Fig. 1The serum glucose levels (A) and hypothalamic expressions of proopiomelanocortin (POMC; B) and neuropeptide Y (NPY; C) mRNA following intraperitoneal saline or glucose injection in overnight fasted C57BL/6 and Kir6.2 knockout (KO) mice. Values are the mean±standard error of 5 to 10 experimental animals per group. aP<0.05 vs. the saline group.
Fig. 2The average daily caloric intake (A) and deposition of retroperitoneal white adipose tissue (RT-WAT; B) in control or high fat diet-fed C57BL/6 (normal) and Kir6.2-deficient (KO) mice. Values are the mean±standard error of 5 to 10 experimental animals per group. N-C, normal control group; N-HF, high fat-fed normal mice; KO-C, control diet fed Kir6.2 KO mice; KO-HF, high fat diet-fed Kir6.2 KO mice. aP<0.05 vs. N-C, bP<0.05 vs. KO-C.
Fig. 3The serum levels of glucose (A), free fatty acids (FFA; B), insulin (C), and leptin (D), and the hypothalamic expressions of proopiomelanocortin (POMC; E) and neuropeptide Y (NPY; F) mRNA in control or high fat diet-fed C57BL/6 (normal) and Kir6.2-deficient (KO) mice. Values are the mean±standard error of 5 to 10 experimental animals per group. N-C, normal control group; N-HF, high fat-fed normal mice; KO-C, control diet-fed Kir6.2 KO mice; KO-HF, high fat diet-fed Kir6.2 KO mice. aP<0.05 vs. N-C.
Table 1Changes in body weight following a control or high fat diet in the experimental animals