- Comparisons between Several Neurologic Tests of Large Myelinated Nerves in Type 2 Diabetic Patients with Peripheral Polyneuropathy.
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Bo Wan Kim, Dong Hee Kim, Jung Guk Kim
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Korean Diabetes J. 1999;23(4):562-574. Published online January 1, 2001
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 Abstract
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- BACKGROUND
Neuropathy is the most common complication of diabetes mellitus but the prevalence is variable because there are many neurologic tests and criteria for diagnosis of neuropathy. Subjective symptoms of patients alone are not accurate for diagnosis of neuropathy, so objective sensory tests must be added. There have been few studies about correlation between each neurologic tests; furthermore there have been no studies on comparisons between each neurologic test in Korean diabetic patients. METHODS: From September 1997 to June 1998, 142 type 2 diabetic patients visited Kyungpook National University Hospital and included in this study. Every patient had nerve conduction study and vibration threshold test, pressure threshold test of 1 point and 2 point touch stimuli by pressure specified sensory device. Some of these patients had 10g monofilament test. From receiver operating characteristics curve, sensitivities of each test were calculated and compared with each test. RESULTS: 1. From receiver operating characteristics curve, when specificities of each test reached 90%, sensitivity of vibration perception threshold test of left great toe was 69.2 %, one point discrimination touch threshold test of left great toe was 50 %, and two point test was 31.6 %. Sensitivity of 10 g monofilament test was 57% and specificity was 85%. 2. Comparisons between each component of nerve conduction study and other neurologic test showed conduction velocity and amplitude were highly correlated with vibration perception threshold test, but F wave latency was highly correlated with one point discrimination threshold test. CONCLUSION: We though vibration perception threshold, lOg monofilament and quantitative sensory tests is adequate, simple and convenient tests in order to diagnose peripheral polyneuropathy. Of all these tests, vibration perception threshold was most useful as well as a sensitive test for screening and diagnosis of peripheral polyneuropathy in nan-insulin dependent diabetic patients.
- Lipopolysaccharide-Induced Changes in Vascular Reactivity of Diabetic Rat Aorta.
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Ye Kyung Seo, Sang Won Chung, Jik Hwa Nam, Byoung Ho Sin, Dong Hee Kim, Jung Guk Kim, Sung Woo Ha, Bo Wan Kim
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Korean Diabetes J. 1997;21(3):280-288. Published online January 1, 2001
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Abstract
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- Backgound: Hemodynamic deteriorations in diabetes mellitus may be mediated by increased contractile response to catecholamines and/or by decreased relaxative response to vasodilators such as acetylcholine(Ach). Decrease in peripheral vascular reactivity to vasoconstrictor was known to be an ominous sign that happens during sepsis or after injection of bacterial lipopolysaccharides(LPS). In this study, we compared the effects of LPS on function of diabetic rat aorta with impaired vascular reactivity with those of control rat aorta. METHODS: Contractile responses to cumulative concentrations(10'M to 3X10'M) of norepinephrine (NE) were measured in aorta isolated ftom the control and 4 to 5-week streptozotocin-induced diabetic rat at 6 hours after LPS treatment to compare with contractile responses of untreated group. We measured relaxative responses to cumulative concentrations(10'M to 10M) of Ach and nitroprusside (NTP) in these aortas contracted submaximally by NE. RESULTS: Diabetic rat aortas showed significantly more impairment in relaxative responses to Ach than control rat aortas before LPS treatment(p0.05 = 0.0l). LPS treatment in those diabetic rat aortas decreased contractile responses to NE by 26.6%(p < 0.01); the changes were sirnilar to those of control (30.9%, p0.01). Relaxative responses to Ach were also significantly decreased by 25.0%(p 0.01) after L.PS treatment; the changes were similar to those of control(34.1%, p0.01). However relaxative responses to NTP were not changed in control and d.iabetic rat aortas by LPS treatment. CONCLUSION: These results suggest that diabetes may induce impairment in endothelium-dependent vascular relaxation and there rnay be no difference of L,P,S-induced effects on hemodynamic deterioration between 4 to 5-week diabetic and control rats.
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