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Adanma Ironkwe  (Ironkwe A) 1 Article
Effect of Livingstone Potato (Plectranthus esculenthus N.E.Br) on Diabetes and Its Complications in Streptozotocin Induced Diabetes in Rats
Chinedum Ogbonnaya Eleazu, Kate Chinedum Eleazu, Adanma Ironkwe, Mercy Amarachi Iroaganachi
Diabetes Metab J. 2014;38(5):366-374.   Published online October 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.5.366
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AbstractAbstract PDFPubReader   
Background

The effect of livingstone potato (Plectranthus esculenthus N.E.Br) on diabetes and its complications in Streptozotocin induced diabetic rats was investigated. The duration of the experiment was 4 weeks.

Methods

The blood glucose level of the rats was measured with a glucometer, the protein and glucose and specific gravity in the urine samples of the rats were measured using urine assay strips and urinometer respectively. The liver and kidney function parameters in the serum of the rats were determined using Biosystem Kits.

Results

The diabetic rats given livingstonepotato incorporated feeds, had 129.7% decrease in their hyperglycemia with corresponding amelioration of their elevated urinary protein, sugars, specific gravity, renal growth, liver growth as well as 15.64% decrease in body weights compared with the nondiabetic rats that had 5.54% decrease in blood glucose and 20.39% increase in body weight unlike the diabetic control rats that had 18.34% decrease in blood glucose and 52.68% decrease in body weight. There were significant differences (P<0.05) in the relative liver, pancreas, and kidney weights of the diabetic rats given livingstone potato feeds compared with the diabetic control while there were no significant differences (P>0.05) in the relative heart weights of all the rats in the three different groups. In terms of liver and kidney function parameters, values obtained for the diabetic rats given livingstone potato incorporated feeds were not significantly different from that of the nondiabetic rats except for total bilurubin, aspartate transaminase, and creatinine (P>0.05) while they were significantly different from the values obtained for the diabetic control rats (P<0.05). In addition, the serum amylase of the diabetic control rats were significantly higher (P<0.05) than that of the nondiabetic and diabetic rats treated with livingstone potato incorporated feeds.

Conclusion

Results show the antidiabetic actions of livingstone potato and its ability to ameliorate glomerular complication and liver hypertrophy in diabetics.

Citations

Citations to this article as recorded by  
  • Plectranthus esculentus (Livingstone potato)

    CABI Compendium.2022;[Epub]     CrossRef
  • Biogenic Synthesis of Silver Nanoparticles Using Phagnalon niveum and Its In Vivo Anti-Diabetic Effect against Alloxan-Induced Diabetic Wistar Rats
    Muhammad Nisar Ul Haq, Ghulam Mujtaba Shah, Alia Gul, Ahmed Ibrahim Foudah, Mohammad Hamed Alqarni, Hasan Soliman Yusufoglu, Masroor Hussain, Huda Mohammed Alkreathy, Ihsan Ullah, Amir Muhammad Khan, Shahid Jamil, Mushtaq Ahmed, Rahmat Ali Khan
    Nanomaterials.2022; 12(5): 830.     CrossRef
  • Green Silver Nanoparticles Synthesized from Taverniera couneifolia Elicits Effective Anti-Diabetic Effect in Alloxan-Induced Diabetic Wistar Rats
    Muhammad Nisar Ul Haq, Ghulam Mujtaba Shah, Farid Menaa, Rahmat Ali Khan, Norah A. Althobaiti, Aishah E. Albalawi, Huda Mohammed Alkreathy
    Nanomaterials.2022; 12(7): 1035.     CrossRef
  • Nutrient Composition, Antioxidant Capacity and Natural Products in Livingstone Potato (Plectranthus esculentus )
    C.O. Eleazu, K.C. Eleazu
    Journal of Food Processing and Preservation.2015; 39(6): 3050.     CrossRef

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