    Nutrients.2022; 14(3): 598.     CrossRef
  • PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool
    Yen-Wei Chen, Graciel Diamante, Jessica Ding, Thien Xuan Nghiem, Jessica Yang, Sung-Min Ha, Peter Cohn, Douglas Arneson, Montgomery Blencowe, Jennifer Garcia, Nima Zaghari, Paul Patel, Xia Yang
    iScience.2022; 25(4): 104052.     CrossRef
  • Pleyotropic Effects of Statins Non-Alcoholic Fat Disease of the Liver Non-Alcoholic Steatohepatitis
    И.Р. Агабабян, Ш.Ш. Садыкова
    Рецепт.2022; (2): 194.     CrossRef
  • PPAR Alpha as a Metabolic Modulator of the Liver: Role in the Pathogenesis of Nonalcoholic Steatohepatitis (NASH)
    Simona Todisco, Anna Santarsiero, Paolo Convertini, Giulio De Stefano, Michele Gilio, Vito Iacobazzi, Vittoria Infantino
    Biology.2022; 11(5): 792.     CrossRef
  • Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003–2004
    Hyunji Sang, Kyu-Na Lee, Chang Hee Jung, Kyungdo Han, Eun Hee Koh
    Scientific Reports.2022;[Epub]     CrossRef
  • Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis
    Curtis C. Hughey, Patrycja Puchalska, Peter A. Crawford
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2022; 1867(11): 159209.     CrossRef
  • Supplementation of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α Pathway
    Dou-Dou Li, Jia-Min Ma, Ming-Jing Li, Lu-Lu Gao, Yan-Na Fan, Yan-Nan Zhang, Xiu-Juan Tao, Jian-Jun Yang
    Nutrients.2022; 14(15): 3247.     CrossRef
  • Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
    Xiaohan Xu, Kyle L. Poulsen, Lijuan Wu, Shan Liu, Tatsunori Miyata, Qiaoling Song, Qingda Wei, Chenyang Zhao, Chunhua Lin, Jinbo Yang
    Signal Transduction and Targeted Therapy.2022;[Epub]     CrossRef
  • Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1
    Rachel J. Perry
    Diabetes.2022; 71(9): 1834.     CrossRef
  • Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment
    Lilian Fernandes Silva, Rowmika Ravi, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso
    Metabolites.2022; 12(12): 1159.     CrossRef
  • Acute and chronic effects of environmental realistic concentrations of simvastatin in danio rerio: evidences of oxidative alterations and endocrine disruptive activity
    D. Rebelo, A.T. Correia, B. Nunes
    Environmental Toxicology and Pharmacology.2021; 81: 103522.     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis
    Hana Lastuvkova, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Milos Hroch, Jaroslav Mokry, Hana Faistova, Zuzana Nova, Radomír Hyspler, Ivone Cristina Igreja Sa, Petr Nachtigal, Alzbeta Stefela, Petr Pavek, Stanislav Micuda
    International Journal of Molecular Sciences.2021; 22(12): 6468.     CrossRef
  • PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases
    Hugo Christian Monroy-Ramirez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Alejandra Meza-Rios, Arturo Santos, Juan Armendariz-Borunda
    International Journal of Molecular Sciences.2021; 22(15): 8298.     CrossRef
  • Simvastatin affects the PPARα signaling pathway and causes oxidative stress and embryonic development interference in Mugilogobius abei
    Chao Wang, Tianli Tang, Yimeng Wang, Xiangping Nie, Kaibin Li
    Aquatic Toxicology.2021; 239: 105951.     CrossRef
  • Impact of statin use on the risk and prognosis of hepatocellular carcinoma: a meta-analysis
    Jianfeng Wang, Xiaogang Li
    European Journal of Gastroenterology & Hepatology.2021; 33(12): 1603.     CrossRef
  • Statins in Non-alcoholic Steatohepatitis
    Jose D. Torres-Peña, Laura Martín-Piedra, Francisco Fuentes-Jiménez
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats
    Tadakazu Takahashi, Yusuke Suzuki, Naohito Yamada, Kaoru Toyoda, Keisuke Goda, Katsunori Ryoke, Chizuru Matsuura, Akio Kobayashi, Shoichiro Sugai, Kayoko Shimoi
    Fundamental Toxicological Sciences.2020; 7(1): 41.     CrossRef
  • Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis
    Joeri Lambrecht, Leo A. van Grunsven, Frank Tacke
    Expert Opinion on Pharmacotherapy.2020; 21(13): 1637.     CrossRef
  • The Influence of Statins on the Aerobic Metabolism of Endothelial Cells
    Izabela Broniarek, Karolina Dominiak, Lukasz Galganski, Wieslawa Jarmuszkiewicz
    International Journal of Molecular Sciences.2020; 21(4): 1485.     CrossRef
  • NADPH Oxidase Inhibition in Fibrotic Pathologies
    Karen Bernard, Victor J. Thannickal
    Antioxidants & Redox Signaling.2020; 33(6): 455.     CrossRef
  • Pleiotropic Effects of Statins in the Light of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
    Farah Ahsan, Federico Oliveri, Harshit K Goud, Zainab Mehkari, Lubna Mohammed, Moiz Javed, Aldanah Althwanay, Ian H Rutkofsky
    Cureus.2020;[Epub]     CrossRef
  • Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis
    S.M. Touhidul Islam, Jeseong Won, Mushfiquddin Khan, Kenneth D. Chavin, Inderjit Singh
    Annals of Hepatology.2020; 19(5): 466.     CrossRef
  • Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin
    Weijie You, Clemens Steegborn
    ACS Medicinal Chemistry Letters.2020; 11(11): 2285.     CrossRef
  • Specificity of transaminase activities in the prediction of drug-induced hepatotoxicity
    Akio Kobayashi, Yusuke Suzuki, Shoichiro Sugai
    The Journal of Toxicological Sciences.2020; 45(9): 515.     CrossRef
  • Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease
    Kate L. Bowerman, Saima Firdous Rehman, Annalicia Vaughan, Nancy Lachner, Kurtis F. Budden, Richard Y. Kim, David L. A. Wood, Shaan L. Gellatly, Shakti D. Shukla, Lisa G. Wood, Ian A. Yang, Peter A. Wark, Philip Hugenholtz, Philip M. Hansbro
    Nature Communications.2020;[Epub]     CrossRef
  • Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model
    Graziella Rodrigues, Andrea Janz Moreira, Silvia Bona, Elizângela Schemitt, Cláudio Augusto Marroni, Fábio Cangeri Di Naso, Alexandre Simões Dias, Thienne Rocha Pires, Jaqueline Nascimento Picada, Norma Possa Marroni
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction via Oxidative Stress
    Lingjuan Piao, Debra Dorotea, Songling Jiang, Eun Hee Koh, Goo Taeg Oh, Hunjoo Ha
    Antioxidants & Redox Signaling.2019; 31(18): 1339.     CrossRef
  • (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice
    Yunxia Dong, Henglei Lu, Qiang Li, Xinming Qi, Yuanchao Li, Zean Zhang, Jing Chen, Jin Ren
    Life Sciences.2019; 232: 116644.     CrossRef
  • Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy‐related osteoblast apoptosis
    C.‐N. Yang, S.‐H. Kok, H.‐W. Wang, J. Z.‐C. Chang, E. H.‐H. Lai, C.‐T. Shun, H. Yang, M.‐H. Chen, C.‐Y. Hong, S.‐K. Lin
    International Endodontic Journal.2019; 52(5): 676.     CrossRef
  • Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models
    Jing Huai, Zi Yang, Yan-Hong Yi, Guang-Jiao Wang
    Chinese Medical Journal.2018; 131(4): 461.     CrossRef
  • Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)
    Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
    European Journal of Pharmacology.2018; 822: 147.     CrossRef
  • Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells
    Ji-Hye Kim, Jun Mi Lee, Jong-Hoon Kim, Kwang Rok Kim
    Biochemical and Biophysical Research Communications.2018; 503(3): 1415.     CrossRef
  • Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study
    Gyuri Kim, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang
    Journal of Hepatology.2018; 68(3): 476.     CrossRef
  • Membrane Remodeling as a Key Player of the Hepatotoxicity Induced by Co-Exposure to Benzo[a]pyrene and Ethanol of Obese Zebrafish Larvae
    Muhammad Imran, Odile Sergent, Arnaud Tête, Isabelle Gallais, Martine Chevanne, Dominique Lagadic-Gossmann, Normand Podechard
    Biomolecules.2018; 8(2): 26.     CrossRef
  • Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation
    Yun Hu, Qinwei Sun, Yan Hu, Zhen Hou, Yibo Zong, Nagmeldin A Omer, Halima Abobaker, Ruqian Zhao
    The Journal of Nutrition.2018; 148(3): 316.     CrossRef
  • Simvastatin protects against acetaminophen-induced liver injury in mice
    Huan Liang, Yang Feng, Ruixia Cui, Minglong Qiu, Jingyao Zhang, Chang Liu
    Biomedicine & Pharmacotherapy.2018; 98: 916.     CrossRef
  • Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial
    Laurie R Braun, Meghan N Feldpausch, Natalia Czerwonka, Julian Weiss, Karen Branch, Hang Lee, Edgar L Martinez-Salazar, Martin Torriani, Craig A Sponseller, Steven K Grinspoon, Takara L Stanley
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(11): 4176.     CrossRef
  • Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes
    Birgit Knebel, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Waltraud Passlack, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
    International Journal of Molecular Sciences.2018; 19(4): 980.     CrossRef
  • MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis
    Tyler A. Shaw, Ragunath Singaravelu, Megan H. Powdrill, Jordan Nhan, Nadine Ahmed, Dennis Özcelik, John Paul Pezacki
    iScience.2018; 10: 149.     CrossRef
  • Liver Disease in Singapore
    Mark Muthiah, Chern H Chong, Seng G Lim
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 66.     CrossRef
  • Accelerating Treatment of Skeletal Class II Malocclusion using Fixed Twin Block Appliances
    Snigdha Pattanaik, Navya Puvvula, Noorjahan Mohammad
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 146.     CrossRef
  • Effect of a Papain-based Chemomechanical Agent on Structure of Dentin and Bond Strength: Anin vitroStudy
    Veena S Pai, Yashwanth Gowda, Sruthi Nair
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 161.     CrossRef
  • Perception of Indian Dental Surgeons regarding Molar Incisor Hypomineralization
    Sumita Upadhyay, Jatinder K Dhillon
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 116.     CrossRef
  • Association between Obesity and Oral Health Status in Schoolchildren: A Survey in Five Districts of West Bengal, India
    Rahul Kaul, Paras Angrish, Subrata Saha, Sonali Halder, Bhaswar Bhattacharya, Malay Mitra
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 233.     CrossRef
  • Burden of Alcoholic Liver Disease: Bhutan Scenario
    Pelden Wangchuk
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 81.     CrossRef
  • Comparative Evaluation of Effects ofTriphala, Garlic Extracts, and Chlorhexidine Mouthwashes on SalivaryStreptococcus mutansCounts and Oral Hygiene Status
    Shweta Gupta, Narendra Padiyar, Bharathi Padiyar
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 299.     CrossRef
  • Evaluation of Dentin–Pulp Complex Response after Conservative Clinical Procedures in Primary Teeth
    Thais Marchini Oliveira, Bianca Mello, Tassia C Stafuzza, Luciana Vitor, Daniela Rios, Thiago Silva, Maria Machado
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 188.     CrossRef
  • Nonalcoholic Fatty Liver Disease: Time to Take the Bull by the Horns
    Preetam Nath, Shivaram P Singh
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 47.     CrossRef
  • F-18 Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography Findings of Isolated Gastric Tuberculosis mimicking Gastric Cancer and Lymphoma
    Remzi A Akdogan, Halil Rakici, Serkan Güngör, Recep Bedir, Elif Akdogan
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 93.     CrossRef
  • Clinical, Radiological, and Histological Assessment of Magnetic Nanoparticles as Pulpotomy Medicament in Primary Molars
    Manoj K Mallela, Harivinder R Konyala, Ajay R Mareddy, N Venugopal Reddy, Keerthi P Susheela
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 283.     CrossRef
  • Determination of ABO Blood Groups and Rh Typing from Dry Salivary Samples
    Laxmi Lakade, Priyam R Velani
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 100.     CrossRef
  • Orofacial Manifestations of Leukemic Children on Treatment: A Descriptive Study
    Keerthilatha M Pai, Aparna Aggarwal
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 193.     CrossRef
  • Mandibular Regional Odontodysplasia in an 8-year-old Boy showing Teeth Disorders, Gubernaculum Tracts, and Altered Bone Fractal Pattern
    Davi de Sá Cavalcante, Cristiane SR Fonteles, Thyciana R Ribeiro, Lúcio M Kurita, Alynne Vde M Pimenta, Francisco SR Carvalho, Fábio WG Costa
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 128.     CrossRef
  • Evaluation of Chemokines in the Gingival Crevicular Fluid of Children with Down Syndrome
    Harshini Togaru, Veerakishore Kumar Reddy, Naveen K Kommineni, Prathyusha Padakandla, John P Indupalli, Swapna P Nanga
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 288.     CrossRef
  • Hepatitis B Virus Infection among Health Care Workers in Indonesia
    David H Muljono, Teguh Wijayadi, Rizalinda Sjahril
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 88.     CrossRef
  • Comparison of the Effectiveness of Probiotic, Chlorhexidine-based Mouthwashes, and Oil Pulling Therapy on Plaque Accumulation and Gingival Inflammation in 10- to 12-year-old Schoolchildren: A Randomized Controlled Trial
    Saravana K Kandaswamy, Asokan Sharath, PR Geetha Priya
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 66.     CrossRef
  • Evaluation of Changes in Salivary pH after Intake of Different Eatables and Beverages in Children at Different Time Intervals
    Ankit Pachori, Haalaswamy Kambalimath, Garima Bhambhani, Garima Malhotra
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 177.     CrossRef
  • Customized Hybrid Bluegrass Appliance: An Innovative Technique
    Ziauddin Mohammad, Apeksha Bagalkotkar, Ashank Mishra, Gopi Veerala
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 141.     CrossRef
  • Postobstructive Cyst Formation in Pancreatic Duct affecting Surgical Approach
    Alper Parlakgumus, Ali Ezer
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 99.     CrossRef
  • Validating the Usage of Cariogram in 5- and 12-year-old School-going Children in Paonta Sahib, Himachal Pradesh, India: A 12-month Prospective Study
    Manish Madan, Pallav Singhal, Anu Garg, Akash Dupper
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 110.     CrossRef
  • Epidemiology of Chronic Hepatitis B in Turkey
    Hasan Ozkan
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 73.     CrossRef
  • A Comparative Evaluation of Time-dependent Changes on the Surface Hardness of Bulk Cure Composites: Anin vitroStudy
    Anindita Sarma
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 183.     CrossRef
  • Management of Hepatocellular Carcinoma: Bangladesh Perspective
    Mohammad Noor-E-Alam
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 52.     CrossRef
  • Trichobezoar: Ravenous for Hair
    Aman Kamra
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 97.     CrossRef
  • Comparative Evaluation of the Fracture Resistance of Two Different Fiber-reinforced Composite Restorations with Particulate Filler Composite Restorations
    Vanga V Narasimha Rao, Srinivas K Chandrabhatla, Vabbala R Rajasekhar
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 277.     CrossRef
  • A Comparative Evaluation of Efficacy ofStreptococcus mutansCounts in Saliva: Anin vivoStudy
    Inder K Pandit
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 94.     CrossRef
  • Liver Cancer in Nepal
    Ananta Shrestha
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 63.     CrossRef
  • Pre-eruptive Intracoronal Radiolucency in First Permanent Molar
    Mariana C Ilha, Paulo F Kramer, Simone H Ferreira, Henrique C Ruschel
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 151.     CrossRef
  • Comparative Evaluation of Various Temperature Changes on Stress Distribution in Class II Mesial-occlusal-distal Preparation restored with Different Restorative Materials: A Finite Element Analysis
    Binita Srivastava, Neorem N Devi
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 167.     CrossRef
  • A Survey on the Use of Antibiotics among the Dentists of Kolkata, West Bengal, India
    Rahul Kaul, Paras Angrish, Subrata Saha, Ashok V Sengupta, Shantanu Mukherjee
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 122.     CrossRef
  • Changing Etiology in Liver Cirrhosis in Sapporo, Japan
    Jong-Hon Kang, Takeshi Matsui
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 77.     CrossRef
  • Epidemiology, Genotype Distribution, Prognosis, Control, and Management of Viral Hepatitis B, C, D, and Hepatocellular Carcinoma in Mongolia
    Oidov Baatarkhuu, Tsagaantsooj Gerelchimeg, Dashchirev Munkh-Orshikh, Badamnachin Batsukh, Ganbold Sarangua, Jazag Amarsanaa
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 57.     CrossRef
  • Impact of Diabetes Mellitus Type 1 on Lebanese Families’ Quality of Life
    Nahla Nassif, Balsam Noueiri
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 61.     CrossRef
  • Pediatric Dental Appointments No-show: Rates and Reasons
    Anup Panda, Rupinder Bhatia, Esha C Vora
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 171.     CrossRef
  • A Case of Painless Excision
    Rupinder Bhatia, Ipshita A Suyash
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 135.     CrossRef
  • Manuka Honey: A Potent Cariostatic Agent–Anin vitroStudy
    Sapna Konde, Javaregowda P Beena, Punyatoya Sahoo, N Sunil Raj, Narayana C Kumar
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 105.     CrossRef
  • Reviewing of Research Finding of Hepatitis B Virus Infection in Lao People's Democratic Republic
    Angkham Ounavong
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 75.     CrossRef
  • Nonalcoholic Fatty Liver Disease: Identifying the Disease Burden in Sri Lanka
    Anuradha S Dassanayake
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 69.     CrossRef
  • Comparative Evaluation of Microhardness by Common Drinks on Esthetic Restorative Materials and Enamel: Anin vitroStudy
    Manish Madan, Akash Dupper, Roli Gupta, Trilok Kainthla
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 155.     CrossRef
  • Hepatocellular Carcinoma Surveillance: Benefit of Serum Alfa-fetoprotein in Real-world Practice
    Patharapan Lersritwimanmaen, Supot Nimanong
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 83.     CrossRef
  • Body Mass Index and Dental Caries: A Systematic Review

    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 228.     CrossRef
  • Evaluation of Surgical Options for Supernumerary Teeth in the Anterior Maxilla
    Gianluca Porcaro, Luca Mirabelli, Ernesto Amosso
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 294.     CrossRef
  • A Comparative Study to evaluate Parent's Ability to assess Dental Fear in their 6- to 10-year-old Children using Children's Fear Survey Schedule—Dental Subscale
    Ritika Malhotra, Anchal Sahni
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 205.     CrossRef
  • Estimation of Salivary Glucose, Calcium, Phosphorus, Alkaline Phosphatase, and Immunoglobulin A among Diabetic and Nondiabetic Children: A Case–Control Study
    Kalyani Uppu, Suzan Sahana, Ghanashyam P Madu, Aron AK Vasa, Sowjanya Nalluri
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 71.     CrossRef
  • Pedodontic Considerations in a Child with Attention Deficit Hyperactivity Disorder: Literature Review and a Case Report
    Siddhi Sinha, Prasanna Praveen, S Prathibha Rani, Athimuthu Anantharaj
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 254.     CrossRef
  • Salivary Cortisol and Alpha-amylase—Biomarkers of Stress in Children undergoing Extraction: Anin vivoStudy
    Neha Agarwal, Shefali Chaturvedy, Saurabh Chaturvedi, Yogita Chaturvedi
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 214.     CrossRef
  • Influence of Storage Media and Duration of Fragment in the Media on the Bond Strength of the Reattached Tooth Fragment
    Prashant Jalannavar
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 83.     CrossRef
  • Comparative Evaluation of Mucosal Vibrator with Topical Anesthetic Gel to reduce Pain during Administration of Local Anesthesia in Pediatric Patients: Anin vivoStudy
    Mahima Gandhi, Garima Kalia, Khushboo Rathore
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 261.     CrossRef
  • Management of Autistic Patients in Dental Office: A Clinical Update
    Jyothi S Bommangoudar
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 219.     CrossRef
  • Foreign Body causing Displacement of Immature Fractured Apical Root Fragment: An Unusual Case Report
    Aman Moda, Rajesh Singla, Preeti M Agrawal
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 247.     CrossRef
  • Validity and Reliability of the Hindi Version of the Modified Child Perceptions Questionnaire 11 to 14
    Mohit Sharma, Prasanna Kumar, Dempsy CM Mandanna
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 271.     CrossRef
  • Nonsyndromic Gingival Fibromatosis: A Rare Case Report
    Mahima Gandhi, Akshat Vijay
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 250.     CrossRef
  • Prevalence of Deleterious Oral Habits among 3- to 5-yearold Preschool Children in Bhubaneswar, Odisha, India
    Brahmananda Dutta, Tulika Verma
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 210.     CrossRef
  • Evaluation of Antimicrobial Activity of Two Endodontic Sealers: Zinc Oxide with Thyme Oil and Zinc Oxide Eugenol against Root Canal Microorganisms—Anin vitroStudy
    Manoj Chandak, Nilima Thosar, Silpi Basak
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 79.     CrossRef
  • Prevalence and Risk Factors for Dental Caries among Preschool Children: A Cross-sectional Study in Eastern India
    Vinay K Chugh, Kushal K Sahu, Ankita Chugh
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 238.     CrossRef
  • Squamous Papilloma on Hard Palate: Case Report and Literature Review
    Penmatsa Chaitanya, Satyam Martha, Ramachandran Punithvathy, Madhusudhan Reddy
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 244.     CrossRef
  • Comparison of Vitamin D Level of Children with Severe Early Childhood Caries and Children with No Caries
    Anchal Chhonkar, Vishal Arya
    International Journal of Clinical Pediatric Dentistry.2018; 11(3): 199.     CrossRef
  • Use of “Surface Analyzer” to evaluate the Effect of Two Polishing Systems on Surface Texture of Four Newer Composites
    Shefally Garg, Munish Goel, Shweta Verma, Nanika Mahajan, Bhawna Kaul, Vikas Garg
    International Journal of Clinical Pediatric Dentistry.2018; 11(4): 266.     CrossRef
  • Clinical Evaluation of Preventive Effect of Fissure Sealants on Initial Carious Lesion of Permanent Mandibular Molars Pretreated with and without Fluoride Varnish by Fluorescence Camera
    Madhagudanahalli S Lakshmi, Kudlapur T Srilatha, Bhojraj Nandlal, Seema Deshmukh
    International Journal of Clinical Pediatric Dentistry.2018; 11(2): 89.     CrossRef
  • Hepatocellular Carcinoma in Malaysia and Its Changing Trend
    Rosmawati Mohamed, Ruksana Raihan, Amirah Azzeri, Fatiha H Shabaruddin
    Euroasian Journal of Hepato-Gastroenterology.2018; 8(1): 54.     CrossRef
  • Advances in the Understanding and Treatment of Mitochondrial Fatty Acid Oxidation Disorders
    Eric S. Goetzman
    Current Genetic Medicine Reports.2017; 5(3): 132.     CrossRef
  • Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
    Ruth C. R. Meex, Matthew J. Watt
    Nature Reviews Endocrinology.2017; 13(9): 509.     CrossRef
  • In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications
    Yun Hu, Qinwei Sun, Jie Liu, Yimin Jia, Demin Cai, Abdulrahman A. Idriss, Nagmeldin A. Omer, Ruqian Zhao
    Scientific Reports.2017;[Epub]     CrossRef
  • The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease
    Sheng Zhong, Yuxiang Fan, Qi Yan, Xingyu Fan, Bo Wu, Yujuan Han, Ying Zhang, Yong Chen, Huimao Zhang, Junqi Niu
    Medicine.2017; 96(49): e9061.     CrossRef
  • Atorvastatin reduces lipid accumulation in the liver by activating protein kinase A-mediated phosphorylation of perilipin 5
    Xing Gao, Yang Nan, Yuanlin Zhao, Yuan Yuan, Bincheng Ren, Chao Sun, Kaiyu Cao, Ming Yu, Xuyang Feng, Jing Ye
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2017; 1862(12): 1512.     CrossRef
  • Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis
    E. Matthew Morris, Colin S. McCoin, Julie A. Allen, Michelle L. Gastecki, Lauren G. Koch, Steven L. Britton, Justin A. Fletcher, Xiarong Fu, Wen‐Xing Ding, Shawn C. Burgess, R. Scott Rector, John P. Thyfault
    The Journal of Physiology.2017; 595(14): 4909.     CrossRef
  • Use of Statins in Patients with Chronic Liver Disease and Cirrhosis: Current Views and Prospects
    Jose Ignacio Vargas, Marco Arrese, Vijay H. Shah, Juan Pablo Arab
    Current Gastroenterology Reports.2017;[Epub]     CrossRef
  • Endogenous catalase delays high-fat diet-induced liver injury in mice
    Lingjuan Piao, Jiyeon Choi, Guideock Kwon, Hunjoo Ha
    The Korean Journal of Physiology & Pharmacology.2017; 21(3): 317.     CrossRef
  • Clinical implications of understanding the association between oxidative stress and pediatric NAFLD
    Jake P. Mann, Massimiliano Raponi, Valerio Nobili
    Expert Review of Gastroenterology & Hepatology.2017; 11(4): 371.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP