Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. Glucotoxicity, lipotoxicity, and glucolipotoxicity have been suggested to be a major cause of β-cell dysfunction for decades, but not yet fully understood. Fatty acid translocase cluster determinant 36 (CD36), which is part of the free fatty acid (FFA) transporter system, has been identified in several tissues such as muscle, liver, and insulin-producing cells. Several studies have reported that induction of CD36 increases uptake of FFA in several cells, suggesting the functional interplay between glucose and FFA in terms of insulin secretion and oxidative metabolism. However, we do not currently know the regulating mechanism and physiological role of CD36 on glucolipotoxicity in pancreatic β-cells. Also, the downstream and upstream targets of CD36 related signaling have not been defined. In the present review, we will focus on the expression and function of CD36 related signaling in the pancreatic β-cells in response to hyperglycemia and hyperlipidemia (ceramide) along with the clinical studies on the association between CD36 and metabolic disorders.

Citations

Citations to this article as recorded by  

• Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function
  Alpana Mukhuty, Samanwita Mandal, Chandrani Fouzder, Snehasis Das, Dipanjan Chattopadhyay, Tanmay Majumdar, Rakesh Kundu
  Molecular and Cellular Endocrinology.2024; 581: 112112.     CrossRef
• CD36 gene variant rs1761667(G/A) as a biomarker in obese type 2 diabetes mellitus cases
  Ashwin Kumar Shukla, Amreen Shamsad, Atar Singh Kushwah, Shalini Singh, Kauser Usman, Monisha Banerjee
  Egyptian Journal of Medical Human Genetics.2024;[Epub]     CrossRef
• CD36 regulates macrophage and endothelial cell activation and multinucleate giant cell formation in anti neutrophil cytoplasm antibody vasculitis
  Xiang Zhang, Catherine King, Alexander Dowell, Paul Moss, Lorraine Harper, Dimitrios Chanouzas, Xiong-zhong Ruan, Alan David Salama
  Clinical Immunology.2024; 260: 109914.     CrossRef
• The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target
  Yun Li, Yaxi Chen, Xiong Z. Ruan
  Pediatric Discovery.2023;[Epub]     CrossRef
• The role of candidate transport proteins in β‐cell long‐chain fatty acid uptake: Where are we now?
  Christina Clavelo‐Farrow, Patricia Thomas
  Diabetic Medicine.2023;[Epub]     CrossRef
• SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients
  Ningfei Ji, Mingshun Zhang, Liang Ren, Yunyun Wang, Bicheng Hu, Jie Xiang, Yingyun Gong, Chaojie Wu, Guoqiang Qu, Wenqiu Ding, Zhiqiang Yin, Shan Li, Zhengxia Wang, Lianzheng Zhou, Xueqin Chen, Yuan Ma, Jinhai Tang, Yun Liu, Liang Liu, Mao Huang
  Emerging Microbes & Infections.2022; 11(1): 1115.     CrossRef
• Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies
  Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
  Diabetes Research and Clinical Practice.2022; 189: 109939.     CrossRef
• Lipotoxicity in a Vicious Cycle of Pancreatic Beta Cell Exhaustion
  Vladimir Grubelnik, Jan Zmazek, Matej Završnik, Marko Marhl
  Biomedicines.2022; 10(7): 1627.     CrossRef
• Association of cluster determinant 36, scavenger receptor class B type 1, and major facilitator superfamily domain containing the 2a genetic polymorphism with serum lipid profile in aging population with type 2 diabetes mellitus
  Xixiang Wang, Xiaojun Ma, Jingjing Xu, Yujie Guo, Shaobo Zhou, Huiyan Yu, Linhong Yuan
  Frontiers in Nutrition.2022;[Epub]     CrossRef
• CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
  Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean-Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Wan-Hee Cheng, Kok-Song Lai, Nik Mohd Afizan Nik Abd Rahman
  Cells.2022; 11(22): 3556.     CrossRef
• The Past and Present Lives of the Intraocular Transmembrane Protein CD36
  Rucui Yang, Qingping Liu, Mingzhi Zhang
  Cells.2022; 12(1): 171.     CrossRef
• Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus
  Sachin Kumar, Tapan Behl, Monika Sachdeva, Aayush Sehgal, Shilpa Kumari, Arun Kumar, Gagandeep Kaur, Harlokesh Narayan Yadav, Simona Bungau
  Life Sciences.2021; 264: 118661.     CrossRef
• Contribution of rs3211938 polymorphism at CD36 to glucose levels, oxidized low-density lipoproteins, insulin resistance, and body mass index in Mexican mestizos with type-2 diabetes from western Mexico
  Beatriz Teresita Martín-Márquez, Flavio Sandoval-Garcia, Mónica Vazquez-Del Mercado, Erika-Aurora Martínez-García, Fernanda-Isadora Corona-Meraz, Ana-Lilia Fletes-Rayas, Soraya-Amalí Zavaleta-Muñiz
  Nutrición Hospitalaria.2021;[Epub]     CrossRef
• Investigating the association of CD36 gene polymorphisms (rs1761667 and rs1527483) with T2DM and dyslipidemia: Statistical analysis, machine learning based prediction, and meta-analysis
  Ma’mon M. Hatmal, Walhan Alshaer, Ismail S. Mahmoud, Mohammad A. I. Al-Hatamleh, Hamzeh J. Al-Ameer, Omar Abuyaman, Malek Zihlif, Rohimah Mohamud, Mais Darras, Mohammad Al Shhab, Rand Abu-Raideh, Hilweh Ismail, Ali Al-Hamadi, Ali Abdelhay, Kanhaiya Singh
  PLOS ONE.2021; 16(10): e0257857.     CrossRef
• Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
  Mustafa Karabicici, Yagmur Azbazdar, Evin Iscan, Gunes Ozhan
  Membranes.2021; 11(11): 844.     CrossRef

Citations

Citations to this article as recorded by  

• Interplay of lipid metabolism and inflammation in podocyte injury
  Zilv Luo, Zhaowei Chen, Jijia Hu, Guohua Ding
  Metabolism.2024; 150: 155718.     CrossRef
• Associations of plasma sphingolipids with measures of insulin sensitivity, β-cell function, and incident diabetes in Japanese Americans
  Ji Cheol Bae, Pandora L. Wander, Rozenn N. Lemaitre, Amanda M. Fretts, Colleen M. Sitlani, Hai H. Bui, Melissa K. Thomas, Donna Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko, Kristina M. Utzschneider
  Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 633.     CrossRef
• A review of the mechanisms of abnormal ceramide metabolism in type 2 diabetes mellitus, Alzheimer’s disease, and their co-morbidities
  Yun Pan, Jieying Li, Panjie Lin, Lihua Wan, Yiqian Qu, Lingyong Cao, Lei Wang
  Frontiers in Pharmacology.2024;[Epub]     CrossRef
• Ceramides and mitochondrial homeostasis
  Song Ding, Guorui Li, Tinglv Fu, Tianyu Zhang, Xiao Lu, Ning Li, Qing Geng
  Cellular Signalling.2024; 117: 111099.     CrossRef
• Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity
  Nathaniel L. Hepowit, Eric Blalock, Sangderk Lee, Kimberly M. Bretland, Jason A. MacGurn, Robert C. Dickson
  Aging.2023; 15(2): 472.     CrossRef
• Protective effect of natural products in the metabolic-associated kidney diseases via regulating mitochondrial dysfunction
  Peng Liu, Yao Chen, Jing Xiao, Wenhui Zhu, Xiaoming Yan, Ming Chen
  Frontiers in Pharmacology.2023;[Epub]     CrossRef
• BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
  Xiao Guo, Yuemeng Zhu, Lu Guo, Yiwen Qi, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang, Chao Gu, Bin Li,
  EMBO Molecular Medicine.2023;[Epub]     CrossRef
• Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease
  Peng Liu, Wenhui Zhu, Yang Wang, Guijie Ma, Hailing Zhao, Ping Li
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Integrated gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐mass spectrometry renal metabolomics and lipidomics deciphered the metabolic regulation mechanism of Gushudan on kidney‐yang‐deficiency‐syndrome rats
  Qing Lu, Jing Zhang, Ling Xin, Yanwei Lou, Feng Qin, Longshan Zhao, Zhili Xiong
  Journal of Separation Science.2023;[Epub]     CrossRef
• Advances in the pharmacological study of Chinese herbal medicine to alleviate diabetic nephropathy by improving mitochondrial oxidative stress
  Ming Chen, Yao Chen, Wenhui Zhu, Xiaoming Yan, Jing Xiao, Peiqing Zhang, Peng Liu, Ping Li
  Biomedicine & Pharmacotherapy.2023; 165: 115088.     CrossRef
• Rodent models to study type 1 and type 2 diabetes induced human diabetic nephropathy
  Amit Talukdar, Mandira Basumatary
  Molecular Biology Reports.2023; 50(9): 7759.     CrossRef
• Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
  Nathaniel L. Hepowit, Bradley Moon, Adam C. Ebert, Robert C. Dickson, Jason A. MacGurn
  Journal of Cell Science.2023;[Epub]     CrossRef
• Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
  Alla Mitrofanova, Sandra Merscher, Alessia Fornoni
  Nature Reviews Nephrology.2023; 19(10): 629.     CrossRef
• Research progress of autophagy in pathogenesis of diabetes nephropathy
  Shengnan Zeng, Ying Li
  Diabetic Nephropathy.2023; 3(3): 51.     CrossRef
• Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease
  Judy Baek, Chenchen He, Farsad Afshinnia, George Michailidis, Subramaniam Pennathur
  Nature Reviews Nephrology.2022; 18(1): 38.     CrossRef
• Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria
  Irena Audzeyenka, Agnieszka Bierżyńska, Abigail C Lay
  Endocrinology.2022;[Epub]     CrossRef
• Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?
  Xiaodie Mu, Min Yang, Peiyao Ling, Aihua Wu, Hua Zhou, Jingting Jiang
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 247.     CrossRef
• Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels
  Jinshan He, Sicong Li, Yumeng Ding, Yujia Tong, Xuebin Li, Simona Saponara
  Cardiovascular Therapeutics.2022; 2022: 1.     CrossRef
• Mechanisms of podocyte injury and implications for diabetic nephropathy
  Federica Barutta, Stefania Bellini, Gabriella Gruden
  Clinical Science.2022; 136(7): 493.     CrossRef
• A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury
  Norishi Ueda
  International Journal of Molecular Sciences.2022; 23(7): 4010.     CrossRef
• Implications of Sphingolipid Metabolites in Kidney Diseases
  Shamroop kumar Mallela, Sandra Merscher, Alessia Fornoni
  International Journal of Molecular Sciences.2022; 23(8): 4244.     CrossRef
• Role of ceramides in the pathogenesis of diabetes mellitus and its complications
  Nawajes Mandal, Richard Grambergs, Koushik Mondal, Sandip K. Basu, Faiza Tahia, Sam Dagogo-Jack
  Journal of Diabetes and its Complications.2021; 35(2): 107734.     CrossRef
• Rotten to the Cortex: Ceramide-Mediated Lipotoxicity in Diabetic Kidney Disease
  Rebekah J. Nicholson, Marcus G. Pezzolesi, Scott A. Summers
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools
  Nathaniel L. Hepowit, Jessica K. A. Macedo, Lyndsay E. A. Young, Ke Liu, Ramon C. Sun, Jason A. MacGurn, Robert C. Dickson
  Aging.2021; 13(6): 7846.     CrossRef
• New insights into renal lipid dysmetabolism in diabetic kidney disease
  Alla Mitrofanova, George Burke, Sandra Merscher, Alessia Fornoni
  World Journal of Diabetes.2021; 12(5): 524.     CrossRef
• Excessively Enlarged Mitochondria in the Kidneys of Diabetic Nephropathy
  Kiyoung Kim, Eun-Young Lee
  Antioxidants.2021; 10(5): 741.     CrossRef
• Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review
  Saba Noor, Taj Mohammad, Gulam M. Ashraf, Joviana Farhat, Anwar L. Bilgrami, Mathew Suji Eapen, Sukhwinder Singh Sohal, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
  International Journal of Biological Macromolecules.2021; 193: 562.     CrossRef
• The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
  Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
  Kidney Diseases.2021; 7(6): 438.     CrossRef
• Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1
  Benoit Denhez, Marina Rousseau, Crysta Spino, David-Alexandre Dancosst, Marie-Ève Dumas, Andréanne Guay, Farah Lizotte, Pedro Geraldes
  Scientific Reports.2020;[Epub]     CrossRef

Obesity resulting from the delivery of an excess amount of energy to adipose tissue from glucose or free fatty acids is associated with insulin resistance and adipose tissue inflammation. Reactive oxygen species (ROS) have been implicated as contributors to both the onset and the progression of insulin resistance. ROS can be generated by overloading the mitochondrial oxidative phosphorylation system, and also by nicotinamide adenine dinucleotide phosphate oxidases (NOX) produced by either adipocytes, which only produce NOX4, or by macrophages, which produce mainly NOX2. The source of the ROS might differ in the early, intermediate and late stages of obesity, switching from NOX4-dependence in the early phases to NOX2-dependence, in the intermediate phase, and transiting to mitochondria-dependence later in the time course of obesity. Thus, depending on the stage of obesity, ROS can be generated by three distinct mechanisms: i.e., NOX4, NOX2, and mitochondria. In this review, we will discuss whether NOX4-, NOX2-, and/or mitochondria-derived ROS is/are causal in the onset of adipocyte insulin resistance as obesity progresses. Moreover, we will review the pathophysiological roles of NOX4, NOX2, and mitochondria-derived ROS on adipose tissue inflammation.

Citations

Citations to this article as recorded by  

• The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study
  Mikiko Shibata, Kyoko Kogawa Sato, Hideo Koh, Izumi Shibata, Kaori Okamura, Yuka Takeuchi, Keiko Oue, Michio Morimoto, Tomoshige Hayashi
  Journal of Epidemiology.2024; 34(3): 137.     CrossRef
• Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity
  J. P. Shirley Niveta, Cordelia Mano John, Sumathy Arockiasamy
  Molecular Biology Reports.2024;[Epub]     CrossRef
• The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
  Amir Barzegar Behrooz, Marco Cordani, Alessandra Fiore, Massimo Donadelli, Joseph W. Gordon, Daniel J. Klionsky, Saeid Ghavami
  Seminars in Cancer Biology.2024; 99: 24.     CrossRef
• Pathogenesis and management of diabetic gastroparesis: An updated clinically oriented review
  Srikar Uppaluri, Manisha Ashok Jain, Hira Ali, Jay Shingala, Dhruti Amin, Trisha Ajwani, Irum Fatima, Neil Patel, Nirja Kaka, Yashendra Sethi, Nitin Kapoor
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(3): 102994.     CrossRef
• The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
  Helen Ye Rim Huang, Sarah Badar, Mohammad Said, Siddiqah Shah, Hareesha Rishab Bharadwaj, Krishna Ramamoorthy, Maen Monketh Alrawashdeh, Faaraea Haroon, Jawad Basit, Sajeel Saeed, Narjiss Aji, Gary Tse, Priyanka Roy, Mainak Bardhan
  Molecular Biology Reports.2024;[Epub]     CrossRef
• The complex interplay between oxinflammation, mitochondrial dysfunction and lipotoxicity: Focus on their role in the pathogenesis of skeletal muscle insulin resistance and modulation by dietary fatty acids
  Angelina Passaro, Juana Maria Sanz, Nenad Naumovski, Domenico Sergi
  Advances in Redox Research.2024; 11: 100100.     CrossRef
• Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases
  Biao Li, Wan Li, Tiancai Liu, Longying Zha
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• Oxidative stress in metabolic diseases: current scenario and therapeutic relevance
  Satish K. Raut, Madhu Khullar
  Molecular and Cellular Biochemistry.2023; 478(1): 185.     CrossRef
• Rainbow Trout (Oncorhynchus mykiss) as Source of Multifunctional Peptides with Antioxidant, ACE and DPP-IV Inhibitory Activities
  Martina Bartolomei, Janna Cropotova, Carlotta Bollati, Kristine Kvangarsnes, Lorenza d’Adduzio, Jianqiang Li, Giovanna Boschin, Carmen Lammi
  Nutrients.2023; 15(4): 829.     CrossRef
• Current Status of Obesity: Protective Role of Catechins
  Tanisha Basu, Ashley Selman, Arubala P. Reddy, P. Hemachandra Reddy
  Antioxidants.2023; 12(2): 474.     CrossRef
• Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation
  Nanaka Arimura, Hiroshi Watanabe, Hiromasa Kato, Tadashi Imafuku, Takehiro Nakano, Miyu Sueyoshi, Mayuko Chikamatsu, Kai Tokumaru, Taisei Nagasaki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Toru Maruyama
  Toxins.2023; 15(3): 179.     CrossRef
• The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
  Iwona Świątkiewicz, Marcin Wróblewski, Jarosław Nuszkiewicz, Paweł Sutkowy, Joanna Wróblewska, Alina Woźniak
  International Journal of Molecular Sciences.2023; 24(7): 6382.     CrossRef
• Understanding the Impact of Obesity on Ageing in the Radiance of DNA Metabolism
  S.G. Chowdhury, S. Misra, Parimal Karmakar
  The Journal of nutrition, health and aging.2023; 27(5): 314.     CrossRef
• Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis
  Priyanshy Sharma, V. Sri Swetha Victoria, P. Praneeth Kumar, Sarbani Karmakar, Mudduluru Swetha, Amala Reddy
  International Immunopharmacology.2023; 122: 110472.     CrossRef
• Mechanisms of Formation and Persistence of IgE Products and Potential Innovative Means of Therapy for Allergic Pathologies
  D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
  Applied Biochemistry and Microbiology.2023; 59(6): 754.     CrossRef
• Mechanism and application of Lactobacillus in type 2 diabetes-associated periodontitis
  Sisi Chen, Yuhan Zhang
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Mechanisms of Formation and Persistence of Ige Products and Potential Innovative Means of Therapy for Allergic Pathologies
  D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
  Прикладная биохимия и микробиология.2023; 59(6): 538.     CrossRef
• Activated monocytes as a therapeutic target to attenuate vascular inflammation and lower cardiovascular disease-risk in patients with type 2 diabetes: A systematic review of preclinical and clinical studies
  Siphamandla R. Ngcobo, Bongani B. Nkambule, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Aviwe Ntsethe, Vuyolwethu Mxinwa, Khanyisani Ziqubu, Yonela Ntamo, Thembeka A. Nyawo, Phiwayinkosi V. Dludla
  Biomedicine & Pharmacotherapy.2022; 146: 112579.     CrossRef
• Genomic Analysis of Visceral Fat Accumulation in Holstein Cows
  Larissa C. Novo, Ligia Cavani, Pablo Pinedo, Pedro Melendez, Francisco Peñagaricano
  Frontiers in Genetics.2022;[Epub]     CrossRef
• Regulation of immune cell function by nicotinamide nucleotide transhydrogenase
  Thomas Regan, Rachel Conway, Leena P. Bharath
  American Journal of Physiology-Cell Physiology.2022; 322(4): C666.     CrossRef
• d-Allulose Ameliorates Hyperglycemia Through IRE1α Sulfonation-RIDD-Sirt1 Decay Axis in the Skeletal Muscle
  Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seon-Ah Park, Juwon Lee, Junghyun Lim, Soonok Sa, Go Eun Kim, Jung Sook Han, Junghyun Kim, Han-Jung Chae
  Antioxidants & Redox Signaling.2022; 37(4-6): 229.     CrossRef
• Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets
  Sinenhlanhla X.H. Mthembu, Sithandiwe E. Mazibuko-Mbeje, Khanyisani Ziqubu, Thembeka A. Nyawo, Nnini Obonye, Tawanda M. Nyambuya, Bongani B. Nkambule, Sonia Silvestri, Luca Tiano, Christo J.F. Muller, Phiwayinkosi V. Dludla
  Life Sciences.2022; 297: 120467.     CrossRef
• The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity
  Judy Fieres, Marvin Fischer, Christine Sauter, Maria Moreno-Villanueva, Alexander Bürkle, Petra H. Wirtz
  DNA Repair.2022; 114: 103323.     CrossRef
• The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics
  Anushka C. Wickramaratne, Li Li, Jesse B. Hopkins, Lukasz A. Joachimiak, Carla B. Green
  Biochemistry.2022; 61(11): 1091.     CrossRef
• Oxidative stress and obesity
  Maja Malenica, Neven Meseldžić
  Arhiv za farmaciju.2022; 72(2): 166.     CrossRef
• Transcriptomic analysis of Simpson Golabi Behmel Syndrome cells during differentiation exhibit BAT-like function
  M. Colitti, U. Ali, M. Wabitsch, D. Tews
  Tissue and Cell.2022; : 101822.     CrossRef
• Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials
  Sebastián Yalle-Vásquez, Karem Osco-Rosales, Wendy Nieto-Gutierrez, Vicente Benites-Zapata, Faustino R. Pérez-López, Christoper A. Alarcon-Ruiz
  Gynecological Endocrinology.2022; 38(7): 548.     CrossRef
• The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity
  Orestes López-Ortega, Nidia Carolina Moreno-Corona, Victor Javier Cruz-Holguin, Luis Didier Garcia-Gonzalez, Addy Cecilia Helguera-Repetto, Mirza Romero-Valdovinos, Haruki Arevalo-Romero, Leticia Cedillo-Barron, Moisés León-Juárez
  International Journal of Molecular Sciences.2022; 23(11): 6154.     CrossRef
• Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review
  Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Tamires da Cunha Soares, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Jennifer Beatriz Silva Morais, Mickael de Paiva Sousa, Thayanne Gabryelle Visgueira de Sousa, Nilmara Cunha da
  Biological Trace Element Research.2022; 200(8): 3545.     CrossRef
• Nrf2a dependent and independent effects of early life exposure to 3,3’-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio)
  Monika A. Roy, Charlotte K. Gridley, Sida Li, Yeonhwa Park, Alicia R. Timme-Laragy
  Aquatic Toxicology.2022; 249: 106219.     CrossRef
• Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats
  Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Sheu Oluwadare Sulaiman, Edwin Coleridge Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu
  IBRO Neuroscience Reports.2022; 13: 57.     CrossRef
• Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
  Chung-Lin Jiang, Chang-Yu Tsao, Yi-Ching Lee
  Genes & Nutrition.2022;[Epub]     CrossRef
• Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions
  Xiujuan Wang, Meihong Xu, Yong Li
  Nutrients.2022; 14(15): 3134.     CrossRef
• Production of Reactive Oxygen Species by Epicardial Adipocytes Is Associated with an Increase in Postprandial Glycemia, Postprandial Insulin, and a Decrease in Serum Adiponectin in Patients with Severe Coronary Atherosclerosis
  Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Kharitonova, Sergey L. Andreev, Alexander S. Gorbunov, Boris K. Kurbatov, Alla A. Boshchenko
  Biomedicines.2022; 10(8): 2054.     CrossRef
• Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer
  Konstantinos Prokopidis, Panagiotis Giannos, Oliver C. Witard, Daniel Peckham, Theocharis Ispoglou, Ajay Pratap Singh
  PLOS ONE.2022; 17(9): e0273766.     CrossRef
• Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress
  Mark F. McCarty, James J. DiNicolantonio, James H. O’Keefe
  Current Issues in Molecular Biology.2022; 44(9): 4314.     CrossRef
• Fructose promotes more than glucose the adipocytic differentiation of pig mesenchymal stem cells
  Francisco Campos‐Maldonado, María L. González‐Dávalos, Enrique Piña, Miriam Aracely Anaya‐Loyola, Armando Shimada, Alfredo Varela‐Echavarria, Ofelia Mora
  Journal of Food Biochemistry.2022;[Epub]     CrossRef
• Understanding the effect of obesity on papillary thyroid cancer: is there a need for tailored diagnostic and therapeutic management?
  Antonio Matrone, Alessio Basolo, Ferruccio Santini, Rossella Elisei
  Expert Review of Endocrinology & Metabolism.2022; 17(6): 475.     CrossRef
• The Role of Inflammation as a Preponderant Risk Factor in Cardiovascular Diseases
  Rodrigo Damián García, Joana Antonela Asensio, Diahann Jeanette Perdicaro, María de los Ángeles Peral
  Current Vascular Pharmacology.2022; 20(3): 244.     CrossRef
• Synthesis and Catalytic Studies of Nanoalloy Particles Based on Bismuth, Silver, and Rhenium
  Konrad Wojtaszek, Katarzyna Skibińska, Filip Cebula, Tomasz Tokarski, Marc Escribà-Gelonch, Volker Hessel, Marek Wojnicki
  Metals.2022; 12(11): 1819.     CrossRef
• Endothelium-Derived Relaxing Factors and Endothelial Function: A Systematic Review
  Francesco Nappi, Antonio Fiore, Joyce Masiglat, Teresa Cavuoti, Michela Romandini, Pierluigi Nappi, Sanjeet Singh Avtaar Singh, Jean-Paul Couetil
  Biomedicines.2022; 10(11): 2884.     CrossRef
• MicroRNAs in the Regulation of NADPH Oxidases in Vascular Diabetic and Ischemic Pathologies: A Case for Alternate Inhibitory Strategies?
  Sean R. Wallace, Patrick J. Pagano, Damir Kračun
  Antioxidants.2022; 12(1): 70.     CrossRef
• Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance
  Yujeong Kim, Ok-Kyung Kim
  Advances in Nutrition.2021; 12(2): 566.     CrossRef
• Mesenchymal stem cell conditioned medium ameliorates diabetic serum‐induced insulin resistance in 3T3‐L1 cells
  Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
  Chronic Diseases and Translational Medicine.2021; 7(1): 47.     CrossRef
• F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes
  M. T. Kaartinen, M. Arora, S. Heinonen, A. Hang, A. Barry, J. Lundbom, A. Hakkarainen, N. Lundholm, A. Rissanen, J. Kaprio, K. H. Pietiläinen
  International Journal of Obesity.2021; 45(3): 577.     CrossRef
• Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer – Pooled results of 24 million cohorts
  Mohanad R. Youssef, Adin S.C. Reisner, Abdallah S. Attia, Mohamed Hosny Hussein, Mahmoud Omar, Anna LaRussa, Carlos A. Galvani, Mohamed Aboueisha, Mohamed Abdelgawad, Eman Ali Toraih, Gregory W. Randolph, Emad Kandil
  Oral Oncology.2021; 112: 105085.     CrossRef
• Thioredoxin deficiency exacerbates vascular dysfunction during diet‐induced obesity in small mesenteric artery in mice
  Shannon Dunn, Robert H. Hilgers, Kumuda C. Das
  Microcirculation.2021;[Epub]     CrossRef
• Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes
  Mariana Grancieri, Hércia Stampini Duarte Martino, Elvira Gonzalez de Mejia
  Nutrients.2021; 13(1): 176.     CrossRef
• The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity
  Yawen Zhou, Huige Li, Ning Xia
  Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
• Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
  Safaa H. Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H. Eid, Assaad A. Eid, Ahmed F. El-Yazbi
  Biochemical Pharmacology.2021; 186: 114491.     CrossRef
• Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents
  Li Xiao, Nobuhiko Miwa
  Cells.2021; 10(3): 626.     CrossRef
• Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
  Štěpánka Benáková, Blanka Holendová, Lydie Plecitá-Hlavatá
  Antioxidants.2021; 10(4): 526.     CrossRef
• Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes
  Mengqi Zeng, Jie Xu, Zhengyi Zhang, Xuan Zou, Xueqiang Wang, Ke Cao, Weiqiang Lv, Yuting Cui, Jiangang Long, Zhihui Feng, Jiankang Liu
  Redox Biology.2021; 41: 101948.     CrossRef
• Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
  Mark F. McCarty
  International Journal of Molecular Sciences.2021; 22(7): 3321.     CrossRef
• Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry
  Pamela A. Nono Nankam, Télesphore B. Nguelefack, Julia H. Goedecke, Matthias Blüher
  Antioxidants.2021; 10(4): 622.     CrossRef
• Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats
  Joanna Sadowska, Wioleta Dudzińska, Izabela Dziaduch, Mahmoud A.O. Dawood
  PLOS ONE.2021; 16(5): e0251789.     CrossRef
• Oxidative stress in oocyte aging and female reproduction
  Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
  Journal of Cellular Physiology.2021; 236(12): 7966.     CrossRef
• Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation
  Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni
  BioFactors.2021; 47(5): 837.     CrossRef
• Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals
  Letícia Mattei, Fabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Artur Junio Togneri Ferron, Carol Cristina Vágula de Almeida Silva, Cristina Schmitt Gregolin, Erika Tiemi Nakandakare-Maia, Janaína das Chagas Paixão Silva, Fernando Moreto, Igo
  Molecular and Cellular Endocrinology.2021; 537: 111423.     CrossRef
• Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses
  Lovro Žiberna, Zala Jenko-Pražnikar, Ana Petelin
  Antioxidants.2021; 10(9): 1352.     CrossRef
• The level of reactive oxygen species production by adipocytes of epicardial adipose tissue is associated with an increase in postprandial glycemia in patients with severe coronary atherosclerosis
  O. A. Koshelskaya, N. V. Naryzhnaya, I. V. Kologrivova, T. E. Suslova, O. A. Kharitonova, V. V. Evtushenko, S. L. Andreev, A. S. Gorbunov, A. A. Gudkova
  The Siberian Journal of Clinical and Experimental Medicine.2021; 36(3): 59.     CrossRef
• Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
  Amy E. Mendham, Steen Larsen, Cindy George, Kevin Adams, Jon Hauksson, Tommy Olsson, Melony C. Fortuin-de Smidt, Pamela A. Nono Nankam, Olah Hakim, Louise M. Goff, Carmen Pheiffer, Julia H. Goedecke
  Scientific Reports.2020;[Epub]     CrossRef
• Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes
  Su-Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Seung-Soon Im, Jae-Hoon Bae, Dae-Kyu Song
  Redox Biology.2020; 37: 101749.     CrossRef
• Pathogenic Role of Air Pollution Particulate Matter in Cardiometabolic Disease: Evidence from Mice and Humans
  Timoteo Marchini, Andreas Zirlik, Dennis Wolf
  Antioxidants & Redox Signaling.2020; 33(4): 263.     CrossRef
• Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte
  Allison M. Manuel, Michael D. Walla, Margaret T. Dorn, Ross M. Tanis, Gerardo G. Piroli, Norma Frizzell
  Free Radical Biology and Medicine.2020; 148: 70.     CrossRef
• TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women
  Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka
  Molecular Biology Reports.2020; 47(2): 855.     CrossRef
• Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows
  G. Andres Contreras, Jenne De Koster, Jonas de Souza, Juliana Laguna, Vengai Mavangira, Rahul K. Nelli, Jeff Gandy, Adam L. Lock, Lorraine M. Sordillo
  Journal of Dairy Science.2020; 103(2): 1944.     CrossRef
• Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
  Bianka Bojková, Pawel J. Winklewski, Magdalena Wszedybyl-Winklewska
  International Journal of Molecular Sciences.2020; 21(11): 4114.     CrossRef
• Adipose tissue macrophages: Unique polarization and bioenergetics in obesity
  Heather L. Caslin, Monica Bhanot, W. Reid Bolus, Alyssa H. Hasty
  Immunological Reviews.2020; 295(1): 101.     CrossRef
• Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases
  Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
  European Journal of Pharmacology.2020; 881: 173215.     CrossRef
• Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro
  María Herranz-López, Mariló Olivares-Vicente, Esther Rodríguez Gallego, Jose Antonio Encinar, Almudena Pérez-Sánchez, Verónica Ruiz-Torres, Jorge Joven, Enrique Roche, Vicente Micol
  Food and Chemical Toxicology.2020; 144: 111606.     CrossRef
• Elastin-derived peptide VGVAPG decreases differentiation of mouse embryo fibroblast (3T3-L1) cells into adipocytes
  Konrad A. Szychowski, Bartosz Skóra, Jakub Tobiasz, Jan Gmiński
  Adipocyte.2020; 9(1): 234.     CrossRef
• Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications
  John O. Orgah, Shuang He, Yule Wang, Miaomiao Jiang, Yuefei Wang, Emmanuel A. Orgah, Yajun Duan, Buchang Zhao, Boli Zhang, Jihong Han, Yan Zhu
  Pharmacological Research.2020; 153: 104654.     CrossRef
• Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes
  Teresa Vezza, Zaida Abad-Jiménez, Miguel Marti-Cabrera, Milagros Rocha, Víctor Manuel Víctor
  Antioxidants.2020; 9(9): 848.     CrossRef
• Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
  Mari T. Kaartinen, Mansi Arora, Sini Heinonen, Aila Rissanen, Jaakko Kaprio, Kirsi H. Pietiläinen
  International Journal of Molecular Sciences.2020; 21(21): 8289.     CrossRef
• Phytosterols: Nutritional Health Players in the Management of Obesity and Its Related Disorders
  Teresa Vezza, Francisco Canet, Aranzazu M. de Marañón, Celia Bañuls, Milagros Rocha, Víctor Manuel Víctor
  Antioxidants.2020; 9(12): 1266.     CrossRef
• Metabolic programming of macrophage functions and pathogens control
  Sue-jie Koo, Nisha J. Garg
  Redox Biology.2019; 24: 101198.     CrossRef
• Effects of bariatric surgery on telomere length and T-cell aging
  F. Jongbloed, R. W. J. Meijers, J. N. M. IJzermans, R. A. Klaassen, M. E. T. Dollé, S. van den Berg, M. G. H. Betjes, R. W. F. de Bruin, E. van der Harst, N. H. R. Litjens
  International Journal of Obesity.2019; 43(11): 2189.     CrossRef
• Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
  Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder, Michael Berk
  Neuroscience & Biobehavioral Reviews.2019; 107: 862.     CrossRef
• Adipose oxidative stress and protein carbonylation
  Amy K. Hauck, Yimao Huang, Ann V. Hertzel, David A. Bernlohr
  Journal of Biological Chemistry.2019; 294(4): 1083.     CrossRef
• Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis
  Priyanka Sarkar, Kavitha Thirumurugan
  Journal of Functional Foods.2019; 53: 318.     CrossRef
• Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
  Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
  Diabetologia.2019; 62(5): 779.     CrossRef
• Obesity, DNA Damage, and Development of Obesity-Related Diseases
  Marta Włodarczyk, Grażyna Nowicka
  International Journal of Molecular Sciences.2019; 20(5): 1146.     CrossRef
• Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
  Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
  Scientific Reports.2019;[Epub]     CrossRef
• The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology
  Evan DeVallance, Yao Li, Michael J. Jurczak, Eugenia Cifuentes-Pagano, Patrick J. Pagano
  Antioxidants & Redox Signaling.2019; 31(10): 687.     CrossRef
• Phenolic compounds as natural and multifunctional anti-obesity agents: A review
  Celia Rodríguez-Pérez, Antonio Segura-Carretero, María del Mar Contreras
  Critical Reviews in Food Science and Nutrition.2019; 59(8): 1212.     CrossRef
• Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C
  Eraci Drehmer, Mari Ángeles Navarro-Moreno, Sandra Carrera, Vincent M. Villar, Mari Luz Moreno
  Food & Function.2019; 10(6): 3567.     CrossRef
• High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production
  Tareck Rharass, Stéphanie Lucas
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation
  Pratik Adhya, Shyam Sunder Sharma
  Pharmacological Research.2019; 146: 104271.     CrossRef
• Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
  Maria A. Pabon, Kevin Manocha, Jim W. Cheung, James C. Lo
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Strawberry extract attenuates oxidative stress in 3T3-L1 cells
  Tamara Y. Forbes-Hernández, Sadia Afrin, Danila Cianciosi, Piera Pia Manna, Jiaojiao Zhang, Massimiliano Gasparrini, Patricia Reboredo-Rodríguez
  Journal of Berry Research.2018; 8(3): 193.     CrossRef
• The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
  Hyon-Seung Yi, Joon Young Chang, Minho Shong
  Journal of Molecular Endocrinology.2018; 61(3): R91.     CrossRef
• Emerging Roles for Adipose Tissue in Cardiovascular Disease
  Elizabeth E. Ha, Robert C. Bauer
  Arteriosclerosis, Thrombosis, and Vascular Biology.2018;[Epub]     CrossRef
• miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway
  Yao Gao, Yan Cao, Xianwei Cui, Xingyun Wang, Yahui Zhou, Fangyan Huang, Xing Wang, Juan Wen, Kaipeng Xie, Pengfei Xu, Xirong Guo, Lianghui You, Chenbo Ji
  Molecular and Cellular Endocrinology.2018; 476: 155.     CrossRef
• Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
  Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
  Scientific Reports.2018;[Epub]     CrossRef
• Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells
  Eun-Bin Kwon, Myung-Ji Kang, Soo-Yeon Kim, Yong-Moon Lee, Mi-Kyeong Lee, Heung Joo Yuk, Hyung Won Ryu, Su Ui Lee, Sei-Ryang Oh, Dong-Oh Moon, Hyun-Sun Lee, Mun-Ock Kim
  Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
• Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet
  Alice Martinic, Javad Barouei, Zach Bendiks, Darya Mishchuk, Dustin D. Heeney, Roy Martin, Maria L. Marco, Carolyn M. Slupsky
  Journal of Proteome Research.2018; 17(8): 2790.     CrossRef
• The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
  Xuan Wang, Andris Elksnis, Per Wikström, Erik Walum, Nils Welsh, Per-Ola Carlsson, Harald H. H. W. Schmidt
  PLOS ONE.2018; 13(9): e0204271.     CrossRef
• Involvement of adipose tissue inflammation and dysfunction in virus-induced type 1 diabetes
  James C Needell, Madalyn N Brown, Danny Zipris
  Journal of Endocrinology.2018; 238(1): 61.     CrossRef
• Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
  Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers, Jun Ren
  Pharmacology & Therapeutics.2018; 191: 1.     CrossRef
• Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid
  Phiwayinkosi Dludla, Bongani Nkambule, Babalwa Jack, Zibusiso Mkandla, Tinashe Mutize, Sonia Silvestri, Patrick Orlando, Luca Tiano, Johan Louw, Sithandiwe Mazibuko-Mbeje
  Nutrients.2018; 11(1): 23.     CrossRef
• Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity
  Laura J. Den Hartigh, Mohamed Omer, Leela Goodspeed, Shari Wang, Tomasz Wietecha, Kevin D. O’Brien, Chang Yeop Han
  Arteriosclerosis, Thrombosis, and Vascular Biology.2017; 37(3): 466.     CrossRef
• Novel lipid-mimetic prodrugs delivering active compounds to adipose tissue
  Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
  European Journal of Medicinal Chemistry.2017; 135: 77.     CrossRef
• Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients
  Morana Jaganjac, Shamma Almuraikhy, Fatima Al-Khelaifi, Mashael Al-Jaber, Moataz Bashah, Nayef A. Mazloum, Kamelija Zarkovic, Neven Zarkovic, Georg Waeg, Wael Kafienah, Mohamed A. Elrayess
  Redox Biology.2017; 12: 483.     CrossRef
• A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
  Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
  Endocrinology and Metabolism.2017; 32(3): 375.     CrossRef
• Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
  Maimaiti Yisireyili, Motoharu Hayashi, Hongxian Wu, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Mohammad Shoaib Hamrah, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toshimitsu Niwa, Toyoaki Murohara, Kyosuke Takeshita
  Scientific Reports.2017;[Epub]     CrossRef
• Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress
  Adriana Rosas-Villegas, Mónica Sánchez-Tapia, Azalia Avila-Nava, Victoria Ramírez, Armando Tovar, Nimbe Torres
  Nutrients.2017; 9(4): 393.     CrossRef
• Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome
  Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena María Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones
  Metabolism.2017; 71: 132.     CrossRef
• Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling
  Ann V. Hertzel, Hongliang Xu, Michael Downey, Nicholas Kvalheim, David A. Bernlohr
  Journal of Lipid Research.2017; 58(7): 1354.     CrossRef
• Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
  Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
  Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
• Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice
  Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
  Vascular Pharmacology.2017; 96-98: 19.     CrossRef
• Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
  Anil Bhatta, Lin Yao, Zhimin Xu, Haroldo A. Toque, Jijun Chen, Reem T. Atawia, Abdelrahman Y. Fouda, Zsolt Bagi, Rudolf Lucas, Ruth B. Caldwell, Robert W. Caldwell
  Cardiovascular Research.2017; 113(13): 1664.     CrossRef
• Change in serum albumin concentration is inversely and independently associated with risk of incident metabolic syndrome
  Sang-Man Jin, Yong Joo Hong, Jae Hwan Jee, Ji Cheol Bae, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
  Metabolism.2016; 65(11): 1629.     CrossRef

A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pancreatic β-cells. However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and β-cell death due to a lack of antioxidant defense systems. Taking into account the vulnerability of islets to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed as a way to protect β-cells against diabetic insults. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions, as well as the therapeutic benefits of antioxidants, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with β-cell failure.

Citations

Citations to this article as recorded by  

• Association Between Serum Ferritin and the Duration of Type 2 Diabetes Mellitus in a Tertiary Care Hospital in Chennai
  Sankar Arumugam, Anbalagan Suyambulingam
  Cureus.2024;[Epub]     CrossRef
• Pancreatic Parenchymal Atrophy and Pancreatic Fat Accumulation Measured by Multidetector Computed Tomography as a Stable Marker of Chronic Progressive Type 2 Diabetes Mellitus—A Cross Sectional Observational Study
  Kshipra Devadiga, Khanak K Nandolia, Mahendra Singh, Pankaj Sharma, Udit Chauhan, Ravi Kant
  Avicenna Journal of Medicine.2024;[Epub]     CrossRef
• Toward Ultrasound Molecular Imaging of Endothelial Dysfunction in Diabetes: Targets, Strategies, and Challenges
  Jiahan Liu, Chen Wang, Shuo Qiu, Wenqi Sun, Guodong Yang, Lijun Yuan
  ACS Applied Bio Materials.2024; 7(3): 1416.     CrossRef
• Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus: focus on the selenium
  Asma Bouazza, Eric Fontaine, Xavier Leverve, Elhadj-Ahmed Koceir
  Archives of Physiology and Biochemistry.2023; 129(2): 505.     CrossRef
• Vanillic acid potentiates insulin secretion and prevents pancreatic β-cells cytotoxicity under H2O2-induced oxidative stress
  Chandan Muddahally Naganna, K. Yogendra Prasad, V. P. Mahendra, P. Ganesan, Ravi Kumar
  Molecular Biology Reports.2023; 50(2): 1311.     CrossRef
• Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
  Phiwayinkosi V Dludla, Sihle E Mabhida, Khanyisani Ziqubu, Bongani B Nkambule, Sithandiwe E Mazibuko-Mbeje, Sidney Hanser, Albert Kotze Basson, Carmen Pheiffer, Andre Pascal Kengne
  World Journal of Diabetes.2023; 14(3): 130.     CrossRef
• Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy
  Lital Argaev-Frenkel, Tovit Rosenzweig
  Antioxidants.2023; 12(5): 994.     CrossRef
• Polygenic Variants Linked to Oxidative Stress and the Antioxidant System Are Associated with Type 2 Diabetes Risk and Interact with Lifestyle Factors
  Youngjin Choi, Hyuk-Ku Kwon, Sunmin Park
  Antioxidants.2023; 12(6): 1280.     CrossRef
• Food Anthocyanins: Malvidin and Its Glycosides as Promising Antioxidant and Anti-Inflammatory Agents with Potential Health Benefits
  Anna Merecz-Sadowska, Przemysław Sitarek, Tomasz Kowalczyk, Karolina Zajdel, Mariusz Jęcek, Paweł Nowak, Radosław Zajdel
  Nutrients.2023; 15(13): 3016.     CrossRef
• Selenium—More than Just a Fortuitous Sulfur Substitute in Redox Biology
  Luisa B. Maia, Biplab K. Maiti, Isabel Moura, José J. G. Moura
  Molecules.2023; 29(1): 120.     CrossRef
• Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging
  Ken-ichiro Matsumoto, Ikuo Nakanishi, Zhivko Zhelev, Rumiana Bakalova, Ichio Aoki
  Antioxidants & Redox Signaling.2022; 36(1-3): 95.     CrossRef
• Speciation study and biological activity of copper (II) complexes with picolinic and 6-methylpicolinic acid with different components of blood serum of low molecular mass in KNO3 1.0 mol·L−1 at 25 °C
  Edgar Del Carpio, María L. Serrano, Lino Hernández, Waleska Madden, Vito Lubes, Vanessa R. Landaeta, Rafael E. Rodríguez-Lugo, Giuseppe Lubes, Anita Stern, Carlos Ciangherotti, Lissette Jiménez
  Polyhedron.2022; 211: 115562.     CrossRef
• Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem
  Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Hani Al-Salami
  Therapeutic Delivery.2022; 13(1): 51.     CrossRef
• Racial Differences in Pain, Nutrition, and Oxidative Stress
  Larissa J. Strath, Robert E. Sorge
  Pain and Therapy.2022; 11(1): 37.     CrossRef
• Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
  Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
  Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
• Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide
  Bushra Waheed, Syed Muhammad Mukarram Shah, Fida Hussain, Mohammad Ijaz Khan, Anwar Zeb, Muhammad Saeed Jan, Arpita Roy
  Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1.     CrossRef
• Recent Advances and Mechanistic Insights into Antibacterial Activity, Antibiofilm Activity, and Cytotoxicity of Silver Nanoparticles
  Neetu Tripathi, Manoj Kumar Goshisht
  ACS Applied Bio Materials.2022; 5(4): 1391.     CrossRef
• Chemical speciation, antioxidant activity and molecular docking of copper(II) complexes with pyridinedicarboxylic acids and different ligands of low molecular mass
  Edgar Del Carpio, María L. Serrano, Lino Hernández, Waleska Madden, Vito Lubes, Vanessa R. Landaeta, Rafael E. Rodríguez-Lugo, Giuseppe Lubes, Anita Stern, Carlos Ciangherotti, Lissette Jiménez
  Physics and Chemistry of Liquids.2022; 60(6): 943.     CrossRef
• Inflammaging and Osteoarthritis
  Francesca Motta, Elisa Barone, Antonio Sica, Carlo Selmi
  Clinical Reviews in Allergy & Immunology.2022; 64(2): 222.     CrossRef
• Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation
  Thobekile S. Leyane, Sandy W. Jere, Nicolette N. Houreld
  International Journal of Molecular Sciences.2022; 23(13): 7273.     CrossRef
• Validation of the traditional medicinal use of a Mexican endemic orchid (Prosthechea karwinskii) through UPLC-ESI-qTOF-MS/MS characterization of its bioactive compounds
  Gabriela Soledad Barragán-Zarate, Luicita Lagunez-Rivera, Rodolfo Solano, Candy Carranza-Álvarez, Diego Manuel Hernández-Benavides, Gerard Vilarem
  Heliyon.2022; 8(7): e09867.     CrossRef
• N-acetyl-L-cysteine ameliorates hepatocyte pyroptosis of dog type 1 diabetes mellitus via suppression of NLRP3/NF-κB pathway
  Haihua Huo, Haitong Wu, Feiyang Ma, Xinrun Li, Jianzhao Liao, Lianmei Hu, Qingyue Han, Ying Li, Jiaqiang Pan, Hui Zhang, Zhaoxin Tang, Jianying Guo
  Life Sciences.2022; 306: 120802.     CrossRef
• Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes
  Fatima El Zahra M. Fathi, Kadry M. Sadek, Asmaa F. Khafaga, Abdel Wahab Al senosy, Hanan A. Ghoniem, Sahar Fayez, Mohamed F. Zeweil
  Environmental Science and Pollution Research.2022; 29(60): 90219.     CrossRef
• Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale in Streptozotocin-Induced Diabetic Rats
  F. A Bamisaye, R. A Ibrahim, A.O. Sulyman, A.O. Jubril, Olawale Ajuwon
  Nigerian Journal of Physiological Sciences.2022; 37(1): 137.     CrossRef
• Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats
  Qiang Su, Jing Dong, Donglei Zhang, Lu Yang, Rupak Roy
  Applied Biochemistry and Biotechnology.2022; 194(12): 6407.     CrossRef
• Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice
  Marta Balog, Allison C Anderson, Marija Heffer, Zeljka Korade, Karoly Mirnics
  Biomolecules.2022; 12(10): 1535.     CrossRef
• Myricitrin and Its Solid Lipid Nanoparticle Increase Insulin Secretion and Content of Isolated Islets from the Pancreas of Male Mice
  Akram Ahangarpour, Ali Akbar Oroojan
  Brazilian Journal of Pharmaceutical Sciences.2022;[Epub]     CrossRef
• Diabetes and plant‐derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development
  Arun K. Jugran, Sandeep Rawat, Hari P. Devkota, Indra D. Bhatt, Ranbeer S. Rawal
  Phytotherapy Research.2021; 35(1): 223.     CrossRef
• Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin
  Rodrigo B. Mansur, Francheska Delgado-Peraza, Mehala Subramaniapillai, Yena Lee, Michelle Iacobucci, Flora Nasri, Nelson Rodrigues, Joshua D. Rosenblat, Elisa Brietzke, Victoria E. Cosgrove, Nicole E. Kramer, Trisha Suppes, Charles L. Raison, Andrea Fagio
  Journal of Psychiatric Research.2021; 133: 82.     CrossRef
• Protective Effects of Iridoid Glycoside from Corni Fructus on Type 2 Diabetes with Nonalcoholic Fatty Liver in Mice
  Dou Niu, Xue Chen, Ting Wang, Fuxing Wang, Qiusheng Zhang, Xiaochang Xue, Jiefang Kang, Dan Qian Chen
  BioMed Research International.2021; 2021: 1.     CrossRef
• Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes
  Jiahui Zhang, Fnu Anshul, Deepak K. Malhotra, Juan Jaume, Lance D. Dworkin, Rujun Gong
  Antioxidants.2021; 10(1): 138.     CrossRef
• p-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities
  Yanchao Xu, Yong Wang, Dan Wu, Wenwen He, Liping Wang, Weiming Zhu
  Frontiers in Microbiology.2021;[Epub]     CrossRef
• Updated Role of Neuropeptide Y in Nicotine-Induced Endothelial Dysfunction and Atherosclerosis
  Yan-li Zheng, Wan-da Wang, Mei-mei Li, Shu Lin, Hui-li Lin
  Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
• IRS-2/Akt/GSK-3β/Nrf2 Pathway Contributes to the Protective Effects of Chikusetsu Saponin IVa against Lipotoxicity
  Lei Wang, Jialin Duan, Na Jia, Meiyou Liu, Shanshan Cao, Yan Weng, Wei Zhang, Jinyi Cao, Ruili Li, Jia Cui, Jingwen Wang, Silvana Hrelia
  Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
• In Vivo and In Vitro Assays Evaluating the Biological Activity of Taurine, Glucose and Energetic Beverages
  Marcos Mateo-Fernández, Fernando Valenzuela-Gómez, Rafael Font, Mercedes Del Río-Celestino, Tania Merinas-Amo, Ángeles Alonso-Moraga
  Molecules.2021; 26(8): 2198.     CrossRef
• Effect of propolis on glycemic control in patients with type 2 diabetes: an updated systematic review and meta-analysis of randomized controlled trials
  Zahra Mosallanezhad, Cain Clark, Fatemeh Bahreini, Zahra Motamed, Abdolhamid Mosallanezhad, Seyedeh Fatemeh Hosseini, Aneseh Shaban-Khalaf, Zahra Sohrabi
  Nutrition & Food Science .2021; 51(7): 1124.     CrossRef
• The Correlation between Selenium Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy
  Abdulateef Altuhafi, Muhammed Altun, Mahmoud Hussein Hadwan
  Reports of Biochemistry and Molecular Biology.2021; 10(2): 164.     CrossRef
• Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis
  Sanaz Rezaei Zonooz, Motahareh Hasani, Mojgan Morvaridzadeh, Ana Beatriz Pizarro, Hafez Heydari, Somaye Yosaee, Gholamreza Rezamand, Javad Heshmati
  Journal of Functional Foods.2021; 87: 104774.     CrossRef
• The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
  Kristian Leisegang, Shubhadeep Roychoudhury, Petr Slama, Renata Finelli
  Antioxidants.2021; 10(11): 1834.     CrossRef
• Роль системы врождённого иммунитета и окислительного стресса в развитии сахарного диабета 1-типа. Пероксиредоксин 6 как новый антидиабетический препарат
  Е.Г. Новосёлова, О.В. Глушкова, М.О. Хренов, С.М. Лунин, Т.В. Новосёлова, С.Б. Парфенюк
  Биохимия.2021; 86(12): 1840.     CrossRef
• Role of Innate Immunity and Oxidative Stress in the Development of Type 1 Diabetes Mellitus. Peroxiredoxin 6 as a New Anti-Diabetic Agent
  Elena G. Novoselova, Olga V. Glushkova, Maxim O. Khrenov, Sergey M. Lunin, Tatyana V. Novoselova, Svetlana B. Parfenuyk
  Biochemistry (Moscow).2021; 86(12-13): 1579.     CrossRef
• Participation of Hsp70 and Hsp90α Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus
  E. G. Novoselova, O. V. Glushkova, M. O. Khrenov, S. B. Parfenyuk, S. M. Lunin, T. V. Novoselova, E. E. Fesenko
  Doklady Biological Sciences.2020; 493(1): 124.     CrossRef
• The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia
  Sedigheh Shahvali, Armita Shahesmaeili, Mojgan Sanjari, Somayyeh Karami-Mohajeri
  Diabetology International.2020; 11(1): 19.     CrossRef
• Green synthesis of gold nanoparticles from Fritillaria cirrhosa and its anti-diabetic activity on Streptozotocin induced rats
  Ying Guo, Nan Jiang, Li Zhang, Min Yin
  Arabian Journal of Chemistry.2020; 13(4): 5096.     CrossRef
• The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases
  Andrés García-Sánchez, Alejandra Guillermina Miranda-Díaz, Ernesto Germán Cardona-Muñoz
  Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
• Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations
  Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian, Hani Al-Salami
  Pharmaceutics.2020; 12(8): 708.     CrossRef
• Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states
  Minglei Ma, Haibin Liu, Jie Yu, Shuli He, Pingping Li, Chunxiao Ma, Huabing Zhang, Lingling Xu, Fan Ping, Wei Li, Qi Sun, Yuxiu Li
  Lipids in Health and Disease.2020;[Epub]     CrossRef
• Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway
  Yusong Ding, Haiyan Li, Yang Li, Dandan Liu, Liyuan Zhang, Tongling Wang, Tao Liu, Long Ma, Rocío De la Puerta
  Evidence-Based Complementary and Alternative Medicine.2020; 2020: 1.     CrossRef
• The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
  Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
  Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
• Roles of Autophagy in Oxidative Stress
  Hyeong Rok Yun, Yong Hwa Jo, Jieun Kim, Yoonhwa Shin, Sung Soo Kim, Tae Gyu Choi
  International Journal of Molecular Sciences.2020; 21(9): 3289.     CrossRef
• Antioxidant and prebiotic effects of a beverage composed by tropical fruits and yacon in alloxan-induced diabetic rats
  Ana Paula DIONISIO, Luciano Bruno de CARVALHO-SILVA, Nara Menezes VIEIRA, Nedio Jair WURLITZER, Ana Carolina da Silva PEREIRA, Maria de Fatima BORGES, Deborah dos Santos GARRUTI, Idila dos Santos ARAÚJO
  Food Science and Technology.2020; 40(1): 202.     CrossRef
• Pro-oxidant–antioxidant balance (PAB) as a prognostic index in assessing the cardiovascular risk factors: A narrative review
  Hamideh Ghazizadeh, Maryam Saberi-Karimian, Maliheh Aghasizadeh, Reza Sahebi, Hamed Ghazavi, Hamed Khedmatgozar, Ameneh Timar, Mohadeseh Rohban, Ali Javandoost, Majid Ghayour-Mobarhan
  Obesity Medicine.2020; 19: 100272.     CrossRef
• Rosemary Leaf Extract Inhibits Glycation, Breast Cancer Proliferation, and Diabetes Risks
  Yixiao Shen, Jing Han, Xiaoyan Zheng, Binling Ai, Yang Yang, Dao Xiao, Lili Zheng, Zhanwu Sheng
  Applied Sciences.2020; 10(7): 2249.     CrossRef
• Trigonella stellata reduced the deleterious effects of diabetes mellitus through alleviation of oxidative stress, antioxidant- and drug-metabolizing enzymes activities
  Salah A. Sheweita, Sara A. ElHady, Hala M. Hammoda
  Journal of Ethnopharmacology.2020; 256: 112821.     CrossRef
• A Shift Toward a Plant-Centered Diet From Young to Middle Adulthood and Subsequent Risk of Type 2 Diabetes and Weight Gain: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
  Yuni Choi, Nicole Larson, Daniel D. Gallaher, Andrew O. Odegaard, Jamal S. Rana, James M. Shikany, Lyn M. Steffen, David R. Jacobs
  Diabetes Care.2020; 43(11): 2796.     CrossRef
• Ascorbic acid supplementation in type 2 diabetes mellitus
  Lipeng Shi, Xuqin Du, Pei Guo, Lumei Huang, Peng Qi, Qianhui Gong
  Medicine.2020; 99(45): e23125.     CrossRef
• Analysis of the Effect of Fish Bars Made of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour to Reduce Oxidative Stress in a Diabetic Rat Model
  Deni ELNOVRIZA, Hadi RIYADI, Rimbawan RIMBAWAN, Evy DAMAYANTHI, Adi WINARTO
  Journal of Nutritional Science and Vitaminology.2020; 66(Supplement): S36.     CrossRef
• Antioxidant activity of crude ethanolic extract and fractions of Ziziphus mauritiana Lam. (Rhamnaceae) leaves from Burkina Faso
  Estelle N.H. Youl, Cyrille A.P. Ouédraogo, Moustapha Gambo, Moussa Ouédraogo, Martin Kiendrebéogo, Aristide Traoré, Innocent Pierre Guissou
  Journal of Basic and Clinical Physiology and Pharmacology.2019;[Epub]     CrossRef
• CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation
  Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
  Free Radical Biology and Medicine.2019; 134: 505.     CrossRef
• Comparative proteomic analysis reveals drug resistance of Staphylococcus xylosus ATCC700404 under tylosin stress
  Xin Liu, Jinpeng Wang, Mo Chen, Ruixiang Che, Wenya Ding, Fei Yu, Yonghui Zhou, Wenqiang Cui, Xing Xiaoxu, Bello-Onaghise God’spower, Yanhua Li
  BMC Veterinary Research.2019;[Epub]     CrossRef
• The Potential of Bilih Fish (Mystacoleuseus padangensis Blkr) Flour as a Zinc Source to Control Blood Glucose and Impact on Oxidative Stress in a Diabetic Rat Model
  Deni Elnovriza, Hadi Riyadi, Rimbawan ., Evy Damayanthi, Adi Winarto
  Pakistan Journal of Nutrition.2019; 18(3): 264.     CrossRef
• Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
  Zuo, Prather, Stetskiv, Garrison, Meade, Peace, Zhou
  International Journal of Molecular Sciences.2019; 20(18): 4472.     CrossRef
• The variations of some salivary parameters as probable indices of the hereditary diabetes
  Menicagli Roberto, Marotta Ortensio
  International Journal of Preventive Medicine.2019; 10(1): 11.     CrossRef
• The Interrelationship between Job Stress with the Immune System and Functional Memory of Women Working in Diagnostic Laboratories
  Mansoureh Sadeghi-Yarandi, Anahita Khodabakhshi-Koolaee, Mohammad Reza Falsafinejad, Neda Khaletbari
  The Neuroscience Journal of Shefaye Khatam.2019; 7(2): 23.     CrossRef
• Effect of Cinnamon Administration on Fertility of Normal and Diabetic Male Rats
  Mahmoud Al-Shawabk, Abdulrahim Al Jamal
  Pakistan Journal of Nutrition.2019; 18(5): 491.     CrossRef
• White Sesame Seed Oil Mitigates Blood Glucose Level, Reduces Oxidative Stress, and Improves Biomarkers of Hepatic and Renal Function in Participants with Type 2 Diabetes Mellitus
  Farhan Aslam, Sanaullah Iqbal, Muhammad Nasir, Aftab Ahmad Anjum
  Journal of the American College of Nutrition.2019; 38(3): 235.     CrossRef
• Effect of combination of Gynura procumbens aqueous extract and Trigona spp. honey on fertility and libido of streptozotocin-induced hyperglycaemic male rats
  Khaidatul Akmar, MahanemMat Noor
  Asian Pacific Journal of Reproduction.2019; 8(2): 56.     CrossRef
• Serum Antioxidant Parameters are Significantly Increased in Patients with Type 2 Diabetes Mellitus after Consumption of Chinese Propolis: A Randomized Controlled Trial Based on Fasting Serum Glucose Level
  Weina Gao, Lingling Pu, Jingyu Wei, Zhanxin Yao, Yawen Wang, Tala Shi, Liting Zhao, Changya Jiao, Changjiang Guo
  Diabetes Therapy.2018; 9(1): 101.     CrossRef
• Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes
  Natália Nogueira do Nascimento Kaut, Ana Carolina Silveira Rabelo, Glaucy Rodrigues Araujo, Jason Guy Taylor, Marcelo Eustáquio Silva, Maria Lúcia Pedrosa, Miriam Martins Chaves, Joamyr Victor Rossoni Junior, Daniela Caldeira Costa
  Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
• The Potential of South African Herbal Tisanes, Rooibos and Honeybush in the Management of Type 2 Diabetes Mellitus
  Olawale Ajuwon, Ademola Ayeleso, Gbenga Adefolaju
  Molecules.2018; 23(12): 3207.     CrossRef
• Clinical variables and ethnicity may influenced by polymorphism of CAT −262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications
  A. Eddaikra, H. Amroun, R. Raache, A. Galleze, N. Abdallah-Elhadj, M. Azzouz, F. Meçabih, B. Mechti, M.C. Abbadi, C. Touil-Boukoffa, N. Attal
  Gene.2018; 670: 182.     CrossRef
• Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
  Astrid Borchert, Jacqueline Kalms, Sophia R. Roth, Marlena Rademacher, Andrea Schmidt, Hermann-Georg Holzhutter, Hartmut Kuhn, Patrick Scheerer
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2018; 1863(9): 1095.     CrossRef
• The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial
  Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
  BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• Mice pancreatic islets protection from oxidative stress induced by single-walled carbon nanotubes through naringin
  A Ahangarpour, S Alboghobeish, AA Oroojan, MA Dehghani
  Human & Experimental Toxicology.2018; 37(12): 1268.     CrossRef
• Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity
  Biplab Giri, Sananda Dey, Tanaya Das, Mrinmoy Sarkar, Jhimli Banerjee, Sandeep Kumar Dash
  Biomedicine & Pharmacotherapy.2018; 107: 306.     CrossRef
• Cognitive dysfunction and metabolic comorbidities in mood disorders: A repurposing opportunity for glucagon-like peptide 1 receptor agonists?
  Rodrigo B. Mansur, Yena Lee, Mehala Subramaniapillai, Elisa Brietzke, Roger S. McIntyre
  Neuropharmacology.2018; 136: 335.     CrossRef
• The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways
  Khalil Ali Ahmad, Hong Ze, Jichao Chen, Farhan Ullah Khan, Chen Xuezhuo, Jinyi Xu, Ding Qilong
  Biomedicine & Pharmacotherapy.2018; 106: 1734.     CrossRef
• Curcumin alleviates liver oxidative stress in type 1 diabetic rats
  Zhenglu Xie, Binbin Wu, Guozhi Shen, Xiaqing Li, Qianying Wu
  Molecular Medicine Reports.2017;[Epub]     CrossRef
• Treatment with a GLP−1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders
  Rodrigo B. Mansur, Andre Zugman, Juhie Ahmed, Danielle S. Cha, Mehala Subramaniapillai, Yena Lee, Julie Lovshin, Jung G. Lee, Jae-Hon Lee, Vladislav Drobinin, Jason Newport, Elisa Brietzke, Eva Z. Reininghaus, Kang Sim, Maj Vinberg, Natalie Rasgon, Tomas
  European Neuropsychopharmacology.2017; 27(11): 1153.     CrossRef
• Plasma vascular endothelial growth factor B levels are increased in patients with newly diagnosed type 2 diabetes mellitus and associated with the first phase of glucose-stimulated insulin secretion function of β-cell
  J. Wu, H. Wei, H. Qu, Z. Feng, J. Long, Q. Ge, H. Deng
  Journal of Endocrinological Investigation.2017; 40(11): 1219.     CrossRef
• Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey
  Dan Quansah, Kyungho Ha, Shinyoung Jun, Seong-Ah Kim, Sangah Shin, Gyung-Ah Wie, Hyojee Joung
  Molecules.2017; 22(10): 1664.     CrossRef
• Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats
  Zhenglu Xie, Xinqi Zeng, Xiaqing Li, Binbin Wu, Guozhi Shen, Qianying Wu, Changbiao Wu
  Open Life Sciences.2017; 12(1): 452.     CrossRef
• Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset
  Cüneyt A. Aral, Özlem Nalbantoğlu, Bilge G. Nur, Mustafa Altunsoy, Kübra Aral
  Archives of Oral Biology.2017; 82: 115.     CrossRef
• Evaluation and Application of a Novel Quantitative Antioxidant Activity Assay Based on Cellular Metabolomics
  Jianteng Wei, Qingping Hu, Ningli Wang, Yewei Liu, Dong Pei, Duolong Di
  Chromatographia.2017; 80(4): 617.     CrossRef
• C-X-C motif chemokine ligand 8 promotes endothelial cell homing via the Akt-signal transducer and activator of transcription pathway to accelerate healing of ischemic and hypoxic skin ulcers
  Lei Shen, Peng Zhang, Shanqiang Zhang, Liping Xie, Lijie Yao, Weiya Lang, Jie Lian, Wei Qin, Meng Zhang, Liang Ji
  Experimental and Therapeutic Medicine.2017; 13(6): 3021.     CrossRef
• STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper
  Rachel T Scarl, C Martin Lawrence, Hannah M Gordon, Craig S Nunemaker
  Journal of Endocrinology.2017; 234(3): R123.     CrossRef
• Current views on neuropeptide Y and diabetes-related atherosclerosis
  Wei-wei Sun, Ping Zhu, Yan-chuan Shi, Chen-liang Zhang, Xu-feng Huang, Shi-yu Liang, Zhi-yuan Song, Shu Lin
  Diabetes and Vascular Disease Research.2017; 14(4): 277.     CrossRef
• Teucrium polium extract reverses symptoms of streptozotocin-induced diabetes in rats via rebalancing the Pdx1 and FoxO1 expressions
  Parvaneh Sadat Tabatabaie, Razieh Yazdanparast
  Biomedicine & Pharmacotherapy.2017; 93: 1033.     CrossRef
• Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells
  Pachamuthu Vanitha, Sankareswaran Senthilkumar, Sireesh Dornadula, Sundaramurthy Anandhakumar, Palanisamy Rajaguru, Kunka Mohanram Ramkumar
  European Journal of Pharmacology.2017; 801: 9.     CrossRef
• Antioxidant status and gut microbiota change in an aging mouse model as influenced by exopolysaccharide produced by Lactobacillus plantarum YW11 isolated from Tibetan kefir
  Jian Zhang, Xiao Zhao, Yunyun Jiang, Wen Zhao, Ting Guo, Yongqiang Cao, Junwei Teng, Xiaona Hao, Juan Zhao, Zhennai Yang
  Journal of Dairy Science.2017; 100(8): 6025.     CrossRef
• Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
  Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
  Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
• Differential dose-dependent effects of zinc oxide nanoparticles on oxidative stress-mediated pancreatic β-cell death
  Swati C Asani, Rinku D Umrani, Kishore M Paknikar
  Nanomedicine.2017; 12(7): 745.     CrossRef
• Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy
  Yu-Guo Yuan, Qiu-Ling Peng, Sangiliyandi Gurunathan
  International Journal of Molecular Sciences.2017; 18(3): 569.     CrossRef
• Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells
  Suma Elumalai, Udayakumar Karunakaran, In Kyu Lee, Jun Sung Moon, Kyu Chang Won
  Redox Biology.2017; 11: 126.     CrossRef
• Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin
  Samsulrizal Nurdiana, Yong Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal’ain Azmi, Noor Syaffinaz Noor Mohamad Zin, Mahdi Ebrahimi
  BMC Complementary and Alternative Medicine.2017;[Epub]     CrossRef
• Murraya paniculata (L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats
  Cicero Diego Almino Menezes, Francisca Adilfa de Oliveira Garcia, Glauce Socorro de Barros Viana, Patricia Gonçalves Pinheiro, Cícero Francisco Bezerra Felipe, Thaís Rodrigues de Albuquerque, Alisson Cordeiro Moreira, Enaide Soares Santos, Maynara Rodrigu
  Phytotherapy Research.2017; 31(11): 1747.     CrossRef
• Exploiting biological activities of brown seaweed Ishige okamurae Yendo for potential industrial applications: a review
  K. K. Asanka Sanjeewa, Won Woo Lee, Jae-Il Kim, You-Jin Jeon
  Journal of Applied Phycology.2017; 29(6): 3109.     CrossRef
• The thioredoxin and glutathione-dependent H2O2 consumption pathways in muscle mitochondria: Involvement in H2O2 metabolism and consequence to H2O2 efflux assays
  Daniel Munro, Sheena Banh, Emianka Sotiri, Nahid Tamanna, Jason R. Treberg
  Free Radical Biology and Medicine.2016; 96: 334.     CrossRef
• Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial
  I. Nikbakht-Jam, M. Khademi, M. Nosrati, S. Eslami, M. Foroutan-Tanha, A. Sahebkar, S. Tavalaie, M. Ghayour-Mobarhan, G.A.A. Ferns, F. Hadizadeh, S.A.S. Tabassi, S.A. Mohajeri, M. Emamian
  European Journal of Integrative Medicine.2016; 8(3): 307.     CrossRef
• Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line
  Armin Mooranian, Rebecca Negrulj, Frank Arfuso, Hani Al-Salami
  Artificial Cells, Nanomedicine, and Biotechnology.2016; 44(7): 1642.     CrossRef
• Lipid peroxidation is associated with poor control of type-2 diabetes mellitus
  Sameer Hassan Fatani, Abdullatif Taha Babakr, EssamEldin Mohamed NourEldin, Abdalla A. Almarzouki
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(2): S64.     CrossRef
• Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer’s disease Mouse Brain
  Du Fang, Zhihua Zhang, Hang Li, Qing Yu, Justin T. Douglas, Anna Bratasz, Periannan Kuppusamy, Shirley ShiDu Yan, Hemachandra Reddy
  Journal of Alzheimer's Disease.2016; 51(2): 571.     CrossRef
• Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic INS-1E beta cells
  Beatriz Fernandez-Gomez, Sonia Ramos, Luis Goya, María Dolores Mesa, María Dolores del Castillo, María Ángeles Martín
  Food Research International.2016; 89: 1015.     CrossRef
• Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene
  Simone Hanna Brütsch, Marlena Rademacher, Sophia Regina Roth, Karin Müller, Susanne Eder, Dagmar Viertel, Christiane Franz, Hartmut Kuhn, Astrid Borchert
  Journal of Biological Chemistry.2016; 291(45): 23578.     CrossRef
• Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5
  C.S. Moura, P.C.B. Lollo, P.N. Morato, E.A. Esmerino, L.P. Margalho, V.A. Santos-Junior, P.T. Coimbra, L.P. Cappato, M.C. Silva, A.S. Garcia-Gomes, D. Granato, H.M. A. Bolini, A.S. Sant'Ana, A.G. Cruz, Jaime Amaya-Farfan
  Food Research International.2016; 90: 275.     CrossRef
• Discovery of biomarkers for oxidative stress based on cellular metabolomics
  Ningli Wang, Jianteng Wei, Yewei Liu, Dong Pei, Qingping Hu, Yu Wang, Duolong Di
  Biomarkers.2016; 21(5): 449.     CrossRef
• Diabetic nephropathy and endothelial dysfunction: Current and future therapies, and emerging of vascular imaging for preclinical renal-kinetic study
  Wilson KC Leung, L Gao, Parco M Siu, Christopher WK Lai
  Life Sciences.2016; 166: 121.     CrossRef
• Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus
  Liting Zhao, Lingling Pu, Jingyu Wei, Jinghua Li, Jianquan Wu, Zhonghao Xin, Weina Gao, Changjiang Guo
  International Journal of Environmental Research and Public Health.2016; 13(5): 498.     CrossRef
• Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection
  Stephen F. Vatner, Ronald E. Pachon, Dorothy E. Vatner
  Oxidative Medicine and Cellular Longevity.2015; 2015: 1.     CrossRef
• Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species
  Bruno Silva, Ana Seca, Maria Barreto, Diana Pinto
  International Journal of Molecular Sciences.2015; 16(8): 17160.     CrossRef
• Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells
  Nathalie Auberval, Stéphanie Dal, William Bietiger, Elodie Seyfritz, Jean Peluso, Christian Muller, Minjie Zhao, Eric Marchioni, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Valérie Schini-Kerth, Séverine Sigrist
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells
  Udayakumar Karunakaran, Jun Sung Moon, Hyoung Woo Lee, Kyu Chang Won
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(11): 2414.     CrossRef
• Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health
  James P. Kehrer, Lars-Oliver Klotz
  Critical Reviews in Toxicology.2015; 45(9): 765.     CrossRef
• Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of theAlox15Gene Does Not Rescue Such Knock-In Mice
  Simone Hanna Brütsch, Chi Chiu Wang, Lu Li, Hannelore Stender, Nilgün Neziroglu, Constanze Richter, Hartmut Kuhn, Astrid Borchert
  Antioxidants & Redox Signaling.2015; 22(4): 281.     CrossRef
• Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids
  Justyna Janikiewicz, Katarzyna Hanzelka, Kamil Kozinski, Katarzyna Kolczynska, Agnieszka Dobrzyn
  Biochemical and Biophysical Research Communications.2015; 460(3): 491.     CrossRef
• Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals
  C. Mozzini, U. Garbin, C. Stranieri, A. Pasini, E. Solani, I. A. Tinelli, L. Cominacini, A.M. Fratta Pasini
  Free Radical Research.2015; 49(3): 244.     CrossRef
• El estrés oxidativo como predictor de longevidad; estudio de casos y controles
  Ángel Belenguer Varea, Kheira Mohamed Abdelaziz, Juan Antonio Avellana Zaragoza, Consuelo Borrás Blasco, Paula Sanchis Aguilar, José Viña Ribes
  Revista Española de Geriatría y Gerontología.2015; 50(1): 16.     CrossRef
• Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways
  Elisa Fernández-Millán, Sonia Ramos, Carmen Alvarez, Laura Bravo, Luis Goya, María Ángeles Martín
  Food and Chemical Toxicology.2014; 66: 245.     CrossRef
• Decreased serum CA19‐9 is associated with improvement of insulin resistance and metabolic control in patients with obesity and type 2 diabetes after Roux‐en‐Y gastric bypass
  Yinfang Tu, Haoyong Yu, Pin Zhang, Jianzhong Di, Xiaodong Han, Songhua Wu, Yuqian Bao, Weiping Jia
  Journal of Diabetes Investigation.2014; 5(6): 694.     CrossRef
• Oxidative Stress Is Associated with an Increased Antioxidant Defense in Elderly Subjects: A Multilevel Approach
  Gemma Flores-Mateo, Roberto Elosua, Teresa Rodriguez-Blanco, Josep Basora-Gallisà, Mònica Bulló, Jordi Salas-Salvadó, Miguel Ángel Martínez-González, Ramon Estruch, Dolores Corella, Montserrat Fitó, Miquel Fiol, Fernando Arós, Enrique Gómez-Gracia, Isaac
  PLoS ONE.2014; 9(9): e105881.     CrossRef
• Inflamed moods: A review of the interactions between inflammation and mood disorders
  Joshua D. Rosenblat, Danielle S. Cha, Rodrigo B. Mansur, Roger S. McIntyre
  Progress in Neuro-Psychopharmacology and Biological Psychiatry.2014; 53: 23.     CrossRef
• Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes
  Soo Lim, Jae Hyun Bae, Eun Ju Chun, Haeryoung Kim, So Yeon Kim, Kyoung Min Kim, Sung Hee Choi, Kyong Soo Park, Jose C. Florez, Hak Chul Jang
  Acta Diabetologica.2014; 51(5): 739.     CrossRef
• Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics
  Sylwia Dzięgielewska-Gęsiak, Ewa Wysocka, Sławomir Michalak, Ewa Nowakowska-Zajdel, Teresa Kokot, Małgorzata Muc-Wierzgoń
  Oxidative Medicine and Cellular Longevity.2014; 2014: 1.     CrossRef
• Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus
  Hong Hanh Thi Tran, Minh Chau Nguyen, Hoang Tram Le, Thi Luyen Nguyen, Thanh Binh Pham, Van Minh Chau, Hoai Nam Nguyen, Tien Dat Nguyen
  Pharmaceutical Biology.2014; 52(1): 74.     CrossRef
• Diabetes Mellitus and Disturbances in Brain Connectivity: A Bidirectional Relationship?
  Rodrigo B. Mansur, Danielle S. Cha, Hanna O. Woldeyohannes, Joanna K. Soczynska, Andre Zugman, Elisa Brietzke, Roger S. McIntyre
  NeuroMolecular Medicine.2014; 16(4): 658.     CrossRef
• Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
  Liang-Jun Yan
  Journal of Diabetes Research.2014; 2014: 1.     CrossRef
• Vitamin C Protects against INS832/13 ^|^beta;-Cell Death and/or Dysfunction Caused by Glucolipotoxicity or 3T3-L1 Adipocyte Coculture
  Ruojun WANG, Jia LIU, Xiaoxuan GUO, Fengyi GAO, Baoping JI, Feng ZHOU
  Journal of Nutritional Science and Vitaminology.2014; 60(5): 313.     CrossRef
• Antioxidant activities of novel small-molecule polysaccharide fractions purified from Portulaca oleracea L.
  Yu-Ping Li, Li-Hua Yao, Guan-Jie Wu, Xiao-Fang Pi, Yan-Chun Gong, Ruo-Shong Ye, Chen-Xi Wang
  Food Science and Biotechnology.2014; 23(6): 2045.     CrossRef
• Anti-diabetic properties of a non-conventional radical scavenger, as compared to pioglitazone and exendin-4, in streptozotocin-nicotinamide diabetic mice
  Michela Novelli, Donatella Canistro, Manuela Martano, Niccola Funel, Andrea Sapone, Simone Melega, Matilde Masini, Vincenzo De Tata, Anna Pippa, Cecilia Vecoli, Daniela Campani, Rocco De Siena, Antonio Soleti, Moreno Paolini, Pellegrino Masiello
  European Journal of Pharmacology.2014; 729: 37.     CrossRef
• Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1
  Yong Son, Ju Hwan Lee, Hun-Taeg Chung, Hyun-Ock Pae
  Oxidative Medicine and Cellular Longevity.2013; 2013: 1.     CrossRef
• Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress
  Jordan Wright, Julia Birk, Leena Haataja, Ming Liu, Thomas Ramming, Michael A. Weiss, Christian Appenzeller-Herzog, Peter Arvan
  Journal of Biological Chemistry.2013; 288(43): 31010.     CrossRef
• Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose
  Richard M. O’Brien
  Current Diabetes Reports.2013; 13(6): 768.     CrossRef

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.

Citations

Citations to this article as recorded by  

• Relationship of phytochemicals and antioxidant activities in Gymnema inodorum leaf extracts
  Onanong Nuchuchua, Wanwisa Srinuanchai, Chaisak Chansriniyom, Uthaiwan Suttisansanee, Piya Temviriyanukul, Nitra Nuengchamnong, Uracha Ruktanonchai
  Heliyon.2024; 10(1): e23175.     CrossRef
• The Role of Glutathione and Its Precursors in Type 2 Diabetes
  Dawn Tuell, George Ford, Evan Los, William Stone
  Antioxidants.2024; 13(2): 184.     CrossRef
• Combined toxicity of microplastics and copper on Goniopora columns
  Ya-Ting Chen, De-Sing Ding, Yee Cheng Lim, Cheng-Di Dong, Shu-Ling Hsieh
  Environmental Pollution.2024; 345: 123515.     CrossRef
• Oxidative stress, endothelial dysfunction, and N-acetylcysteine in type-2 diabetes mellitus
  Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
  Antioxidants & Redox Signaling.2024;[Epub]     CrossRef
• Acacia gum: Chemistry, properties & food applications
  Deepak Mudgil, Sheweta Mudgil
  Food and Humanity.2024; 2: 100264.     CrossRef
• High glucose-induced increasing reactive nitrogen species accumulation triggered mitochondrial dysfunction, inflammation, and apoptosis in keratinocytes
  Huma Rizwan, Sonu Kumar, Golden Kumari, Arttatrana Pal
  Life Sciences.2023; 312: 121208.     CrossRef
• Vitamin D–vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3
  Xueqin Wu, Shiqi Tang, Qing Dai, Bin Yi, Shikun Yang, Jian Sun, Yong Zhong, Wei Lin, Jun Liu, Yan Liu, Jianwen Wang, Jishi Liu, Qin Liao, Wei Zhang, Hao Zhang
  The FASEB Journal.2023;[Epub]     CrossRef
• Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using Phragmanthera austroarabica A. G. Mill and J. A. Nyberg extract
  Dina M. Khodeer, Ali M. Nasr, Shady A. Swidan, Sarah Shabayek, Roaa M. Khinkar, Mohammed M. Aldurdunji, Maryam A. Ramadan, Jihan M. Badr
  Frontiers in Microbiology.2023;[Epub]     CrossRef
• Toxic Effects of Copper Sulfate and Trichlorfon on the Intestines of Zebrafish (Danio rerio)
  Qing Li, Yangyang Cao, Yuting Wang, Xiaodong Long, Wenbo Sun, Hui Yang, Yingying Zhang, Zhitao Qi
  Aquaculture Research.2023; 2023: 1.     CrossRef
• Early Detection Is the Best Prevention—Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System
  Sanela Rajlic, Hendrik Treede, Thomas Münzel, Andreas Daiber, Georg Daniel Duerr
  Cells.2023; 12(4): 583.     CrossRef
• In vitroand computational studies of the antioxidant and anti-diabetic properties ofBridelia ferruginea
  Olajumoke Oyebode, Ochuko Lucky Erukainure, Lindiwe Zuma, Collins U. Ibeji, Neil Anthony Koorbanally, Md. Shahidul Islam
  Journal of Biomolecular Structure and Dynamics.2022; 40(9): 3989.     CrossRef
• Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
  Sergey Zavadskiy, Susanna Sologova, Nurbubu Moldogazieva
  Biochimie.2022; 195: 114.     CrossRef
• Effects of Smoking on Diabetic Nephropathy
  Yasemin Gündoğdu, İnan Anaforoğlu
  Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
• Endogenous Protective Factors and Potential Therapeutic Agents for Diabetes-Associated Atherosclerosis
  Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
  Habibu Tijjani, Abdulkadir Mohammed Danyaro, Ahmed Olatunde, Aminu Umar Kura
  Beni-Suef University Journal of Basic and Applied Sciences.2022;[Epub]     CrossRef
• Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish
  Hui Yang, Zhu Zhu, Yuexuan Xie, Chen Zheng, Zhenyuan Zhou, Tianhao Zhu, Yingying Zhang
  Aquatic Toxicology.2022; 250: 106259.     CrossRef
• “EVALUATION OF HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN TYPE-2 DIABETIC PATIENT”
  Ameerul Hasan Amir, Faisal Iqubal, Savita Rathor, Afreena Nasir
  INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 12.     CrossRef
• Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
  Nittiya Suwannasom, Chutamas Thepmalee, Krissana Khoothiam, Chonthida Thephinlap
  Molecules.2022; 27(22): 8043.     CrossRef
• p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
  Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
  Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
• Elucidation of phytochemicals and antioxidants properties of Sasa quelpaertensis
  Hee Chul Ko, Mi Gyeong Jang, Jae-Won Kim, Songyee Baek, Nam Ho Lee, Se-Jae Kim
  International Journal of Food Properties.2021; 24(1): 210.     CrossRef
• Organelle dynamics of endothelial mitochondria in diabetic angiopathy
  Hong Xiang, Ruipeng Song, Jie Ouyang, Ruifang Zhu, Zhihao Shu, Yulan Liu, Xuewen Wang, Dongtao Zhang, Jiangwei Zhao, Hongwei Lu
  European Journal of Pharmacology.2021; 895: 173865.     CrossRef
• Hypoglycemic and antioxidant effects of green tomato ( Physalis ixocarpa Brot.) calyxes’ extracts
  Fernando Guerrero‐Romero, Luis E. Simental‐Mendía, María Inés Guerra Rosas, Víctor Iván Sayago‐Monreal, Juliana Morales Castro, Claudia I. Gamboa‐Gómez
  Journal of Food Biochemistry.2021;[Epub]     CrossRef
• Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
  Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, Khalid Talha Biobaku
  Journal of Complementary and Integrative Medicine.2021; 18(1): 87.     CrossRef
• NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
  Ilona M. Gora, Anna Ciechanowska, Piotr Ladyzynski
  Cells.2021; 10(2): 314.     CrossRef
• Potential Roles of Endoplasmic Reticulum Stress and Cellular Proteins Implicated in Diabesity
  Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Ismaeel Yunusa, Aishatu Shehu, Lukman Mustapha, Yusuf Wada, Mubarak Hussaini Ahmad, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar, Silvana Hrelia
  Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
• Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells
  Sweta Pal, G. Nageswar Rao, Arttatrana Pal
  Life Sciences.2021; 279: 119693.     CrossRef
• The Predictive Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Levels of Diabetic Peripheral Neuropathy
  Meiqiao Chen, Yuyou Zhu, Jumei Wang, Guoping Wang, Yuanbo Wu
  Journal of Pain Research.2021; Volume 14: 2049.     CrossRef
• The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
  V. V. Pushkarev, L. K. Sokolova, O. I. Kovzun, V. M. Pushkarev, M. D. Tronko
  Cytology and Genetics.2021; 55(4): 331.     CrossRef
• Aging under Pressure: The Roles of Reactive Oxygen and Nitrogen Species (RONS) Production and Aging Skeletal Muscle in Endothelial Function and Hypertension—From Biological Processes to Potential Interventions
  Hollie Speer, Andrew J. McKune
  Antioxidants.2021; 10(8): 1247.     CrossRef
• Natural Antioxidants in New Age-Related Diseases
  Arti Devi, Vagish Dwibedi, Zaved Ahmed Khan
  Revista Brasileira de Farmacognosia.2021; 31(4): 387.     CrossRef
• Potential risks of endoplasmic reticulum stress on vasculopathy in diabetes
  Sagir Mustapha, Mustapha Mohammed, Ismaeel Yunusa, Aida Hanum Ghulam Rasool, Siti Safiah Mokhtar
  Obesity Medicine.2020; 19: 100274.     CrossRef
• Potential roles of Citrulline and watermelon extract on metabolic and inflammatory variables in diabetes mellitus, current evidence and future directions: A systematic review
  Samaneh Azizi, Reza Mahdavi, Elnaz Vaghef‐Mehrabany, Vahid Maleki, Nahid Karamzad, Mehrangiz Ebrahimi‐Mameghani
  Clinical and Experimental Pharmacology and Physiology.2020; 47(2): 187.     CrossRef
• Enzymic polypeptide antioxidant activity and inhibitory activity on α-glucosidase and α-amylase from Paeonia ostii cake
  Huiru Qiao, Xiaojuan Bi, Yuanyuan Zhang, Mengran Liu, Shuchong Zu, Nan Jia, Shougang Jiang, Qi Lu, Yuangang Zu, Yihong Bao
  Industrial Crops and Products.2020; 146: 112158.     CrossRef
• Hypoglycemic and antioxidant properties of konjac ( Amorphophallus konjac ) in vitro and in vivo
  Claudia I. Gamboa‐Gómez, Fernando Guerrero‐Romero, Miguel A. Sánchez‐Meraz, Luis E. Simental‐Mendía
  Journal of Food Biochemistry.2020;[Epub]     CrossRef
• Heme on Pulmonary Malaria: Friend or Foe?
  Tatiana Almeida Pádua, Mariana Conceição Souza
  Frontiers in Immunology.2020;[Epub]     CrossRef
• The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
  Thomas CW. Chan, Jennifer L. Wilkinson Berka, Devy Deliyanti, Damien Hunter, Adrian Fung, Gerald Liew, Andrew White
  Experimental Eye Research.2020; 201: 108255.     CrossRef
• The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific
  Alexander Tacey, Tawar Qaradakhi, Cassandra Smith, Chris Pittappillil, Alan Hayes, Anthony Zulli, Itamar Levinger
  Nutrients.2020; 12(7): 2108.     CrossRef
• Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway
  Xiaoliang Dong, Di Wu, Yihan Zhang, Lingling Jia, Xiaohua Pan, Jia Sun, Li-Long Pan
  Antioxidants.2020; 9(6): 491.     CrossRef
• Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
  Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525.     CrossRef
• Fabrication of sensitive D-fructose sensor based on facile ternary mixed ZnO/CdO/SnO2 nanocomposites by electrochemical approach
  M.M. Alam, Abdullah M. Asiri, Mohammed M. Rahman, M.A. Islam
  Surfaces and Interfaces.2020; 19: 100540.     CrossRef
• The role of glutathione and glutathione peroxidase in regulating cellular level of reactive oxygen and nitrogen species
  Sheetal Panday, Raghav Talreja, Mahendra Kavdia
  Microvascular Research.2020; 131: 104010.     CrossRef
• Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors
  V.V. Sathibabu Uddandrao, Parim Brahmanaidu, Saravanan Ganapathy
  Cardiovascular & Hematological Agents in Medicinal Chemistry.2020; 18(2): 111.     CrossRef
• Rule of UA on Cardiac Myocytes Uric Acid Differently Influence the Oxidative Damage Induced by Acute Exposure of High Level of Glucose in Chicken Cardiac Myocytes
  Xiaolong Sun, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai Lin
  Frontiers in Veterinary Science.2020;[Epub]     CrossRef
• Elevated Serum Levels of Ischemia Modified Albumin and Malondialdehyde are Related to Atherogenic Index of Plasma in a Cohort of Prediabetes
  Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
  Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(8): 1347.     CrossRef
• Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes
  J. Jin, W. Wang, T. Gu, C. Chen, J. Sun, W. Chen, Y. Bi, D. Zhu
  Diabetes & Metabolism.2019; 45(1): 47.     CrossRef
• Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications
  Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee
  Journal of Diabetes Research.2019; 2019: 1.     CrossRef
• The impact of xanthine oxidase (XO) on hemolytic diseases
  Heidi M. Schmidt, Eric E. Kelley, Adam C. Straub
  Redox Biology.2019; 21: 101072.     CrossRef
• What is responsible for antioxidant properties of polyphenolic compounds from plants?
  Małgorzata Olszowy
  Plant Physiology and Biochemistry.2019; 144: 135.     CrossRef
• Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans
  Cecil J. Weale, Glenda M. Davison, Gloudina M. Hon, Andre P. Kengne, Rajiv T. Erasmus, Tandi E. Matsha
  Cells.2019; 8(5): 464.     CrossRef
• Chronic Inhibition of Mitochondrial Dihydrolipoamide Dehydrogenase (DLDH) as an Approach to Managing Diabetic Oxidative Stress
  Xiaojuan Yang, Jing Song, Liang-Jun Yan
  Antioxidants.2019; 8(2): 32.     CrossRef
• Cilostazol Attenuates Retinal Oxidative Stress and Inflammation in a Streptozotocin-Induced Diabetic Animal Model
  Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
  Current Eye Research.2019; 44(3): 294.     CrossRef
• Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
  Hatem Maamoun, Tarek Benameur, Gianfranco Pintus, Shankar Munusamy, Abdelali Agouni
  Frontiers in Physiology.2019;[Epub]     CrossRef
• Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
  Cheng Li, Xiao Miao, Shudong Wang, Binay Kumar Adhikari, Xin Wang, Jian Sun, Quan Liu, Qian Tong, Yonggang Wang
  Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
• Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
  Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
  Naunyn-Schmiedeberg's Archives of Pharmacology.2018; 391(2): 207.     CrossRef
• Angiogenic Dysregulation in Pregnancy-Related Hypertension—A Role for Metformin
  Nerolen Soobryan, Saravanakumar Murugesan, Arunagiri Pandiyan, Jagidesa Moodley, Irene Mackraj
  Reproductive Sciences.2018; 25(11): 1531.     CrossRef
• Nutrients and Oxidative Stress: Friend or Foe?
  Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew
  Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
• Free radical scavenging, α-glucosidase inhibitory and lipase inhibitory activities of eighteen Sudanese medicinal plants
  Sara Mustafa Idris Elbashir, Hari Prasad Devkota, Mikiyo Wada, Naoki Kishimoto, Masataka Moriuchi, Tsuyoshi Shuto, Shogo Misumi, Hirofumi Kai, Takashi Watanabe
  BMC Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• An Update on Hypertension in Children With Type 1 Diabetes
  Mallory L. Downie, Emma H. Ulrich, Damien G. Noone
  Canadian Journal of Diabetes.2018; 42(2): 199.     CrossRef
• Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling
  Gobinath Shanmugam, Madhusudhanan Narasimhan, Robbie L. Conley, Thiagarajan Sairam, Ashutosh Kumar, Ronald P. Mason, Ramalingam Sankaran, John R. Hoidal, Namakkal S. Rajasekaran
  Frontiers in Physiology.2017;[Epub]     CrossRef
• Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
  Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
  Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
• Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling
  Fabrício L. Tulini, Volnei B. Souza, Marcelo Thomazini, Marluci P. Silva, Adna P. Massarioli, Severino M. Alencar, Eliria M.J.A. Pallone, Maria I. Genovese, Carmen S. Favaro-Trindade
  Food Research International.2017; 95: 117.     CrossRef
• Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet
  Veerappan Ramanathan, Malarvili Thekkumala
  Journal of Pharmacology and Toxicology.2017; 12(3): 154.     CrossRef
• Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure
  Bakhta Aouey, Mohamed Derbali, Yassine Chtourou, Michèle Bouchard, Abdelmajid Khabir, Hamadi Fetoui
  Environmental Science and Pollution Research.2017; 24(6): 5841.     CrossRef
• Effect of hydroxychloroquine on oxidative/nitrosative status and angiogenesis in endothelial cells under high glucose condition
  Aysa Rezabakhsh, Soheila Montazersaheb, Elahe Nabat, Mehdi Hassanpour, Azadeh Montaseri, Hassan Malekinejad, Ali Akbar Movassaghpour, Reza Rahbarghazi, Alireza Garjani
  BioImpacts.2017; 7(4): 219.     CrossRef
• The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy
  Irini P. Chatziralli, George Theodossiadis, Prodromos Dimitriadis, Michail Charalambidis, Antonios Agorastos, Zisis Migkos, Nikolaos Platogiannis, Marilita M. Moschos, Panagiotis Theodossiadis, Petros Keryttopoulos
  The Open Ophthalmology Journal.2017; 11(1): 51.     CrossRef
• Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
  Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
  BioMed Research International.2017; 2017: 1.     CrossRef
• Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
  Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
  Aging and disease.2016; 7(1): 90.     CrossRef
• İNSAN VE HAYVANLARDA DİABETES MELLİTUS
  Özlem ÖZMEN, Senay TOPSAKAL
  Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi.2016; 1(1): 47.     CrossRef
• The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
  Domokos Gerő, Roberta Torregrossa, Alexis Perry, Alicia Waters, Sophie Le-Trionnaire, Jacqueline L. Whatmore, Mark Wood, Matthew Whiteman
  Pharmacological Research.2016; 113: 186.     CrossRef
• Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index
  Bonggi Lee, Jeong Dae Seo, Jin-Kyu Rhee, Choon Young Kim
  Food Chemistry.2016; 201: 315.     CrossRef
• Inverse association between serum total bilirubin levels and diabetic peripheral neuropathy in patients with type 2 diabetes
  Eun Sook Kim, Sung Won Lee, Eun Young Mo, Sung Dae Moon, Je Ho Han
  Endocrine.2015; 50(2): 405.     CrossRef
• Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination
  Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk, Barbara Pilawa
  International Journal of Pharmaceutics.2015; 490(1-2): 9.     CrossRef
• Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells
  L. F. Heinrich, D. K. Andersen, M. E. Cleasby, C. Lawson
  British Journal of Nutrition.2015; 113(11): 1704.     CrossRef
• Gum Arabic extracts protect against hepatic oxidative stress in alloxan induced diabetes in rats
  Abdelkareem A. Ahmed, Jaafar S. Fedail, Hassan H. Musa, Asghar Ali Kamboh, Amal Z. Sifaldin, Taha H. Musa
  Pathophysiology.2015; 22(4): 189.     CrossRef
• Reduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbits
  J Roganović, LJ Djukić, E Kršljak, N Tanić, D Stojić
  Oral Diseases.2015; 21(5): 634.     CrossRef
• Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy
  Michael Anthony Ruiz, Biao Feng, Subrata Chakrabarti, Rong Wen
  PLOS ONE.2015; 10(4): e0123987.     CrossRef
• Anti-hyperglycaemic effect ofPhragmenthera austroarabicaA.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats
  Abeer Hanafy, Jihan M. Badr
  Natural Product Research.2014; 28(24): 2351.     CrossRef
• Functional and morphological changes of the diencephalon vascular endothelium of rats in experimental ischemia-reperfusion injury and diabetes mellitus
  TM Boĭchuk, TP Savchuk
  Fiziolohichnyĭ zhurnal.2014; 59(6): 30.     CrossRef
• Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
  Paulo Zoé Costa, Raquel Soares
  Life Sciences.2013; 92(22): 1037.     CrossRef
• Oxidative-stress-induced epigenetic changes in chronic diabetic complications
  Biao Feng, Michael Anthony Ruiz, Subrata Chakrabarti
  Canadian Journal of Physiology and Pharmacology.2013; 91(3): 213.     CrossRef
• Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic Retinopathy Indices In Vivo
  Jun-hui Shen, Qi Ma, Shen-grong Shen, Guo-Tong Xu, Undurti N. Das
  Archives of Medical Research.2013; 44(7): 514.     CrossRef
• Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
  Daye Cheng, Bin Liang, Yunhui Li
  BioMed Research International.2013; 2013: 1.     CrossRef

Citations

Citations to this article as recorded by  

• Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors—A review
  Abdur Rauf, Anees Ahmed Khalil, Samir Awadallah, Shahid Ali Khan, Tareq Abu‐Izneid, Muhammad Kamran, Hassan A. Hemeg, Mohammad S. Mubarak, Ahood Khalid, Polrat Wilairatana
  Food Science & Nutrition.2024; 12(2): 675.     CrossRef
• The Protective Effects of Chrysanthemum cornarium L. var. spatiosum Extract on HIT-T15 Pancreatic β-Cells against Alloxan-induced Oxidative Stress
  In-Hye Kim, Kang-Jin Cho, Jeong-Sook Ko, Jae-Hyun Kim, Ae-Son Om
  The Korean Journal of Food And Nutrition.2012; 25(1): 123.     CrossRef