- Effect of Pinitol on Glucose Metabolism and Adipocytokines in Uncontrolled Type 2 Diabetes Mellitus.
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Mi Jin Kim, Kwang Ha Yoo, Hyung Suk Park, Sang Man Chung, Choon Jo Chin, Young Sook Choi, Choon Hee Chung
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Korean Diabetes J. 2005;29(4):344-351. Published online July 1, 2005
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 Abstract
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- BACKGROUND
Pinitol(3-O-methyl-D-chiro-inositol) has been identified in putative insulin mediator fractions possessing hypoglycemic activity, and appears to act downstream in the insulin-signaling pathway to mimic the effects of insulin. We evaluated the effect of pinitol therapy in type 2 diabetic patients who were poorly controlled with hypoglycemic drugs such as sulfonylurea, metformin and/or insulin. METHODS: Twenty type 2 diabetic patients were enrolled in this our study. The fasting glucose and c-peptide, total cholesterol, triglyceride, HDL-and LDL-cholesterols were checked before and after treatment with 20mg.kg(-1).day(-1) pinitol for twelve weeks. All subjects continued their current medications during the study. Adipocytokines, such as adiponectin, leptin, free fatty acid and CRP, were checked before and after the pinitol treatment. RESULTS: After the pinitol treatment, the fasting and post-prandial glucose levels and hemoglobin A1c were significantly decreased(P<0.05). The fasting serum adiponectin, leptin, free fatty acid and CRP levels remained unchanged after the pinitol treatment. In the non-responder groups, the serum c-peptide levels were higher than those in the responder groups. CONCLUSION: Twelve weeks of pinitol treatment altered glucose metabolism, but not the lipid profiles or adipocytokine levels. Additional research will be required are needed to define the physiological and potential therapeutic effects of pinitol.
- The Effect of Chronic Alcohol Intake on Insulin Secretion in NIDDM Rats.
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Mi Jin Kim, Myoung Sook Shim, Mun Kyu Kim, Dong Gu Kang, Hyung Suk Park, Sang Man Chung, Tae Sun Hwang, Young Goo Shin, Choon Jo Chin, Choon Hee Chung
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Korean Diabetes J. 2002;26(5):366-376. Published online October 1, 2002
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Abstract
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- BACKGROUND
The effect of alcohol on glucose metabolism is dependent on the daily amount of alcohol ingestion and the timing of intake. Heavy alcohol consumption in the fasting state may lead to serious hypoglycemia, whereas an excessive alcohol intake during meals may lead to hyperglycemia. In Korea, AIDDM (atypical insulin dependent diabetes mellitus) which shows firstly similar to the NIDDM and progresses slowly into IDDM is related to heavy alcohol drinking. So we studied that the effect of chronic alcohol intake on insulin secretion of beta cell in streptozotocin (STZ)-induced non-insulin dependent diabetic Sprangue- Dawley rats. METHODS: 40 male newborn (12 hours old) Sprague-Dawley rats were made diabetic by streptozotocin (50 mg/kg, intraperitoneal injection) and 20 male newborn (12 hours old) Sprague-Dawley rats were injected by citrate buffer solution. At 14 weeks old, diabetic group were confirmed by intraperitoneal glucose tolerance test (30% D/W, 2 g/kg). After that, diabetic group were divided into two groups. One group were fed on 5% ethanol and the other group were fed on water for 8 weeks. Control groups were divided into two groups. One group were fed on 5% ethanol and the other group were fed on water for 8 weeks. All rats were divided into 4 groups; group I: diabetic and 5% ethanol, group II: non- diabetic and 5% ethanol, group III: diabetic and water, group IV: non-diabetic and water. At the age of 22 weeks, we determined insulin level among 4 groups. After we extracted pancreas, determined the ratio of area of beta cell to islet cell. RESULTS: 1) There was no difference of weight among 4 groups in 22 week old rats. 2) Group I freely ingested 2.08g (5.50 g/kg/day) ethanol daily and group II ingested 2.04g (4.89g/kg/day) ethanol daily. 3) Plasma insulin levels of group I were lower than those of group III but not significant. 4) Plasma insulin levels of group II were higher than those of group IV but not significant. 5) In the light microscopic findings of pancreas, the ratios of area of beta cells to islet cells in group I were the lowest but not significant. CONCLUSION: These findings suggested that chronic moderate alcohol ingestion in NIDDM rats didn't impair insulin secretion and morphology of pancreatic beta cells.
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