Obesity has quickly become a worldwide pandemic, causing major adverse health outcomes such as dyslipidemia, type 2 diabetes mellitus, cardiovascular disease and cancers. Obesity-induced insulin resistance is the key for developing these metabolic disorders, and investigation to understand the molecular mechanisms involved has been vibrant for the past few decades. Of these, low-grade chronic inflammation is suggested as a critical concept in the development of obesity-induced insulin resistance, and the anti-inflammatory effect of nitric oxide (NO) signaling has been reported to be linked to improvement of insulin resistance in multiple organs involved in glucose metabolism. Recently, a body of evidence suggested that vasodilatory-stimulated phosphoprotein (VASP), a downstream mediator of NO signaling plays a crucial role in the anti-inflammatory effect and improvement of peripheral insulin resistance. These preclinical studies suggest that NO/VASP signaling could be an ideal therapeutic target in the treatment of obesity-related metabolic dysfunction. In this review, we introduce studies that investigated the protective role of NO/VASP signaling against obesity-related inflammation and insulin resistance in various tissues.

Citations

Citations to this article as recorded by  

• Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline
  Ping Lu, Cun-Xiu Gao, Fei-Jian Luo, Yu-Ting Huang, Mei-Mei Gao, Yue-Sheng Long
  The Journal of Nutritional Biochemistry.2024; 125: 109554.     CrossRef
• Leptina, obesidad y enfermedades cardiovasculares
  Jorly Mejia-Montilla , Nadia Reyna-Villasmil, Andreina Fernández-Ramírez, Eduardo Reyna-Villasmil
  Revista Repertorio de Medicina y Cirugía.2023; 32(3): 218.     CrossRef
• Urinary and circulatory netrin-1 as biomarker in diabetes and its related complications: a systematic review and meta-analysis
  Amir Hossein Behnoush, Amirmohammad Khalaji, Zahra Shokri Varniab, Afshin Rahbarghazi, Elahe Amini, Aleksandra Klisic
  Endocrine.2023;[Epub]     CrossRef
• Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D
  Qing‐Ling Quan, Kyeong‐No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee
  Photodermatology, Photoimmunology & Photomedicine.2023; 39(6): 573.     CrossRef
• Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model
  Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway
  Hui Ye, Yanan He, Chuan Zheng, Fang Wang, Ming Yang, Junzhi Lin, Runchun Xu, Dingkun Zhang
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Effect of low-dose tadalafil once daily on glycemic control in patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, placebo-controlled pilot study
  Min-Kyung Lee, Jae-Hyuk Lee, Seo-Young Sohn, Seo Yeon Lee, Tae-Yoong Jeong, Sae Chul Kim
  Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
• In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot
  Yingzheng Zhao, Lanzi Luo, Lantian Huang, Yingying Zhang, Mengqi Tong, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
  Journal of Controlled Release.2022; 350: 93.     CrossRef
• Amelioration effect of black seed oil against high‐fat diet‐induced obesity in rats through Nrf2/HO‐1 pathway
  Nada F. Abo El‐Magd, Mohamed El‐Mesery, Amro El‐Karef, Mamdouh M. El‐Shishtawy
  Journal of Food Biochemistry.2021;[Epub]     CrossRef
• An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
  John P. Hanrahan, Jelena P. Seferovic, James D. Wakefield, Phebe J. Wilson, Jennifer G. Chickering, Joon Jung, Kenneth E. Carlson, Daniel P. Zimmer, Andrew L. Frelinger, Alan D. Michelson, Linda Morrow, Michael Hall, Mark G. Currie, G. Todd Milne, Albert
  Diabetologia.2020; 63(4): 733.     CrossRef
• Advantages of Phosphodiesterase Type 5 Inhibitors in the Management of Glucose Metabolism Disorders: A Clinical and Translational Issue
  Cristina Antinozzi, Paolo Sgrò, Luigi Di Luigi
  International Journal of Endocrinology.2020; 2020: 1.     CrossRef
• Association of endothelial dysfunction with incident prediabetes, type 2 diabetes and related traits: the KORA F4/FF4 study
  Marie-Theres Huemer, Cornelia Huth, Florian Schederecker, Stefanie J Klug, Christa Meisinger, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Barbara Thorand
  BMJ Open Diabetes Research & Care.2020; 8(1): e001321.     CrossRef
• Embelin from Embelia ribes ameliorates oxidative stress and inflammation in high-fat diet-fed obese C57BL/6 mice
  Priyanka Bansal, Uma Bhandari, Sayeed Ahmad
  Pharmacognosy Magazine.2020; 16(5): 443.     CrossRef
• Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
  Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
  Scientific Reports.2019;[Epub]     CrossRef
• Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment
  Sunghwan Suh, Kwang-Won Kim
  Diabetes & Metabolism Journal.2019; 43(6): 733.     CrossRef
• Antioxidant, antihyperglycemic, and antidiabetic activity of Apis mellifera bee tea
  Janielle da Silva Melo da Cunha, Tamaeh Monteiro Alfredo, Jéssica Maurino dos Santos, Valter Vieira Alves Junior, Luiza Antas Rabelo, Emerson Silva Lima, Ana Paula de Araújo Boleti, Carlos Alexandre Carollo, Edson Lucas dos Santos, Kely de Picoli Souza, M
  PLOS ONE.2018; 13(6): e0197071.     CrossRef
• Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes
  Jisook Yim, Gyuri Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jeong-Ho Kim, Jin Won Cho, Sang-Guk Lee, Yong-ho Lee
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Glycyrrhizin ameliorates high fat diet-induced obesity in rats by activating NrF2 pathway
  Nada F. Abo El-Magd, Mohamed El-Mesery, Amro El-Karef, Mamdouh M. El-Shishtawy
  Life Sciences.2018; 193: 159.     CrossRef
• cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation
  Andras Franko, Marketa Kovarova, Susanne Feil, Robert Feil, Robert Wagner, Martin Heni, Alfred Königsrainer, Marc Ruoß, Andreas K. Nüssler, Cora Weigert, Hans-Ulrich Häring, Stefan Z. Lutz, Andreas Peter
  Metabolism.2018; 88: 22.     CrossRef