Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Abhijit N. Gurav  (Gurav AN) 1 Article
Periodontitis and Insulin Resistance: Casual or Causal Relationship?
Abhijit N. Gurav
Diabetes Metab J. 2012;36(6):404-411.   Published online December 12, 2012
  • 4,651 View
  • 48 Download
  • 46 Crossref
AbstractAbstract PDFPubReader   

Insulin resistance (IR) is now considered as a chronic and low level inflammatory condition. It is closely related to altered glucose tolerance, hypertriglyceridemia, abdominal obesity, and coronary heart disease. IR is accompanied by the increase in the levels of inflammatory cytokines like interleukin-1 and 6, tumor necrosis factor-α. These inflammatory cytokines also play a crucial part in pathogenesis and progression of insulin resistance. Periodontitis is the commonest of oral diseases, affecting tooth investing tissues. Pro-inflammatory cytokines are released in the disease process of periodontitis. Periodontitis can be attributed with exacerbation of IR. Data in the literature supports a "two way relationship" between diabetes and periodontitis. Periodontitis is asymptomatic in the initial stages of disease process and it often escapes diagnosis. This review presents the blurred nexus between periodontitis and IR, underlining the pathophysiology of the insidious link. The knowledge of the association between periodontitis and IR can be valuable in planning effectual treatment modalities for subjects with altered glucose homeostasis and diabetics. Presently, the studies supporting this association are miniscule. Further studies are mandatory to substantiate the role of periodontitis in the deterioration of IR.


Citations to this article as recorded by  
  • Recent Aspects of Periodontitis and Alzheimer’s Disease—A Narrative Review
    Dominika Cichońska, Magda Mazuś, Aida Kusiak
    International Journal of Molecular Sciences.2024; 25(5): 2612.     CrossRef
  • More than just teeth: How oral health can affect the heart
    Steven Hopkins, Saivaroon Gajagowni, Yusuf Qadeer, Zhen Wang, Salim S. Virani, Jukka H. Meurman, Roman Leischik, Carl J. Lavie, Markus Strauss, Chayakrit Krittanawong
    American Heart Journal Plus: Cardiology Research and Practice.2024; 43: 100407.     CrossRef
  • Association of endogenous sex hormone levels with tooth loss due to periodontitis in men and post‐menopausal women: The multi‐ethnic study of atherosclerosis
    Maria Doughan, Omar Chehab, Bassel Doughan, Joao A. C. Lima, Erin D. Michos
    Journal of Periodontal Research.2024;[Epub]     CrossRef
  • Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
    Athanasios Tsimpiris, Ioannis Tsolianos, Andreas Grigoriadis, Ioannis Moschos, Dimitrios G. Goulis, Georgios Kouklakis
    European Journal of Dentistry.2023; 17(02): 270.     CrossRef
  • Bidirectional association between polycystic ovary syndrome and periodontal diseases
    Yang Dou, Jinglei Xin, Peng Zhou, Jianming Tang, Hongliang Xie, Wanting Fan, Zheng Zhang, Donglei Wu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Comparison of the triglyceride glucose index and modified triglyceride glucose indices in assessing periodontitis in Korean adults
    Hyun‐Jeong Lee, Ji‐Won Lee, Sue Kim, Yu‐Jin Kwon
    Journal of Periodontal Research.2023; 58(3): 503.     CrossRef
  • Risk Assessment of Periodontitis according to Metabolic Score for Insulin Resistance in Korean Population: Korea National Health and Nutrition Examination Survey VI (2013–2015)
    In-Hwan Kim, Yea-Chan Lee, Yu-Jin Kwon, Yong-Jae Lee
    Korean Journal of Family Practice.2023; 13(1): 38.     CrossRef
    Maria Eduarda Ribeiro Da Silva, Karina Sarno Paes Alves Dias, Pedro Gomes Fonseca Rocha, Paollo Teixeira de Amorim Santos, Matheus Feliphe Lima De Melo, Iago Fraga Araújo, Caio Santos Porto, Cícero Gabriel dos Santos Coutinho, Gledyson Sousa Caires
    REVISTA FOCO.2023; 16(6): e2257.     CrossRef
  • Non-Insulin-Based Insulin Resistance Indices and Localized Periodontitis in Physically Active Young Male Adults: CHIEF Oral Health Study
    Kun-Zhe Tsai, Yen-Po Lin, Shiue-Wei Lai, Chia-Hsin Liu, Yun-Chen Chang, Gen-Min Lin
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(7): 937.     CrossRef
  • Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review
    Itay Aizenbud, Asaf Wilensky, Galit Almoznino
    International Journal of Molecular Sciences.2023; 24(16): 13011.     CrossRef
  • Periodontitis is associated with insulin resistance in adults living with diabetes mellitus in Uganda: a cross- sectional study
    Haruna Muhmood Kiryowa, Ian Guyton Munabi, William Buwembo, Charles Mugisha Rwenyonyi, Erisa Sabakaki Mwaka, Mark Kaddumukasa
    BMC Research Notes.2023;[Epub]     CrossRef
  • Periodontal and systemic health of morbidly obese patients eligible for bariatric surgery: a cross-sectional study
    Dejana Čolak, Alja Cmok Kučič, Tadeja Pintar, Boris Gašpirc, Rok Gašperšič
    BMC Oral Health.2022;[Epub]     CrossRef
  • Impact of Periodontitis on Glycemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Therapeutic Perspectives
    Simona Santonocito, Alessandro Polizzi, Enrico Marchetti, Domenico Dalessandri, Marco Migliorati, Saturnino Marco Lupi, Marco Cicciù, Gaetano Isola, Alessandro Trentini
    Mediators of Inflammation.2022; 2022: 1.     CrossRef
  • Do Cytokines Associate Periodontitis with Metabolic Disorders? An Overview of Current Documents
    Reza Aref Nezhad, Hossein Motedayyen, Hossein Roghani-Shahraki
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(7): 778.     CrossRef
  • Comparison of the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) associated with periodontitis in Korean adults
    Yea-Chan Lee, Ji-Won Lee, Yu-Jin Kwon
    Therapeutic Advances in Chronic Disease.2022; 13: 204062232211226.     CrossRef
  • Markers, pathways, and current evidence for periodontitis-associated insulin resistance: A narrative review
    VivekKumar Bains, Jaideep Mahendra, Little Mahendra, Madhukar Mittal, Gunam Valli
    Journal of International Society of Preventive and Community Dentistry.2022; 12(5): 475.     CrossRef
  • Periodontal Therapy in Bariatric Surgery Patients with Periodontitis: Randomized Control Clinical Trial
    Dejana Čolak, Alja Cmok Kučič, Tadeja Pintar, Rok Gašperšič
    Journal of Clinical Medicine.2022; 11(22): 6837.     CrossRef
  • Systemic Diseases and Biological Dental Implant Complications: A Narrative Review
    Luca Sbricoli, Elissar Bazzi, Edoardo Stellini, Christian Bacci
    Dentistry Journal.2022; 11(1): 10.     CrossRef
  • Association Between Diabetic Retinopathy and Periodontitis—A Systematic Review
    María Olimpia Paz Alvarenga, Giza Hellen Nonato Miranda, Railson Oliveira Ferreira, Miki Taketomi Saito, Nathália Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima
    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Why is exercise important to dentistry?
    Rishiniy Pushparatnam
    BDJ Team.2021; 8(2): 20.     CrossRef
  • The role of Wnt pathway in obesity induced inflammation and diabetes: a review
    Bhabajyoti Das, Manas Das, Anuradha Kalita, Momita Rani Baro
    Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1871.     CrossRef
  • Association between obesity and chronic periodontitis
    Tsung-Po Chen, Hui-Chieh Yu, Tai-Hsin Lin, Yu-Hsun Wang, Yu-Chao Chang
    Medicine.2021; 100(41): e27506.     CrossRef
  • Association Between Triglyceride-Glucose Index and Risk of Periodontitis: A Cross-Sectional Study
    Lili Li, Lu Li, Yi Zhou, Xu Chen, Yan Xu
    International Journal of General Medicine.2021; Volume 14: 9807.     CrossRef
  • Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial

    Ahmad Zare Javid, Seyed Ahmad Hosseini, Hassan Gholinezhad, Leila Moradi, Mohammad Hosein Haghighi-zadeh, Hadi Bazyar
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 753.     CrossRef
  • Influence of non-surgical periodontal therapy on insulin resistance in chronic periodontitis subjects with prediabetes
    Shravani Babladi, Rupali Agnihotri, Pratibha Gopalkrishna, Shobha U. Kamath, Sushma Jogi, Brunda Arun
    International Journal of Diabetes in Developing Countries.2019; 39(2): 273.     CrossRef
  • The relationship of diabetes, periodontitis and cardiovascular disease
    Anandhara Indriani Khumaedi, Dyah Purnamasari, Ika Prasetya Wijaya, Yuniarti Soeroso
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(2): 1675.     CrossRef
  • Association between Regular Electronic Nicotine Product Use and Self-Reported Periodontal Disease Status: Population Assessment of Tobacco and Health Survey
    Nkiruka Atuegwu, Mario Perez, Cheryl Oncken, Sejal Thacker, Erin Mead, Eric Mortensen
    International Journal of Environmental Research and Public Health.2019; 16(7): 1263.     CrossRef
  • Evaluation and comparison of serum vitamin D and calcium levels in periodontally healthy, chronic gingivitis and chronic periodontitis in patients with and without diabetes mellitus – a cross-sectional study
    Anshuka A. Agrawal, Abhay P. Kolte, Rajashri A. Kolte, Suresh Chari, Madhur Gupta, Resham Pakhmode
    Acta Odontologica Scandinavica.2019; 77(8): 592.     CrossRef
  • Periodontal inflammation correlates with systemic inflammation and insulin resistance in patients with recent diagnosis of type 2 diabetes
    Natacha Oyarzo, María Riveros, Constanza Andaur, Jessica Liberona, Víctor Cortés
    ARS MEDICA Revista de Ciencias Médicas.2019; 44(1): 6.     CrossRef
  • A longitudinal study on the relationship between dental health and metabolic syndrome in Japan
    Shin‐ichi Sakurai, Shin‐ichi Yamada, Imahito Karasawa, Akinari Sakurai, Hiroshi Kurita
    Journal of Periodontology.2019; 90(7): 728.     CrossRef
  • Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey
    Yu-Jin Kwon, Jeong-Won Park, Hyoung-Ji Lim, Yong-Jae Lee, Hye-Sun Lee, Jae-Yong Shim
    Clinical Oral Investigations.2018; 22(1): 515.     CrossRef
  • Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge
    Thomas Kocher, Jörgen König, Wenche Sylling Borgnakke, Christiane Pink, Peter Meisel
    Periodontology 2000.2018; 78(1): 59.     CrossRef
  • Nanofibrous Spongy Microspheres To Distinctly Release miRNA and Growth Factors To Enrich Regulatory T Cells and Rescue Periodontal Bone Loss
    Zhongning Liu, Xin Chen, Zhanpeng Zhang, Xiaojin Zhang, Laura Saunders, Yongsheng Zhou, Peter X. Ma
    ACS Nano.2018; 12(10): 9785.     CrossRef
  • The role of dental practitioners in addressing overweight and obesity among children: A scoping review of current interventions and strategies
    Amy R. Villarosa, David George, Lucie M. Ramjan, Ravi Srinivas, Ajesh George
    Obesity Research & Clinical Practice.2018; 12(5): 405.     CrossRef
  • Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos
    Aderonke A. Akinkugbe, A. Sidney Barritt, Jianwen Cai, Steven Offenbacher, Bharat Thyagarajan, Tasneem Khambaty, Richard Singer, Eric Kallwitz, Gerardo Heiss, Gary D. Slade
    Journal of Periodontology.2018; 89(8): 949.     CrossRef
  • Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis
    Junfei Zhu, Bin Guo, Xueqi Gan, Ling Zhang, Yuting He, Beilei Liu, Xin Chen, Suhan Zhang, Haiyang Yu
    BMC Oral Health.2017;[Epub]     CrossRef
  • Normal Oral Flora and the Oral Ecosystem
    Lakshman Samaranayake, Victor H. Matsubara
    Dental Clinics of North America.2017; 61(2): 199.     CrossRef
  • Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross‐sectional study
    Mayte Martinez‐Herrera, Francisco Javier Silvestre, Javier Silvestre‐Rangil, Celia Bañuls, Milagros Rocha, Antonio Hernández‐Mijares
    Journal of Clinical Periodontology.2017; 44(10): 981.     CrossRef
  • The relationship between insulin resistance and periodontitis is not affected by Mediterranean diet in a Spanish population
    M. Pulido-Moran, P. Bullon, J.M. Morillo, M. Battino, J.L. Quiles, MCarmen Ramirez-Tortosa
    Archives of Oral Biology.2017; 77: 62.     CrossRef
  • Periodontitis contributes to adipose tissue inflammation through the NF-B, JNK and ERK pathways to promote insulin resistance in a rat model
    Yanli Huang, Jin Zeng, Guoqing Chen, Xudong Xie, Weihua Guo, Weidong Tian
    Microbes and Infection.2016; 18(12): 804.     CrossRef
  • Systemic Inflammatory Biomarkers and Their Association With Periodontal and Diabetes‐Related Factors in the Diabetes and Periodontal Therapy Trial, A Randomized Controlled Trial
    Maria L. Geisinger, Bryan S. Michalowicz, Wei Hou, Elinor Schoenfeld, Marie Gelato, Steven P. Engebretson, Michael S. Reddy, Leslie Hyman
    Journal of Periodontology.2016; 87(8): 900.     CrossRef
  • Association of Periodontitis and Subsequent Depression
    Chih-Chao Hsu, Yi-Chao Hsu, Hsuan-Ju Chen, Che-Chen Lin, Kuang-Hsi Chang, Chang-Yin Lee, Lee-Won Chong, Chia-Hung Kao
    Medicine.2015; 94(51): e2347.     CrossRef
  • Association between insulin resistance and periodontitis in Korean adults
    Sang Gyu Lim, Kyungdo Han, Hyun‐Ah Kim, Sung Woon Pyo, Young‐Sik Cho, Kyung‐Soo Kim, Hyeon Woo Yim, Won‐Chul Lee, Yong Gyu Park, Yong‐Moon Park
    Journal of Clinical Periodontology.2014; 41(2): 121.     CrossRef
  • Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study
    Subodh P. Gaikwad, Abhijit N. Gurav, Abhijeet R. Shete, Hitesh M. Desarda
    Journal of Periodontal & Implant Science.2013; 43(2): 79.     CrossRef
  • Diabetes Mellitus and Inflammation
    Eric Lontchi-Yimagou, Eugene Sobngwi, Tandi E. Matsha, Andre Pascal Kengne
    Current Diabetes Reports.2013; 13(3): 435.     CrossRef
  • Bacterial Infection Increases Periodontal Bone Loss in Diabetic Rats through Enhanced Apoptosis
    Sandra Pacios, Oelisoa Andriankaja, Jun Kang, Maher Alnammary, Jason Bae, Beatriz de Brito Bezerra, Helen Schreiner, Daniel H. Fine, Dana T. Graves
    The American Journal of Pathology.2013; 183(6): 1928.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer