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Abdolreza Sotoodeh Jahromi  (Jahromi AS) 1 Article
Genetics
Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran
Mohammad Pourahmadi, Saiedeh Erfanian, Malihe Moradzadeh, Abdolreza Sotoodeh Jahromi
Diabetes Metab J. 2015;39(6):512-517.   Published online November 13, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.6.512
  • 3,078 View
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  • 21 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Transcription factor 7-like 2 (TCF7L2) is a transcription factor in the Wnt signaling pathway. High levels of TCF7L2 have been reported in most human tissues, including the heart, lung, brain, liver, kidney, placenta, adipose tissues, and pancreatic β-cells. The purpose of this study was to assess the association between TCF7L2 polymorphisms (rs12255372 and rs7903146) and type 2 diabetes mellitus in the city of Jahrom, Iran.

Methods

This case-control study was conducted with 200 patients referred to Diabetes Clinics and 200 healthy subjects in Jahrom City. Biochemical characteristics were first determined. TCF7L2 rs1255372 and rs7903146 polymorphisms were then genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.

Results

T-allele frequencies of both single nucleotide polymorphisms (SNPs) were significantly higher in diabetic patients than in normal glucose-tolerant subjects (rs12255372: 20.3% vs. 14.5%; rs7903146: 28.5% vs. 22.25%). The rs12255372 (G/T) polymorphism analysis showed an odds ratio of 0.473 (95% confidence interval [CI], 0.170 to 1.314; P=0.151) for the TT genotype and 0.646 (95% CI, 0.410 to 1.019; P=0.060) for the TG genotype, compared with the GG genotype. The rs7903146 (C/T) polymorphism odds ratios for TT and TC genotypes were 0.564 (95% CI, 0.280 to 1.135; P=0.109) and 0.751 (95% CI, 0.487 to 1.157; P=0.194) compared with the CC genotype, respectively.

Conclusion

The rs12255372 and rs7903146 SNPs of the TCF7L2 gene were not associated with insulin resistance in the evaluated population.

Citations

Citations to this article as recorded by  
  • Association between Transcription Factor 7-Like 2 Gene Polymorphisms rs7903146 and rs12255372 with the Risk of Diabetic Nephropathy among South Indian Population
    Balaji Ramanathan, Kumaravel Velayutham
    Chronicle of Diabetes Research and Practice.2024; 3(1): 8.     CrossRef
  • Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case–control study among the Bangladeshi population
    Asma Salauddin, Kallyan Chakma, Md. Mahbub Hasan, Farhana Akter, Nowshad Asgar Chowdhury, Sumon Rahman Chowdhury, Adnan Mannan
    Molecular Biology Reports.2023; 50(1): 609.     CrossRef
  • Role of rs7903146 polymorphism and adropin serum level in patients with diabetes mellitus; a case–control study from Isfahan, Iran
    Abbas-Ali Palizban, Abdol-Hamid Yazdani, Hamidreza Jahanbani-Ardakani
    Archives of Physiology and Biochemistry.2022; 128(2): 378.     CrossRef
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    Journal of Diabetes & Metabolic Disorders.2022; 21(1): 241.     CrossRef
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    Herz.2021; 46(1): 71.     CrossRef
  • Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population
    Valeriy V. Benberin, Tamara A. Vochshenkova, Gulshara Zh. Abildinova, Anna V. Borovikova, Almagul A. Nagimtayeva
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 131.     CrossRef
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    Zhensheng Zhang, Li Xu, Xiao Xu
    Obesity Reviews.2021;[Epub]     CrossRef
  • Association of transcription factor 7-like 2 (rs7903146) gene polymorphism with diabetic retinopathy
    Hadeel Ahmed Shawki, Ekbal M.Abo-Hashem, Magdy M. Youssef, Maha Shahin, Rasha Elzehery
    Ophthalmic Genetics.2020; 41(5): 420.     CrossRef
  • Association of SLC30A8, CDKAL1, TCF7L2 and HHEX Gene Polymorphisms with Type 2 Diabetes in the Population of North East India
    A. Bhowmick, P. Sarkar, M. P. Baruah, D. Bodhini, V. Radha, V. Mohan, S. Banu
    Cytology and Genetics.2020; 54(2): 165.     CrossRef
  • Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus
    Ahmed Mohamed Bahaaeldin, Arig Aly Seif, Amira Ibrahim Hamed, Walaa Ahmed Yousry Kabiel
    Dubai Diabetes and Endocrinology Journal.2020; 26(3): 112.     CrossRef
  • The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review
    Maliheh Moradzadeh, Mohamad Reza Kalani, Amir Avan
    Journal of Cellular Biochemistry.2019; 120(4): 4732.     CrossRef
  • Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population
    Kui-Chen Zhou, Hong-Wei Liu, Chen Wang, Yan-Jun Fu, Feng Jin
    Medicine.2019; 98(5): e14288.     CrossRef
  • Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
    Gisela Geoghegan, Judith Simcox, Marcus M. Seldin, Timothy J. Parnell, Chris Stubben, Steven Just, Lori Begaye, Aldons J. Lusis, Claudio J. Villanueva
    Molecular Metabolism.2019; 24: 44.     CrossRef
  • Association study of the rs46522 polymorphism in UBE2Z and rs7903146 polymorphism in TCF7L2 gene with T2DM in Arab population of Khuzestan province: case-control study
    Sana Shafidelpour, Ali Mohammad Foroughmand, Merhrnoosh Zakerkish, Mahdi Pourmahdi Borujeni
    Medical Journal of Tabriz University of Medical Sciences and Health Services.2019; 41(6): 59.     CrossRef
  • Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese
    Sukma Oktavianthi, Made R. Saraswati, Ketut Suastika, Pande Dwipayana, Asri Sulfianti, Rahma F. Hayati, Hidayat Trimarsanto, Clarissa A. Febinia, Herawati Sudoyo, Safarina G. Malik
    Molecular Biology Reports.2018; 45(5): 1135.     CrossRef
  • Association of TCF7L2 mutation and atypical diabetes in a Uruguayan population
    Carolina Beloso, Jorge Souto, Matias Fábregat, Gerardo Romanelli, Gerardo Javiel, Adriana Mimbacas
    World Journal of Diabetes.2018; 9(9): 157.     CrossRef
  • Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy
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Diabetes Metab J : Diabetes & Metabolism Journal