- Mitochondrial Dysfunction in Diabetic Cardiomyopathy.
-
Ji Hyun Ahn, Jae Taek Kim
-
Korean Diabetes J. 2008;32(6):467-473. Published online December 1, 2008
-
DOI: https://doi.org/10.4093/kdj.2008.32.6.467
-
-
 Abstract
 PDF
- Metabolic syndrome and diabetes are associated with increased risk of cardiac dysfunction independently of underlying coronary artery disease. The underlying pathogenesis is partially understood but accumulating evidence suggests that alterations of cardiac energy metabolism might contribute to the development of contractile dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction may play an important role in the pathogenesis of cardiac contractile dysfunction in type 2 diabetes. This review is focused on evaluating mechanisms for the mitochondrial abnormalities that may be involved in the development and progression of cardiac dysfunction in diabetes.
- Association of Adiponectin and Hepatic Steatosis in Adults with Normal Transaminase Levels.
-
Jeong Hyun Mun, Seung Eun Lee, Ji Hyun Ahn, Soon Hyun Shinn
-
Korean Diabetes J. 2008;32(2):149-156. Published online April 1, 2008
-
DOI: https://doi.org/10.4093/kdj.2008.32.2.149
-
-
2,595
View
-
23
Download
-
1
Crossref
-
Abstract
PDF
- BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome including insulin resistance, hypertension, dyslipidemia, central obesity, type 2 diabetes, and cardiovascular disease. In NAFLD, insulin resistance plays an important role in the progression of liver damage. In this study, we evaluated insulin resistance, plasma adiponectin, hepatic steatosis, and their association in adults with normal liver transaminase concentrations. METHODS: We analyzed 111 subjects, aged over 20 years old, who visited the Health Management Center at Chung-Ang University Hospital between May 2006 and August 2006. They had neither history nor clinical evidence of diabetes, cardiovascular or liver disease. They were divided into three groups by the degree of hepatic steatosis based on ultrasound findings. Anthropometric parameters were measured and blood samples were drawn after eight hours of fasting. RESULTS: Hepatic steatosis had a positive correlation with body mass index, waist circumference, blood pressure, triglycerides, HOMA-IR, and QUICKI. Moreover, it had a negative correlation with high-density lipoprotein cholesterol and adiponectin. Triglycerides, Adiponectin, and QUICKI were independent variables in predicting the degree of hepatic steatosis. CONCLUSION: This finding suggests that triglycerides and plasma adiponectin are independent predictors of hepatic steatosis in adults with normal liver transaminase concentrations.
-
Citations
Citations to this article as recorded by  - Analysis of Biochemical Markers Related to Fatty Liver Patients
Jae-Hwan Cho, Jang-Sun Namgung, Jin Lee, Deog-Hwan Moon, Hae-Kag Lee
Journal of Physical Therapy Science.2014; 26(12): 1865. CrossRef
|
KDA
