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Jeong Hyun Park  (Park JH) 22 Articles
Mitochondria DNA Polymorphism and Type 2 Diabetes Mellitus.
Jeong Hyun Park
Korean Diabetes J. 2009;33(5):373-374.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.373
  • 1,726 View
  • 19 Download
  • 1 Crossref
AbstractAbstract PDF
No abstract available.

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  • Effect of Euonymus alatus Extracts on Diabetes Related Markers in Pancreatic β-Cells and C57BL/Ksj-db/db Mice
    Ye Rin Kim, Eun-young Kim, Seong Uk Lee, Young Wan Kim, Yoon Hee Kim
    Journal of the Korean Society of Food Science and Nutrition.2022; 51(9): 894.     CrossRef
Impaired Wound Healing in Diabetes Mellitus.
Min Jeong Kwon, Jeong Hyun Park
Korean Diabetes J. 2009;33(2):83-90.   Published online April 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.2.83
  • 1,859 View
  • 38 Download
  • 3 Crossref
AbstractAbstract PDF
The normal healing of a cutaneous wound is achieved via well-orchestrated integration of complex biological and molecular events of cell migration, proliferation, extracellular matrix deposition and tissue remodeling. Chronic wounds fail to progress through the normal stages of healing, and enter a state of pathologic inflammation. Complicated diabetic patients show delayed wound healing caused by multiple factors including vascular insufficiency, abnormalities of the biochemical environment and hyperglycemia per se. Novel technologies including growth factor therapy, gene therapy, stem cell technologies, synthetic skins and hyperbaric oxygen treatment are under development. In the near future, these therapeutic strategies will be clinically available.

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  • Promotion of wound healing through low-fluence ablative fractional laser treatment in diabetic mice
    Han Na Lee, Jung Min Bae, Bon Cheol Leo Goo, Young Min Park
    Lasers in Medical Science.2019; 34(2): 421.     CrossRef
  • Ethanol Extracts of Chungkookjang Stimulate the Proliferation and Migration of Human Umbilical Vascular Endothelial Cells
    Jae Sung Hwang, Dae Il Sung, Whan Myung Lee, Young Shin Chung, Han Bok Kim
    The Korean Journal of Microbiology.2014; 50(3): 223.     CrossRef
  • Comparison of Outcome of Trabeculectomy With Mitomycin C and Ahmed Valve Implantation for Uveitic Glaucoma
    Joo Yeon Kim, Hyoung Sub Shim, Hwang Ki Kim, Yong Ho Sohn
    Journal of the Korean Ophthalmological Society.2010; 51(4): 575.     CrossRef
A Nationwide Survey about the Current Status of Glycemic Control and Complications in Diabetic Patients in 2006: The Committee of the Korean Diabetes Association on the Epidemiology of Diabetes Mellitus.
Soo Lim, Dae Jung Kim, In Kyung Jeong, Hyun Shik Son, Choon Hee Chung, Gwanpyo Koh, Dae Ho Lee, Kyu Chang Won, Jeong Hyun Park, Tae Sun Park, Jihyun Ahn, Jaetaek Kim, Keun Gyu Park, Seung Hyun Ko, Yu Bae Ahn, Inkyu Lee
Korean Diabetes J. 2009;33(1):48-57.   Published online February 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.1.48
  • 2,843 View
  • 56 Download
  • 43 Crossref
AbstractAbstract PDF
BACKGROUND
The Committee of the Korean Diabetes Association on the Epidemiology of Diabetes Mellitus performed a nationwide survey about the current status of glycemic control and diabetic complications in 2006. METHODS: The current study included 5,652 diabetic patients recruited from the rosters of endocrinology clinics of 13 tertiary hospitals in Korea. Age, gender, height, weight, waist circumference and blood pressure were investigated by standard method. Fasting and postprandial 2 hour glucose, glycosylated hemoglobin (HbA1c), lipid profiles, fasting insulin and c-peptide levels were measured. Microvascular (microalbuminuria, retinopathy and neuropathy) and macrovascular (coronary artery disease [CAD], cerebrovascular disease [CVD] and peripheral artery disease [PAD]) complications were reviewed in their medical records. RESULTS: Mean age of total subjects was 58.7 (+/- 11.6) years and duration of diabetes was 8.8 (0~50) years. Mean fasting and postprandial 2 hour glucose levels were 145.9 +/- 55.0 and 208.0 +/- 84.4 mg/dL, respectively. Their mean HbA1c was 7.9 +/- 1.9%: the percentage of patients within target goal of glycemic control (< 7% of HbA1c) was 36.7%. In this study, 30.3%, 38.3% and 44.6% of patients was found to have microalbuminuria, retinopathy and nephropathy, respectively. Prevalence of CAD, CVD and PAD was 8.7%, 6.7% and 3.0%, respectively. Diabetic complications were closely related with age, duration of diabetes and glycemic control, and this relationship was stronger in microvascular complications than macrovascular ones. CONCLUSION: Only about one third of patients with diabetes was found to reach target glycemic control in tertiary hospitals of Korea. More tight control is needed to reduce deleterious complications of diabetes in Korea.

Citations

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  • Risk of Diabetic Complications in Type 2 Diabetes Patients with Dementia: A Population-Based Study Using National Health Insurance Claims Data
    Eun Sik Jeong, Ah-Young Kim, Hye-Young Kang
    Drug Targets and Therapeutics.2023; 2(1): 49.     CrossRef
  • Prevalence of thyroid disorders in type 2 diabetic patients – A 1-year cross-sectional study
    RikitaRamesh Mudhol, ShivakumarVeeranna Turamari, RekhaRamesh Mudhol, B Srinivas
    BLDE University Journal of Health Sciences.2022; 7(1): 56.     CrossRef
  • Associations of fasting glucose and glycated hemoglobin with vitamin D levels according to diabetes mellitus status in Korean adults
    Yerin Hwang, Jiyoung Jang, Myung-Hee Shin
    Epidemiology and Health.2022; 44: e2022025.     CrossRef
  • Atherectomy in Peripheral Artery Disease: Current and Future
    Yohan Kwon, Jinoo Kim, Je-Hwan Won, Seong Ho Kim, Jeong-Eun Kim, Sung-Joon Park
    Journal of the Korean Society of Radiology.2021; 82(3): 551.     CrossRef
  • Diabetic Retinopathy and Related Clinical Practice for People with Diabetes in Korea: A 10-Year Trend Analysis
    Yoo-Ri Chung, Kyoung Hwa Ha, Kihwang Lee, Dae Jung Kim
    Diabetes & Metabolism Journal.2020; 44(6): 928.     CrossRef
  • Current status of treatment of type 2 diabetes mellitus in Ningbo, China
    Tianmeng Yang, Rongjiong Zheng, Qingmei Chen, Yushan Mao
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • Recently Uncontrolled Glycemia in Diabetic Patients Is Associated with the Severity of Intracranial Atherosclerosis
    Nari Choi, Jeong-Yoon Lee, Jun-Sang Sunwoo, Hakjae Roh, Moo-Young Ahn, Sung-Tae Park, Kyung Bok Lee
    Journal of Stroke and Cerebrovascular Diseases.2017; 26(11): 2615.     CrossRef
  • The effect of educational program based on the precede-proceed model on improving self-care behaviors in a semi-urban population with type 2 diabetes referred to health centers of Bavi, Iran
    Neda Barasheh, Ghodratollah Shakerinejad, Sedigheh Nouhjah, Mohammad Hossein Haghighizadeh
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2017; 11: S759.     CrossRef
  • Increased prevalence of albuminuria in individuals with higher range of impaired fasting glucose: the 2011 Korea National Health and Nutrition Examination Survey
    Jong Chul Won, Jae Won Hong, Jung Min Kim, Tae Nyun Kim, Jung Hyun Noh, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
    Journal of Diabetes and its Complications.2015; 29(1): 50.     CrossRef
  • Assessment of glycemic control in patients with type 2 diabetes mellitus treated with metformin–sulfonylurea combination: Results of a multicenter, cross‐sectional, observational study in Korea
    Sin Gon Kim, Jong Ryeal Hahm, Duk Kyu Kim, Sung Rae Cho, Dong Seop Choi
    Journal of Diabetes Investigation.2015; 6(3): 317.     CrossRef
  • Current Status of Management in Type 2 Diabetes Mellitus at General Hospitals in South Korea
    Jin-Hee Jung, Jung-Hwa Lee, Jin-Won Noh, Jeong-Eun Park, Hee-Sook Kim, Joo-Wha Yoo, Bok-Rye Song, Jeong-rim Lee, Myeong-Hee Hong, Hyang-Mi Jang, Young Na, Hyun-Joo Lee, Jeong-Mi Lee, Yang-Gyo Kang, Sun-Young Kim, Kang-Hee Sim
    Diabetes & Metabolism Journal.2015; 39(4): 307.     CrossRef
  • Kidney injury molecule-1 (Kim-1): an early biomarker for nephropathy in type II diabetic patients
    Nahla E. El-Ashmawy, Enas A. El-Zamarany, Naglaa F. Khedr, Abeer I. Abd El-Fattah, Shereen A. Eltoukhy
    International Journal of Diabetes in Developing Countries.2015; 35(S3): 431.     CrossRef
  • The Effect of the Experience of Diabetes Education on Knowledge, Self-Care Behavior and Glycosylated Hemoglobin in Type 2 Diabetic Patients
    Seung Hei Moon, Young Whee Lee, Ok-Kyung Ham, Soo-Hyun Kim
    The Journal of Korean Academic Society of Nursing Education.2014; 20(1): 81.     CrossRef
  • Clinical Characteristics of Diabetic Patients Transferred to Korean Referral Hospitals
    Min Young Oh, Sang Soo Kim, In Joo Kim, In Kyu Lee, Hong Sun Baek, Hyoung Woo Lee, Min Young Chung
    Diabetes & Metabolism Journal.2014; 38(5): 388.     CrossRef
  • Current Status of Prescription in Type 2 Diabetic Patients from General Hospitals in Busan
    Ji Hye Suk, Chang Won Lee, Sung Pyo Son, Min Cheol Kim, Jun Hyeob Ahn, Kwang Jae Lee, Ja Young Park, Sun Hye Shin, Min Jeong Kwon, Sang Soo Kim, Bo Hyun Kim, Soon Hee Lee, Jeong Hyun Park, In Joo Kim
    Diabetes & Metabolism Journal.2014; 38(3): 230.     CrossRef
  • The Influence of Admission Hypoglycemia on Clinical Outcomes in Acute Myocardial Infarction Patients with Diabetes Mellitus
    Eun Jung Kim, Myung Ho Jeong, In Seok Jeong, Sang Gi Oh, Sang Hyung Kim, Young keun Ahn, Ju Han Kim, Young Jo Kim, Shung Chull Chae, Taek Jong Hong, In Whan Seong, Jei Keon Chae, Chong Jin Kim, Myeong Chan Cho, Ki Bae Seung, Hyo Soo Kim
    Korean Journal of Medicine.2014; 87(5): 565.     CrossRef
  • Duration of diabetes and effectiveness of insulin in the management of insulin-naïve Korean patients uncontrolled on oral antidiabetic drugs: a sub-analysis of the MOdaliTy of Insulin treatment eValuation (MOTIV) registry results
    Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek, Kyoung Soo Ha
    Acta Diabetologica.2014; 51(4): 655.     CrossRef
  • Is the Indicator Magnifying Window for Insulin Pens Helpful for Elderly Diabetic Patients?
    Ju Hee Lee, Eun Shil Hong, Jung Hun Ohn, Young Min Cho
    Diabetes & Metabolism Journal.2013; 37(2): 149.     CrossRef
  • Prevalence of and Factors Associated with Albuminuria in the Korean Adult Population: The 2011 Korea National Health and Nutrition Examination Survey
    Jong Chul Won, Yun Jeong Lee, Jung Min Kim, Sang Youb Han, Jung Hyun Noh, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim, Harald Mischak
    PLoS ONE.2013; 8(12): e83273.     CrossRef
  • The Epidemiology of Diabetic Nephropathy
    Jin Hwa Kim
    The Journal of Korean Diabetes.2013; 14(1): 11.     CrossRef
  • The Relationship between Neuropathic Pain and Glycemic Control, Self Management in Type II Diabetes Mellitus Patients
    Yeong-Mi Seo, Won-Hee Choi
    Journal of the Korea Academia-Industrial cooperation Society.2013; 14(4): 1774.     CrossRef
  • Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study
    Kee-Ho Song, Jung Min Kim, Jung-Hyun Noh, Yongsoo Park, Hyun-Shik Son, Kyong Wan Min, Kyung Soo Ko
    Diabetes & Metabolism Journal.2013; 37(2): 117.     CrossRef
  • Comorbidity Study on Type 2 Diabetes Mellitus Using Data Mining
    Hye Soon Kim, A Mi Shin, Mi Kyung Kim, Yoon Nyun Kim
    The Korean Journal of Internal Medicine.2012; 27(2): 197.     CrossRef
  • Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction
    Jinkwon Kim, Dong Hyun Lee, Myoung-Jin Cha, Tae-Jin Song, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo
    Atherosclerosis.2012; 224(1): 113.     CrossRef
  • Glucose, Blood Pressure, and Lipid Control in Korean Adults with Diagnosed Diabetes
    Sun-Joo Boo
    Korean Journal of Adult Nursing.2012; 24(4): 406.     CrossRef
  • Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus in Korea
    Seung-Hyun Ko, Bong-Yun Cha
    Diabetes & Metabolism Journal.2012; 36(1): 6.     CrossRef
  • The Association of Self-Reported Coronary Heart Disease with Diabetes Duration in Korea
    Hye Mi Kang, Yun Jeong Lee, Dong-Jun Kim
    Diabetes & Metabolism Journal.2012; 36(5): 350.     CrossRef
  • Response: The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital (Diabetes Metab J 2011;35:543-50)
    Ji Hee Yu, Ki-Up Lee
    Diabetes & Metabolism Journal.2012; 36(1): 77.     CrossRef
  • Reduction in glycated albumin can predict change in HbA1c: comparison of oral hypoglycaemic agent and insulin treatments
    H. K. Won, K. J. Kim, B.‐W. Lee, E. S. Kang, B. S. Cha, H. C. Lee
    Diabetic Medicine.2012; 29(1): 74.     CrossRef
  • Management of Blood Pressure in Patients with Type 2 Diabetes Mellitus: A Nationwide Survey in Korean
    Mi Hae Seo, Woo Je Lee, Cheol Young Park, Sung Rae Kim, Joong Yeol Park, Kun-Ho Yoon, Moon Kyu Lee, Sung Woo Park
    Diabetes & Metabolism Journal.2011; 35(4): 348.     CrossRef
  • Accuracy Evaluation of the Alternative Site Blood Glucose Test Using Error Grid
    Kyung-Soon Park, Eun-Jong Cha
    Journal of Biomedical Engineering Research.2011; 32(1): 25.     CrossRef
  • Glycated albumin is a useful glycation index for monitoring fluctuating and poorly controlled type 2 diabetic patients
    Eun Young Lee, Byung-Wan Lee, Daham Kim, Yong-ho Lee, Kwang Joon Kim, Eun Seok Kang, Bong-Soo Cha, Eun Jig Lee, Hyun Chul Lee
    Acta Diabetologica.2011; 48(2): 167.     CrossRef
  • Group Classification on Management Behavior of Diabetic Mellitus
    Sung-Hong Kang, Soon-Ho Choi
    Journal of the Korea Academia-Industrial cooperation Society.2011; 12(2): 765.     CrossRef
  • Predictive Clinical Parameters for the Therapeutic Efficacy of Sitagliptin in Korean Type 2 Diabetes Mellitus
    Soon Ae Kim, Woo Ho Shim, Eun Hae Lee, Young Mi Lee, Sun Hee Beom, Eun Sook Kim, Jeong Seon Yoo, Ji Sun Nam, Min Ho Cho, Jong Suk Park, Chul Woo Ahn, Kyung Rae Kim
    Diabetes & Metabolism Journal.2011; 35(2): 159.     CrossRef
  • Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
    Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi
    Diabetes & Metabolism Journal.2011; 35(6): 571.     CrossRef
  • Increasing Trend in the Number of Severe Hypoglycemia Patients in Korea
    Jin Taek Kim, Tae Jung Oh, Ye An Lee, Jun Ho Bae, Hyo Jeong Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park, Soo Lim, Hak Chul Jang, Hong Kyu Lee
    Diabetes & Metabolism Journal.2011; 35(2): 166.     CrossRef
  • Prevalence and Associated Factors of Diabetic Retinopathy in Rural Korea: The Chungju Metabolic Disease Cohort Study
    Ji-Hyun Kim, Hyuk-Sang Kwon, Yong-Moon Park, Jin-Hee Lee, Man-Soo Kim, Kun-Ho Yoon, Won Chul Lee, Bong-Yun Cha, Ho-Young Son
    Journal of Korean Medical Science.2011; 26(8): 1068.     CrossRef
  • The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital
    Ji Hee Yu, Jenie Yoonoo Hwang, Mi-Seon Shin, Chang Hee Jung, Eun Hee Kim, Sang Ah Lee, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Ki-Up Lee
    Diabetes & Metabolism Journal.2011; 35(5): 543.     CrossRef
  • Prevalence, Awareness, and Control of Hypertension among Diabetic Koreans
    Hyun Hee Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2011; 35(4): 337.     CrossRef
  • Factors Influencing Physical Activity Behavior among Iranian Women with Type 2 Diabetes Using the Extended Theory of Reasoned Action
    Alireza Didarloo, Davoud Shojaeizadeh, Hassan Eftekhar Ardebili, Shamsaddin Niknami, Ebrahim Hajizadeh, Mohammad Alizadeh
    Diabetes & Metabolism Journal.2011; 35(5): 513.     CrossRef
  • Factors that Affect Medication Adherence in Elderly Patients with Diabetes Mellitus
    Kyung-Ae Park, Jung-Guk Kim, Bo-Wan Kim, Sin Kam, Keon-Yeop Kim, Sung-Woo Ha, Sung-Taek Hyun
    Korean Diabetes Journal.2010; 34(1): 55.     CrossRef
  • The Effects of Tailored Diabetes Education on Blood Glucose Control and Self-Care
    Kyung Sun Hyun, Kwang Mi Kim, Sook Hee Jang
    Journal of Korean Academy of Nursing.2009; 39(5): 720.     CrossRef
  • Epidemiologic Characteristics of Diabetes Mellitus in Korea: Current Status of Diabetic Patients Using Korean Health Insurance Database
    Ie Byung Park, Sei Hyun Baik
    Korean Diabetes Journal.2009; 33(5): 357.     CrossRef
Prevalence of the Metabolic Syndrome in Type 2 Diabetic Patients.
Tae Ho Kim, Dae Jung Kim, Soo Lim, In Kyung Jeong, Hyun Shik Son, Choon Hee Chung, Gwanpyo Koh, Dae Ho Lee, Kyu Chang Won, Jeong Hyun Park, Tae Sun Park, Jihyun Ahn, Jaetaek Kim, Keun Gyu Park, Seung Hyun Ko, Yu Bae Ahn, Inkyu Lee
Korean Diabetes J. 2009;33(1):40-47.   Published online February 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.1.40
  • 2,442 View
  • 27 Download
  • 13 Crossref
AbstractAbstract PDF
BACKGROUND
The aim of this study was to analyze the prevalence of metabolic syndrome in Korean type 2 diabetic patients. METHODS: A total of 4,240 diabetic patients (male 2,033, female 2,207; mean age 58.7 +/- 11.3 years; DM duration 8.9 +/- 7.6 years) were selected from the data of endocrine clinics of 13 university hospitals in 2006. Metabolic syndrome was defined using the criteria of the American Heart Association/National Heart Lung and Blood Institute and the criteria of waist circumference from the Korean Society for the Study of Obesity. RESULTS: The prevalence of metabolic syndrome was 77.9% (76.7% of males, 78.9% of females). The average number of the components of metabolic syndrome was 2.4 +/- 1.1. Abdominal obesity was seen in 56.8% of the patients, hypertriglyceridemia in 42.0%, low HDL cholesterol in 65.1%, and high blood pressure in 74.9%. Abdominal obesity and high blood pressure were much more prevalent among females than males, and low HDL cholesterol was much more prevalent among males than females. The prevalence of metabolic syndrome was not different according to the duration of diabetes. Metabolic syndrome was strongly related with obesity (odds ratio, 6.3) and increased age (odds ratio in the over 70 group, 3.4). CONCLUSION: The prevalence of metabolic syndrome was 77.9% in Korean type 2 diabetic patients. Its prevalence was greater in obese patients and in those over 40 years of age.

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  • A Novel Clinical Predictor of Metabolic Syndrome: Vascular Risk Age
    Abdulrahman Naser, Didar Elif Akgün, Rengin Çetin Güvenç, Samet Sayılan, Özgen Şafak
    Bagcilar Medical Bulletin.2023; 9(1): 1.     CrossRef
  • Risk of Carotid Atherosclerosis in Subjects with Prediabetes Overlapping Metabolic Syndrome
    Seol A Jang, Kyoung Min Kim, Seok Won Park, Chul Sik Kim
    Metabolic Syndrome and Related Disorders.2022; 20(10): 599.     CrossRef
  • Metabolic Age, an Index Based on Basal Metabolic Rate, Can Predict Individuals That are High Risk of Developing Metabolic Syndrome
    Sarahi Vásquez-Alvarez, Sergio K. Bustamante-Villagomez, Gabriela Vazquez-Marroquin, Leonardo M. Porchia, Ricardo Pérez-Fuentes, Enrique Torres-Rasgado, Oscar Herrera-Fomperosa, Ivette Montes-Arana, M. Elba Gonzalez-Mejia
    High Blood Pressure & Cardiovascular Prevention.2021; 28(3): 263.     CrossRef
  • Metabolic syndrome among type 2 diabetic patients in Sub-Saharan African countries: A systematic review and meta-analysis
    Wondimeneh Shibabaw Shiferaw, Tadesse Yirga Akalu, Mihretie Gedefaw, Denis Anthony, Ayelign Mengesha Kassie, Worku Misganaw Kebede, Henok Mulugeta, Getenet Dessie, Yared Asmare Aynalem
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(5): 1403.     CrossRef
  • Optimal Waist Circumference Cutoff Value Based on Insulin Resistance and Visceral Obesity in Koreans with Type 2 Diabetes
    Jung Soo Lim, Young Ju Choi, Soo-Kyung Kim, Byoung Wook Huh, Eun Jig Lee, Kap Bum Huh
    Diabetes & Metabolism Journal.2015; 39(3): 253.     CrossRef
  • The Relations between Diabetic Dietary Compliance, Dietary Intake, and Physical Activity and the Prevalence of Metabolic Syndrome (MS) in Type 2 Diabetic Patients
    Dong Eun Kim, Seung Hee Hong, Ji-Myung Kim
    Korean Journal of Community Nutrition.2015; 20(5): 351.     CrossRef
  • The Comparison between Periodontal Health Status and the Findings of Hypertension and Diabetes Disease of some Workers
    In-Young Ku, Seon-Jeong Moon, Kyung-Hwan Ka, Myeong-Seon Lee
    The Korean Journal of Health Service Management.2013; 7(2): 81.     CrossRef
  • The Relationship between Factors of Metabolic Syndrome in Korean Adult Males and the Parents' Family History of Diabetes
    Hyung-Su Park, Jin-Gyu Jeong, Jin-Ho Yu
    The Journal of the Korea institute of electronic communication sciences.2013; 8(5): 779.     CrossRef
  • Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes
    Chan-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Sang-Hee Jung, Ji-Oh Mok
    Diabetes and Vascular Disease Research.2013; 10(5): 459.     CrossRef
  • Cardio-Metabolic Features of Type 2 Diabetes Subjects Discordant in the Diagnosis of Metabolic Syndrome
    Sa Rah Lee, Ying Han, Ja Won Kim, Ja Young Park, Ji Min Kim, Sunghwan Suh, Mi-Kyoung Park, Hye-Jeong Lee, Duk Kyu Kim
    Diabetes & Metabolism Journal.2012; 36(5): 357.     CrossRef
  • Comorbidity Study on Type 2 Diabetes Mellitus Using Data Mining
    Hye Soon Kim, A Mi Shin, Mi Kyung Kim, Yoon Nyun Kim
    The Korean Journal of Internal Medicine.2012; 27(2): 197.     CrossRef
  • Therapeutic Target Achievement in Type 2 Diabetic Patients after Hyperglycemia, Hypertension, Dyslipidemia Management
    Ah Young Kang, Su Kyung Park, So Young Park, Hye Jeong Lee, Ying Han, Sa Ra Lee, Sung Hwan Suh, Duk Kyu Kim, Mi Kyoung Park
    Diabetes & Metabolism Journal.2011; 35(3): 264.     CrossRef
  • The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
    Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
    Diabetes & Metabolism Journal.2011; 35(4): 374.     CrossRef
Association Study of the Peroxisome Proliferators-Activated Receptor gamma2 Pro12Ala Polymorphism with Diabetic Nephropathy.
Min Jeong Kwon, Jeong Hyun Park
Korean Diabetes J. 2008;32(5):399-401.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.399
  • 1,713 View
  • 16 Download
AbstractAbstract PDF
No abstract available.
Cloning of Novel Epidermal Growth Factor (EGF) Plasmid for Gene Therapy on Diabetic Foot Ulcer.
Hye Sook Chung, Chang Shin Yoon, Min Jeong Kwon, Mi Kyung Kim, Soon Hee Lee, Kyung Soo Ko, Byung Doo Rhee, Jeong Hyun Park
Korean Diabetes J. 2008;32(2):131-140.   Published online April 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.2.131
  • 1,844 View
  • 44 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Epidermal Growth Factor (EGF) is one of the important growth factors involved in the epithelialization during cutaneous wound healing. Peptide EGF has been used for the treatment of diabetic foot ulcer. But the inferiority of cost-effectiveness and the inconvenience of daily application might have restricted its wide clinical usage. EGF gene therapy could dramatically improve the efficacy and inconvenience through long-term expression and bypassing the EGF degradation by hostile non-specific proteinases expressed in the wound bed. METHODS: EGF DNAs were amplified via PCR. For the more effective secretion from the transfected cell, we inserted furin cleavage site into EGF plasmids. The efficacy of novel plasmid pbeta-EGF was verified by transfection into the various animal cell lines, and the biologic potency of expressed EGF was confirmed via phosphorylation of PI3K and GSK3beta by Western blotting. RESULTS: We tested various kinds of human EGFs. One of the human EGF isoforms, EGF(828) including a membrane-anchoring domain was successfully released as the mature EGF protein in the cell culture media. Also EGF plasmid including furin cleavage site showed more than 2-fold increased EGF expression compared with the sequence without furin cleavage site. CONCLUSION: In conclusion, these findings suggest that mature EGF could be released easily out of cells by modifying EGF DNA sequence. Our novel EGF plasmid DNA could markedly increase the efficiency of non-viral gene therapy for diabetic foot ulcer.

Citations

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  • Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer
    Min J. Kwon, Songhie An, Sunghyun Choi, Kihoon Nam, Hye S. Jung, Chang S. Yoon, Jung H. Ko, Hye J. Jun, Tae K. Kim, Soo J. Jung, Jeong H. Park, Yan Lee, Jong‐Sang Park
    The Journal of Gene Medicine.2012; 14(4): 272.     CrossRef
The Protective Effect of EGCG on INS-1 Cell in the Oxidative Stress and Mechanism.
Mi Kyung Kim, Hye Sook Jung, Chang Shin Yoon, Min Jeong Kwon, Kyung Soo Koh, Byung Doo Rhee, Jeong Hyun Park
Korean Diabetes J. 2008;32(2):121-130.   Published online April 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.2.121
  • 2,108 View
  • 24 Download
  • 3 Crossref
AbstractAbstract PDF
BACKGROUND
Oxidative stress is important in both diabetic complications and the development and the progression of type 2 diabetes via the effects on the pancreatic beta-cells. EGCG (epigallocatechin galleate), a major constituent of green tea, has been known to have beneficial effects on various diseases through the mechanisms of antioxidant and cell signaling modulation. But, very small numbers of studies were published about the direct effects of EGCG on the pancreatic beta cell lines. We performed this study to see the protective effect of EGCG on pancreatic beta cell line under H2O2 and the mechanisms of this phenomenon. METHODS: We used INS-1 cells and hydrogen peroxide as an oxidative stressor. Their viabilities were verified by MTT assay and FACS. The activity of glutathione peroxidase was assessed by total glutathione quantification kit. Western blot and semi-quantitative RT-PCR for the catalase, SOD (superoxide dismutase), PI3K and Akt were performed. Functional status of INS-1 cells was tested by GSIS (glucose stimulated insulin secretion). RESULTS: The biological effects of EGCG were different according to its concentrations. 10 micrometer EGCG effectively protected hydrogen peroxide induced damage in INS-1 cells. The expression and the activity of SOD, catalase and the glutathione peroxidase were significantly increased by EGCG. EGCG significantly increased PI3K and Akt activity and its effect was inhibited partially by wortmannin. GSIS was well preserved by EGCG. CONCLUSION: EGCG in low concentration effectively protected INS-1 cells from the oxidative stress through the activation of both antioxidant systems and anti-apoptosis signaling. Further studies will be necessary for the more detailed mechanisms and the clinical implications.

Citations

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  • Suppressive Effects of Epigallocatechin Gallate Pretreatment on the Expression of Inflammatory Cytokines in RAW264.7 Cells Activated by Lipopolysaccharide
    Eun Ji Seo, Jun Go, Ji Eun Kim, Eun Kyoung Koh, Sung Hwa Song, Ji Eun Sung, Chan Kyu Park, Hyun Ah Lee, Dong Seob Kim, Hong Joo Son, Cung Yeoul Lee, Hee Seob Lee, Dae Youn Hwang
    Journal of Life Science.2015; 25(9): 961.     CrossRef
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    In-Hye Kim, Kang-Jin Cho, Jeong-Sook Ko, Jae-Hyun Kim, Ae-Son Om
    The Korean Journal of Food And Nutrition.2012; 25(1): 123.     CrossRef
  • Protective Effects of Sasa Borealis Leaves Extract on High Glucose-Induced Oxidative Stress in Human Umbilical Vein Endothelial Cells
    Ji-Young Hwang, Ji-Sook Han
    Journal of the Korean Society of Food Science and Nutrition.2010; 39(12): 1753.     CrossRef
Cytoprotective Effect by Antioxidant Activity of Quercetin in INS-1 Cell Line.
Min Jeong Kwon, Hye Sook Jung, Mi Kyung Kim, Seong Hoon Kang, Gwang Wook Seo, Jae Kwang Song, Tae Yeon Yoon, Min Kyeong Jeon, Tae Hwan Ha, Chang Shin Yoon, Mi Kyung Kim, Woo Je Lee, Jeong Hyun Noh, Soo Kyung Kwon, Dong Joon Kim, Kyung Soo Koh, Byung Doo Rhee, Kyung Ho Lim, Soon Hee Lee, Jeong Hyun Park
Korean Diabetes J. 2007;31(5):383-390.   Published online September 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.5.383
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AbstractAbstract PDF
BACKGROUND
Oxidative stress is induced under diabetic conditions and causes various forms of tissue damages in the patients with diabetes. Recently, pancreatic beta cells are regarded as a putative target of oxidative stress-induced tissue damage, and this seems to explain in part the progressive deterioration of beta cell function in type 2 diabetes. The aim of this study was to examine the potential of Quercetin (QE) to protect INS-1 cells from the H2O2-induced oxidative stress and the effects of QE on the glucose-stimulated insulin secretion in INS-1 cells. METHODS: To study the cell viability, cells were incubated with H2O2 and/or QE at the various concentrations. To confirm the protective effect by QE in response to H2O2, the levels of antioxidant enzymes were assessed by RT-PCR and Western blot, and glutathione peroxidase activities were quantified by spectrophotometrical method. Glucose-stimulated insulin secretion (GSIS) was measured by ELISA. RESULTS: Cell incubations were performed with 80 microM of H2O2 for 5 hours to induce 40 - 50% of cell death. QE gradually showed protective effect (IC50 = 50 microM) in dose-dependent manner. Superoxide dismutase (SOD) mRNA level in H2O2 + QE group was increased as compared to H2O2 group, but catalase did not changed. And the QE recruited glutathione peroxidase activity against H2O2-induced oxidative injuries in INS-1 cells. CONCLUSION: In conclusion, these findings suggest that QE might have protective effect on beta cells by ameliorating oxidative stress and preserving insulin secretory function.

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  • Anti-diabetic effects of Allium tuberosum rottler extracts and lactic acid bacteria fermented extracts in type 2 diabetic mice model
    Bae Jin Kim, Seung Kyeung Jo, Yoo Seok Jeong, Hee Kyoung Jung
    Korean Journal of Food Preservation.2015; 22(1): 134.     CrossRef
  • Protective Effects of Sasa Borealis Leaves Extract on High Glucose-Induced Oxidative Stress in Human Umbilical Vein Endothelial Cells
    Ji-Young Hwang, Ji-Sook Han
    Journal of the Korean Society of Food Science and Nutrition.2010; 39(12): 1753.     CrossRef
Current Status of Diabetes Management in Korea Using National Health Insurance Database.
Seok Won Park, Dae Jung Kim, Kyung Wan Min, Sei Hyun Baik, Kyung Mook Choi, Ie Byung Park, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Juneyoung Lee, Choon Hee Chung, Jaiyong Kim, Hwayoung Kim
Korean Diabetes J. 2007;31(4):362-367.   Published online July 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.4.362
  • 2,900 View
  • 35 Download
  • 31 Crossref
AbstractAbstract PDF
BACKGROUND
The prevalence of diabetes is steadily increasing in Korea. The increase in number of people with diabetes would ultimately result in premature death, poor quality of life, and increasing economic burden. However, in our country, researches regarding on the quality of diabetes management are lacking. This study was conducted in 2005 using National Health Insurance Database to know the current status of diabetes management in Korea. METHODS: We have randomly selected 3,902 subjects out of 2,503,754 subjects who had claims with diagnosis of diabetes between January 2003 to December 2003 by using two staged cluster sampling method. Field survey with review of medical records and telephone survey was conducted with standardized record forms developed by Korean Diabetes Association; Task Force Team For Basic Statistical Study of Korean Diabetes Mellitus. RESULTS: The age of diabetic subjects was 58.1 +/- 12.6 years and the duration of diabetes was 6.2 +/- 5.5 years. Hypertension was present in 54% of diabetic subjects. Among those with hypertension, 59% were controlled with blood pressure below 140/90 mmHg, but only 19% were controlled with blood pressure below 130/80 mmHg. Hyperlipidemia was present in 29% of diabetic subjects. Only 38% of those with hyperlipidemia were controlled with LDL-cholesterol below 100 mg/dL. For glycemic control, only 40% of diabetic subjects achieved the goal of HbA1c less than 7%, which was suggested by ADA. CONCLUSION: We found that only 20~40% of diabetic subjects in Korea achieved the management goal for glucose, blood pressure, and lipids. It seems urgent to develop a quality management program for diabetes subjects in Korea.

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Current Status of the Continuity of Ambulatory Diabetes Care and its Impact on Health Outcomes and Medical Cost in Korea Using National Health Insurance Database.
Jaiyong Kim, Hyeyoung Kim, Hwayoung Kim, Kyung Wan Min, Seok Won Park, Ie Byung Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Choon Hee Chung, Kyung Mook Choi, Injeoung Choi, Dae Jung Kim
Korean Diabetes J. 2006;30(5):377-387.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.377
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  • 36 Download
  • 21 Crossref
AbstractAbstract PDF
BACKGROUND
The continuity of care in chronic diseases, especially in diabetes, was emphasized from many studies. But large scale studies with long-term observation which confirm the impact of continuity of care on health outcomes are rare. This study tried national level 3 year observation to find differences in hospitalization, mortality and medical costs among patient groups with different utilization pattern. METHODS: The 1,088,564 patients with diabetes diagnosis and diabetes drug prescription in 2002, from 20 to 79 years old, and survived until the end of 2004 were included. Annual drug prescription days, number of visited clinics and quarterly continuity of care were measured. Gender, age group, living area, health insurance premium level (as a proxy of the income level), years of first DM diagnosis, five co-morbidities (hypertension, heart disease, stroke, renal disease, admission with DM), hospitalization experience and the type of main attending clinic were adjusted. Hospitalization, mortality and high costs group (top quintile) in 2005 were predicted by multiple logistic regression model. RESULTS: Patients who failed in continuity of care in 2003 and 2004 showed higher hospitalization (OR =1.29), higher mortality (OR =1.75) and they are more likely to be high costs group (OR =1.34) in 2005 than who fulfilled the continuity of care. Patients who have single attending clinic also showed lower hospitalization, lower mortality and lower cost. Completeness in diabetic drug prescription were correlated with lower hospitalization, lower mortality but with higher cost. Possible cost saving from continual care with single attending clinic was estimated at Won 417 billion (Dollar 1 = Won 943.7). Possible expenditure from complete drug prescription was Won 228 billion. So, net saving was Won 139 billion in our study population. CONCLUSION: Continual care and single attending clinic saves patient's life and national costs. Fragmented primary care system in Korea should be reformed for more effective care of chronic diseases. National Health Insurance Database in Korea enables nationwide long-term observation study which overcomes the many limitations found in hospital-based studies and cross-sectional surveys.

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Current Status of Diabetic Foot in Korean Patients Using National Health Insurance Database.
Choon Hee Chung, Dae Jung Kim, Jaiyong Kim, Hyeyoung Kim, Hwayoung Kim, Kyung Wan Min, Seok Won Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Kyung Mook Choi, Injeoung Choi, Ie Byung Park
Korean Diabetes J. 2006;30(5):372-376.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.372
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AbstractAbstract PDF
BACKGROUND
Foot ulcer diseases are more prevalent in diabetic patients than that those of non-diabetic patients. Several reports showed the risk of amputation and the medical cost were increased when foot ulcer developed. Therefore, strict glycemic control from the initial period of diabetes is necessary. Since there is no enough epidemiologic data, large scaled studies for medical and economic consequences about diabetic foot ulcer are needed. METHODS: This study was based on health insurance claims submitted to the National Health Insurance Review Agency during the period from December 1994 through December 2002. We investigated the incidence and medical cost of foot disorders in Korean population using the disease-classification codes on the health insurance claim forms. RESULTS: The incidences of foot disorders (per 100,000 of population) were 49.7 for amputations, 99.7 for ulcers, and 1,051 for injuries in diabetic patients, and 4.2 for amputations, 10.3 for ulcers, and 943 for injuries in non-diabetic patients. Relative risk of the incidences of foot amputation, ulcer, and injury in diabetic patients comparing with non-diabetic patients were 11.7, 9.7, and 1.1, respectively. Total medical costs (per capita) of foot amputation, ulcer, and injury in diabetic patients were 2.0, 1.7, and 2.1 times higher, respectively, than those of non-diabetic patients. Mean hospital stay of foot amputation, ulcer, and injury in diabetic patients were 1.6, 1.3, and 1.7 times more, respectively, than those of non-diabetic patients. CONCLUSION: In diabetic patients, the incidences of foot amputation and ulcer are higher than those of non-diabetic patients. To reduce those incidences, we need to early strict glycemic control as well as government based management.

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    Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
    Diabetes & Metabolism Journal.2013; 37(4): 233.     CrossRef
  • Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft
    Hyojin Jeon, Junhyung Kim, Hyeonjung Yeo, Hoijoon Jeong, Daegu Son, Kihwan Han
    Archives of Plastic Surgery.2013; 40(04): 403.     CrossRef
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    Nam Soo Han, Hyung-Cheol Park
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    Ji Ho Lee, Choon Hee Chung
    Journal of Korean Diabetes.2011; 12(2): 69.     CrossRef
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    Kyu Jeung Ahn
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Current Status of Aspirin User in Korean Diabetic Patients Using Korean Health Insurance Database.
Ie Byung Park, Dae Jung Kim, Jaiyong Kim, Hyeyoung Kim, Hwayoung Kim, Kyung Wan Min, Seok Won Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Choon Hee Chung, Injeoung Choi, Kyung Mook Choi
Korean Diabetes J. 2006;30(5):363-371.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.363
  • 2,477 View
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AbstractAbstract PDF
AIMS: ADA guidelines recommend aspirin for all patients with diabetes who have had a prior CHD events as well as a primary prevention strategy among those with at least one other risk factor. We examined the current status of regular aspirin intake among Korean adults who diagnosed as diabetes. METHODS: This study examined the characteristics of aspirin user in new-onset diabetes over 40 years based on health insurance claims submitted to the Health Insurance Review Agency (HIRA) of Korea during the period from January 2001 through December 2003. New onset diabetes defined as the first health insurance claim of antidiabetic drugs submitted to HIRA for the three months (January to March 2001) that never submitted for previous 6 years. RESULTS: The number of total new-onset diabetic patients was 30,014 in 2001, 29,819 in 2002, and 32,061 in 2003. The incidence rate of diabetes over 40 years for 3 months in 2001, 2002 and 2003 were 0.172%, 0.167% and 0.18. Mean age of women who diagnosed diabetes were significant higher than that of men in 2001 (women 59.2+/-10.6 yrs, men 54.8+/-9.8 yrs), in 2002 (women 59.5+/-10.6 yrs, men 54.6+/-9.3 yrs) and in 2003 (women 59.6+/-10.7 yrs, men 54.7+/-9.9 yrs) (p < 0.001). The number of aspirin user increased from 2,065 (6.9%) in 2001, 2,638 (8.9%) in 2002 and 3,711 (11.6%) in 2003. 30.5% of new-onset diabetics in 2001 had hypertension, 12.4% of them had hypercholesterolemia, 11.8% of them had cerebral infarct, 2.6% of them had cerebral hemorrhage, 3.8% of them had coronary heart disease and, but, 55.6% of them had not any CVD. Logistic regression analysis using aspirin use as a dependent variable showed that the number of aspirin use in patients with hypertension, hypercholesterolemia, cerebral infarct and coronary heart disease was higher than in patients without those (hypertension [OR], 3.89 (95% CI, 3.52~4.31); hypercholesterolemia [OR], 2.16 (95% CI, 1.90~2.46; cerebral infarct [OR], 2.05 (95% CI, 1.82~2.30); coronary heart disease [OR], 9.41 (95% CI, 8.20~10.80), respectively). Coronary heart disease was the most important associated factor of aspirin use. CONCLUSIONS: We found significant underuse of aspirin therapy among our population compared with that of America. Major efforts are needed to increase aspirin use in diabetic patients.

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  • Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
    Ye-Jee Kim, Nam-Kyong Choi, Mi-Sook Kim, Joongyub Lee, Yoosoo Chang, Jong-Mi Seong, Sun-Young Jung, Ju-Young Shin, Ji-Eun Park, Byung-Joo Park
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Current Status of Prescription in Type 2 Diabetic Patients from General Hospitals in Busan
    Ji Hye Suk, Chang Won Lee, Sung Pyo Son, Min Cheol Kim, Jun Hyeob Ahn, Kwang Jae Lee, Ja Young Park, Sun Hye Shin, Min Jeong Kwon, Sang Soo Kim, Bo Hyun Kim, Soon Hee Lee, Jeong Hyun Park, In Joo Kim
    Diabetes & Metabolism Journal.2014; 38(3): 230.     CrossRef
  • Epidural Hematoma Related with Low-Dose Aspirin : Complete Recovery without Surgical Treatment
    Kyoung-Tae Kim, Dae-Chul Cho, Suk-Won Ahn, Suk-Hyung Kang
    Journal of Korean Neurosurgical Society.2012; 51(5): 308.     CrossRef
  • The Prevalence and Features of Korean Gout Patients Using the National Health Insurance Corporation Database
    Chan Hee Lee, Na Young Sung
    Journal of Rheumatic Diseases.2011; 18(2): 94.     CrossRef
  • Overlapping Medication Associated with Healthcare Switching among Korean Elderly Diabetic Patients
    Ju-Young Shin, Nam-Kyong Choi, Sun-Young Jung, Ye-Jee Kim, Jong-Mi Seong, Byung-Joo Park
    Journal of Korean Medical Science.2011; 26(11): 1461.     CrossRef
  • Cause-of-Death Trends for Diabetes Mellitus over 10 Years
    Su Kyung Park, Mi-Kyoung Park, Ji Hye Suk, Mi Kyung Kim, Yong Ki Kim, In Ju Kim, Yang Ho Kang, Kwang Jae Lee, Hyun Seung Lee, Chang Won Lee, Bo Hyun Kim, Kyung Il Lee, Mi Kyoung Kim, Duk Kyu Kim
    Korean Diabetes Journal.2009; 33(1): 65.     CrossRef
  • The Current Status of Type 2 Diabetes Management at a University Hospital
    Young Sil Lee
    Korean Diabetes Journal.2009; 33(3): 241.     CrossRef
Current Status of Diabetic End-Stage Renal Disease Using Korean Health Insurance Database.
Dae Jung Kim, Jaiyong Kim, Hyeyoung Kim, Kyung Wan Min, Seok Won Park, Ie Byung Park, Jeong Hyun Park, Sei Hyun Baik, Hyun Shik Son, Chul Woo Ahn, Jee Young Oh, Sunhee Lee, Juneyoung Lee, Choon Hee Chung, Kyung Mook Choi, Injeoung Choi, Hwayoung Kim
Korean Diabetes J. 2006;30(5):355-362.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.355
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AbstractAbstract PDF
BACKGROUND
Diabetes is becoming one of the main causes of end-stage renal disease (ESRD) worldwide. We studied the prevalence and incidence of end-stage renal disease (ESRD) in the Korean population based on health insurance claims submitted to the Health Insurance Review Agency. We also investigated the proportion of medications taken by the ESRD patients, and frequency of hospital admission or visits, and medical expenses between ESRD patients with and without diabetes. METHODS: This study was based on health insurance claims submitted to the Health Insurance Review Agency during the period from January 2001 through December 2003. Using the disease-classification codes on the health insurance claim forms, those who were diagnosed with chronic renal disease (N18 or N19) and received dialysis-related treatment (Z49), treatment with a kidney dialysis machine (Z99.2), or kidney transplantation (Z94.0) were defined as ESRD patients. Among the ESRD patients, those who were diagnosed with diabetes (E10-E14) and/or took anti-diabetic drugs were defined as ESRD patients with diabetes. RESULTS: The ESRD patients totaled 33,870 in 2001, 37,894 in 2002, and 41,167 (858.3 per million population) in 2003. ESRD patients with diabetes increased to 56.7% in 2003. The number of ESRD patients in whom renal replacement therapy was initiated was 8,134 in 2002 and 8,322 (173.5 per million population) in 2003. ESRD patients with diabetes used more anti-hypertensive drugs (1.2 times as many), lipid-lowering drugs (1.6 times), and anti-platelet agents (1.8 times) than did ESRD patients without diabetes. In 2003, 66.5% of the ESRD patients with diabetes were hospitalized, which was 1.6 times the hospital admissions of ESRD patients without diabetes. ESRD patients with diabetes also had hospital stays that were 1.6 times longer per patient and inpatient service expenses that were 1.6times greater per patient, compared with those reported for ESRD patients without diabetes. CONCLUSION: The incidence of ESRD accompanied by diabetes has risen rapidly. Given the burden of medical treatment costs placed on ESRD patients with diabetes, more aggressive interventions should be implemented to prevent diabetes and renal complications among patients with diabetes.

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  • Health-Related Quality of Life Based on Comorbidities Among Patients with End-Stage Renal Disease
    Jieun Cha, Dallong Han
    Osong Public Health and Research Perspectives.2020; 11(4): 194.     CrossRef
  • Effects for Comorbidities of Chronic Kidney Disease on the Progression to End-stage Renal Disease
    Hwa Jeong Seo
    Journal of Health Informatics and Statistics.2020; 45(4): 356.     CrossRef
  • The Impact of Physical, Psychological, Social Factors on Illness Burden of Long-term Hemodialysis Patients in South Korea
    Jieun Cha
    Journal of Health Informatics and Statistics.2018; 43(3): 159.     CrossRef
  • Effect of diabetic case management intervention on health service utilization in Korea
    Soon Ae Shin, Hyeongsu Kim, Kunsei Lee, Vivian Lin, George Liu
    International Journal of Nursing Practice.2015; 21(6): 780.     CrossRef
  • The Quality of Medical Care Provided to Homeless Diabetes Patients in a General Hospital in Seoul, and the Prevalence of Diabetes Comorbidities
    Sun Hee Beom, Moo Kyung Oh, Chul Woo Ahn
    Korean Journal of Medicine.2014; 86(5): 585.     CrossRef
  • Diabetes Epidemics in Korea: Reappraise Nationwide Survey of Diabetes "Diabetes in Korea 2007"
    Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
    Diabetes & Metabolism Journal.2013; 37(4): 233.     CrossRef
  • Posttransplant Diabetes Mellitus
    Hye Soo Kim, Suk Young Kim
    Korean Journal of Transplantation.2009; 23(2): 123.     CrossRef
The Effect of Green Tea Polyphenol on Plasma Glucose, Lipid Levels and Antioxidant Systems in Type 2 Diabetic Patients.
Ji Hye Suk, Mi Kyung Kim, Jae Won Ju, Ji Sook Han, Jeong Hyun Park
Korean Diabetes J. 2006;30(3):217-225.   Published online May 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.3.217
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AbstractAbstract PDF
BACKGROUND
Green-tea polyphenol (GTP) is a well known antioxidant with favorable effect on blood glucose and lipid level in animal models. We were to investigate the effects of GTP on plasma glucose, lipid and antioxidant systems in patients with type 2 diabetes. METHODS: We recruited non-complicated type 2 diabetic patients with stable glycemic control by oral hypoglycemic agents. Subjects were randomly assigned to GTP group or placebo group for 12 weeks. Fasting plasma glucose (FPG), HbA1c, C-peptide, lipid levels, liver function test, renal function test, urine microalbumin, malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities were measured at baseline and after 12 weeks of treatment. RESULTS: At baseline, there were no significant differences in age, body mass index, duration of diabetes, dietary status, HbA1c, total cholesterol, LDL cholesterol, and HDL cholesterol levels between GTP and placebo group. However, FPG levels and triglyceride levels were significantly different between GTP and placebo group at baseline. In both of GTP and placebo group, there were no significant change after 12 weeks of treatment in FPG, HbA1c, total cholesterol, LDL cholesterol, triglyceride, levels of MDA, and GSHPx activities. SOD activities significantly increased after 12 weeks of treatment in both of GTP and placebo group. The increase of SOD activities were significantly higher in GTP group than in placebo group (P = 0.01). CONCLUSIONS: Supplementation of green tea polyphenol increased antioxidant activity in type 2 diabetic patients. The effect on plasma glucose and lipid level was not significant but should be confirmed in further large scaled studies.

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  • Effect of Young Barley Leaf Powder on Glucose Control in the Diabetic Rats
    Hee-Kyoung Son, Yu-Mi Lee, Yong-Hyun Park, Jae-Joon Lee
    The Korean Journal of Community Living Science.2016; 27(1): 19.     CrossRef
Serum Adiponectin, TNF-alpha, IL-6 and Insulin Resistance in Women with Polycystic Ovary Syndrome.
Young A Kim, Jung Hyun Noh, Dong Jun Kim, Tae Hyun Um, Chong Rae Cho, Na young Jang, Soo Kyung Kwon, Soon Hee Lee, Jeong Hyun Park, Kyung Soo Ko, Byoung Doo Rhee, Kyung Ho Lim
Korean Diabetes J. 2006;30(2):104-111.   Published online March 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.2.104
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AbstractAbstract PDF
BACKGROUND
To determine plasma adipokines such as adiponectin, IL-6 and TNF-alpha concentrations in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adipocytokines to the hormonal and metabolic parameters, including measures of insulin resistance (IR). METHODS: Forty-four selected women were classified as follows: 13 obese (body mass index [BMI] > or = 25 kg/m(2)) with PCOS; 15 non-obese (BMI < 25 kg/m(2)) with PCOS; 8 obese without PCOS, and 8 non-obese without PCOS. Blood samples were collected from all women with or without PCOS after an overnight fast. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), insulin, glucose, adiponectin, TNF-alpha and IL-6 were measured. Measures of IR included HOMA-IR and QUICKI. RESULTS: In non-obese group, fasting insulin levels and HOMA-IR in PCOS were significantly higher compared to control. However, Adiponectin, TNF-alpha and IL-6 concentrations were found not to be different in obese women with PCOS as compared with obese women without PCOS and in non-obese women with PCOS as compared with non-obese women without PCOS. Adiponectin concentrations correlated inversely with BMI, waist circumference (WC), total fat mass, serum insulin, and HOMA-IR in PCOS group. However, multiple regression analysis showed that BMI was the only independent determinant of adiponectin concentration. CONCLUSION: Our results suggest that insulin sensitivity per se probably does not play any role in the control of adipokines levels such as adiponectin, TNF-alpha and IL-6 in PCOS women

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  • Adiponectin in Women with Polycystic Ovary Syndrome
    Hyun-Young Shin, Duk-Chul Lee, Ji-Won Lee
    Korean Journal of Family Medicine.2011; 32(4): 243.     CrossRef
Gene Therapy for Diabetes Mellitus.
Jeong Hyun Park
Korean Diabetes J. 2005;29(3):173-180.   Published online May 1, 2005
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AbstractAbstract PDF
No abstract available.
Evaluation of Glycemic Control in Type 2 Diabetic Patients have been Treated in General Hospital.
Joung Ho Park, Kwan Woo Kim, Eun Jin Kang, Tak Young Kim, Sa Ra Lee, Su Chan Bae, Mi Kyung Kim, Sin Yeong Choi, Jeong Hyun Park
Korean Diabetes J. 2004;28(3):208-218.   Published online June 1, 2004
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AbstractAbstract PDF
BACKGROUND
Good metabolic control is one of the most important parts of managing diabetes. Several studies in western countries have shown glycemic control in type 2 diabetic patients to be poorer than expected. Similar reports in Korea are very limited. Therefore, this study was performed to estimate the degree in glycemic control of type 2 diabetic patients that have been treated in general hospitals in Korea. METHODS: This was a cross-sectional retrospective study conducted on 1012 type 2 diabetic patients treated at the Maryknoll Hospital. Subjects with type 1 diabetes or a treatment duration of less than 6 month were excluded. The glycemic control was estimated by HbA1c and the clinical characteristics, including duration of diabetes, age, height and body weight, checked. The treatment methods were divided into four groups, namely diet, oral hypoglycemic agent, insulin alone, and insulin and oral hypoglycemic agent combination. Data were analyzedsed by SPSS version 11.0. RESULTS: The mean age, BMI, duration of diabetes and HbA1c of the subjects were 61.6+/-9.8 years, 24.6+/-3.2kg/m(2), 12.1+/-6.5 year and 7.6+/-1.3%, respectively, and the percentage of those achieving the goal of glycemic control(HbA1c<7%) was 35.7%. Those who achieved glycemic control were older than those who could not and also had a shorter duration of diabetes(p<0.001). There were no significant differences in the BMI, gender and HbA1c levels before treatment between the four groups. The subjects on diet treatment had a lower mean HbA1c level than those on insulin alone or combined therapy(p<0.05) CONCLUSION: The percentage of type 2 diabetic patients in good glycemic control in our general hospital was less than 40%, which was similar to previous western data. It is our suggestion that a large nationwide study is required to more accurately evaluate the state of glycemic control and find the reasons why certain patients could not reach this goal.
Analysis of the Body Mass Index of Newly Diagnosed Type 2 Diabetic Patients and Its Temporal Trends.
Ji Hye Suk, Jung Choi, Yong Wuk Kim, Jae Suk Park, Ji Sup Kim, Mi Kyung Kim, Sin Yeong Choi, Jeong Hyun Park, Byung Doo Rhee
Korean Diabetes J. 2003;27(2):132-140.   Published online April 1, 2003
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AbstractAbstract PDF
BACKGROUND
Previous epidemiological studies have shown that Korean type 2 diabetic patients were mainly non-obese compared to their Western counterparts. This retrospective study was performed to find the percentage of obese type 2 diabetic patients, and its temporal changes, using the newly proposed Asian criteria for the diagnosis of obesity. In addition, our results were compared with Caucasian data. METHODS: The subjects of our study were all newly diagnosed type 2 diabetic patients; 157 for 1991, 176 for 1996 and 275 for 2001. The all the study subjects were aged over 30 years. They all had visited the Mary Knoll General Hospital for the first time, and were diagnosed with type 2 diabetes mellitus within 1 year. The maximum BMI (Body Mass Index) was calculated from the patients heaviest life-time body weight, and their current BMI from the values obtained at their first visit to our institution. The delta BMI (deltaBMI) was calculated by subtracting the current BMI from the maximum BMI the HbA1c value at the time of the first visit was also recorded. Obesity was defined as a body mass index greater than 25kg/m2. RESULTS: The mean values of maximum BMI were 25.7+/-4.5, 26.4+/-4.3 and 25.9+/-6.0 kg/m2 for the years of 1991, 1996 and 2001, respectively. The mean values of the current BMI were 24.0+/-3.0, 24.2+/-3.0 and 24.8+/-3.6 kg/m2 for the years of 1991, 1996 and 2001, respectively. None of these values showed statistically significant differences. The percentages of obese type 2 diabetic patients in 1991, 1996 and 2001 were 64.3, 69.0 and 66.9%, according to their maximum BMI, respectively. The percentages of obese type 2 diabetic patients, from their current BMI, were 31.8, 39.8 and 43.6% in 1991, 1996 and 2001, respectively, and these values showed statistically significant increases over time (p=0.016). The mean value of the delta BMI was significantly lower in 2001 compared with 1996, and it was positively correlated with the HbA1c at the time of the first visit (p< 0.01). CONCLUSION: The percentage of obese type 2 diabetic patients at the time of the maximum body weight was 60 to 70%, but the percentage at the time of diagnosis had decreased to 30 to 40%. The percentage of obese type 2 diabetic patients at the time of diagnosis significantly increased over time. The mean BMI value of the Korean type 2 diabetic patients was lower than that of Caucasians, but the percentage of obese type 2 diabetic patients and its temporal trends were similar to those of Caucasians. Our study shows that Korean type 2 diabetic patients are as obese as Caucasians when they meet their own diagnostic criteria for obesity.
Serum Uric Acid Levels and Insulin Resistance Syndrome in the People Living at Kijang County of Busan City.
Bo Young Yoon, Doo Geun Chai, Sung Mok Kim, Moon Suk Cho, Dong Joon Kim, Jeong Hyun Park, Byung Doo Rhee, Kyung Ho Lim, Chang Il Kang
Korean Diabetes J. 2001;25(4):307-315.   Published online August 1, 2001
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AbstractAbstract PDF
BACKGROUND
Insulin resistance syndrome is defined as the constellation of central obesity, hypertension, glucose abnormality and dyslipidemia. Other constituents of insulin resistance syndrome have recently been reported including serum uric acid. Causative correlation between serum uric acid and insulin resistance syndrome is still not clear. We performed epidemiologic study to clarify its correlation with insulin resistance syndrome in the people living at Kijang district of Busan City. METHODS: We performed volunteer study of the people living at Kijang district of Busan City from 16th to 19th day of November in 1998 (n=232). Height, body weight, abdominal and hip circumference, and blood pressure were measured. We also measured fasting blood glucose, fasting serum insulin (Linco RIA), HDL-cholesterol, triglyceride, total cholesterol and serum uric acid. Insulin resistance was calculated by HOMA (homeostasis model assessment) method. RESULTS: Total number of subjects were 232 (male 61, female 171), and their mean age was 5.1+/-13.4 (years), BMI (body mass index) 23.4+/-3.2 kg/m2, and WHR (waist to hip ratio) 0.82+/-0.07. Mean HOMA-IR value derived from fasting blood glucose and insulin was 2.5+/-2.4, mean serum uric acid was 270+/-72 mol/L. The serum uric acid level showed positive correlation with BMI (r=.324), WHR (r=.403), log transformed triglyceride value (r=.135), systolic blood pressure (r=.181), diastolic blood pressure (r=.185) and negative correlation with HDL-cholesterol (r=-.185,p<0.01). Stepwise linear regression revealed that only serum creatinine, WHR and natural logarithmic value of triglyceride showed statistically independent correlation with serum uric acid level. CONCLUSION: Serum uric acid level in the people living at Kijang district of Busan City showed statistically significant correlation with other well-known constituents of insulin resistance syndrome. Thus, we may conclude that the level of serum uric acid can be regarded as the component of insulin resistance syndrome in the people living at Kijang district. However, its relationship with insulin resistance syndrome may be indirect.
Status and Associating Factors of Complementary and Altemative Medicine Among Korean Diabetic Patients.
Yun Sook Kim, Jin Ho Chun, Jeong Hyun Park, Chang II Kang
Korean Diabetes J. 2000;24(1):78-89.   Published online January 1, 2001
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AbstractAbstract PDF
BACKGROUND
Although it is not clarified the effect of complementary and alternative medicine (CAM), yet it was widely applied to the treatment of many chronic diseases. This study aimed to propose a guide for appropriate use of CAM for the treatment of diabetes mellitus in Korea. METHODS: The study subjects were 192 patients (male 93, female 99), who diagnosed with type 2 diabetes at Pusan Paik Hospital. The status and associating factors of CAM used by the patients were asked from March 1 to 31, 1999. RESULTS: The mean age of the study subjects were 57.0+/-9.6 years, and the mean duration of disease was 8.2+/-6.0 years. Approximately 71% of the subjects experience CAM at least once in past. In total, 132 kinds of CAM had been taken and the average number of CAM taken by one patient was 7.6. Silkworm was used most frequently (80.9%), then followed by ginseng (34.6%), black bean (33.1%), concoction of herbs (18.4%) and pine tree leaves (17,6%). In general, CAM was introduced by their acquaintances(64.7%), of which family relatives and friends was 51.5%, and the information about CAM were gathered from the mass media (25,0%) or health publications (20.6%). Among them, 86.8% simultaneously took CAM with the conventional therapy - diet, exercise and medication. Only 27.9% approved the effect of CAM. In logistic regression, the duration of disease (OR=1.09), contact with the mass media or health publications(OR=4.34) and education(OR=0.33) were detected as the independent factors for the use of CAM. CONCLUSION: Many diabetic patients use the various as-yet-unverified CAM without any guidelines. It is considered that there is no patient's education about CAM and the mass media and various health publications have significant impact on the spread of CAM. Therefore, to lead the appropriate use of CAM for diabetic control, it is necessary to strengthen patient's education and to filter these informations from the mass media and various health publications.
Canditate Gene Approach for the Genetics of Type 2 Diabetes Mellitus.
Jeong Hyun Park
Korean Diabetes J. 1998;22(4):439-441.   Published online January 1, 2001
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AbstractAbstract PDF
No abstract is available.
Disturbance of Cutaneous Microcirculation assessed by Laser Doppler Flowmetry in Non-Insulin Dependent Diabetic patients.
Jeong Hyun Park, Sang Hee Nam
Korean Diabetes J. 1997;21(1):56-64.   Published online January 1, 2001
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AbstractAbstract PDF
BACKGROUND
Diabetic microangiopathies are well-known long-term complication of diabetes mellitus, These are wide-spread phenomena, but little is known about the nature of cutaneous microcirculatory disturbance in diabetic patients which could be considered as cutaneous diabetic microangiopathy. To assess the cutaneous microcirculatory disturbance of diabetic patients, we performed this study. METHODS: We performed the laser Doppler flowmetry which has been known to be an accurate device for measuring cutaneous microcirculatory blood flow to 14 control subjects and 16 non-insulin dependent diabetic patients. We used thermal reactive hyperemic technique to the dorsum of right index finger and right great toe for measuring both baseline and maximum cutaneous microcirculatory blood flow. RESULTS: The baseline microcirculatory blood flow measured at 35C did not show any statistically significant differences between control subjects and diabetic patients, on both finger dorsum and toe dorsum. The maximurn microcirculatory blood flow measured at 44C showed statistically significant difference between control subjects and diabetic patients only at toe dorsum, but not at finger dorsum (p<0.05). CONCLUSION: From the above results, we conclude that cutaneous microcirculation is disturbed in noninsulin dependent diabetic patients, which was manifested at the toe dorsum in the condition of maximum blood flow induced by thermal stimulation. Further studies an exact pathophysiology and possible correlations with diabetic microangiopathies, diabetic duration and the level of glycemic control are needed along with more refinement of measurement techniques.

Diabetes Metab J : Diabetes & Metabolism Journal