Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by  

• Gut microbiome-derived secondary bile acids: therapeutic targets for reducing cardiovascular disease in type 2 diabetes?
  Sarah A. Johnson, Tiffany L. Weir
  The American Journal of Clinical Nutrition.2024; 119(2): 241.     CrossRef
• Current updates on metabolites and its interlinked pathways as biomarkers for diabetic kidney disease: A systematic review
  Soumik Das, V Devi Rajeswari, Ganesh Venkatraman, Ramprasad Elumalai, Sivaraman Dhanasekaran, Gnanasambandan Ramanathan
  Translational Research.2024; 265: 71.     CrossRef
• Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes
  Kai Luo, Guo-Chong Chen, Yanbo Zhang, Jee-Young Moon, Jiaqian Xing, Brandilyn A. Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M. Rebholz, Tao Wang, Carmen R. Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D. Burk, Rober
  Nature Metabolism.2024; 6(1): 169.     CrossRef
• Predictive value of serum TBA for 2-year MACEs in ACS patients undergoing PCI: a prospective cohort study
  Wen Wen, Qinze Li, Jianqing She, Xiaofang Bai, Lisha Zhang, Ruifeng Li, Yan Wu, Juan Zhou, Zuyi Yuan
  Scientific Reports.2024;[Epub]     CrossRef
• Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism
  John C. Rowe, Jenessa A. Winston
  Veterinary Sciences.2024; 11(2): 94.     CrossRef
• The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation
  Olga Golubnitschaja, Jiri Polivka, Pavel Potuznik, Martin Pesta, Ivana Stetkarova, Alena Mazurakova, Lenka Lackova, Peter Kubatka, Martina Kropp, Gabriele Thumann, Carl Erb, Holger Fröhlich, Wei Wang, Babak Baban, Marko Kapalla, Niva Shapira, Kneginja Ric
  EPMA Journal.2024; 15(1): 1.     CrossRef
• Investigating the mechanism of cornel iridoid glycosides on type 2 diabetes mellitus using serum and urine metabolites in rats
  Yadi Hou, Yanmei Huang, Zihui Shang, Shichao Ma, Tianyi Cui, Ali Chen, Yongxia Cui, Suiqing Chen
  Journal of Ethnopharmacology.2024; 328: 118065.     CrossRef
• Improvement of myocardial injury and gut microbiota disturbance in type 2 diabetic mice by inulin with various degrees of polymerization
  Siqiang Jia, Jianpeng Li, Bin Yu, Mengjie Li, Bo Cui
  Food Bioscience.2023; 51: 102318.     CrossRef
• Bile acids and their receptors in regulation of gut health and diseases
  Sen Lin, Sutian Wang, Peng Wang, Cuiming Tang, Zhenjiang Wang, Lian Chen, Guoqing Luo, Hong Chen, Yuntao Liu, Bin Feng, De Wu, Douglas G. Burrin, Zhengfeng Fang
  Progress in Lipid Research.2023; 89: 101210.     CrossRef
• Effects of dietary oat supplementation on carcass traits, muscle metabolites, amino acid profiles, and its association with meat quality of Small-tail Han sheep
  Li-wei Wang, Shao-feng Su, Jie Zhao, Xiao-long He, Shao-yin Fu, Biao Wang, Yun-fei Wang, Da-qing Wang, Na-na Yun, Xin Chen, Damien P Belobrajdic, Terigele, Xiao-dong Li, Li-li Jiang, Jiang-feng He, Yong-bin Liu
  Food Chemistry.2023; 411: 135456.     CrossRef
• Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism
  Wenjing Mo, Jiaqi Zou, Ming Wu, Zijun Peng, Wenjiang He, Wenzhi Li, Xiaoyong Wu
  Journal of Functional Foods.2023; 101: 105408.     CrossRef
• Sodium glucose co-transporter 2 (SGLT2) inhibition via dapagliflozin improves diabetic kidney disease (DKD) over time associatied with increasing effect on the gut microbiota in db/db mice
  Jiajia Wu, Yan Chen, Huinan Yang, Leyi Gu, Zhaohui Ni, Shan Mou, Jianxiao Shen, Xiajing Che
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Short communication: unique metabolic signature of proliferative retinopathy in the tear fluid of diabetic patients with comorbidities — preliminary data for PPPM validation
  Martina Kropp, Eline De Clerck, Trong-Tin Kevin Steve Vo, Gabriele Thumann, Vincenzo Costigliola, Olga Golubnitschaja
  EPMA Journal.2023; 14(1): 43.     CrossRef
• Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice
  Kaichi Kasai, Naoya Igarashi, Yuki Tada, Koudai Kani, Shun Takano, Tsutomu Yanagibashi, Fumitake Usui-Kawanishi, Shiho Fujisaka, Shiro Watanabe, Mayuko Ichimura-Shimizu, Kiyoshi Takatsu, Kazuyuki Tobe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai
  International Journal of Molecular Sciences.2023; 24(4): 4050.     CrossRef
• Mitochondrial Cholesterol Metabolites in a Bile Acid Synthetic Pathway Drive Nonalcoholic Fatty Liver Disease: A Revised “Two-Hit” Hypothesis
  Genta Kakiyama, Daniel Rodriguez-Agudo, William M. Pandak
  Cells.2023; 12(10): 1434.     CrossRef
• Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols
  Kevin M. Tveter, Esther Mezhibovsky, Yue Wu, Diana E. Roopchand
  Pharmacology & Therapeutics.2023; 248: 108457.     CrossRef
• Role of liver parameters in diabetes mellitus – a narrative review
  Sana Rafaqat, Aqsa Sattar, Amber Khalid, Saira Rafaqat
  Endocrine Regulations.2023; 57(1): 200.     CrossRef
• Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells
  Ewa Oleszycka, Eoin C. O’Brien, Michael Freeley, Ed C. Lavelle, Aideen Long
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Machine learning for predicting diabetic metabolism in the Indian population using polar metabolomic and lipidomic features
  Nikita Jain, Bhaumik Patel, Manjesh Hanawal, Anurag R. Lila, Saba Memon, Tushar Bandgar, Ashutosh Kumar
  Metabolomics.2023;[Epub]     CrossRef
• The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
  Yuchang Li, Liting Chen, Vassilios Papadopoulos
  Biochimie.2023;[Epub]     CrossRef
• Sodium+/taurocholate cotransporting polypeptide as target therapy for liver fibrosis
  Ahmad Salhab, Johnny Amer, Yinying Lu, Rifaat Safadi
  Gut.2022; 71(7): 1373.     CrossRef
• Comparative Evaluation of the Effect of Metformin and Insulin on Gut Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by the Combination of Streptozotocin and High-Fat Diet
  Nan Hu, Qi Zhang, Hui Wang, Xuping Yang, Yan Jiang, Rong Chen, Liying Wang
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Immunomodulatory functions of FXR
  Stefano Fiorucci, Angela Zampella, Patrizia Ricci, Eleonora Distrutti, Michele Biagioli
  Molecular and Cellular Endocrinology.2022; 551: 111650.     CrossRef
• Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota
  Carlos J. Garcia, Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, Jana Hajslova
  Biomolecules.2022; 12(5): 687.     CrossRef
• Regulation of the intestinal flora: A potential mechanism of natural medicines in the treatment of type 2 diabetes mellitus
  liying he, Fang-Qing Yang, Pan Tang, Ting-Hui Gao, Cai-Xia Yang, Li Tan, Pan Yue, Ya-Nan Hua, Si-Jing Liu, Jin-Lin Guo
  Biomedicine & Pharmacotherapy.2022; 151: 113091.     CrossRef
• Acrylamide induced glucose metabolism disorder in rats involves gut microbiota dysbiosis and changed bile acids metabolism
  Zonghao Yue, Yanjuan Chen, Qian Dong, Dan Li, Meng Guo, Li Zhang, Yini Shi, Huiting Wu, Lili Li, Zhongke Sun
  Food Research International.2022; 157: 111405.     CrossRef
• Effects of Herbal Therapy on Intestinal Microbiota and Serum Metabolomics in Different Rat Models of Mongolian Medicine
  Guniang Jiu, Riao Dao, Dongxing Wu, Wang Hung, Haburi Jin, Li Li, Xiquan Fu, Chula Sa, Eerdunchaolu, Maulidiani .M
  Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
• The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors
  Tomonori Kamiya, Naoko Ohtani
  International Immunology.2022; 34(9): 467.     CrossRef
• Reduced Cytokine Tumour Necrosis Factor by Pharmacological Intervention in a Preclinical Study
  Armin Mooranian, Jacqueline Chester, Edan Johnston, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Momir Mikov, Hani Al-Salami
  Biomolecules.2022; 12(7): 877.     CrossRef
• Crisis of the Asian gut: associations among diet, microbiota, and metabolic diseases
  Phatthanaphong THERDTATHA, Akari SHINODA, Jiro NAKAYAMA
  Bioscience of Microbiota, Food and Health.2022; 41(3): 83.     CrossRef
• Valorization of avocado seeds with antioxidant capacity using pressurized hot water extraction
  Eng Shi Ong, Janelle Low, Joseph Choon Wee Tan, Su Yi Foo, Chen Huei Leo
  Scientific Reports.2022;[Epub]     CrossRef
• The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the liver-gut axis in mice
  Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian, Yuanxiang Jin
  Chemosphere.2022; 307: 136141.     CrossRef
• Gut Microbiota and Bile Acids Mediate the Clinical Benefits of YH1 in Male Patients with Type 2 Diabetes Mellitus: A Pilot Observational Study
  Yueh-Hsiang Huang, Yi-Hong Wu, Hsiang-Yu Tang, Szu-Tah Chen, Chih-Ching Wang, Wan-Jing Ho, Yi-Hsuan Lin, Geng-Hao Liu, Pei-Yeh Lin, Chi-Jen Lo, Yuan-Ming Yeh, Mei-Ling Cheng
  Pharmaceutics.2022; 14(9): 1857.     CrossRef
• Gut–Liver Axis and Non-Alcoholic Fatty Liver Disease: A Vicious Circle of Dysfunctions Orchestrated by the Gut Microbiome
  Salvatore Pezzino, Maria Sofia, Gloria Faletra, Chiara Mazzone, Giorgia Litrico, Gaetano La Greca, Saverio Latteri
  Biology.2022; 11(11): 1622.     CrossRef
• The Role of Bile Acids in Cardiovascular Diseases: from Mechanisms to Clinical Implications
  Shuwen Zhang, Junteng Zhou, Wenchao Wu, Ye Zhu, Xiaojing Liu
  Aging and disease.2022;[Epub]     CrossRef
• Role of bile acids in overweight and obese children and adolescents
  Cosimo Giannini, Concetta Mastromauro, Serena Scapaticci, Cristina Gentile, Francesco Chiarelli
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Bile acids and microbes in metabolic disease
  Dhiraj Kumar Sah, Archana Arjunan, Sun Young Park, Young Do Jung
  World Journal of Gastroenterology.2022; 28(48): 6846.     CrossRef
• The Fungicide Prothioconazole and its Metabolite Prothioconazole-Desthio Disturbed the Liver-Gut Axis in Mice
  Yuanxiang Jin, Lingyu Hu, Xiaofang Wang, Zhiwei Bao, Qihao Xu, Mingrong Qian
  SSRN Electronic Journal .2022;[Epub]     CrossRef
• The Critical Effect of Bile Acids in Atherosclerosis
  Shangwen Qi, Xu Luo, Shuangfang Liu, Bishi Ling, Hua Jin
  Journal of Cardiovascular Pharmacology.2022; 80(4): 562.     CrossRef
• Role of sirtuin-1 (SIRT1) in hypoxic injury in pancreatic β-cells
  Ye-Jee Lee, Esder Lee, Young-Hye You, Yu-Bae Ahn, Ki-Ho Song, Ji-Won Kim, Seung-Hyun Ko
  Journal of Drug Targeting.2021; 29(1): 88.     CrossRef
• Impact of gut microbiota: How it could play roles beyond the digestive system on development of cardiovascular and renal diseases
  Kanmani Suganya, Taekwon Son, Kyu-Won Kim, Byung-Soo Koo
  Microbial Pathogenesis.2021; 152: 104583.     CrossRef
• Determination of bile acids from human gallbladder by 1H‐MRS—Protocol optimization and estimation of reproducibility
  Peter Vermathen, Gaëlle Diserens, Dino Kröll, Philipp Nett, Guido Stirnimann, Reiner Wiest
  NMR in Biomedicine.2021;[Epub]     CrossRef
• The gut microbiome-bile acid axis in hepatocarcinogenesis
  Liwei Wu, Jiao Feng, Jingjing Li, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo
  Biomedicine & Pharmacotherapy.2021; 133: 111036.     CrossRef
• Gut microbiome and bile acids in obesity-related diseases
  Rumei Li, Sergio Andreu-Sánchez, Folkert Kuipers, Jingyuan Fu
  Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(3): 101493.     CrossRef
• Gut Microbiome of Indonesian Adults Associated with Obesity and Type 2 Diabetes: A Cross-Sectional Study in an Asian City, Yogyakarta
  Phatthanaphong Therdtatha, Yayi Song, Masaru Tanaka, Mariyatun Mariyatun, Maisaroh Almunifah, Nancy Eka Putri Manurung, Siska Indriarsih, Yi Lu, Koji Nagata, Katsuya Fukami, Tetsuo Ikeda, Yuan-Kun Lee, Endang Sutriswati Rahayu, Jiro Nakayama
  Microorganisms.2021; 9(5): 897.     CrossRef
• Microbial Ecosystem in Diabetes Mellitus: Consideration of the Gastrointestinal System
  Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 1841.     CrossRef
• Role of bile acids in inflammatory liver diseases
  Ioannis Evangelakos, Joerg Heeren, Esther Verkade, Folkert Kuipers
  Seminars in Immunopathology.2021; 43(4): 577.     CrossRef
• Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes
  Alessandro Mantovani, Andrea Dalbeni, Denise Peserico, Filippo Cattazzo, Michele Bevilacqua, Gian Luca Salvagno, Giuseppe Lippi, Giovanni Targher, Elisa Danese, Cristiano Fava
  Metabolites.2021; 11(7): 453.     CrossRef
• Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice
  Xue-Song Zhang, Yue Sandra Yin, Jincheng Wang, Thomas Battaglia, Kimberly Krautkramer, Wei Vivian Li, Jackie Li, Mark Brown, Meifan Zhang, Michelle H. Badri, Abigail J.S. Armstrong, Christopher M. Strauch, Zeneng Wang, Ina Nemet, Nicole Altomare, Joseph C
  Cell Host & Microbe.2021; 29(8): 1249.     CrossRef
• Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature
  Sarah Kim, Sora Choi, Moumita Dutta, Jeffrey O. Asubonteng, Marianne Polunas, Michael Goedken, Frank J. Gonzalez, Julia Yue Cui, Maxwell A. Gyamfi
  Biochemical Pharmacology.2021; 193: 114698.     CrossRef
• Gut microbiota as a target for prevention and treatment of type 2 diabetes: Mechanisms and dietary natural products
  Fan Xia, Lu-Ping Wen, Bing-Chen Ge, Yu-Xin Li, Fang-Ping Li, Ben-Jie Zhou
  World Journal of Diabetes.2021; 12(8): 1146.     CrossRef
• Association between circulating bile acid alterations and nonalcoholic steatohepatitis independent of obesity and diabetes mellitus
  Youngae Jung, Bo Kyung Koo, Seo Young Jang, Dain Kim, Heeyeon Lee, Dong Hyeon Lee, Sae Kyung Joo, Yong Jin Jung, Jeong Hwan Park, Taekyeong Yoo, Murim Choi, Min Kyung Lee, Sang Won Kang, Mee Soo Chang, Won Kim, Geum‐Sook Hwang
  Liver International.2021; 41(12): 2892.     CrossRef
• Bile acid activated receptors: Integrating immune and metabolic regulation in non-alcoholic fatty liver disease
  Michele Biagioli, Stefano Fiorucci
  Liver Research.2021; 5(3): 119.     CrossRef
• Synthesis of 12β-Methyl-18-nor-bile Acids
  Andreas Luxenburger, Lawrence D. Harris, Elizabeth M. Ure, Roselis A. Landaeta Aponte, Anthony D. Woolhouse, Scott A. Cameron, Chris D. Ling, Ross O. Piltz, Andrew R. Lewis, Graeme J. Gainsford, Alex Weymouth-Wilson, Richard H. Furneaux
  ACS Omega.2021; 6(38): 25019.     CrossRef
• Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification
  Kamil Borkowski, Ameer Y. Taha, Theresa L. Pedersen, Philip L. De Jager, David A. Bennett, Matthias Arnold, Rima Kaddurah-Daouk, John W. Newman
  Scientific Reports.2021;[Epub]     CrossRef
• Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids
  Xunxun Feng, Guangyao Zhai, Jiaqi Yang, Yang Liu, Yujie Zhou, Qianyun Guo
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)
  Xian Wei, Ting Yao, Fatou Ndoye Fall, Min Xue, Xiaofang Liang, Jie Wang, Wenlong Du, Xu Gu
  Foods.2021; 10(10): 2465.     CrossRef
• Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
  Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim, Ji Hye Huh
  Cardiovascular Diabetology.2020;[Epub]     CrossRef
• Methionine restriction alleviates high-fat diet-induced obesity: Involvement of diurnal metabolism of lipids and bile acids
  Luanfeng Wang, Bo Ren, Qian Zhang, Chuanqi Chu, Zhenting Zhao, Jianbin Wu, Weiyang Zhao, Zhigang Liu, Xuebo Liu
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(11): 165908.     CrossRef
• Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes
  Yingjie Wu, An Zhou, Li Tang, Yuanyuan Lei, Bo Tang, Linjing Zhang
  Journal of Diabetes Research.2020; 2020: 1.     CrossRef
• Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
  John Y. L. Chiang, Jessica M. Ferrell
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2020; 318(3): G554.     CrossRef
• Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice
  Guiling Yang, Xianling Yuan, Cuiyuan Jin, Dou Wang, Yanhua Wang, Wenyu Miao, Yuanxiang Jin
  Environmental Pollution.2020; 266: 115290.     CrossRef
• Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
  John Y.L. Chiang, Jessica M. Ferrell
  Liver Research.2020; 4(2): 47.     CrossRef
• Diabetes and Metabolism Journal in 2020: Good to Great
  In-Kyung Jeong
  Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
• Healthy dietary patterns to reduce obesity-related metabolic disease: polyphenol-microbiome interactions unifying health effects across geography
  Camilla Diotallevi, Francesca Fava, Marco Gobbetti, Kieran Tuohy
  Current Opinion in Clinical Nutrition & Metabolic Care.2020; 23(6): 437.     CrossRef
• Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery
  Ilhame Diboun, Manjunath Ramanjaneya, Yasser Majeed, Lina Ahmed, Mohammed Bashir, Alexandra E. Butler, Abdul Badi Abou-Samra, Stephen L. Atkin, Nayef A. Mazloum, Mohamed A. Elrayess
  Journal of Translational Medicine.2020;[Epub]     CrossRef
• Quantification of common and planar bile acids in tissues and cultured cells
  Stephanie J. Shiffka, Jace W. Jones, Linhao Li, Ann M. Farese, Thomas J. MacVittie, Hongbing Wang, Peter W. Swaan, Maureen A. Kane
  Journal of Lipid Research.2020; 61(11): 1524.     CrossRef
• Influência da microbiota intestinal na Doença Hepática Gordurosa Não Alcoólica
  Isadora Barbosa de Almeida, Wermerson Assunção Barroso, Caroline Amélia Gonçalves
  Revista Científica Multidisciplinar Núcleo do Conhecimento.2020; : 14.     CrossRef
• Ultra-Early and Early Changes in Bile Acids and Insulin after Sleeve Gastrectomy among Obese Patients
  Adriana Florinela Cӑtoi, Alina Elena Pârvu, Aurel Mironiuc, Horațiu Silaghi, Ioana Delia Pop, Andra Diana Andreicuț
  Medicina.2019; 55(12): 757.     CrossRef

Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have emerged as potential treatments for insulin resistance. The mechanistic basis for these antidiabetic effects has primarily been attributed to multiple metabolic and inflammatory functions. Here we review recent advances in our understanding of the association of ER stress with insulin resistance and the role of nuclear receptors in promoting ER stress resolution and improving insulin resistance in the liver.

Citations

Citations to this article as recorded by  

• Duality of Nrf2 in iron-overload cardiomyopathy
  Enrica Federti, Francesca Vinchi, Iana Iatcenko, Alessandra Ghigo, Alessandro Matte, Serge Cedrick Mbiandjeu Toya, Angela Siciliano, Deborah Chiabrando, Emanuela Tolosano, Steven Zebulon Vance, Veronica Riccardi, Immacolata Andolfo, Manuela Iezzi, Alessia
  Haematologica.2023; 108(5): 1335.     CrossRef
• Endoplasmic Reticulum Stress and Its Impact on Adipogenesis: Molecular Mechanisms Implicated
  Gyuhui Kim, Jiyoon Lee, Joohun Ha, Insug Kang, Wonchae Choe
  Nutrients.2023; 15(24): 5082.     CrossRef
• Qingluotongbi formula regulates the LXRα-ERS-SREBP-1c pathway in hepatocytes to alleviate the liver injury caused by Tripterygium wilfordii Hook. f.
  Zhichao Yu, Zhe Feng, Ling Fu, Jing Wang, Changqing Li, Huaxu Zhu, Tong Xie, Jie Zhou, Lingling Zhou, Xueping Zhou
  Journal of Ethnopharmacology.2022; 287: 114952.     CrossRef
• Nuclear‐mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog‐1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer
  Svenja Michalek, Thomas Brunner
  IUBMB Life.2021; 73(3): 592.     CrossRef
• NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity
  Yi Chen, Wenquan Hu, Qi Li, Shiwei Zhao, Dan Zhao, Shuang Zhang, Zhuo Wei, Xiaoxiao Yang, Yuanli Chen, Xiaoju Li, Chenzhong Liao, Jihong Han, Qing Robert Miao, Yajun Duan
  Journal of Biological Chemistry.2021; 296: 100624.     CrossRef
• Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress
  Chunjie Jiang, Shanshan Zhang, Dan Li, Li Chen, Ying Zhao, Guibin Mei, Jingjing Liu, Yuhan Tang, Chao Gao, Ping Yao
  Food and Chemical Toxicology.2020; 140: 111329.     CrossRef
• Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression
  Minyoung Lee, Eugene Shin, Jaehyun Bae, Yongin Cho, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
  Scientific Reports.2020;[Epub]     CrossRef
• Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study
  Nam Hoon Kim, Ki Hoon Han, Jimi Choi, Juneyoung Lee, Sin Gon Kim
  BMJ.2019; : l5125.     CrossRef
• Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity—Short Communication
  Michalina Alicka, Katarzyna Kornicka-Garbowska, Michael Roecken, Krzysztof Marycz
  International Journal of Molecular Sciences.2019; 20(23): 5873.     CrossRef
• Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction
  Udayakumar Karunakaran, Ji Eun Lee, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
  Free Radical Biology and Medicine.2019; 141: 59.     CrossRef
• Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
  Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
  Diabetologia.2019; 62(5): 779.     CrossRef
• CCAAT/enhancer binding protein homologous protein knockdown alleviates hypoxia-induced myocardial injury in rat cardiomyocytes exposed to high glucose
  Wenqi Yang, Fang Wu, Ting Luo, Yuelan Zhang
  Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
• Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate
  Chan-Min Liu, Jie-Qiong Ma, Jian-Mei Sun, Zhao-Jun Feng, Chao Cheng, Wei Yang, Hong Jiang
  Food and Chemical Toxicology.2017; 110: 325.     CrossRef

Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in endocrine and metabolic functions which are the underlying causes of the metabolic syndrome. Many adipokines, hormones secreted by adipose tissue, regulate cells from the immune system. Interestingly, most of these adipokines are proinflammatory mediators, which increase dramatically in the obese state and are believed to be involved in the pathogenesis of insulin resistance. Drugs that target peroxisome proliferator-activated receptor-γ have been shown to possess anti-inflammatory effects in animal models of diabetes. These findings, and the link between inflammation and the metabolic syndrome, will be reviewed here.

Citations

Citations to this article as recorded by  

• Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification
  Yucheng Fan, Fangjing Xu, Rui Wang, Jun He
  Scientific Reports.2023;[Epub]     CrossRef
• Heart failure and diabetes: Clinical significance and epidemiology of this two‐way association
  Terri Jerkins, Janet B. McGill, David S. H. Bell
  Diabetes, Obesity and Metabolism.2023; 25(S3): 3.     CrossRef
• The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics
  Gargi Dixit, Arati Prabhu
  Experimental and Molecular Pathology.2022; 124: 104723.     CrossRef
• The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis
  Wei-Teing Chen, Chih-Chien Chiu, Dung-Jang Tsai, Pi-Shao Ko, Meng-Chang Lee, Hsiao-Ting Lin, Ying-Kai Chen, Wen Su, Yuh-Feng Lin, Sui-Lung Su
  Frontiers in Genetics.2022;[Epub]     CrossRef
• Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC
  Hyunmi Kim, Da Som Lee, Tae Hyeon An, Hyun-Ju Park, Won Kon Kim, Kwang-Hee Bae, Kyoung-Jin Oh
  International Journal of Molecular Sciences.2021; 22(9): 4495.     CrossRef
• Associations between obesity-related gene expression in maternal and cord blood and newborn adiposity: findings from the Araraquara Cohort study
  P. Nakandakare, C. F. Nicoletti, N. Y. Noronha, C. B. Nonino, P. P. Argentato, N. N. Dejani, L. A. Luzia, M. M. Rogero, P. H. C. Rondó
  International Journal of Obesity.2021; 45(9): 1958.     CrossRef
• PPARG Pro12Ala Polymorphism with CKD in Asians: A Meta-Analysis Combined with a Case-Control Study—A Key for Reaching Null Association
  Hsiang-Cheng Chen, Wei-Teing Chen, Tzu-Ling Sung, Dung-Jang Tsai, Chin Lin, Hao Su, Yuh-Feng Lin, Hung-Yi Chiu, Sui-Lung Su
  Genes.2020; 11(6): 705.     CrossRef
• Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
  Mebrahtom Gebrelibanos Hiben, Laura de Haan, Bert Spenkelink, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M. C. M. Rietjens
  BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
• UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis
  Brahmchetna Bedi, Kuo-Chuan. Lin, Nicholas M. Maurice, Zhihong Yuan, Kaiser Bijli, Michael Koval, C. Michael Hart, Joanna B. Goldberg, Arlene Stecenko, Ruxana T. Sadikot
  Clinical Science.2020; 134(14): 1911.     CrossRef
• Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response
  Ioannis Koutroulis, Rachael Batabyal, Brittany McNamara, Matthew Ledda, Claire Hoptay, Robert J. Freishtat
  Critical Care Explorations.2019; 1(11): e0061.     CrossRef
• Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus
  Eugene Han, Eugene Shin, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Role of oral hypoglycemic drugs on inflammatory condition associated with type 2 diabetes mellitus
  Shamim Shaikh Mohiuddin
  Journal of Diabetes, Metabolic Disorders & Control.2018; 5(2): 78.     CrossRef
• Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice
  Bong-Hoi Choi, Zhen Jin, Chin-ok Yi, Juhong Oh, Eun Ae Jeong, Jong Youl Lee, Kyung-ah Park, Kyung Eun Kim, Jung Eun Lee, Hyun-Jin Kim, Jong Ryeal Hahm, Gu Seob Roh, Jonathan M Peterson
  PLOS ONE.2018; 13(7): e0200336.     CrossRef
• Cucurbita ficifolia (Cucurbitaceae) modulates inflammatory cytokines and IFN-γ in obese mice
  Á. Fortis-Barrera, R. García-Macedo, J.C. Almanza-Perez, G. Blancas-Flores, A. Zamilpa-Alvarez, J.L. Flores-Sáenz, M. Cruz, R. Román-Ramos, F.J. Alarcón-Aguilar
  Canadian Journal of Physiology and Pharmacology.2017; 95(2): 170.     CrossRef
• Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
  Yong-ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun-Jung Rhee, Young Min Cho, Byung-Wan Lee
  Journal of Korean Medical Science.2017; 32(1): 60.     CrossRef
• Peroxisome proliferator‐activated receptor‐γ agonists attenuate biofilm formation by Pseudomonas aeruginosa
  Brahmchetna Bedi, Nicholas M. Maurice, Vincent T. Ciavatta, K. Sabrina Lynn, Zhihong Yuan, Samuel A. Molina, Myungsoo Joo, William R. Tyor, Joanna B. Goldberg, Michael Koval, C. Michael Hart, Ruxana T. Sadikot
  The FASEB Journal.2017; 31(8): 3608.     CrossRef
• Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials
  Marit de Jong, H. Bart van der Worp, Yolanda van der Graaf, Frank L. J. Visseren, Jan Westerink
  Cardiovascular Diabetology.2017;[Epub]     CrossRef
• Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation
  Shih-Chun Pan, Ching-Chun Huang, Shio-Jean Lin, Bing-Yu Chen, Chang-Chuan Chan, Yue-Liang Leon Guo
  Environmental Research.2017; 158: 318.     CrossRef
• The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism
  Margherita Maffei, Ilaria Barone, Gaia Scabia, Ferruccio Santini
  Endocrine Reviews.2016; 37(4): 403.     CrossRef
• Enhanced Clearance of Pseudomonas aeruginosa by Peroxisome Proliferator-Activated Receptor Gamma
  Brahmchetna Bedi, Zhihong Yuan, Myungsoo Joo, Susu M. Zughaier, Joanna B. Goldberg, Jack L. Arbiser, C. Michael Hart, Ruxana T. Sadikot, B. A. McCormick
  Infection and Immunity.2016; 84(7): 1975.     CrossRef
• F-box only protein 9 is an E3 ubiquitin ligase of PPARγ
  Kyeong Won Lee, Soo Heon Kwak, Young Do Koo, Yun-Kyung Cho, Hak Mo Lee, Hye Seung Jung, Young Min Cho, Young Joo Park, Sung Soo Chung, Kyong Soo Park
  Experimental & Molecular Medicine.2016; 48(5): e234.     CrossRef
• The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
  Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Lobeglitazone and pioglitazone as add‐ons to metformin for patients with type 2 diabetes: a 24‐week, multicentre, randomized, double‐blind, parallel‐group, active‐controlled, phase III clinical trial with a 28‐week extension
  S.‐M. Jin, C.‐Y. Park, Y. M. Cho, B. J. Ku, C. W. Ahn, B.‐S. Cha, K. W. Min, Y. A. Sung, S. H. Baik, K. W. Lee, K.‐H. Yoon, M.‐K. Lee, S. W. Park
  Diabetes, Obesity and Metabolism.2015; 17(6): 599.     CrossRef
• Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection
  Travis S. Hughes, Henry D. Wilson, Ian Mitchelle S. de Vera, Douglas J. Kojetin, Paul C. Driscoll
  PLOS ONE.2015; 10(8): e0134474.     CrossRef
• PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes
  Flora Aparecida Milton, Aleksandra Cvoro, Angelica A. Amato, Douglas H. Sieglaff, Carly S. Filgueira, Anithachristy Sigamani Arumanayagam, Maria do Carmo Alves de Lima, Ivan Rocha Pitta, Francisco de Assis Rocha Neves, Paul Webb
  Biochemical and Biophysical Research Communications.2015; 464(3): 718.     CrossRef
• Voluntary exercise prevents colonic inflammation in high-fat diet-induced obese mice by up-regulating PPAR-γ activity
  Wei-Xin Liu, Ting Wang, Feng Zhou, Ying Wang, Jun-Wei Xing, Shen Zhang, Shou-Zhi Gu, Li-Xuan Sang, Cong Dai, Hai-Lan Wang
  Biochemical and Biophysical Research Communications.2015; 459(3): 475.     CrossRef
• Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis
  Soo Lim, Kuy-Sook Lee, Jie Eun Lee, Ho Seon Park, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Young Bum Kim, Hak Chul Jang
  Atherosclerosis.2015; 243(1): 107.     CrossRef
• Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
  A.J. Scheen, N. Esser, N. Paquot
  Diabetes & Metabolism.2015; 41(3): 183.     CrossRef
• Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein
  Yanxiao Zhang, Jingcheng Yu, Chee Lee, Bin Xu, Maureen A. Sartor, Ronald J. Koenig
  Oncotarget.2015; 6(38): 40418.     CrossRef
• Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Ligand Choreography: Newcomers Take the Stage
  Santiago Garcia-Vallvé, Laura Guasch, Sarah Tomas-Hernández, Josep Maria del Bas, Vincent Ollendorff, Lluís Arola, Gerard Pujadas, Miquel Mulero
  Journal of Medicinal Chemistry.2015; 58(14): 5381.     CrossRef
• Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts
  Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim
  Genomics & Informatics.2014; 12(4): 195.     CrossRef
• Pax-8–PPAR-γ fusion protein in thyroid carcinoma
  Priyadarshini Raman, Ronald J. Koenig
  Nature Reviews Endocrinology.2014; 10(10): 616.     CrossRef
• Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis
  Shinan Yin, Hua Bai, Danqing Jing
  Diagnostic Pathology.2014;[Epub]     CrossRef
• Common biological mechanisms between bipolar disorder and type 2 diabetes: Focus on inflammation
  Ajaykumar N. Sharma, Isabelle E. Bauer, Marsal Sanches, Juan F. Galvez, Giovana B. Zunta-Soares, Joao Quevedo, Flavio Kapczinski, Jair C. Soares
  Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014; 54: 289.     CrossRef

The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it has been reported that PDC is phosphorylated and inactivated by PDK2 and PDK4 in metabolically active tissues including liver, skeletal muscle, heart, and kidney during starvation and diabetes, the precise mechanisms by which expression of PDK2 and PDK4 are transcriptionally regulated still remains unclear. Insulin represses the expression of PDK2 and PDK4 via phosphorylation of FOXO through PI3K/Akt signaling pathway. Several nuclear hormone receptors activated due to fasting or increased fat supply, including peroxisome proliferator-activated receptors, glucocorticoid receptors, estrogen-related receptors, and thyroid hormone receptors, also participate in the up-regulation of PDK2 and PDK4; however, the endogenous ligands that bind those nuclear receptors have not been identified. It has been recently suggested that growth hormone, adiponectin, epinephrine, and rosiglitazone also control the expression of PDK4 in tissue-specific manners. In this review, we discuss several factors involved in the expressional regulation of PDK2 and PDK4, and introduce current studies aimed at providing a better understanding of the molecular mechanisms that underlie the development of metabolic diseases such as diabetes.

Citations

Citations to this article as recorded by  

• Molecules and targets of antidiabetic interest
  Kavishankar Gawli, Kavya Sritha Bojja
  Phytomedicine Plus.2024; 4(1): 100506.     CrossRef
• Transcriptome analysis reveals dysfunction of the endoplasmic reticulum protein processing in the sonic muscle of small yellow croaker (Larimichthys polyactis) following noise exposure
  Xuguang Zhang, Xianming Tang, Jianan Xu, Yueping Zheng, Jun Lin, Huafeng Zou
  Marine Environmental Research.2024; 194: 106299.     CrossRef
• Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation
  Jinyong Chen, Tanchen Ren, Lan Xie, Haochang Hu, Xu Li, Miribani Maitusong, Xuhao Zhou, Wangxing Hu, Dilin Xu, Yi Qian, Si Cheng, Kaixiang Yu, Jian`an Wang, Xianbao Liu
  Nature Communications.2024;[Epub]     CrossRef
• Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
  Wonyoung Park, Jung Ho Han, Shibo Wei, Eun-Sun Yang, Se-Yun Cheon, Sung-Jin Bae, Dongryeol Ryu, Hwan-Suck Chung, Ki-Tae Ha
  International Journal of Molecular Sciences.2024; 25(2): 807.     CrossRef
• 1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation
  Huasu Zhu, Huixian Ma, Na Dong, Min Wu, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju
  BMC Cancer.2023;[Epub]     CrossRef
• The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
  Peter W. Stacpoole, Charles E. McCall
  Mitochondrion.2023; 70: 59.     CrossRef
• A Conceptual Approach for Examining Effects of the Adolescent Bone Marrow Milieu on MSC Phenotype
  Sanjana Kannikeswaran, Daniel G Whitney, Maureen J Devlin, Ying Li, Michelle S Caird, Andrea I Alford
  JBMR Plus.2023;[Epub]     CrossRef
• Targeting PDK2 rescues stress-induced impaired brain energy metabolism
  Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang
  Molecular Psychiatry.2023; 28(10): 4138.     CrossRef
• Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
  Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah
  Kidney International.2023; 104(4): 724.     CrossRef
• High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression
  Pengyu Wei, Dongxu Lin, Changcheng Luo, Mengyang Zhang, Bolang Deng, Kai Cui, Zhong Chen
  Scientific Reports.2023;[Epub]     CrossRef
• PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF‐1α protein stability and gene expression
  Zhouji Ma, Ran Mo, Ping Yang, Youjun Ding, Hao Zhang, Zheng Dong, Yutong Chen, Qian Tan
  The FASEB Journal.2023;[Epub]     CrossRef
• PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
  Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan
  Cell Death Discovery.2023;[Epub]     CrossRef
• CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function
  Huimin Niu, Xiayu Ren, Enxue Tan, Xing Wan, Yu Wang, Honghong Shi, Yanjuan Hou, Lihua Wang
  Renal Failure.2023;[Epub]     CrossRef
• PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
  Xuan Gao, Yong-Yue Gao, Hui-Ying Yan, Guang-Jie Liu, Yan Zhou, Tao Tao, Ting-Ting Yue, Cong Pang, Xiang-Xin Chen, Sen Gao, Ling-Yun Wu, Chun-Hua Hang, Wei Li
  Antioxidants & Redox Signaling.2022; 36(7-9): 505.     CrossRef
• microRNA-15b-5p shuttled by mesenchymal stem cell-derived extracellular vesicles protects podocytes from diabetic nephropathy via downregulation of VEGF/PDK4 axis
  Tiantian Zhao, Qingsong Jin, Lili Kong, Dongdong Zhang, Yaqin Teng, Liangyan Lin, Xiaoyan Yao, Yongjun Jin, Minglong Li
  Journal of Bioenergetics and Biomembranes.2022; 54(1): 17.     CrossRef
• Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
  Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer’s Disease Consistent With Cerebral Pantothenate Deficiency
  Crystal Sang, Sasha A. Philbert, Danielle Hartland, Richard. D Unwin, Andrew W. Dowsey, Jingshu Xu, Garth J. S. Cooper
  Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
• Identification of candidate aberrant differentially methylated/expressed genes in asthma
  Zongling Wang, Lizhi Wang, Lina Dai, Yanan Wang, Erhong Li, Shuyuan An, Fengliang Wang, Dan Liu, Wen Pan
  Allergy, Asthma & Clinical Immunology.2022;[Epub]     CrossRef
• Innervation and electrical pulse stimulation — in vitro effects on human skeletal muscle cells
  Tomaz Marš, Katarina Miš, Marija Meznarič, Sonja Prpar Mihevc, Vid Jan, Fred Haugen, Boris Rogelj, Arild C. Rustan, G. Hege Thoresen, Sergej Pirkmajer, Nataša Nikolić
  Applied Physiology, Nutrition, and Metabolism.2021; 46(4): 299.     CrossRef
• Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?
  Kanchan Phadwal, Christina Vrahnas, Ian G. Ganley, Vicky E. MacRae
  Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
• BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
  Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer
  Developmental Cell.2021; 56(8): 1182.     CrossRef
• Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows
  Valentino Palombo, Abdulrahman Alharthi, Fernanda Batistel, Claudia Parys, Jessie Guyader, Erminio Trevisi, Mariasilvia D’Andrea, Juan J. Loor
  BMC Genomics.2021;[Epub]     CrossRef
• PDK2: An Underappreciated Regulator of Liver Metabolism
  Benjamin L. Woolbright, Robert A. Harris
  Livers.2021; 1(2): 82.     CrossRef
• Endocrine Influence on Cardiac Metabolism in Development and Regeneration
  Niall Graham, Guo N Huang
  Endocrinology.2021;[Epub]     CrossRef
• Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas
  Kristina M. Cook, Han Shen, Kelly J. McKelvey, Harriet E. Gee, Eric Hau
  International Journal of Molecular Sciences.2021; 22(14): 7265.     CrossRef
• Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20
  Duanfeng Jiang, Qiuyu Mo, Xiaoying Sun, Xiaotao Wang, Min Dong, Guozhen Zhang, Fangping Chen, Qiangqiang Zhao
  Cancer Science.2021; 112(9): 3585.     CrossRef
• Skeletal muscle energy metabolism in obesity
  Abel M. Mengeste, Arild C. Rustan, Jenny Lund
  Obesity.2021; 29(10): 1582.     CrossRef
• Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
  Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Je
  PLOS Pathogens.2021; 17(10): e1009991.     CrossRef
• Transcriptional and free radical responses to LVAD therapy
  Kajari Dhar, Asmini KC, Fang Qiu, Hesham Basma, Krupa K. Savalia, Jocelyn Jones, Alexandra M. Moulton, Matthew C. Zimmerman, John Um, Daniel Anderson, Marshall Hyden, Brian D. Lowes
  Translational Medicine Communications.2020;[Epub]     CrossRef
• Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
  Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
  Cancer & Metabolism.2020;[Epub]     CrossRef
• Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply
  Emilio Mármol-Sánchez, Yuliaxis Ramayo-Caldas, Raquel Quintanilla, Tainã Figueiredo Cardoso, Rayner González-Prendes, Joan Tibau, Marcel Amills
  Journal of Animal Science and Biotechnology.2020;[Epub]     CrossRef
• Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
  Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall
  Journal of Leukocyte Biology.2020; 107(3): 467.     CrossRef
• GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia
  Masahiro Hata, Hiroto Kinoshita, Yoku Hayakawa, Mitsuru Konishi, Mayo Tsuboi, Yukiko Oya, Ken Kurokawa, Yuki Hayata, Hayato Nakagawa, Keisuke Tateishi, Hiroaki Fujiwara, Yoshihiro Hirata, Daniel L. Worthley, Yuki Muranishi, Takahisa Furukawa, Shunsuke Kon
  Gastroenterology.2020; 158(6): 1650.     CrossRef
• The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum
  Tao Gao, Dan He, Xin Liu, Fang Ji, Jianhong Xu, Jianrong Shi
  Food Production, Processing and Nutrition.2020;[Epub]     CrossRef
• PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis
  Ji-Min Lee, Min-Ji Kim, Sun Joo Lee, Byung-Gyu Kim, Je-Yong Choi, Seung Mi Lee, Hye Jin Ham, Jung-Min Koh, Jae-Han Jeon, In-Kyu Lee
  Journal of Bone and Mineral Research.2020; 36(3): 553.     CrossRef
• Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
  Ling Jin, Eun-Yeong Kim, Tae-Wook Chung, Chang Woo Han, So Young Park, Jung Ho Han, Sung-Jin Bae, Jong Rok Lee, Young Woo Kim, Se Bok Jang, Ki-Tae Ha
  Scientific Reports.2020;[Epub]     CrossRef
• Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells
  Marlena Zyśk, Piotr Pikul, Robert Kowalski, Krzysztof Lewandowski, Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk
  International Journal of Molecular Sciences.2020; 21(22): 8541.     CrossRef
• PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming
  Wen-Qi Ma, Xue-Jiao Sun, Yi Zhu, Nai-Feng Liu
  Cell Death & Disease.2020;[Epub]     CrossRef
• Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
  Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
• Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle
  Yan Li, Haiou Pan, Xuetong Zhang, Hui Wang, Shengnan Liu, Hui Zhang, Haifeng Qian, Li Wang, Hao Ying
  Journal of Agricultural and Food Chemistry.2019; 67(16): 4483.     CrossRef
• The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury
  A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Jeong Hyun Jeong, Beom Seok Kang, Dong Hyeon Kang, Kyoung-Ha Park, Jae Bong Park, Sang Won Suh
  Cells.2019; 8(5): 405.     CrossRef
• Predictive factors for the development of diabetes in cancer patients treated with phosphatidylinositol 3-kinase inhibitors
  Gyuri Kim, Myungeun Yoo, Min Hee Hong, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hye Ryun Kim, Yong-ho Lee, Byoung Chul Cho
  Cancer Chemotherapy and Pharmacology.2019; 84(2): 405.     CrossRef
• Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
  Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
  Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
• PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
  Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee
  Diabetes.2019; 68(3): 571.     CrossRef
• Membrane-initiated cortisol action modulates early pyruvate dehydrogenase kinase 2 (pdk2) expression in fish skeletal muscle
  Jorge E. Aedo, Rodrigo Zuloaga, Sebastián Boltaña, Alfredo Molina, Juan Antonio Valdés
  Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2019; 233: 24.     CrossRef
• Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
  Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
  Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
• Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation
  Azuma Kosai, Nanao Horike, Yoshiaki Takei, Akihiro Yamashita, Kaori Fujita, Takashi Kamatani, Noriyuki Tsumaki
  Biochemical and Biophysical Research Communications.2019; 516(4): 1097.     CrossRef
• Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
  Maria F. Newhardt, Albert Batushansky, Satoshi Matsuzaki, Zachary T. Young, Melinda West, Ngun Cer Chin, Luke I. Szweda, Michael Kinter, Kenneth M. Humphries
  Journal of Biological Chemistry.2019; 294(45): 16831.     CrossRef
• Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
  Ina Katrine Nitschke Pettersen, Deusdedit Tusubira, Hanan Ashrafi, Sissel Elisabeth Dyrstad, Lena Hansen, Xiao-Zheng Liu, Linn Iren Hodneland Nilsson, Nils Gunnar Løvsletten, Kjetil Berge, Hege Wergedahl, Bodil Bjørndal, Øystein Fluge, Ove Bruland, Arild
  Mitochondrion.2019; 49: 97.     CrossRef
• Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
  Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris, John A. Taylor
  Molecular Cancer Therapeutics.2019; 18(10): 1673.     CrossRef
• Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement
  Patricia G. Rosenstein, Brett S. Tennent‐Brown, Dez Hughes
  Journal of Veterinary Emergency and Critical Care.2018; 28(2): 85.     CrossRef
• SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart
  Danish Khan, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit S. Pandit, Sneha Mishra, Faiz Ahamed, Abhinav Dubey, Nowrin Fathma, Hanudatta S. Atreya, Ullas Kolthur‐Seetharam, Nagalingam R. Sundaresan
  Journal of Cellular Physiology.2018; 233(7): 5478.     CrossRef
• Metabolic Changes Associated With Muscle Expression of SOD1G93A
  Gabriella Dobrowolny, Elisa Lepore, Martina Martini, Laura Barberi, Abigail Nunn, Bianca Maria Scicchitano, Antonio Musarò
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesenteric and perigonadal adipose tissue
  Floriana Rotondo, Ana Cecilia Ho-Palma, Xavier Remesar, José Antonio Fernández-López, María del Mar Romero, Marià Alemany
  PeerJ.2018; 6: e5440.     CrossRef
• Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
  Lidan Zhao, Ryan P. McMillan, Guohao Xie, Samantha G. L. W. Giridhar, Lance H. Baumgard, Samer El-Kadi, Joshua Selsby, Jason Ross, Nicholas Gabler, Matthew W. Hulver, Robert P. Rhoads
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1096.     CrossRef
• Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
  Rong Ke, Qicao Xu, Cong Li, Lingyu Luo, Deqiang Huang
  Cell Biology International.2018; 42(4): 384.     CrossRef
• Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism
  Yi Zhu, Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Nai-Feng Liu
  Scientific Reports.2018;[Epub]     CrossRef
• Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
  Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
  Oncotarget.2017; 8(68): 112841.     CrossRef
• Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
  Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
  Kidney International.2017; 91(4): 880.     CrossRef
• PPARβ/δ in human cancer
  Rolf Müller
  Biochimie.2017; 136: 90.     CrossRef
• The physiological and molecular response of Aurelia sp.1 under hypoxia
  Guoshan Wang, Yu Zhen, Zhigang Yu, Yan Shi, Qing Zhao, Jianyan Wang, Tiezhu Mi
  Scientific Reports.2017;[Epub]     CrossRef
• A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration
  Víctor López del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 801.     CrossRef
• Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
  Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen
  The Journal of Nutritional Biochemistry.2017; 39: 126.     CrossRef
• Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
  Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier
  PLOS ONE.2017; 12(10): e0186021.     CrossRef
• Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy
  Sahoko Ichihara, Yuka Suzuki, Jie Chang, Kentaro Kuzuya, Chisa Inoue, Yuki Kitamura, Shinji Oikawa
  Scientific Reports.2017;[Epub]     CrossRef
• Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes
  Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards A. Park, Chantal Benelli, Sylvie Bortoli
  Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
• Oncogenic role of PDK4 in human colon cancer cells
  D Leclerc, D N T Pham, N Lévesque, M Truongcao, W D Foulkes, C Sapienza, R Rozen
  British Journal of Cancer.2017; 116(7): 930.     CrossRef
• Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
  Kazuhisa Honda, Shoko Takagi, Kiyotaka Kurachi, Haruka Sugimoto, Takaoki Saneyasu, Hiroshi Kamisoyama
  The Journal of Poultry Science.2017; 54(4): 292.     CrossRef
• Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
  Peter W Stacpoole
  JNCI: Journal of the National Cancer Institute.2017;[Epub]     CrossRef
• Reference Gene Selection and Prednisolone Target Gene Expression in Adipose Tissues of Friesian Cattle
  Sara Divari, Enrica Berio, Bartolomeo Biolatti, Francesca Tiziana Cannizzo
  Journal of Agricultural and Food Chemistry.2017; 65(50): 11140.     CrossRef
• Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
  Luana Naia, Teresa Cunha-Oliveira, Joana Rodrigues, Tatiana R. Rosenstock, Ana Oliveira, Márcio Ribeiro, Catarina Carmo, Sofia I. Oliveira-Sousa, Ana I. Duarte, Michael R. Hayden, A. Cristina Rego
  The Journal of Neuroscience.2017; 37(10): 2776.     CrossRef
• Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
  Mina Kim, Dae Keun Kim, Youn-Soo Cha
  Journal of Medicinal Food.2016; 19(5): 442.     CrossRef
• Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
  Hana Park, Nam Ho Jeoung
  Biochemical and Biophysical Research Communications.2016; 469(4): 1049.     CrossRef
• Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
  Jaechan Leem, In-Kyu Lee
  Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
• Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
  Bipradas Roy, Mary E. Curtis, Letimicia S. Fears, Samuel N. Nahashon, Hugh M. Fentress
  Frontiers in Physiology.2016;[Epub]     CrossRef
• MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
  Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang,
  PLOS Genetics.2016; 12(10): e1006308.     CrossRef
• Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer
  Yang Zhang, Yi Zhang, Liying Geng, Haowei Yi, Wei Huo, Geoffrey Talmon, Yeong C. Kim, San Ming Wang, Jing Wang
  Journal of Biological Chemistry.2016; 291(33): 17405.     CrossRef
• Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk
  Franziska Koch, Ole Lamp, Mehdi Eslamizad, Joachim Weitzel, Björn Kuhla, Andrew C. Gill
  PLOS ONE.2016; 11(8): e0160912.     CrossRef
• Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver
  Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland, Brenda K. Richards
  Nutrition & Metabolism.2016;[Epub]     CrossRef
• Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
  Mithilesh Kumar Jha, In-Kyu Lee, Kyoungho Suk
  Neuroscience & Biobehavioral Reviews.2016; 68: 1.     CrossRef
• 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
  Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar
  Journal of Biological Chemistry.2016; 291(3): 1514.     CrossRef
• Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
  Sina Oppermann, Avery J. Lam, Stephanie Tung, Yonghong Shi, Lindsay McCaw, Guizhei Wang, Jarkko Ylanko, Brian Leber, David Andrews, David E. Spaner
  Oncotarget.2016; 7(45): 72608.     CrossRef
• Energy metabolic disorder is a major risk factor in severe influenza virus infection: Proposals for new therapeutic options based on animal model experiments
  Hiroshi Kido, Irene L. Indalao, Hyejin Kim, Takashi Kimoto, Satoko Sakai, Etsuhisa Takahashi
  Respiratory Investigation.2016; 54(5): 312.     CrossRef
• Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity
  Tao Gao, Jian Chen, Zhiqi Shi, Yin-Won Lee
  PLOS ONE.2016; 11(6): e0158077.     CrossRef
• Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase
  Michael J. Bround, Rich Wambolt, Haoning Cen, Parisa Asghari, Razvan F. Albu, Jun Han, Donald McAfee, Marc Pourrier, Nichollas E. Scott, Lubos Bohunek, Jerzy E. Kulpa, S. R. Wayne Chen, David Fedida, Roger W. Brownsey, Christoph H. Borchers, Leonard J. Fo
  Journal of Biological Chemistry.2016; 291(45): 23490.     CrossRef
• Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
  Nam Ho Jeoung
  Diabetes & Metabolism Journal.2015; 39(3): 188.     CrossRef
• Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells
  Mariana Regueira, Silvana Lucía Artagaveytia, María Noel Galardo, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, Silvina Beatriz Meroni, María Fernanda Riera
  REPRODUCTION.2015; 150(4): 311.     CrossRef
• Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes
  Anna Polus, Beata Kiec-Wilk, Urszula Razny, Anna Gielicz, Gerd Schmitz, Aldona Dembinska-Kiec
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2015; 1851(9): 1146.     CrossRef
• A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
  Lavinia Palamiuc, Anna Schlagowski, Shyuan T Ngo, Aurelia Vernay, Sylvie Dirrig‐Grosch, Alexandre Henriques, Anne‐Laurence Boutillier, Joffrey Zoll, Andoni Echaniz‐Laguna, Jean‐Philippe Loeffler, Frédérique René
  EMBO Molecular Medicine.2015; 7(5): 526.     CrossRef
• A genetic perspective on rapid evolution in cane toads (Rhinella marina)
  Lee A. Rollins, Mark F. Richardson, Richard Shine
  Molecular Ecology.2015; 24(9): 2264.     CrossRef
• Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism
  Qin Hao, Rachita Yadav, Astrid L. Basse, Sidsel Petersen, Si B. Sonne, Simon Rasmussen, Qianhua Zhu, Zhike Lu, Jun Wang, Karine Audouze, Ramneek Gupta, Lise Madsen, Karsten Kristiansen, Jacob B. Hansen
  American Journal of Physiology-Endocrinology and Metabolism.2015; 308(5): E380.     CrossRef
• Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
  Sun Joo Lee, Ji Yun Jeong, Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Doo Kim, Young-Keun Choi, Ji-Yeon Do, Younghoon Go, Chae-Myeong Ha, Je-Yong Choi, Seung Huh, Nam Ho Jeoung, Ki-Up Lee, Hueng-Sik Choi, Yu Wang, Keun-Gyu Park, Robert A
  Scientific Reports.2015;[Epub]     CrossRef
• Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction
  Laura D. Brown, Paul J. Rozance, Jennifer L. Bruce, Jacob E. Friedman, William W. Hay, Stephanie R. Wesolowski
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R920.     CrossRef
• The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner
  T Joshi, M Johnson, R Newton, M A Giembycz
  British Journal of Pharmacology.2015; 172(10): 2634.     CrossRef
• The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
  Jianrong Lu, Ming Tan, Qingsong Cai
  Cancer Letters.2015; 356(2): 156.     CrossRef
• The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
  In-Kyu Lee
  Diabetes & Metabolism Journal.2014; 38(3): 181.     CrossRef
• Rapid in Vitro Metabolism of the Flame Retardant Triphenyl Phosphate and Effects on Cytotoxicity and mRNA Expression in Chicken Embryonic Hepatocytes
  Guanyong Su, Doug Crump, Robert J. Letcher, Sean W. Kennedy
  Environmental Science & Technology.2014; 48(22): 13511.     CrossRef
• Low force contractions induce fatigue consistent with muscle mRNA expression in people with spinal cord injury
  Michael A. Petrie, Manish Suneja, Elizabeth Faidley, Richard K. Shields
  Physiological Reports.2014; 2(2): e00248.     CrossRef
• Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
  Kazuhiko Yamane, Irene L. Indalao, Junji Chida, Yoshikazu Yamamoto, Masaaki Hanawa, Hiroshi Kido, Amy Lynn Adamson
  PLoS ONE.2014; 9(5): e98032.     CrossRef
• Fatty Acid Transport Protein 1 (FATP1) Localizes in Mitochondria in Mouse Skeletal Muscle and Regulates Lipid and Ketone Body Disposal
  Maria Guitart, Óscar Osorio-Conles, Thais Pentinat, Judith Cebrià, Judit García-Villoria, David Sala, David Sebastián, Antonio Zorzano, Antonia Ribes, Josep C. Jiménez-Chillarón, Celia García-Martínez, Anna M. Gómez-Foix, Cedric Moro
  PLoS ONE.2014; 9(5): e98109.     CrossRef
• CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
  Blake C. Ellis, Lloyd D. Graham, Peter L. Molloy
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2014; 1843(2): 372.     CrossRef
• DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
  Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, Anne C. Ferguson-Smith
  Proceedings of the National Academy of Sciences.2014; 111(45): 16088.     CrossRef
• The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
  Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert
  Nutrition & Metabolism.2014;[Epub]     CrossRef
• Time‐dependent effects of the flame retardant tris(1,3‐dichloro‐2‐propyl) phosphate (TDCPP) on mRNA expression, in vitro and in ovo, reveal optimal sampling times for rapidly metabolized compounds
  Amani Farhat, Doug Crump, Emily Porter, Suzanne Chiu, Robert J. Letcher, Guanyong Su, Sean W. Kennedy
  Environmental Toxicology and Chemistry.2014; 33(12): 2842.     CrossRef
• Chickens from lines selected for high and low body weight show differences in fatty acid oxidation efficiency and metabolic flexibility in skeletal muscle and white adipose tissue
  S Zhang, R P McMillan, M W Hulver, P B Siegel, L H Sumners, W Zhang, M A Cline, E R Gilbert
  International Journal of Obesity.2014; 38(10): 1374.     CrossRef
• Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
  Yolanda F. Otero, John M. Stafford, Owen P. McGuinness
  Journal of Biological Chemistry.2014; 289(30): 20462.     CrossRef
• Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells
  Eili Tranheim Kase, Nataša Nikolić, Siril Skaret Bakke, Kaja Kamilla Bogen, Vigdis Aas, G. Hege Thoresen, Arild Christian Rustan, Darcy Johannsen
  PLoS ONE.2013; 8(4): e59972.     CrossRef
• Association of Estrogen Receptor α GenesPvuII andXbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
  Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian
  Diabetes & Metabolism Journal.2013; 37(4): 270.     CrossRef
• The orphan nuclear receptors in cancer and diabetes
  Harmit S. Ranhotra
  Journal of Receptors and Signal Transduction.2013; 33(4): 207.     CrossRef
• Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
  Daniel Leclerc, Nancy Lévesque, Yuanhang Cao, Liyuan Deng, Qing Wu, Jasmine Powell, Carmen Sapienza, Rima Rozen
  Cancer Prevention Research.2013; 6(11): 1171.     CrossRef