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Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Jae-Seung Yun, Sun Young Kim, Sung Rae Kim, In-Kyung Jeong, Ji-Oh Mok, Kun Ho Yoon
Diabetes Metab J. 2021;45(1):1-10.   Published online January 13, 2021
DOI: https://doi.org/10.4093/dmj.2020.0254
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
This study aimed to investigate the recent prevalence, management, and comorbidities of diabetes among Korean adults aged ≥30 years by analyzing nationally representative data.
Methods
This study used data from the Korea National Health and Nutrition Examination Survey from 2016 to 2018, and the percentage and total number of people ≥30 years of age with diabetes and impaired fasting glucose (IFG) were estimated.
Results
In 2018, 13.8% of Korean adults aged ≥30 years had diabetes, and adults aged ≥65 years showed a prevalence rate of 28%. The prevalence of IFG was 26.9% in adults aged ≥30 years. From 2016 to 2018, 35% of the subjects with diabetes were not aware of their condition. Regarding comorbidities, 53.2% and 61.3% were obese and hypertensive, respectively, and 72% had hypercholesterolemia as defined by low-density lipoprotein cholesterol (LDL-C) ≥100 mg/dL in people with diabetes. Of the subjects with diabetes, 43.7% had both hypertension and hypercholesterolemia. With regard to glycemic control, only 28.3% reached the target level of <6.5%. Moreover, only 11.5% of subjects with diabetes met all three targets of glycosylated hemoglobin, blood pressure, and LDL-C. The percentage of energy intake from carbohydrates was higher in diabetes patients than in those without diabetes, while that from protein and fat was lower in subjects with diabetes.
Conclusion
The high prevalence and low control rate of diabetes and its comorbidities in Korean adults were confirmed. More stringent efforts are needed to improve the comprehensive management of diabetes to reduce diabetes-related morbidity and mortality.

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  • 호남권 지역주민의 건강행태와 만성질환 관리현황
    선아 김, 정은 이
    Public Health Weekly Report.2024; 17(2): 46.     CrossRef
  • Variability in the association of smoking status with the prevalence of diabetes mellitus in the Korean population according to different definitions of smoking status: analysis based on the Korea National Health and Nutrition Examination Survey (2014-202
    Yechan Kyung, Young Sook Park, Mi Hyeon Jin, Hae Jeong Lee
    International Journal of Environmental Health Research.2024; : 1.     CrossRef
  • Factors Influencing the Dietary Behavior of Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study
    Sohyun Jin, Youngshin Song
    Journal of Korean Academy of Fundamentals of Nursing.2024; 31(1): 80.     CrossRef
  • Analysis of dietary behavior and intake related to glycemic control in patients with type 2 diabetes aged 30 years or older in Korea: Utilizing the 8th Korea National Health and Nutrition Examination Survey (2019–2021)
    Jin-Ah Seok, Yeon-Kyung Lee
    Nutrition Research and Practice.2024; 18(2): 239.     CrossRef
  • Exposure to Bisphenol A, S, and F and its Association with Obesity and Diabetes Mellitus in General Adults of Korea: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Min Joo Kim, Inae Lee, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Young Joo Park, Kyungho Choi
    Exposure and Health.2023; 15(1): 53.     CrossRef
  • The evolution and future of diagnostic criteria for diabetes mellitus
    Eun-Jung Rhee
    Journal of the Korean Medical Association.2023; 66(7): 409.     CrossRef
  • Efficacy of intermittent short‐term use of a real‐time continuous glucose monitoring system in non‐insulin–treated patients with type 2 diabetes: A randomized controlled trial
    Sun Joon Moon, Kyung‐Soo Kim, Woo Je Lee, Mi Yeon Lee, Robert Vigersky, Cheol‐Young Park
    Diabetes, Obesity and Metabolism.2023; 25(1): 110.     CrossRef
  • Ocular motility disorders following coronavirus disease-19 vaccination
    Kyung-Ah Park, Hyeshin Jeon, Dong Gyu Choi, Jae Ho Jung, Hyun-Jin Shin, Byung Joo Lee, Yeji Moon, Se-Youp Lee, Dong Cheol Lee, Soon Young Cho, Seong-Joon Kim, Sei Yeul Oh, Sunghyuk Moon, Shin Yeop Oh, Daye Diana Choi, Mi Young Choi, Won Jae Kim, Ungsoo Sa
    Graefe's Archive for Clinical and Experimental Ophthalmology.2023; 261(4): 1127.     CrossRef
  • Comorbidities associated with high-risk obstructive sleep apnea based on the STOP-BANG questionnaire: a nationwide population-based study
    Gene Huh, Kyoung do Han, Yong-Moon Park, Chan-Soon Park, Kyu-na Lee, Eun Young Lee, Jung-Hae Cho
    The Korean Journal of Internal Medicine.2023; 38(1): 80.     CrossRef
  • Low Skeletal Muscle Mass Accompanied by Abdominal Obesity Additively Increases the Risk of Incident Type 2 Diabetes
    Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Gyuri Kim, Sang-Man Jin, Jae Hwan Jee, Jae Hyeon Kim
    The Journal of Clinical Endocrinology & Metabolism.2023; 108(5): 1173.     CrossRef
  • Threshold dose–response association between smoking pack-years and the risk of gallbladder cancer: A nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    European Journal of Cancer.2023; 180: 99.     CrossRef
  • Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes
    Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
    The Korean Journal of Internal Medicine.2023; 38(1): 93.     CrossRef
  • Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study
    Bukyung Kim, Hak Sung Lee, Hye-Jin Kim, Hyolynn Lee, In-young Lee, Soyoung Ock, Sukyoung Kwon, Sang-Soo Kang, Youngsik Choi
    Food Science and Biotechnology.2023; 32(5): 697.     CrossRef
  • Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh: Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)
    Sabiha Shirin Sara, Ashis Talukder, Ka Yiu Lee, Nayan Basak, Shaharior Rahman Razu, Iqramul Haq, Chuton Deb Nath
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(2): 102706.     CrossRef
  • Effectiveness of Non-Contact Dietary Coaching in Adults with Diabetes or Prediabetes Using a Continuous Glucose Monitoring Device: A Randomized Controlled Trial
    Yeh-Chan Ahn, Yang Seok Kim, Bukyung Kim, Jung Mi Ryu, Myoung Soo Kim, Minkyeong Kang, Jiwon Park
    Healthcare.2023; 11(2): 252.     CrossRef
  • Interactions between Bitter Taste Receptor Gene Variants and Dietary Intake Are Associated with the Incidence of Type 2 Diabetes Mellitus in Middle-Aged and Older Korean Adults
    Kyung Won Lee, Dayeon Shin
    International Journal of Molecular Sciences.2023; 24(3): 2199.     CrossRef
  • Relationship between age at menarche and metabolic diseases in Korean postmenopausal women: The Korea National Health and Nutrition Examination Survey 2016–2018
    Hyein Jung, Yeon-Ah Sung, Young Sun Hong, Do Kyeong Song, So-hyeon Hong, Hyejin Lee, Tatsuo Shimosawa
    PLOS ONE.2023; 18(1): e0280929.     CrossRef
  • Safety and Effectiveness of Empagliflozin in Korean Patients with Type 2 Diabetes Mellitus: Results from a Nationwide Post-Marketing Surveillance
    Jun Sung Moon, Nam Hoon Kim, Jin Oh Na, Jae Hyoung Cho, In-Kyung Jeong, Soon Hee Lee, Ji-Oh Mok, Nan Hee Kim, Dong Jin Chung, Jinhong Cho, Dong Woo Lee, Sun Woo Lee, Kyu Chang Won
    Diabetes & Metabolism Journal.2023; 47(1): 82.     CrossRef
  • Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis
    Shanhu Qiu, Xue Cai, Yan Liang, Wenji Chen, Duolao Wang, Zilin Sun, Bo Xie, Tongzhi Wu
    Diabetes Research and Clinical Practice.2023; 197: 110562.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • Consistency of 1-day and 3-day average dietary intake and the relationship of dietary intake with blood glucose, hbA1c, BMI, and lipids in patients with type 2 diabetes
    DaeEun Lee, Haejung Lee, Sangeun Lee, MinJin Lee, Ah Reum Khang
    Journal of Korean Biological Nursing Science.2023; 25(1): 20.     CrossRef
  • Systematic literature review and meta-analysis of cardiovascular risk factor management in selected Asian countries
    Eric J Yeh, Ruth Bartelli Grigolon, Sarah Ramalho Rodrigues, Ana Paula A Bueno
    Journal of Comparative Effectiveness Research.2023;[Epub]     CrossRef
  • Gut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy
    Ji Eun Kim, Hoonsik Nam, Ji In Park, Hyunjeong Cho, Jangwook Lee, Hyo-Eun Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong-Soo Kim, Sunghyouk Park, Hajeong Lee, Jan Claesen
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Prevalence and associated factors of diabetes mellitus among patients with tuberculosis in South Korea from 2011 to 2018: a nationwide cohort study
    Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Jeong Mi Seo, Hongjo Choi, Young Ae Kang
    BMJ Open.2023; 13(3): e069642.     CrossRef
  • Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
    Kyung-Soo Kim, Kyung Ah Han, Tae Nyun Kim, Cheol-Young Park, Jung Hwan Park, Sang Yong Kim, Yong Hyun Kim, Kee Ho Song, Eun Seok Kang, Chul Sik Kim, Gwanpyo Koh, Jun Goo Kang, Mi Kyung Kim, Ji Min Han, Nan Hee Kim, Ji Oh Mok, Jae Hyuk Lee, Soo Lim, Sang S
    Diabetes & Metabolism.2023; 49(4): 101440.     CrossRef
  • Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
    Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
    PLOS ONE.2023; 18(3): e0283023.     CrossRef
  • Associations Between Modifiable Risk Factors and Changes in Glycemic Status Among Individuals With Prediabetes
    Salma Nabila, Ji-Eun Kim, Jaesung Choi, JooYong Park, Aesun Shin, Sang-Ah Lee, Jong-koo Lee, Daehee Kang, Ji-Yeob Choi
    Diabetes Care.2023; 46(3): 535.     CrossRef
  • Effect of diabetes-specific oral nutritional supplements with allulose on weight and glycemic profiles in overweight or obese type 2 diabetic patients
    Jihye Tak, Minkyung Bok, Hyunkyung Rho, Ju Hyun Park, Yunsook Lim, Suk Chon, Hyunjung Lim
    Nutrition Research and Practice.2023; 17(2): 241.     CrossRef
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    Jung Jea-Bum, Cho Yong-Won , Kim Sang-Yub , Chung Soo-Yeon , Han Kyung-Hoon , Ham Byung-Joo , Han Sung-Hee
    Archives of Food and Nutritional Science.2023; 7(1): 032.     CrossRef
  • Development and Adaptability of Smartphone-based Dietary Coaching Program for Patients Undergoing Diabetes and Prediabetes with Continuous Glucose Monitoring Device
    Myoung Soo Kim, Jung Mi Ryu, Minkyeong Kang, Jiwon Park, Yeh Chan Ahn, Yang Seok Kim
    Journal of Health Informatics and Statistics.2023; 48(1): 36.     CrossRef
  • Risk of Diabetic Complications in Type 2 Diabetes Patients with Dementia: A Population-Based Study Using National Health Insurance Claims Data
    Eun Sik Jeong, Ah-Young Kim, Hye-Young Kang
    Drug Targets and Therapeutics.2023; 2(1): 49.     CrossRef
  • Type 2 Diabetes Mellitus- and Complication-Related Risk of Nontuberculous Mycobacterial Disease in a South Korean Cohort
    Da Som Jeon, Seonok Kim, Mi Ae Kim, Yong Pil Chong, Tae Sun Shim, Chang Hee Jung, Ye-Jee Kim, Kyung-Wook Jo, Paschalis Vergidis, Byung Woo Jhun
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study
    Geun Woo Lee, Chul Ho Lee, Seong Gyu Kim
    Journal of Yeungnam Medical Science.2023; 40(2): 146.     CrossRef
  • RELATIVE RISK OF DIABETES MELLITUS AMONG OBESE POPULATION
    Umair Khalid, Khuram Chaudry, Hina Khuram
    Pakistan Journal of Rehabilitation.2023; 12(1): 93.     CrossRef
  • Public–Private Partnership: Participants’ Experiences of the Web-Based Registration-and-Management System for Patients with Hypertension and Diabetes Mellitus
    Seonah Lee, Nanyoung Song, Suhyun Kim
    Healthcare.2023; 11(9): 1297.     CrossRef
  • Anti-Hyperglycemic Effects of Fermented Mealworm Extract on Type 2 Diabetic Mice
    Hae-In Lee, Asli Turkyilmaz, Mi-Kyung Lee
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(4): 431.     CrossRef
  • A Study on Changes in Nutritional and Blood Conditions Before and After Consumption of Diabetic Soymilk in Elderly Women with Diabetes
    Hyo-Jeong Hwang, Soon-Hee Park, Seon-Young Park, Soo-Rin Ahn, Su-Jin Park, Yoo-Jin Lee, Kwang-Jin Chon, Chung-Hwa Song, Dae-Gyun Moon, Kyung-Ok Shin
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(4): 341.     CrossRef
  • Developing a Classification Algorithm for Prediabetes Risk Detection From Home Care Nursing Notes
    Eunjoo Jeon, Aeri Kim, Jisoo Lee, Hyunsook Heo, Hana Lee, Kyungmi Woo
    CIN: Computers, Informatics, Nursing.2023; 41(7): 539.     CrossRef
  • Chronic disease management program applied to type 2 diabetes patients and prevention of diabetic complications: a retrospective cohort study using nationwide data
    Min Kyung Hyun, Jang Won Lee, Seung-Hyun Ko
    BMC Public Health.2023;[Epub]     CrossRef
  • Peripheral neuropathy and neuropathic pain in the elderly
    Je-Young Shin
    Journal of Geriatric Neurology.2023; 2(1): 7.     CrossRef
  • Cholecystectomy Increases the Risk of Type 2 Diabetes in the Korean Population
    Ji Hye Huh, Kyong Joo Lee, Yun Kyung Cho, Shinje Moon, Yoon Jung Kim, Eun Roh, Kyung-do Han, Dong Hee Koh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
    Annals of Surgery.2023; 278(2): e264.     CrossRef
  • A Novel Salivary Sensor with Integrated Au Electrodes and Conductivity Meters for Screening of Diabetes
    Chen-Wei Lin, Yuan-Hsiung Tsai, Yun-Shing Peng, Jen-Tsung Yang, Yen-Pei Lu, Mei-Yen Chen, Chun-Wu Tung
    Biosensors.2023; 13(7): 702.     CrossRef
  • Pharmacokinetic Comparison Between a Fixed‐Dose Combination of Empagliflozin L‐Proline/Metformin and Empagliflozin/Metformin in Healthy Korean Subjects
    HyunJoon Lee, Jae‐Yong Chung, Kyung‐Sang Yu, Shin‐Jung Park, Soyoung Lee
    Clinical Pharmacology in Drug Development.2023; 12(12): 1156.     CrossRef
  • Comparisons of the prediction models for undiagnosed diabetes between machine learning versus traditional statistical methods
    Seong Gyu Choi, Minsuk Oh, Dong–Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
    Scientific Reports.2023;[Epub]     CrossRef
  • Comparison of therapeutic efficacy and safety of sitagliptin, dapagliflozin, or lobeglitazone adjunct therapy in patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea and metformin: Third agent study
    Jun Hwa Hong, Jun Sung Moon, Kayeon Seong, Soo Lim
    Diabetes Research and Clinical Practice.2023; 203: 110872.     CrossRef
  • Predicting micropollutant fate during wastewater treatment using refined classical kinetic model based on quantitative monitoring in multi-metropolitan regions of South Korea
    Sung Ho Chae, Seung Ji Lim, Mingizem Gashaw Seid, Wondesen Workneh Ejerssa, Aseom Son, Heejong Son, Sangki Choi, Woongbae Lee, Yunho Lee, Seok Won Hong
    Water Research.2023; 245: 120627.     CrossRef
  • Intake of Fruit and Glycemic Control in Korean Patients with Diabetes Mellitus Using the Korea National Health and Nutrition Examination Survey
    Eunju Yoon, Ji Cheol Bae, Sunghwan Suh
    Endocrinology and Metabolism.2023; 38(5): 538.     CrossRef
  • Diabetes Mellitus in the Elderly Adults in Korea: Based on Data from the Korea National Health and Nutrition Examination Survey 2019 to 2020
    Seung-Hyun Ko, Kyung Do Han, Yong-Moon Park, Jae-Seung Yun, Kyuho Kim, Jae-Hyun Bae, Hyuk-Sang Kwon, Nan-Hee Kim
    Diabetes & Metabolism Journal.2023; 47(5): 643.     CrossRef
  • Lower HbA1C of glycemic control is associated with higher risk of depressive symptoms in elderly with type 2 diabetes mellitus–A Nationwide Community-based study
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    Journal of Psychosomatic Research.2023; 174: 111492.     CrossRef
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    Scientific Reports.2023;[Epub]     CrossRef
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    Biomedical Science Letters.2023; 29(3): 159.     CrossRef
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    PLOS ONE.2023; 18(12): e0295556.     CrossRef
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  • Relationships between fasting glucose levels, lifestyle factors, and metabolic parameters in Korean adults without diagnosis of diabetes mellitus
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  • Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015–2017
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    International Journal of Hygiene and Environmental Health.2022; 240: 113886.     CrossRef
  • Trends in intake and sources of dietary protein in Korean adults, 1998–2018
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  • Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study
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  • East Asian perspectives in metabolic and bariatric surgery
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  • Substitution of Carbohydrates for Fats and Risk of Type 2 Diabetes among Korean Middle-Aged Adults: Findings from the Korean Genome and Epidemiology Study
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    Nutrients.2022; 14(3): 654.     CrossRef
  • Comparison of Health Outcomes by Care Provider Type for Newly Diagnosed Mild Type 2 Diabetes Patients in South Korea: A Retrospective Cohort Study
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    Food Bioscience.2022; 47: 101634.     CrossRef
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    PLOS ONE.2022; 17(3): e0264291.     CrossRef
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  • Korean naked waxy barley (saechalssal) extract reduces blood glucose in diabetic mice by modulating the PI3K-Akt-GSK3β pathway
    Ju Ri Ham, Young-Jin Son, Yongjin Lee, Hyun-Jin Lee, Jiyoung Yeo, Mi Ja Lee, Mi-Kyung Lee
    Biomedicine & Pharmacotherapy.2022; 150: 112976.     CrossRef
  • Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study
    Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2022; 37(2): 272.     CrossRef
  • Suicide Risk in Patients With Diabetes Varies by the Duration of Diabetes: The Korea National Health and Nutrition Examination Survey (2019)
    Young-Chan Kim, Yoo Hyun Um, Sung-Min Kim, Tae-Won Kim, Ho-Jun Seo, Seung-Chul Hong, Jong-Hyun Jeong
    Psychiatry Investigation.2022; 19(4): 326.     CrossRef
  • Gene‐environment interaction in type 2 diabetes in Korean cohorts: Interaction of a type 2 diabetes polygenic risk score with triglyceride and cholesterol on fasting glucose levels
    Ji Eun Lim, Ji‐one Kang, Tae‐Woong Ha, Hae‐Un Jung, Dong Jun Kim, Eun Ju Baek, Han Kyul Kim, Ju Yeon Chung, Sang Youl Rhee, Mi Kyung Kim, Yeon‐Jung Kim, Taesung Park, Bermseok Oh
    Genetic Epidemiology.2022; 46(5-6): 285.     CrossRef
  • The predictive value of resting heart rate in identifying undiagnosed diabetes in Korean adults: Korea National Health and Nutrition Examination Survey
    Dong-Hyuk Park, Wonhee Cho, Yong-Ho Lee, Sun Ha Jee, Justin Y. Jeon
    Epidemiology and Health.2022; 44: e2022009.     CrossRef
  • Experiences of Sleep Problems Among Older Korean Immigrants
    Yeonsu Song, Gery W. Ryan, Diane Lee, Haesook Kim, Jennifer L. Martin, B. Josea Kramer, Ron D. Hays, Sarah E. Choi
    Research in Gerontological Nursing.2022; 15(4): 193.     CrossRef
  • Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
    Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sung
    Diabetes & Metabolism Journal.2022; 46(3): 464.     CrossRef
  • Diabetes Fact Sheet in Korea 2021
    Jae Hyun Bae, Kyung-Do Han, Seung-Hyun Ko, Ye Seul Yang, Jong Han Choi, Kyung Mook Choi, Hyuk-Sang Kwon, Kyu Chang Won
    Diabetes & Metabolism Journal.2022; 46(3): 417.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Diabetes & Metabolism Journal.2022; 46(3): 355.     CrossRef
  • Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
    Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim
    Diabetes & Metabolism Journal.2022; 46(3): 402.     CrossRef
  • Effect of carbohydrate-restricted diets and intermittent fasting on obesity, type 2 diabetes mellitus, and hypertension management: consensus statement of the Korean Society for the Study of obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Clinical Hypertension.2022;[Epub]     CrossRef
  • A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study
    Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim
    Diabetes, Obesity and Metabolism.2022; 24(9): 1800.     CrossRef
  • Association of prediabetes with death and diabetic complications in older adults: the pros and cons of active screening for prediabetes
    Giwoong Choi, Hojun Yoon, Hyun Ho Choi, Kyoung Hwa Ha, Dae Jung Kim
    Age and Ageing.2022;[Epub]     CrossRef
  • Recent information on test utilization and intraindividual change in anti-glutamic acid decarboxylase antibody in Korea: a retrospective study
    Rihwa Choi, Wonseo Park, Gayoung Chun, Jiwon Lee, Sang Gon Lee, Eun Hee Lee
    BMJ Open Diabetes Research & Care.2022; 10(3): e002739.     CrossRef
  • Correlation of advanced glycation end products and heme oxygenase-1 in Korean diabetic patients
    Ha-Neul Choi, Da-Hye Koo, Jung-Eun Yim
    Journal of Nutrition and Health.2022; 55(3): 348.     CrossRef
  • The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
    Sung-Soo Kim, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(7): 1099.     CrossRef
  • Development and implementation of patient-level prediction models of end-stage renal disease for type 2 diabetes patients using fast healthcare interoperability resources
    San Wang, Jieun Han, Se Young Jung, Tae Jung Oh, Sen Yao, Sanghee Lim, Hee Hwang, Ho-Young Lee, Haeun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Optical-fibre characteristics based on Fano resonances and sensor application in blood glucose detection
    Jun Zhu, Jinguo Yin
    Optics Express.2022; 30(15): 26749.     CrossRef
  • Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hype
    Jong Han Choi, Yoon Jeong Cho, Hyun-Jin Kim, Seung-Hyun Ko, Suk Chon, Jee-Hyun Kang, Kyoung-Kon Kim, Eun Mi Kim, Hyun Jung Kim, Kee-Ho Song, Ga Eun Nam, Kwang Il Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 100.     CrossRef
  • Maintaining Physical Activity Is Associated with Reduced Major Adverse Cardiovascular Events in People Newly Diagnosed with Diabetes
    Duhoe Kim, Jaehun Seo, Kyoung Hwa Ha, Dae Jung Kim
    Journal of Obesity & Metabolic Syndrome.2022; 31(2): 187.     CrossRef
  • Prevalence of Diabetic Retinopathy in Undiagnosed Diabetic Patients: A Nationwide Population-Based Study
    Han Na Jang, Min Kyong Moon, Bo Kyung Koo
    Diabetes & Metabolism Journal.2022; 46(4): 620.     CrossRef
  • Reproductive Life Span and Severe Hypoglycemia Risk in Postmenopausal Women with Type 2 Diabetes Mellitus
    Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2022; 46(4): 578.     CrossRef
  • Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus
    Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
    Nutrients.2022; 14(15): 3086.     CrossRef
  • The Association of Pachydrusen Characteristics with Choroidal Thickness and Patient’s Age in Polypoidal Choroidal Vasculopathy versus Central Serous Chorioretinopathy
    Young Ho Kim, Yoo-Ri Chung, Chungwoon Kim, Kihwang Lee, Won Ki Lee
    International Journal of Molecular Sciences.2022; 23(15): 8353.     CrossRef
  • Experiences of Using Wearable Continuous Glucose Monitors in Adults With Diabetes: A Qualitative Descriptive Study
    Hee Sun Kang, Hyang Rang Park, Chun-Ja Kim, Savitri Singh-Carlson
    The Science of Diabetes Self-Management and Care.2022; 48(5): 362.     CrossRef
  • Prediction Model for Hypertension and Diabetes Mellitus Using Korean Public Health Examination Data (2002–2017)
    Yong Whi Jeong, Yeojin Jung, Hoyeon Jeong, Ji Hye Huh, Ki-Chul Sung, Jeong-Hun Shin, Hyeon Chang Kim, Jang Young Kim, Dae Ryong Kang
    Diagnostics.2022; 12(8): 1967.     CrossRef
  • Recent Increases in Influenza-Related Hospitalizations, Critical Care Resource Use, and In-Hospital Mortality: A 10-Year Population-Based Study in South Korea
    Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park
    Journal of Clinical Medicine.2022; 11(16): 4911.     CrossRef
  • Clinical and economic impact of changing reimbursement criteria for statin treatment among patients with type 2 diabetes mellitus in South Korea
    Siin Kim, Kyungseon Choi, Ji-yool Kim, Hae Sun Suh
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Experience of Elderly Korean Women with Diabetes and Multimorbidity in Elderly Couple Households: A Qualitative Study
    Oksoo Kim, Hyunju Dan
    Healthcare.2022; 10(9): 1675.     CrossRef
  • Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a Tertiary University Hospital
    Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Sex and Diet-Related Disparities in Low Handgrip Strength among Young and Middle-Aged Koreans: Findings Based on the Korea National Health and Nutrition Examination Survey (KNHANES) from 2014 to 2017
    Inhye Kim, Kumhee Son, Su Jin Jeong, Hyunjung Lim
    Nutrients.2022; 14(18): 3816.     CrossRef
  • Rising Incidence of Diabetes in Young Adults in South Korea: A National Cohort Study
    Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes & Metabolism Journal.2022; 46(5): 803.     CrossRef
  • Analysis of the Association between Metabolic Syndrome and Renal Function in Middle-Aged Patients with Diabetes
    Yoonjin Park, Su Jung Lee
    International Journal of Environmental Research and Public Health.2022; 19(18): 11832.     CrossRef
  • Exploring the risk factors of impaired fasting glucose in middle-aged population living in South Korean communities by using categorical boosting machine
    Haewon Byeon
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Body mass index and stroke risk among patients with diabetes mellitus in Korea
    Do Kyeong Song, Young Sun Hong, Yeon-Ah Sung, Hyejin Lee, Tariq Jamal Siddiqi
    PLOS ONE.2022; 17(9): e0275393.     CrossRef
  • Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population
    Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang, Giacomo Pucci
    PLOS ONE.2022; 17(10): e0275746.     CrossRef
  • Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes
    Tae Kyung Yoo, Mi Yeon Lee, Sul A. Lee, Eun Sun Cheong, Mi Hae Seo, Ki Chul Sung
    Journal of Clinical Medicine.2022; 11(19): 5933.     CrossRef
  • Risk of Carotid Atherosclerosis in Subjects with Prediabetes Overlapping Metabolic Syndrome
    Seol A Jang, Kyoung Min Kim, Seok Won Park, Chul Sik Kim
    Metabolic Syndrome and Related Disorders.2022; 20(10): 599.     CrossRef
  • Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study
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    Frontiers in Endocrinology.2022;[Epub]     CrossRef
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    Journal of the Korean Fracture Society.2022; 35(4): 135.     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
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    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Musculoskeletal complications in patients with diabetes mellitus
    Jong Han Choi, Hae-Rim Kim, Kee-Ho Song
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  • Blood Biochemical Characteristics, Dietary Intake, and Risk Factors Related to Poor HbA1c Control in Elderly Korean Diabetes Patients: Comparison between the 4th(2007-2009) and the 7th(2016-2018) Korea National Health and Nutrition Examination Surveys
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    Korean Journal of Community Nutrition.2022; 27(5): 406.     CrossRef
  • Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness
    Juyoung Shin, Joonyub Lee, Taehoon Ko, Kanghyuck Lee, Yera Choi, Hun-Sung Kim
    Journal of Personalized Medicine.2022; 12(11): 1899.     CrossRef
  • Brachial-ankle pulse wave velocity as a predictor of long-term cardiovascular events in 2174 subjects with type 2 diabetes mellitus: A retrospective cohort study
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    Medicine.2022; 101(45): e31758.     CrossRef
  • Artificial Intelligence-based Prediction of Diabetes and Prediabetes Using Health Checkup Data in Korea
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    Diabetes & Metabolism Journal.2022; 46(6): 879.     CrossRef
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    Diabetes & Metabolism Journal.2022; 46(6): 819.     CrossRef
  • Classification of Type 2 Diabetes Incidence Risk and the Health Behavior of the 30–50-Year-Old Korean Adults: Latent Class Analysis
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    International Journal of Environmental Research and Public Health.2022; 19(24): 16600.     CrossRef
  • Association between Amount of Alcohol Consumption and Serum Fasting Glucose Level in Korean Male in their 40s and 50s: The Seventh Korea National Health and Nutrition Examination Survey 2016-2018
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    Korean Journal of Family Practice.2022; 12(5): 320.     CrossRef
  • Associated Factors with Health-related Quality of Life among Older Adults with Diabetes in Korea
    Eun-Kyung Lee, Sun-Young Jung
    The Korean Journal of Rehabilitation Nursing.2022; 25(2): 61.     CrossRef
  • Chronic Disease Prediction Using the Common Data Model: Development Study
    Chanjung Lee, Brian Jo, Hyunki Woo, Yoori Im, Rae Woong Park, ChulHyoung Park
    JMIR AI.2022; 1(1): e41030.     CrossRef
  • Threshold Dose-Response Association between Smoking Pack-Years and the Risk of Gallbladder Cancer: A Nationwide Cohort Study
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    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • The risk of stroke according to statin medication compliance in older people with chronic periodontitis: an analysis using the Korea National Health Insurance Service-Senior Cohort Database
    Seon-Rye Kim, Minkook Son, Yu-Rin Kim
    Epidemiology and Health.2022; 44: e2022055.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
    Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
  • Treatment Patterns of Type 2 Diabetes Assessed Using a Common Data Model Based on Electronic Health Records of 2000–2019
    Kyung Ae Lee, Heung Yong Jin, Yu Ji Kim, Yong-Jin Im, Eun-Young Kim, Tae Sun Park
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Factors Associated with Depressive Symptoms in Korean Adults with Diabetes Mellitus: A Cross-Sectional Study
    Mihyun Jeong
    Healthcare.2021; 9(8): 1049.     CrossRef
  • Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
    Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
    The Korean Journal of Internal Medicine.2021; 36(5): 1049.     CrossRef
  • Metabolic Effects of Gastrectomy and Duodenal Bypass in Early Gastric Cancer Patients with T2DM: A Prospective Single-Center Cohort Study
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    Journal of Clinical Medicine.2021; 10(17): 4008.     CrossRef
  • Sex- and Age-Specific Trends in Cardiovascular Health in Korea, 2007–2018
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    Korean Circulation Journal.2021; 51(11): 922.     CrossRef
  • Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: 52-Week Results from a Prospective Observational Study
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    Diabetes Therapy.2021; 12(11): 2907.     CrossRef
  • RANTES 59029A/G Polymorphisms Associated with Diabetic Compilations in Korean Patients with Type 2 Diabetes for over 15 Years
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    Genes.2021; 12(9): 1445.     CrossRef
  • Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study
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    Journal of Lipid and Atherosclerosis.2021; 10(3): 303.     CrossRef
  • A Century of Progress in Diabetes Care with Insulin: A History of Innovations and Foundation for the Future
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    Diabetes & Metabolism Journal.2021; 45(5): 629.     CrossRef
  • Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
    Young-eun Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
    Diabetes Research and Clinical Practice.2021; 181: 109082.     CrossRef
  • Symptom Clusters and Quality of Life in Patients with Type 2 Diabetes Mellitus
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  • The association between triglyceride-glucose index, cardio-cerebrovascular diseases, and death in Korean adults: A retrospective study based on the NHIS-HEALS cohort
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    PLOS ONE.2021; 16(11): e0259212.     CrossRef
  • Effect of Breastfeeding and Its Duration on Impaired Fasting Glucose and Diabetes in Perimenopausal and Postmenopausal Women: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2019
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    Medicines.2021; 8(11): 71.     CrossRef
  • The Correlation between Carotid Intima-Media Thickness and Neutrophil to Lymphocyte Ratio in Prediabetes Patients
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    Korean Journal of Family Medicine.2021; 42(6): 464.     CrossRef
  • Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
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    BMC Geriatrics.2021;[Epub]     CrossRef
  • Restoration for the foregut surgery: bridging gaps between foregut surgery practice and academia
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    JAMA.2021; 326(24): 2498.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea
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    The Journal of Korean Diabetes.2021; 22(4): 244.     CrossRef
  • Spatiotemporal analyses of the epidemiological characteristics of diabetes mellitus
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    Epidemiology and Health.2021; 43: e2021102.     CrossRef
  • Associations between grip strength and glycemic control in type 2 diabetes mellitus: an analysis of data from the 2014-2019 Korea National Health and Nutrition Examination Survey
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    Epidemiology and Health.2021; 43: e2021080.     CrossRef
Metabolic Risk/Epidemiology
Metabolic Health, Obesity, and the Risk of Developing Open-Angle Glaucoma: Metabolically Healthy Obese Patients versus Metabolically Unhealthy but Normal Weight Patients
Younhea Jung, Kyungdo Han, Hae-Young L. Park, Seung Hoon Lee, Chan Kee Park
Diabetes Metab J. 2020;44(3):414-425.   Published online December 23, 2019
DOI: https://doi.org/10.4093/dmj.2019.0048
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AbstractAbstract PDFPubReader   
Background

This study sought to investigate the associations between metabolic health status, obesity, and incidence of primary open-angle glaucoma (POAG).

Methods

In this nationwide, population-based, longitudinal prospective cohort study conducted using the Korean National Health Insurance System, we categorized all subjects based on presence and severity of metabolic syndrome and obesity. Insurance claims data were used to identify POAG development. Then, Cox regression was applied to calculate the hazard of developing POAG in people with various components of metabolic syndrome, obesity, or their combination.

Results

Of the total 287,553 subjects, 4,970 (1.3%) developed POAG. High fasting glucose, blood pressure, and total cholesterol levels were all associated with increased risk of developing POAG. Regarding obesity level, people with body mass index (BMI) greater than 30 kg/m2 were more likely to develop POAG than those with normal BMI. Also, people with greater number of metabolic syndrome components showed a greater POAG incidence. People who are metabolically unhealthy and obese (adjusted hazard ratio [HR], 1.574; 95% confidence interval [CI], 1.449 to 1.711) and those who are metabolically unhealthy nonobese (MUNO: adjusted HR, 1.521; 95% CI, 1.405 to 1.645) but not those who are metabolically healthy obese (MHO: adjusted HR, 1.019; 95% CI, 0.907 to 1.144) had an increased hazard of developing POAG compared with metabolically healthy nonobese (MHNO) subjects.

Conclusion

Metabolic health status and obesity were significantly associated with increased risk of POAG incidence. MUNO subjects but not MHO subjects showed a higher risk of POAG development than did MHNO subjects, suggesting that metabolic status is more important than obesity in POAG.

Citations

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  • The Association between the Gut Microbiota and Erectile Dysfunction
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    Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda,
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  • Association between Glucagon-like Peptide-1 Receptor Agonists and the Risk of Glaucoma in Individuals with Type 2 Diabetes
    Siar Niazi, Filip Gnesin, Anna-Sophie Thein, Jens R. Andreasen, Anna Horwitz, Zaynab A. Mouhammad, Baker N. Jawad, Zia Niazi, Nelsan Pourhadi, Bochra Zareini, Amani Meaidi, Christian Torp-Pedersen, Miriam Kolko
    Ophthalmology.2024;[Epub]     CrossRef
  • Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population
    Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Keng
    American Journal of Ophthalmology.2023; 245: 193.     CrossRef
  • Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma
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    International Journal of Molecular Sciences.2023; 24(2): 1166.     CrossRef
  • Phenotypic and Genetic Links between Body Fat Measurements and Primary Open-Angle Glaucoma
    Shi Song Rong, Xinting Yu
    International Journal of Molecular Sciences.2023; 24(4): 3925.     CrossRef
  • Metabolic Health, Obesity, and Intraocular Pressure
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    Journal of Clinical Medicine.2023; 12(5): 2066.     CrossRef
  • Association between lifestyle habits and glaucoma incidence: a retrospective cohort study
    Asahi Fujita, Yohei Hashimoto, Hiroki Matsui, Hideo Yasunaga, Makoto Aihara
    Eye.2023; 37(16): 3470.     CrossRef
  • Towards precision medicine in bariatric surgery prescription
    Sofia S. Pereira, Marta Guimarães, Mariana P. Monteiro
    Reviews in Endocrine and Metabolic Disorders.2023; 24(5): 961.     CrossRef
  • Study of the relationship between serum lipid levels and primary open-angle glaucoma
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    Indian Journal of Ophthalmology.2023; 71(5): 1948.     CrossRef
  • Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype–phenotype correlations in southern Chinese population
    Zhenggen Wu, Chukai Huang, Yuqian Zheng, Xiang-Ling Yuan, Shaowan Chen, Yanxuan Xu, Li Jia Chen, Chi Pui Pang, Mingzhi Zhang, Tsz Kin Ng
    Molecular Genetics and Genomics.2023; 298(6): 1343.     CrossRef
  • Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head
    Ryo Asaoka, Rei Sakata, Takeshi Yoshitomi, Aiko Iwase, Chota Matsumoto, Tomomi Higashide, Motohiro Shirakashi, Makoto Aihara, Kazuhisa Sugiyama, Makoto Araie
    Translational Vision Science & Technology.2023; 12(8): 19.     CrossRef
  • The association between obesity and glaucoma in older adults: evidence from the China Health and Retirement Longitudinal Study
    Xiaohuan Zhao, Qiyu Bo, Junran Sun, Jieqiong Chen, Tong Li, Xiaoxu Huang, Minwen Zhou, Jing Wang, Wenjia Liu, Xiaodong Sun
    Epidemiology and Health.2023; 45: e2023034.     CrossRef
  • Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study
    Jun-Hyuk Lee, Yu-Jin Kwon, Sung Jin Kim, Boyoung Joung
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Angiotensin Converting Enzyme Inhibitors: Interaction Issues in Patients with Glaucoma and Arterial Hypertension. Review
    S. I. Makogon, D. I. Ivanova, A. L. Onishchenko
    Ophthalmology in Russia.2023; 20(4): 641.     CrossRef
  • The role of the microbiota in glaucoma
    Ling Huang, Yiwen Hong, Xiangyu Fu, Haishan Tan, Yongjiang Chen, Yujiao Wang, Danian Chen
    Molecular Aspects of Medicine.2023; 94: 101221.     CrossRef
  • Girl Power in Glaucoma: The Role of Estrogen in Primary Open Angle Glaucoma
    Kyrylo Fotesko, Bo Schneider Vohra Thomsen, Miriam Kolko, Rupali Vohra
    Cellular and Molecular Neurobiology.2022; 42(1): 41.     CrossRef
  • Cholesterol and glaucoma: a systematic review and meta‐analysis
    Laura Posch‐Pertl, Monja Michelitsch, Gernot Wagner, Brigitte Wildner, Günther Silbernagel, Gudrun Pregartner, Andreas Wedrich
    Acta Ophthalmologica.2022; 100(2): 148.     CrossRef
  • Non-drug interventions in glaucoma: Putative roles for lifestyle, diet and nutritional supplements
    Foroogh Fahmideh, Nicoletta Marchesi, Annalisa Barbieri, Stefano Govoni, Alessia Pascale
    Survey of Ophthalmology.2022; 67(3): 675.     CrossRef
  • Relationship between Using Fibrate and Open-Angle Glaucoma in Hyperlipidemic Patients: A Population-Based Cohort Study
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    International Journal of Environmental Research and Public Health.2022; 19(4): 2415.     CrossRef
  • The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study
    Yi Lin, Xiaomin Zhu, Wangdu Luo, Bingcai Jiang, Qianyi Lin, Min Tang, Xiangji Li, Lin Xie
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Enzymatic activity of paraoxonase depending on polymorphism Q192R of the PON1 gene in patients with primary open-angle glaucoma
    Yu.E. Filippova, T.N. Malishevskaya, S.A. Petrov, D.G. Gubin, A.S. Vlasova
    Vestnik oftal'mologii.2022; 138(2): 58.     CrossRef
  • Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population
    Kristi Y. Wu, David O. Hodge, Launia J. White, Jacinta McDonald, Gavin W. Roddy
    Journal of Glaucoma.2022; 31(6): e18.     CrossRef
  • Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Nathalie Kliemann, Romain Ould Ammar, Carine Biessy, Audrey Gicquiau, Verena Katzke, Rudolf Kaaks, Anne Tjønneland, Anja Olsen, Maria-Jose Sánchez, Marta Crous-Bou, Fabrizio Pasanisi, Sandar Tin Tin, Aurora Perez-Cornago, Dagfinn Aune, Sofia Christakoudi,
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(7): 1359.     CrossRef
  • Clinical Practice Management of Primary Open-Angle Glaucoma in the United States: An Analysis of Real-World Evidence
    Joseph S Imperato, Kelly H Zou, Jim Z Li, Tarek A Hassan
    Patient Preference and Adherence.2022; Volume 16: 2213.     CrossRef
  • Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma
    Guimei Huang, Jiayi Wang, Lei Li, Yuan Gao, Yijie Yan, Xi Lou
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Body shape and risk of glaucoma: A Mendelian randomization
    Ruolan Yuan, Kangcheng Liu, Yingjun Cai, Fei He, Xiaoxiong Xiao, Jing Zou
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Impact of Systemic Comorbidities on Ocular Hypertension and Open-Angle Glaucoma, in a Population from Spain and Portugal
    Carolina Garcia-Villanueva, Elena Milla, José M. Bolarin, José J. García-Medina, Javier Cruz-Espinosa, Javier Benítez-del-Castillo, José Salgado-Borges, Francisco J. Hernández-Martínez, Elena Bendala-Tufanisco, Irene Andrés-Blasco, Alex Gallego-Martinez,
    Journal of Clinical Medicine.2022; 11(19): 5649.     CrossRef
  • Metabolic syndrome and its components are associated with non-arteritic anterior ischaemic optic neuropathy
    Darrell Kohli, Kristi Y Wu, Launia J White, David O Hodge, John J Chen, Gavin W Roddy
    BMJ Open Ophthalmology.2022; 7(1): e001111.     CrossRef
  • Blood Pressure Measures and Incident Primary Open-Angle Glaucoma
    Carmelo Macri, Christopher X. Wong, Samuel J. Tu, Robert Casson, Kuldev Singh, Sophia Y. Wang, Michelle T. Sun
    Investigative Opthalmology & Visual Science.2022; 63(13): 3.     CrossRef
  • Relationship between anthropometric and biochemical changes of metabolic syndrome with retinal nerve fiber layer and macular thickness
    Sze Hui New, Sue Ngein Leow, Suresh Kumar Vasudevan, Idayu Badilla Idris, Seng Fai Tang, Norshamsiah Md Din, Bang V Bui
    PLOS ONE.2021; 16(2): e0246830.     CrossRef
  • Metabolic syndrome and the aging retina
    Gavin W. Roddy
    Current Opinion in Ophthalmology.2021; 32(3): 280.     CrossRef
  • Automated Detection of Glaucoma With Interpretable Machine Learning Using Clinical Data and Multimodal Retinal Images
    Parmita Mehta, Christine A. Petersen, Joanne C. Wen, Michael R. Banitt, Philip P. Chen, Karine D. Bojikian, Catherine Egan, Su-In Lee, Magdalena Balazinska, Aaron Y. Lee, Ariel Rokem
    American Journal of Ophthalmology.2021; 231: 154.     CrossRef
  • Association of Hypertriglyceridemia and Incident Glaucoma in a Rural Chinese Population: The Handan Eye Study
    Ye Zhang, Qing Zhang, Ravi Thomas, Si Zhen Li, Ning Li Wang
    Translational Vision Science & Technology.2021; 10(8): 25.     CrossRef
  • Risk of Glaucoma Associated with Components of Metabolic Disease in Taiwan: A Nationwide Population-Based Study
    Ya-Wen Chang, Fung-Chang Sung, Ya-Ling Tzeng, Chih-Hsin Mou, Peng-Tai Tien, Cheng-Wen Su, Yu-Kuei Teng
    International Journal of Environmental Research and Public Health.2021; 19(1): 305.     CrossRef
  • Metabolic Syndrome Is Associated With Ocular Hypertension and Glaucoma
    Gavin W. Roddy
    Journal of Glaucoma.2020; 29(9): 726.     CrossRef
  • Association of dipping status of blood pressure, visual field defects, and retinal nerve fiber layer thickness in patients with normotensive glaucoma
    Seung Uk Lee, Han Su Park, Bong Joon Kim, Hyun Su Kim, Jung Ho Heo, Sung Il Im
    Medicine.2020; 99(50): e23565.     CrossRef
  • Ocular findings in metabolic syndrome: a review
    Mário Lima-Fontes, Pedro Barata, Manuel Falcão, Ângela Carneiro
    Porto Biomedical Journal.2020; 5(6): 104.     CrossRef
Epidemiology
Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
Diabetes Metab J. 2019;43(4):487-494.   Published online July 17, 2019
DOI: https://doi.org/10.4093/dmj.2019.0067
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AbstractAbstract PDFPubReader   
Background

The objective of this study was to investigate the prevalence, management, and comorbidities of diabetes among Korean adults aged 30 years and older.

Methods

This study used 2013 to 2016 data from the Korea National Health and Nutrition Examination Survey, a nationally-representative survey of the Korean population. Diabetes was defined as fasting glucose ≥126 mg/dL, current use of antidiabetic medication, a previous history of diabetes, or glycosylated hemoglobin (HbA1c) ≥6.5%.

Results

In 2016, 14.4% (approximately 5.02 million) of Korean adults had diabetes. The prevalence of impaired fasting glucose was 25.3% (8.71 million). From 2013 to 2016, the awareness, control, and treatment rates for diabetes were 62.6%, 56.7%, and 25.1%, respectively. People with diabetes had the following comorbidities: obesity (50.4%), abdominal obesity (47.8%), hypertension (55.3%), and hypercholesterolemia (34.9%). The 25.1%, 68.4%, and 44.2% of people with diabetes achieved HbA1c <6.5%, blood pressure <140/85 mm Hg, and low density lipoprotein cholesterol <100 mg/dL. Only 8.4% of people with diabetes had good control of all three targets.

Conclusion

This study confirms that diabetes is as an important public health problem. Efforts should be made to increase awareness, detection, and comprehensive management of diabetes to reduce diabetes-related morbidity and mortality.

Citations

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  • Social Support, eHealth Literacy, and mHealth Use in Older Adults With Diabetes
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    CIN: Computers, Informatics, Nursing.2024; 42(2): 136.     CrossRef
  • Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes: a nationwide cohort study
    Sohee Park, Han Eol Jeong, In-Sun Oh, Sangmo Hong, Sung Hoon Yu, Chang Beom Lee, Ju-Young Shin
    BMJ Open.2024; 14(4): e077084.     CrossRef
  • Gamma‐glutamyl transferase and the risk of all‐cause and disease‐specific mortality in patients with diabetes: A nationwide cohort study
    Goh Eun Chung, Su‐Min Jeong, Su Jong Yu, Jeong‐Ju Yoo, Yuri Cho, Kyu‐na Lee, Dong Wook Shin, Yoon Jun Kim, Jung‐Hwan Yoon, Kyungdo Han, Eun Ju Cho
    Journal of Diabetes.2024;[Epub]     CrossRef
  • Prognostic value of resting heart rate in predicting undiagnosed diabetes in adults: Korean National Health and Nutrition Examination Survey 2008–2018
    Dong-Hyuk Park, Seon Young Goo, Sung Hyun Hong, Ji-hee Min, Ji Yong Byeon, Mi-Kyung Lee, Hae Dong Lee, Byoung Wook Ahn, Heejin Kimm, Sun Ha Jee, Dong Hoon Lee, Yong-ho Lee, Eun Seok Kang, Justin Y. Jeon
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(1): 141.     CrossRef
  • Levels and correlates of risk factor control in diabetes mellitus –ELSA-Brasil
    Bruna Cristine Chwal, Rodrigo Citton Padilha dos Reis, Maria Inês Schmidt, Bruce B. Duncan, Sandhi Maria Barreto, Rosane Harter Griep
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients
    Jaewon Khil, Sung Min Kim, Jooyoung Chang, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Sang Min Park, NaNa Keum
    Scientific Reports.2023;[Epub]     CrossRef
  • Effects of dapagliflozin compared with glimepiride on body composition in Asian patients with type 2 diabetes inadequately controlled with metformin: The BEYOND study
    Hyeong Kyu Park, Kyoung‐Ah Kim, Kyung‐Wan Min, Tae‐Seo Sohn, In Kyung Jeong, Chul Woo Ahn, Nan‐Hee Kim, Ie Byung Park, Ho Chan Cho, Choon Hee Chung, Sung Hee Choi, Kang Seo Park, Seoung‐Oh Yang, Kwan Woo Lee
    Diabetes, Obesity and Metabolism.2023; 25(9): 2743.     CrossRef
  • Comparison of SGLT2 inhibitors with DPP-4 inhibitors combined with metformin in patients with acute myocardial infarction and diabetes mellitus
    Young Sang Lyu, Seok Oh, Jin Hwa Kim, Sang Yong Kim, Myung Ho Jeong
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Association between Smoking Cessation and the Risk of Cholangiocarcinoma and Ampulla of Vater Cancer: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    Liver Cancer.2023; 12(5): 457.     CrossRef
  • Achievement of Treatment Goals and Mortality in Individuals with Diabetes: The ELSA-Brasil Study
    Bruna Cristine Chwal, Rodrigo Citton P. dos Reis, Maria Inês Schmidt, Sandhi Maria Barreto, Rosane Harter Griep, Bruce B. Duncan
    Journal of Clinical Medicine.2023; 12(24): 7663.     CrossRef
  • Cigarette Smoking and Risk of Infection-Related Mortality: A Cohort Study
    Hae Suk Cheong, Yoosoo Chang, Eun-Jeong Joo, Seungho Ryu
    Nicotine & Tobacco Research.2022; 24(2): 204.     CrossRef
  • Angiotensin‐converting enzyme inhibitors versus angiotensin receptor blockers: New‐onset diabetes mellitus stratified by statin use
    Juyoung Shin, Hyunah Kim, Hyeon Woo Yim, Ju Han Kim, Suehyun Lee, Hun‐Sung Kim
    Journal of Clinical Pharmacy and Therapeutics.2022; 47(1): 97.     CrossRef
  • Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Inae Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Min Kyong Moon
    International Journal of Hygiene and Environmental Health.2022; 240: 113886.     CrossRef
  • Factors Associated with Chronic Disease and Health Care Utilization Among Young Adults in South Korea
    Jongho Park, Yeaeun Kim
    Population Health Management.2022; 25(3): 407.     CrossRef
  • Sleep duration and mortality in patients with diabetes: Results from the 2007–2015 Korea national health and nutrition examination survey
    Kang-Mo Gu, Se Hee Min, Jaeyoung Cho
    Diabetes & Metabolism.2022; 48(3): 101312.     CrossRef
  • Retinal Vascular Caliber Changes in Early Type 2 Diabetic Patients without Retinopathy
    Jeong Woo Park, Jeong Hun Bae, Su Jeong Song, Joon Mo Kim
    Journal of the Korean Ophthalmological Society.2022; 63(1): 20.     CrossRef
  • Association Between Long Working Hours and Chronic Kidney Disease According to Diabetic Status
    Ki Duk Kim, Suk-Yong Jang
    Journal of Occupational & Environmental Medicine.2022; 64(3): 190.     CrossRef
  • Sodium–glucose cotransporter 2 inhibitors do not increase the risk of fractures in real‐world clinical practice in Korea: A national observational cohort study
    Kyoung Hwa Ha, Dae Jung Kim, Yong Jun Choi
    Journal of Diabetes Investigation.2022; 13(6): 986.     CrossRef
  • Improvement of Lipotoxicity-Induced Islet β Cellular Insulin Secretion Disorder by Osteocalcin
    Yafang Zhang, Ling Li, Yongze Zhang, Sunjie Yan, Lingning Huang, Riccardo Calafiore
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • Association between gastric cancer and the risk of depression among South Korean adults
    Sinyoung Kwon, Jinyeong Kim, Taeyeon Kim, Wonjeong Jeong, Eun-Cheol Park
    BMC Psychiatry.2022;[Epub]     CrossRef
  • Performance of Diabetes and Kidney Disease Screening Scores in Contemporary United States and Korean Populations
    Liela Meng, Keun-Sang Kwon, Dae Jung Kim, Yong-ho Lee, Jeehyoung Kim, Abhijit V. Kshirsagar, Heejung Bang
    Diabetes & Metabolism Journal.2022; 46(2): 273.     CrossRef
  • Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
    Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sung
    Diabetes & Metabolism Journal.2022; 46(3): 464.     CrossRef
  • Normalized Creatinine-to-Cystatin C Ratio and Risk of Diabetes in Middle-Aged and Older Adults: The China Health and Retirement Longitudinal Study
    Shanhu Qiu, Xue Cai, Bo Xie, Yang Yuan, Zilin Sun, Tongzhi Wu
    Diabetes & Metabolism Journal.2022; 46(3): 476.     CrossRef
  • A double‐blind, Randomized controlled trial on glucose‐lowering EFfects and safety of adding 0.25 or 0.5 mg lobeglitazone in type 2 diabetes patients with INadequate control on metformin and dipeptidyl peptidase‐4 inhibitor therapy: REFIND study
    Soree Ryang, Sang Soo Kim, Ji Cheol Bae, Ji Min Han, Su Kyoung Kwon, Young Il Kim, Il Seong Nam‐Goong, Eun Sook Kim, Mi‐kyung Kim, Chang Won Lee, Soyeon Yoo, Gwanpyo Koh, Min Jeong Kwon, Jeong Hyun Park, In Joo Kim
    Diabetes, Obesity and Metabolism.2022; 24(9): 1800.     CrossRef
  • Long‐term clinical outcomes of oral antidiabetic drugs as fixed‐dose combinations: A nationwide retrospective cohort study
    Sang‐Jun Cho, In‐Sun Oh, Han Eol Jeong, Young Min Cho, Yul Hwangbo, Oriana Hoi Yun Yu, Ju‐Young Shin
    Diabetes, Obesity and Metabolism.2022; 24(10): 2051.     CrossRef
  • Improvement in Age at Mortality and Changes in Causes of Death in the Population with Diabetes: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
    Endocrinology and Metabolism.2022; 37(3): 466.     CrossRef
  • Dietary antioxidant consumption and the risk of type 2 diabetes in South Korean adults: a prospective cohort study based on the Health Examinees study
    Li-Juan Tan, Su Bin Hwang, Shinyoung Jun, Hyojee Joung, Sangah Shin
    BMJ Open.2022; 12(7): e065073.     CrossRef
  • Visual Acuity Outcomes in Diseases Associated with Reduced Visual Acuity: An Analysis of the National Health Insurance Service Database in Korea
    Sang-Yeob Kim, Byeong-Yeon Moon, Hyun-Gug Cho, Dong-Sik Yu
    International Journal of Environmental Research and Public Health.2022; 19(14): 8689.     CrossRef
  • Development of Various Diabetes Prediction Models Using Machine Learning Techniques
    Juyoung Shin, Jaewon Kim, Chanjung Lee, Joon Young Yoon, Seyeon Kim, Seungjae Song, Hun-Sung Kim
    Diabetes & Metabolism Journal.2022; 46(4): 650.     CrossRef
  • Real-World Prescription Patterns and Barriers Related to the Use of Sodium-Glucose Cotransporter 2 Inhibitors among Korean Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease
    Jong Ha Baek, Ye Seul Yang, Seung-Hyun Ko, Kyung Do Han, Jae Hyeon Kim, Min Kyong Moon, Jong Suk Park, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Jong Han Choi, Kyu Yeon Hur
    Diabetes & Metabolism Journal.2022; 46(5): 701.     CrossRef
  • Remnant cholesterol and the risk of cardiovascular disease in type 2 diabetes: a nationwide longitudinal cohort study
    Ji Hye Huh, Kyung-do Han, Yun Kyung Cho, Eun Roh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Effective coverage of diabetes and hypertension: an analysis of Thailand’s national insurance database 2016–2019
    Nattadhanai Rajatanavin, Woranan Witthayapipopsakul, Vuthiphan Vongmongkol, Nithiwat Saengruang, Yaowaluk Wanwong, Aniqa Islam Marshall, Walaiporn Patcharanarumol, Viroj Tangcharoensathien
    BMJ Open.2022; 12(12): e066289.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
    Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Ki
    Diabetes & Metabolism Journal.2021; 45(5): 675.     CrossRef
  • Association between secondhand smoke exposure and diabetes mellitus in 131 724 Korean never smokers using self‐reported questionnaires and cotinine levels: Gender differences
    Byung Jin Kim, Ji Hye Kim, Jeong Gyu Kang, Bum Soo Kim, Jin Ho Kang
    Journal of Diabetes.2021; 13(1): 43.     CrossRef
  • Importance of Awareness and Treatment for Diabetes in Influenza Vaccination Coverage of Diabetic Patients under 65 Years: A Population-Based Study
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    Diabetes & Metabolism Journal.2021; 45(1): 55.     CrossRef
  • Associations of urinary concentrations of phthalate metabolites, bisphenol A, and parabens with obesity and diabetes mellitus in a Korean adult population: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Inae Lee, Young Joo Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Kyungho Choi, Min Kyong Moon
    Environment International.2021; 146: 106227.     CrossRef
  • Early combination versus initial metformin monotherapy in the management of newly diagnosed type 2 diabetes: AnEast Asianperspective
    Linong Ji, Juliana C. N. Chan, Miao Yu, Kun Ho Yoon, Sin Gon Kim, Sung Hee Choi, Chien‐Ning Huang, Shih Te Tu, Chih‐Yuan Wang, Päivi Maria Paldánius, Wayne H. H. Sheu
    Diabetes, Obesity and Metabolism.2021; 23(1): 3.     CrossRef
  • Hypertension and stroke in Asia: A comprehensive review from HOPE Asia
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    The Journal of Clinical Hypertension.2021; 23(3): 513.     CrossRef
  • Glycaemic control with add‐on thiazolidinedione or a sodium‐glucose co‐transporter‐2 inhibitor in patients with type 2 diabetes after the failure of an oral triple antidiabetic regimen: A 24‐week, randomized controlled trial
    Jaehyun Bae, Ji Hye Huh, Minyoung Lee, Yong‐Ho Lee, Byung‐Wan Lee
    Diabetes, Obesity and Metabolism.2021; 23(2): 609.     CrossRef
  • Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study
    Jung A Kim, Jinsil Kim, Eun Roh, So-hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo
    Diabetes Research and Clinical Practice.2021; 171: 108533.     CrossRef
  • Effectiveness and safety of sodium‐glucose co‐transporter‐2 inhibitors compared with dipeptidyl peptidase‐4 inhibitors in older adults with type 2 diabetes: A nationwide population‐based study
    Seung Jin Han, Kyoung Hwa Ha, Nami Lee, Dae Jung Kim
    Diabetes, Obesity and Metabolism.2021; 23(3): 682.     CrossRef
  • Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
    Diabetes & Metabolism Journal.2021; 45(1): 1.     CrossRef
  • Prevalence and diagnosis experience of osteoporosis in postmenopausal women over 50: Focusing on socioeconomic factors
    Min Hyeok Choi, Ji Hee Yang, Jae Seung Seo, Yoon-ji Kim, Suk-Woong Kang, Jose M. Moran
    PLOS ONE.2021; 16(3): e0248020.     CrossRef
  • Metformin use in cancer survivors with diabetes reduces all-cause mortality, based on the Korean National Health Insurance Service between 2002 and 2015
    Joungyoun Kim, Yoon-Jong Bae, Jae-woo Lee, Ye-seul Kim, Yonghwan Kim, Hyo-Sun You, Hyeong-Seop Kim, Eun-A Choi, Ye-Eun Han, Hee-Taik Kang
    Medicine.2021; 100(11): e25045.     CrossRef
  • Role of obesity-induced inflammation in the development of insulin resistance and type 2 diabetes: history of the research and remaining questions
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    Annals of Pediatric Endocrinology & Metabolism.2021; 26(1): 1.     CrossRef
  • White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
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    Journal of Inflammation Research.2021; Volume 14: 1235.     CrossRef
  • The Association of Hemoglobin A1c and Fasting Glucose Levels with hs-CRP in Adults Not Diagnosed with Diabetes from the KNHANES, 2017
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    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
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    Seung Hee Kim, Byung Ki Kim, Boo Yeun Park, Jung Min Kim, Young Jik Lee, Mi Kyung Lee, Sung-Tae Yee, Mi Yeon Kang
    The Journal of Korean Diabetes.2021; 22(1): 60.     CrossRef
  • Health State Utility Values for Type 2 Diabetes and Related Complications in East and Southeast Asia: A Systematic Review and Meta-Analysis
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    Value in Health.2021; 24(7): 1059.     CrossRef
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    BMC Public Health.2021;[Epub]     CrossRef
  • Epidemiology of cardiovascular disease and its risk factors in Korea
    Hyeon Chang Kim
    Global Health & Medicine.2021; 3(3): 134.     CrossRef
  • Korea Heart Disease Fact Sheet 2020: Analysis of Nationwide Data
    Hyeok-Hee Lee, So Mi Jemma Cho, Hokyou Lee, Jongmin Baek, Jang-Ho Bae, Wook-Jin Chung, Hyeon Chang Kim
    Korean Circulation Journal.2021; 51(6): 495.     CrossRef
  • Personalized Type 2 Diabetes Management Using a Mobile Application Integrated with Electronic Medical Records: An Ongoing Randomized Controlled Trial
    Eun-Young Lee, Jae-Seung Yun, Seon-Ah Cha, Sun-Young Lim, Jin-Hee Lee, Yu-Bae Ahn, Kun-Ho Yoon, Seung-Hyun Ko
    International Journal of Environmental Research and Public Health.2021; 18(10): 5300.     CrossRef
  • Association between toothbrushing and non-alcoholic fatty liver disease
    Ji-Youn Kim, Yong-Moon Park, Gyu-Na Lee, Hyun Chul Song, Yu-Bae Ahn, Kyungdo Han, Seung-Hyun Ko, Houkai Li
    PLOS ONE.2021; 16(5): e0243686.     CrossRef
  • Control of Glucose, Blood Pressure, and Cholesterol among Adults with Diabetes: The Brazilian National Health Survey
    Rodrigo Citton P. dos Reis, Bruce B. Duncan, Célia Landmann Szwarcwald, Deborah Carvalho Malta, Maria Inês Schmidt
    Journal of Clinical Medicine.2021; 10(15): 3428.     CrossRef
  • Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data
    J. Ha, C. Jeong, K.-D. Han, Y. Lim, M.K. Kim, H.-S. Kwon, K.-H. Song, M.I. Kang, K.-H. Baek
    Osteoporosis International.2021; 32(12): 2543.     CrossRef
  • Treatment Patterns of Type 2 Diabetes Assessed Using a Common Data Model Based on Electronic Health Records of 2000–2019
    Kyung Ae Lee, Heung Yong Jin, Yu Ji Kim, Yong-Jin Im, Eun-Young Kim, Tae Sun Park
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Etiology, diagnosis, complications, and treatments of diabetic foot
    Dong-Kyo Seo
    Journal of the Korean Medical Association.2021; 64(8): 523.     CrossRef
  • Occupational Noise Exposure and Incidence of High Fasting Blood Glucose: A 3-Year, Multicenter, Retrospective Study
    Seunghan Kim, Byungyoon Yun, Seunghyun Lee, Changyoung Kim, Juho Sim, Ara Cho, Yeonsuh Oh, Jiho Lee, Jinha Yoon
    International Journal of Environmental Research and Public Health.2021; 18(17): 9388.     CrossRef
  • Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults
    Joungyoun Kim, Sang-Jun Shin, Ye-Seul Kim, Hee-Taik Kang
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Comparative Evaluation of Standard E TB-Feron ELISA and QuantiFERON-TB Gold Plus Assays in Patients with Tuberculosis and Healthcare Workers
    In Young Yoo, Jaewoong Lee, Ae Ran Choi, Yoon Hee Jun, Hwa Young Lee, Ji Young Kang, Yeon-Joon Park
    Diagnostics.2021; 11(9): 1659.     CrossRef
  • Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study
    Bo-Yeon Kim, Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • Real-World Efficacy and Safety of Dulaglutide in Korean Patients with Type 2 Diabetes Mellitus: A Retrospective Study in a Tertiary Referral Center
    Jee Hee Yoon, A Ram Hong, Wonsuk Choi, Ji Yong Park, Hee Kyung Kim, Ho-Cheol Kang
    Chonnam Medical Journal.2021; 57(3): 211.     CrossRef
  • The History of Insulin Therapy in Korea
    Jun Sung Moon, Jong Chul Won, Young Min Cho
    Diabetes & Metabolism Journal.2021; 45(5): 623.     CrossRef
  • How Can We Adopt the Glucose Tolerance Test to Facilitate Predicting Pregnancy Outcome in Gestational Diabetes Mellitus?
    Kyeong Jin Kim, Nam Hoon Kim, Jimi Choi, Sin Gon Kim, Kyung Ju Lee
    Endocrinology and Metabolism.2021; 36(5): 988.     CrossRef
  • Blood Pressure and Cardiovascular Disease in Older Patients With Diabetes: Retrospective Cohort Study
    Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Long-Term Glycaemic Durability of Early Combination Therapy Strategy versus Metformin Monotherapy in Korean Patients with Newly Diagnosed Type 2 Diabetes Mellitus
    Soon-Jib Yoo, Sang-Ah Chang, Tae Seo Sohn, Hyuk-Sang Kwon, Jong Min Lee, Sungdae Moon, Pieter Proot, Päivi M Paldánius, Kun Ho Yoon
    Diabetes & Metabolism Journal.2021; 45(6): 954.     CrossRef
  • Short-Term Effects of the Internet-Based Korea Diabetes Prevention Study: 6-Month Results of a Community-Based Randomized Controlled Trial
    Jin-Hee Lee, Sun-Young Lim, Seon-Ah Cha, Chan-Jung Han, Ah Reum Jung, Kook-Rye Kim, Kun-Ho Yoon, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2021; 45(6): 960.     CrossRef
  • Anti-diabetic effects of aqueous extract of Dendropanax morbifera Lev. leaves in streptozotocin-induced diabetic Sprague-Dawley rats
    Min-Jae Kim, Ye-Jin Kang, Dong-Eon Lee, Suk Kim, Se-Hun Lim, Hu-Jang Lee
    Korean Journal of Veterinary Research.2021; 61(4): e38.     CrossRef
  • The Potential Role of MicroRNA in Diabetic Cardiomyopathy
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(1): 54.     CrossRef
  • Diabetes and Metabolism Journal in 2020: Good to Great
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
  • Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations
    Wayne Huey-Herng Sheu, Siew Pheng Chan, Bien J. Matawaran, Chaicharn Deerochanawong, Ambrish Mithal, Juliana Chan, Ketut Suastika, Chin Meng Khoo, Huu Man Nguyen, Ji Linong, Andrea Luk, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2020; 44(1): 11.     CrossRef
  • Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009–2017
    Yang-Hyun Kim, Jun Goo Kang, Seong Jin Lee, Kyung-do Han, Sung-Hee Ihm, Kyung-Hwan Cho, Yong-Gyu Park
    Diabetes Care.2020; 43(5): 1118.     CrossRef
  • The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
    Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
    Diabetes & Metabolism Journal.2020; 44(2): 222.     CrossRef
  • Metformin treatment for patients with diabetes and chronic kidney disease: A Korean Diabetes Association and Korean Society of Nephrology consensus statement
    Kyu Yeon Hur, Mee Kyoung Kim, Seung Hyun Ko, Miyeun Han, Dong Won Lee, Hyuk-Sang Kwon
    Kidney Research and Clinical Practice.2020; 39(1): 32.     CrossRef
  • Effect of Smartphone-Based Lifestyle Coaching App on Community-Dwelling Population With Moderate Metabolic Abnormalities: Randomized Controlled Trial
    So Mi Jemma Cho, Jung Hyun Lee, Jee-Seon Shim, Hyungseon Yeom, Su Jin Lee, Yong Woo Jeon, Hyeon Chang Kim
    Journal of Medical Internet Research.2020; 22(10): e17435.     CrossRef
  • Fasting plasma glucose level and the risk of open angle glaucoma: Nationwide population-based cohort study in Korea
    Jin A. Choi, Yong-Moon Park, Kyungdo Han, Jiyoung Lee, Jae-Seung Yun, Seung-Hyun Ko, Bang V Bui
    PLOS ONE.2020; 15(9): e0239529.     CrossRef
  • Smoking as a Target for Prevention of Diabetes
    Ye Seul Yang, Tae Seo Sohn
    Diabetes & Metabolism Journal.2020; 44(3): 402.     CrossRef
  • Association of Snoring with Prediabetes and Type 2 Diabetes Mellitus: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort
    So Mi Jemma Cho, Hokyou Lee, Jee-Seon Shim, Hyeon Chang Kim
    Diabetes & Metabolism Journal.2020; 44(5): 687.     CrossRef
  • Increased Mortality Burden in Young Asian Subjects with Dysglycemia and Comorbidities
    Eun-Jung Rhee, Inha Jung, Hyemi Kwon, Se Eun Park, Yang-Hyun Kim, Kyung-Do Han, Yong-Gyu Park, Won-Young Lee
    Journal of Clinical Medicine.2020; 9(4): 1042.     CrossRef
  • Metformin Treatment for Patients with Diabetes and Chronic Kidney Disease: A Korean Diabetes Association and Korean Society of Nephrology Consensus Statement
    Kyu Yeon Hur, Mee Kyoung Kim, Seung Hyun Ko, Miyeun Han, Dong Won Lee, Hyuk-Sang Kwon
    Diabetes & Metabolism Journal.2020; 44(1): 3.     CrossRef
  • Study of hospitalization and mortality in Korean diabetic patients using the diabetes complications severity index
    Hyunju Yoo, Eunjung Choo, Sukhyang Lee
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Comprehensive Trends and Patterns of Antihypertensive Prescriptions Using a Nationwide Claims Database in Korea


    Minji Jung, Eunjung Choo, Sukhyang Lee
    Clinical Epidemiology.2020; Volume 12: 963.     CrossRef
  • The effects of climate on the incidence of benign paroxysmal positional vertigo
    Seung Ri Oh, Sung Jin Min, Chang Eurn Kim, Munyoung Chang, Seog-Kyun Mun
    International Journal of Biometeorology.2020; 64(12): 2119.     CrossRef
  • Prevalence and Current Management of Cardiovascular Risk Factors in Korean Adults Based on Fact Sheets
    Eun-Jung Rhee
    Endocrinology and Metabolism.2020; 35(1): 85.     CrossRef
  • Diabetic Retinopathy and Related Clinical Practice for People with Diabetes in Korea: A 10-Year Trend Analysis
    Yoo-Ri Chung, Kyoung Hwa Ha, Kihwang Lee, Dae Jung Kim
    Diabetes & Metabolism Journal.2020; 44(6): 928.     CrossRef
  • Association between sleep duration and impaired fasting glucose according to work type in non-regular workers: data from the first and second year (2016, 2017) of the 7th Korean National Health and Nutrition Examination (KNHANE) (a cross-sectional study)
    JaeHan Joo, Jae-Gwang Lee, SangWoo Kim, JaeHan Lee, June-Hee Lee, Kyung-Jae Lee
    Annals of Occupational and Environmental Medicine.2020;[Epub]     CrossRef
  • Hepatocellular Carcinoma in Korea between 2012 and 2014: an Analysis of Data from the Korean Nationwide Cancer Registry
    Young Eun Chon, Han Ah Lee, Jun Sik Yoon, Jun Yong Park, Bo Hyun Kim, In Joon Lee, Suk Kyun Hong, Dong Hyeon Lee, Hyun-Joo Kong, Eunyang Kim, Young-Joo Won, Jeong-Hoon Lee
    Journal of Liver Cancer.2020; 20(2): 135.     CrossRef
  • Effect of Switching from Linagliptin to Teneligliptin Dipeptidyl Peptidase-4 Inhibitors in Older Patients with Type 2 Diabetes Mellitus


    Eugene Han, Minyoung Lee, Yong-ho Lee, Hye Soon Kim, Byung-wan Lee, Bong-Soo Cha, Eun Seok Kang
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4113.     CrossRef
  • Temperature Correction to Enhance Blood Glucose Monitoring Accuracy Using Electrical Impedance Spectroscopy
    Ye Sung Lee, Minkook Son, Alexander Zhbanov, Yugyung Jung, Myoung Hoon Jung, Kunsun Eom, Sung Hyun Nam, Jongae Park, Sung Yang
    Sensors.2020; 20(21): 6231.     CrossRef
  • Predictors of Health-Related Quality of Life in Korean Adults with Diabetes Mellitus
    Mihyun Jeong
    International Journal of Environmental Research and Public Health.2020; 17(23): 9058.     CrossRef
  • The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data
    Byoungjin Park, Yong-Jae Lee, Hye Sun Lee, Dong-Hyuk Jung
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Independent Impact of Diabetes on the Severity of Coronavirus Disease 2019 in 5,307 Patients in South Korea: A Nationwide Cohort Study (Diabetes Metab J 2020;44:737-46)
    Sun Joon Moon, Eun-Jung Rhee, Won-Young Lee, Kun-Ho Yoon
    Diabetes & Metabolism Journal.2020; 44(6): 942.     CrossRef
  • Does Diabetes Increase the Risk of Contracting COVID-19? A Population-Based Study in Korea
    Sung-Youn Chun, Dong Wook Kim, Sang Ah Lee, Su Jung Lee, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim, Sun Ok Song
    Diabetes & Metabolism Journal.2020; 44(6): 897.     CrossRef
  • Independent Impact of Diabetes on the Severity of Coronavirus Disease 2019 in 5,307 Patients in South Korea: A Nationwide-Cohort Study (Diabetes Metab J 2020;44:737-46)
    Kyuho Kim, Tae Jung Oh
    Diabetes & Metabolism Journal.2020; 44(6): 938.     CrossRef
  • Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
    Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko
    Endocrinology and Metabolism.2020; 35(4): 901.     CrossRef
  • The Liability Threshold Model for Predicting the Risk of Cardiovascular Disease in Patients with Type 2 Diabetes: A Multi-Cohort Study of Korean Adults
    Eun Pyo Hong, Seong Gu Heo, Ji Wan Park
    Metabolites.2020; 11(1): 6.     CrossRef
  • Increased Age of Death and Change in Causes of Death Among Persons With Diabetes Mellitus From the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Eugene Han, Sun Ok Song, Hye Soon Kim, Kang Ju Son, Sun Ha Jee, Bong-Soo Cha, Byung-Wan Lee
    SSRN Electronic Journal .2020;[Epub]     CrossRef
  • Diabetes and Muscle Dysfunction in Older Adults
    Hak Chul Jang
    Annals of Geriatric Medicine and Research.2019; 23(4): 160.     CrossRef
  • Letter: Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2019;43:582–9)
    Tae Seo Sohn
    Diabetes & Metabolism Journal.2019; 43(6): 909.     CrossRef
  • Comprehensive Efforts Are Needed to Improve the Quality of Primary Diabetes Care in Korea
    Chan-Hee Jung
    Endocrinology and Metabolism.2019; 34(3): 265.     CrossRef
Epidemiology
Dietary Sodium Intake in People with Diabetes in Korea: The Korean National Health and Nutrition Examination Survey for 2008 to 2010
Myung Shin Kang, Chong Hwa Kim, Su Jin Jeong, Tae Sun Park
Diabetes Metab J. 2016;40(4):290-296.   Published online June 23, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.4.290
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AbstractAbstract PDFPubReader   
Background

Diabetics are likely to receive advice from their physicians concerning lifestyle changes. To understand how much sodium is consumed by diabetics in Korea, we compared the average daily sodium intake between diabetics and non-diabetics after controlling for confounding factors.

Methods

We obtained the sodium intake data for 13,957 individuals who participated in the Korean National Health and Nutrition Examination Survey (KNHANES), 2008 to 2010, which consisted of a health interview and behavioral and nutritional surveys. The KNHANES uses a stratified, multistage, probability-sampling design, and weighting adjustments were conducted to represent the entire population.

Results

Our analysis revealed that, overall, diabetics tended to have lower sodium intake (4,910.2 mg) than healthy individuals (5,188.2 mg). However, both diabetic and healthy individuals reported higher sodium intake than is recommended by the World Health Organization (WHO). Stratified subgroup analyses revealed that the sodium intake (4,314.2 mg) among newly diagnosed diabetics was higher among women when compared to patients with known diabetes (3,812.5 mg, P=0.035). Female diabetics with cardiovascular disease had lower average sodium intake compared to those without cardiovascular disease after adjusting for sex, age, body mass index, and total energy intake (P=0.058). Sodium intake among male diabetics with hypercholesterolemia (P=0.011) and female diabetics with hypertriglyceridemia (P=0.067) tended to be higher than that among those who without dyslipidemia.

Conclusion

The average sodium intake of diabetics in Korea was higher than the WHO recommends. Sodium intake in newly diagnosed diabetics was significantly higher than that in non-diabetics and previously diagnosed diabetics among females. Prospective studies are needed to identify the exact sodium intake.

Citations

Citations to this article as recorded by  
  • Salt Intake in Adults with Diabetes and Hypertension: The Longitudinal Study of Adult Health-Brasil Study
    Natália Gonçalves Ribeiro, Deborah F. Lelis, Rosane H. Griep, Sandhi M. Barreto, Maria del Carmen B Molina, Maria I. Schmidt, Bruce B. Duncan, Isabela Bensenor, Paulo A. Lotufo, José G. Mill, Marcelo Perim Baldo
    Metabolic Syndrome and Related Disorders.2024;[Epub]     CrossRef
  • Effects of different diets on glycemic control among patients with type 2 diabetes: A literature review
    Maryam E Al-Adwi, Zinab M Al-Haswsa, Karmen M Alhmmadi, Yasmin A Eissa, Aya Hamdan, Hiba Bawadi, Reema F Tayyem
    Nutrition and Health.2023; 29(2): 215.     CrossRef
  • Dietary salt intake predicts future development of metabolic syndrome in the general population
    Hiroyuki Takase, Kazusa Hayashi, Fumihiko Kin, Suguru Nakano, Masashi Machii, Shin Takayama, Tomonori Sugiura, Yasuaki Dohi
    Hypertension Research.2023; 46(1): 236.     CrossRef
  • High Sodium Intake, as Assessed by Urinary Sodium Excretion, Is Associated with Nonalcoholic Fatty Liver Disease or Sarcopenia
    Eugene Han, Mi Kyung Kim, Seung-Soon Im, Hye Soon Kim, Taeg Kyu Kwon, Byoung Kuk Jang
    Gut and Liver.2023; 17(3): 456.     CrossRef
  • Trends of Dietary Intakes and Metabolic Diseases in Japanese Adults: Assessment of National Health Promotion Policy and National Health and Nutrition Survey 1995–2019
    Muhammad Fauzi, Indri Kartiko-Sari, Hemant Poudyal
    Journal of Clinical Medicine.2022; 11(9): 2350.     CrossRef
  • Determinants of Type 2 Diabetes Mellitus Among Adults in Dill-Chora Referral Hospital, Dire Dawa, East Ethiopia
    Tewodros Getnet Amera, Yibekal Manaye Tefera, Tameru Menberu, Aminu Mohammed Yassin
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 3565.     CrossRef
  • Dietary sodium and cardiovascular morbidity/mortality: a brief commentary on the ‘J-shape hypothesis’
    Christiana Tsirimiagkou, Kalliopi Karatzi, Antonios Argyris, Eirini D. Basdeki, Panagiota Kaloudi, Mary Yannakoulia, Athanase D. Protogerou
    Journal of Hypertension.2021; 39(12): 2335.     CrossRef
  • Associations of Dietary Salt and Its Sources with Hemoglobin A1c in Patients with Type 2 Diabetes Not Taking Anti-Diabetic Medications: Analysis Based on 6-Month Intervention with a Moderate Low-Carbohydrate Diet
    Hajime Haimoto, Takashi Murase, Shiho Watanabe, Keiko Maeda, Kenji Wakai
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4569.     CrossRef
  • Association of rheumatoid arthritis and high sodium intake with major adverse cardiovascular events: a cross-sectional study from the seventh Korean National Health and Nutrition Examination Survey
    Jeong-Hyeon Bae, Min-Young Shin, Eun Ha Kang, Yun Jong Lee, You-Jung Ha
    BMJ Open.2021; 11(12): e056255.     CrossRef
  • Nineteen-year trends in fermented food consumption and sodium intake from fermented foods for Korean adults from 1998 to 2016
    Sang Young Kim, Jeanne H Freeland-Graves, Hyun Ja Kim
    Public Health Nutrition.2020; 23(3): 515.     CrossRef
  • Dietary Sodium Intake and Health Indicators: A Systematic Review of Published Literature between January 2015 and December 2019
    Katherine J Overwyk, Zerleen S Quader, Joyce Maalouf, Marlana Bates, Jacqui Webster, Mary G George, Robert K Merritt, Mary E Cogswell
    Advances in Nutrition.2020; 11(5): 1174.     CrossRef
  • Lower Leg Fat Depots Are Associated with Albuminuria Independently of Obesity, Insulin Resistance, and Metabolic Syndrome (Korea National Health and Nutrition Examination Surveys 2008 to 2011)
    Eugene Han, Nan Hee Cho, Mi Kyung Kim, Hye Soon Kim
    Diabetes & Metabolism Journal.2019; 43(4): 461.     CrossRef
  • Factors Predicting Sodium Intake of Korean Americans with Type 2 Diabetes
    Jisook Ko, Kim B. Kim, Gayle M. Timmerman, Angela P. Clark, Miyong Kim
    Journal of Immigrant and Minority Health.2018; 20(3): 641.     CrossRef
  • Evaluation of the association between the number of natural teeth and anemia among Korean adults using nationally representative data
    Kyungdo Han, Jun‐Beom Park
    Journal of Periodontology.2018; 89(10): 1184.     CrossRef
  • Clinical implications of age and sex in the prevalence of periodontitis in Korean adults with diabetes
    Kyungdo Han, Jun‑Beom Park
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Association between underweight and tooth loss among Korean adults
    In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
    Scientific Reports.2017;[Epub]     CrossRef
  • The Science of Salt: A regularly updated systematic review of the implementation of salt reduction interventions (March–August 2016)
    Joseph Alvin Santos, Kathy Trieu, Thout Sudhir Raj, JoAnne Arcand, Claire Johnson, Jacqui Webster, Rachael McLean
    The Journal of Clinical Hypertension.2017; 19(4): 439.     CrossRef
  • Salt-sensitive genes and their relation to obesity
    Yong-Pil Cheon, Myoungsook Lee
    Journal of Nutrition and Health.2017; 50(3): 217.     CrossRef
Review
Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
Leigang Jin, Zhuofeng Lin, Aimin Xu
Diabetes Metab J. 2016;40(1):22-31.   Published online January 29, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.22
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AbstractAbstract PDFPubReader   

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects against atherosclerosis. Circulating levels of FGF21 are elevated in patients with atherosclerosis, macrovascular and microvascular complications of diabetes, possibly due to a compensatory upregulation. In apolipoprotein E-deficient mice, formation of atherosclerotic plaques is exacerbated by genetic depletion of FGF21, but is attenuated upon replenishment with recombinant FGF21. However, the blood vessel is not the direct target of FGF21, and the antiatherosclerotic activity of FGF21 is attributed to its actions in adipose tissues and liver. In adipocytes, FGF21 promotes secretion of adiponectin, which in turn acts directly on blood vessels to reduce endothelial dysfunction, inhibit proliferation of smooth muscle cells and block conversion of macrophages to foam cells. Furthermore, FGF21 suppresses cholesterol biosynthesis and attenuates hypercholesterolemia by inhibiting the transcription factor sterol regulatory element-binding protein-2 in hepatocytes. The effects of FGF21 on elevation of adiponectin and reduction of hypercholesterolemia are also observed in a phase-1b clinical trial in patients with obesity and diabetes. Therefore, FGF21 exerts its protection against atherosclerosis by fine-tuning the interorgan crosstalk between liver, brain, adipose tissue, and blood vessels.

Citations

Citations to this article as recorded by  
  • Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications
    Leigang Jin, Ranyao Yang, Leiluo Geng, Aimin Xu
    Annual Review of Pharmacology and Toxicology.2023; 63(1): 359.     CrossRef
  • Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH)
    Tobias Puengel, Frank Tacke
    Expert Opinion on Investigational Drugs.2023; 32(6): 451.     CrossRef
  • The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease
    Meichao Cai, Dongsheng Zhao, Xiao Han, Shuang Han, Wenxin Zhang, Zhennan Zang, Chenchen Gai, Rong Rong, Tian Gao
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
    Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
    Cardiovascular Research.2022; 118(2): 489.     CrossRef
  • Relationship between Serum FGF21 and vWF Expression and Carotid Atherosclerosis in Elderly Patients with Hypertension
    Jing Bian, Lairong Chen, Qin Li, Yunfeng Zhao, Delu Yin, Shanhong Sun, Bhagyaveni M.A
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
  • Serum FGF21 Levels Predict the MACE in Patients With Myocardial Infarction After Coronary Artery Bypass Graft Surgery
    Wei Xie, Dan Li, Yaru Shi, Ning Yu, Yu Yan, Yingchao Zhang, Qiongli Yu, Yulin Li, Jie Du, Zhuofeng Lin, Fan Wu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Adipokines, adiposity, and atherosclerosis
    Longhua Liu, Zunhan Shi, Xiaohui Ji, Wenqian Zhang, Jinwen Luan, Tarik Zahr, Li Qiang
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Current understanding and controversies on the clinical implications of fibroblast growth factor 21
    Yasaman Badakhshi, Tianru Jin
    Critical Reviews in Clinical Laboratory Sciences.2021; 58(5): 311.     CrossRef
  • The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development
    Ting Xie, Liangying Yin, Dan Guo, Zixin Zhang, Yuexin Chen, Bao Liu, Wei Wang, Yuehong Zheng
    Life Sciences.2021; 274: 119346.     CrossRef
  • Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy
    Jiameng Gao, Jingjing Liu, Zheying Meng, Yanming Li, Yuping Hong, Lirui Wang, Lan He, Bing Hu, Yuanyi Zheng, Tianliang Li, Daxiang Cui, E. Shen
    Acta Biomaterialia.2021; 130: 395.     CrossRef
  • Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model
    Hyo Jin Maeng, Gha Young Lee, Jae Hyun Bae, Soo Lim
    International Journal of Molecular Sciences.2020; 21(18): 6836.     CrossRef
  • The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
    Leiluo Geng, Karen S. L. Lam, Aimin Xu
    Nature Reviews Endocrinology.2020; 16(11): 654.     CrossRef
  • Two-hundred-liter scale fermentation, purification of recombinant human fibroblast growth factor-21, and its anti-diabetic effects on ob/ob mice
    Qi Hui, Zhen Huang, Shucai Pang, Xuanxin Yang, Jinghang Li, Bingjie Yu, Lu Tang, Xiaokun Li, Xiaojie Wang
    Applied Microbiology and Biotechnology.2019; 103(2): 719.     CrossRef
  • Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?
    Niki Katsiki, Christos Mantzoros
    Metabolism.2019; 93: iii.     CrossRef
  • Heparin‐poloxamer hydrogel‐encapsulated rhFGF21 enhances wound healing in diabetic mice
    Huan Liu, Yeli Zhao, Yuchi Zou, Wenting Huang, Liyun Zhu, Fei Liu, Dongxue Wang, Kaiming Guo, Jian Hu, Jun Chen, Lixia Ye, Xiaokun Li, Li Lin
    The FASEB Journal.2019; 33(9): 9858.     CrossRef
  • Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes
    Saeed Yafei, Fathy Elsewy, Eman Youssef, Mohammed Ayman, Mohamed El-Shafei
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 882.     CrossRef
  • Myokines in metabolic homeostasis and diabetes
    Jürgen Eckel
    Diabetologia.2019; 62(9): 1523.     CrossRef
  • Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
    Wei Wei, Xiao-Xue Li, Ming Xu
    Atherosclerosis.2019; 289: 132.     CrossRef
  • LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
    Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho, Partha Mukhopadhyay
    PLOS ONE.2018; 13(2): e0192146.     CrossRef
  • Relationship of Selected Adipokines with Markers of Vascular Damage in Patients with Type 2 Diabetes
    Jaromíra Spurná, David Karásek, Veronika Kubíčková, Dominika Goldmannová, Ondřej Krystyník, Jan Schovánek, Josef Zadražil
    Metabolic Syndrome and Related Disorders.2018; 16(5): 246.     CrossRef
  • Serum FGF21 Is Associated with Future Cardiovascular Events in Patients with Coronary Artery Disease
    Yun Shen, Xueli Zhang, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
    Cardiology.2018; 139(4): 212.     CrossRef
  • Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
    Sung Don Park, Kwi-Hyun Bae, Yeon-Kyung Choi, Jae-Han Jeon, Jung Beom Seo, Namkyun Kim, Chang-Yeon Kim, Sung Woo Kim, Won Kee Lee, Jung Guk Kim, In-Kyu Lee, Jang Hoon Lee, Keun-Gyu Park
    Journal of Lipid and Atherosclerosis.2018; 7(1): 42.     CrossRef
  • Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages
    Nan Wang, Jun-yan Li, Shuai Li, Xiao-chen Guo, Tong Wu, Wen-fei Wang, De-shan Li
    Biomedicine & Pharmacotherapy.2018; 108: 1825.     CrossRef
  • Chip‐based high resolution tandem mass spectrometric determination of fibroblast growth factor—chondroitin sulfate disaccharides noncovalent interaction
    Adrian C. Robu, Laurentiu Popescu, Daniela G. Seidler, Alina D. Zamfir
    Journal of Mass Spectrometry.2018; 53(7): 624.     CrossRef
  • Conditioned medium from contracting skeletal muscle cells reverses insulin resistance and dysfunction of endothelial cells
    Yihe Zhao, Nana Li, Zhu Li, Da Zhang, Liming Chen, Zhi Yao, Wenyan Niu
    Metabolism.2018; 82: 36.     CrossRef
  • Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
    Stefanie Worsch, Mathias Heikenwalder, Hans Hauner, Bernhard L. Bader
    Nutrition & Metabolism.2018;[Epub]     CrossRef
  • Metabolic Values of Fibroblasts Growth Factor 21 in Patients with Coronary Artery Disease and Obesity
    L. M. Pasiyeshvili, K. V. Ivanova
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 3(4): 110.     CrossRef
  • FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
    Antero Salminen, Anu Kauppinen, Kai Kaarniranta
    Journal of Molecular Medicine.2017; 95(2): 123.     CrossRef
  • Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
    Antero Salminen, Kai Kaarniranta, Anu Kauppinen
    Ageing Research Reviews.2017; 37: 79.     CrossRef
  • Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death
    Yun Shen, Xueli Zhang, Xiaoping Pan, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Fibroblast growth factor 21 – a key player in cardiovascular disorders?
    Monika Lenart-Lipińska, Dariusz Duma, Magdalena Hałabiś, Marcin Dziedzic, Janusz Solski
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • The role of fibroblast growth factor 21 in atherosclerosis
    John Kokkinos, Shudi Tang, Kerry-Anne Rye, Kwok Leung Ong
    Atherosclerosis.2017; 257: 259.     CrossRef
Original Articles
Low Density Lipoprotein Cholesterol Target Goal Attainment Rate and Physician Perceptions about Target Goal Achievement in Korean Patients with Diabetes
Jenie Yoonoo Hwang, Chang Hee Jung, Woo Je Lee, Cheol Young Park, Sung Rae Kim, Kun-Ho Yoon, Moon Kyu Lee, Sung Woo Park, Joong-Yeol Park
Diabetes Metab J. 2011;35(6):628-636.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.628
  • 4,036 View
  • 41 Download
  • 20 Crossref
AbstractAbstract PDFPubReader   
Background

This study aims to investigate the discrepancy between clinicians' perceptions and actual achievement rates of low density lipoprotein cholesterol (LDL-C) in Korean patients with diabetes according to updated American Diabetes Association (ADA)/American College of Cardiology Foundation (ACC) recommendations.

Methods

This is a multi-center, retrospective, non-interventional, observational study. Diabetic patients aged 18 years or older were eligible if they had been diagnosed with hypercholesterolemia or were receiving a lipid-lowering therapy between May 2010 and August 2010. The information was obtained by reviewing medical records and using a self-completed questionnaire to examine physician perceptions.

Results

A total of 2,591 subjects who satisfied the inclusion criteria were enrolled. Highest-risk and high-risk patients accounted for 61.9% and 38.1% of the patients, respectively. Although most (96.3%) underwent a statin monotherapy or a statin-based combination therapy, just 47.4% of patients attained the LDL-C target. However, the physicians' perceptions on target achievement rate (70.6%) were different from the actual results (47.4%). Many patients (65.3%) remained on the starting doses of statins, despite evidence of poor achievement of lipid goals.

Conclusion

Only less than half of patients with diabetes attained the LDL-C goal. The surveys showed that poor physician performance might be due to the lack of recognition on ADA/ACC consensus causing a low LDL-C target attainment rate. Therefore, changes in doctor perception are needed to attain target LDL-C level and reduce cardiovascular risk in Korean patients with diabetes.

Citations

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  • Lipid Management in Korean People With Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
    Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
    Journal of Lipid and Atherosclerosis.2023; 12(1): 12.     CrossRef
  • Lipid Management in Korean People with Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
    Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
    Diabetes & Metabolism Journal.2023; 47(1): 1.     CrossRef
  • Impact of physician's perception about LDL cholesterol control in clinical practice when treating patients in Spain
    Juan Cosín-Sales, Raquel Campuzano Ruiz, José Luis Díaz Díaz, Carlos Escobar Cervantes, María Rosa Fernández Olmo, Juan José Gómez-Doblas, José María Mostaza, Juan Pedro-Botet, Núria Plana Gil, Pedro Valdivielso
    Atherosclerosis.2023; 375: 38.     CrossRef
  • Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
    Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sung
    Diabetes & Metabolism Journal.2022; 46(3): 464.     CrossRef
  • Lipid-lowering treatment intensity, persistence, adherence and goal attainment in patients with coronary heart disease
    Faizan Mazhar, Paul Hjemdahl, Catherine M Clase, Kristina Johnell, Tomas Jernberg, Juan Jesus Carrero
    American Heart Journal.2022; 251: 78.     CrossRef
  • Evaluation of efficacy and safety of combined rosuvastatin and atorvastatin in treating with coronary heart disease
    Ke Li, Meng-Meng Liu, Xin Yang, Li Chen, Hui Geng, Wei Luo, Jie Ma
    Medicine.2021; 100(24): e26340.     CrossRef
  • Achievement of LDL-C Targets Defined by ESC/EAS (2011) Guidelines in Risk-Stratified Korean Patients with Dyslipidemia Receiving Lipid-Modifying Treatments
    Ye Seul Yang, Seo Young Lee, Jung-Sun Kim, Kyung Mook Choi, Kang Wook Lee, Sang-Chol Lee, Jung Rae Cho, Seung-Jin Oh, Ji-Hyun Kim, Sung Hee Choi
    Endocrinology and Metabolism.2020; 35(2): 367.     CrossRef
  • Low-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study
    Ye Seul Yang, Bo Ram Yang, Mi-Sook Kim, Yunji Hwang, Sung Hee Choi
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Dyslipidemia and Rate of Under-Target Low-Density Lipoprotein-Cholesterol in Patients with Coronary Artery Disease in Korea
    Sang-Hak Lee, Woo-Hyuk Song, Myung Ho Jeong, Seung-Ho Hur, Dong Woon Jeon, Wonju Jeung, Anselm K Gitt, Martin Horack, Ami Vyas, Dominik Lautsch, Baishali Ambegaonkar, Philippe Brudi, Yangsoo Jang
    Journal of Lipid and Atherosclerosis.2019; 8(2): 242.     CrossRef
  • Statin use and site-specific risk of colorectal cancer in individuals with hypercholesterolemia from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS)
    Jae-Woo Lee, Na-Young You, Yeseul Kim, Yonghwan Kim, Joungyoun Kim, Hee-Taik Kang
    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(7): 701.     CrossRef
  • Efficacy and safety of rosuvastatin versus atorvastatin in high-risk Chinese patients with hypercholesterolemia: a randomized, double-blind, active-controlled study
    Shuiping Zhao, Daoquan Peng
    Current Medical Research and Opinion.2018; 34(2): 227.     CrossRef
  • Effect of physician characteristics and knowledge on the quality of dyslipidemia management and LDL–C target goal achievement in China: Subgroup analysis of the Dyslipidemia International Study
    Rongjing Ding, Ping Ye, Shuiping Zhao, Dong Zhao, Xiaowei Yan, Yugang Dong, Jihu Li, Yuqin Ran, Dayi Hu
    Journal of Global Health.2017;[Epub]     CrossRef
  • Trends in the management levels of metabolic risk factors in middle-aged and elderly patients with type 2 diabetes mellitus: The Korean National Health and Nutrition Examination Survey 1998–2014
    Sukyung Cho, Haeun Jang, Kyong Park, Stefan Kiechl
    PLOS ONE.2017; 12(12): e0189361.     CrossRef
  • Increased postprandial apolipoprotein B-48 level after a test meal in diabetic patients: A multicenter, cross-sectional study
    Cheol-Young Park, Joong-Yeol Park, Jongwon Choi, Dae Jung Kim, Kyong Soo Park, Kun-Ho Yoon, Moon-Kyu Lee, Sung-Woo Park
    Metabolism.2016; 65(6): 843.     CrossRef
  • Physicians’ behavior following changes in LDL cholesterol target goals
    Shlomo Vinker, Haim Bitterman, Doron Comaneshter, Arnon D Cohen
    Israel Journal of Health Policy Research.2015;[Epub]     CrossRef
  • Prevalence of dyslipidaemia in patients treated with lipid-lowering agents in China: Results of the DYSlipidemia International Study (DYSIS)
    Shuiping Zhao, Yongjun Wang, Yiming Mu, Bilian Yu, Ping Ye, Xiaowei Yan, Zhanquan Li, Yidong Wei, Baishaili M. Ambegaonakr, Dayi Hu
    Atherosclerosis.2014; 235(2): 463.     CrossRef
  • First-line treatment patterns and lipid target levels attainment in very high cardiovascular risk outpatients
    Ioanna Xanthopoulou, Periklis Davlouros, Simos Siahos, Angelos Perperis, Evangelia Zaharioglou, Dimitrios Alexopoulos
    Lipids in Health and Disease.2013;[Epub]     CrossRef
  • Statin Prescription Adhered to Guidelines for Patients Hospitalized due to Acute Ischemic Stroke or Transient Ischemic Attack
    Keun-Sik Hong, Mi Sun Oh, Hye-Yeon Choi, A-Hyun Cho, Hyung-Min Kwon, Kyung-Ho Yu, Hee-Joon Bae, Juneyoung Lee, Byung-Chul Lee
    Journal of Clinical Neurology.2013; 9(4): 214.     CrossRef
  • LDL-cholesterol target values and actual values in patients with type 2 diabetes (T2D) uncontrolled on oral antidiabetic monotherapy: The lipid results of the French ESCALADE survey
    Alfred Penfornis, Alain Baleydier, Thierry Clavel, Sylvie Picard
    Annales d'Endocrinologie.2012; 73(6): 503.     CrossRef
  • Clinical evaluation of the use of statins in diabetic dyslipidemia
    김나영, 류재곤, 정효근, 백소영, 남상민
    Journal of Korean Society of Health-System Pharmacists.2012; 29(3): 288.     CrossRef
A Retrospective Study on the Efficacy of a Ten-Milligram Dosage of Atorvastatin for Treatment of Hypercholesterolemia in Type 2 Diabetes Mellitus Patients
Dong Kyun Kim, Sa Rah Lee, Min Sik Kim, Suk Hyang Bae, Jin Yeon Hwang, Jung-Min Kim, Sung Hwan Suh, Hye-Jeong Lee, Mi Kyoung Park, Duk Kyu Kim
Korean Diabetes J. 2010;34(6):359-367.   Published online December 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.6.359
  • 5,050 View
  • 25 Download
  • 3 Crossref
AbstractAbstract PDFPubReader   
Background

There have been few clinical studies on 10 mg atorvastatin as a starting dosage for treatment of hypercholesterolemia in type 2 diabetes mellitus (T2DM) patients. This retrospective study aims to evaluate the efficacy of 10 mg dosage of atorvastatin in clinical setting.

Methods

One hundred five enrolled patients with high levels of low density lipoprotein cholesterol (LDL-C, > 100 mg/dL) took 10 mg atorvastatin. After 6 months, they were divided into 'Responder group' (LDL-C < 100 mg/dL) and 'Non-responder group' (LDL-C ≥ 100 mg/dL), and the response rate was calculated. Thereafter, we subdivided the 'Responder group' into Maintenance (10 mg), Reduced dosage (5 mg), and Discontinuance group (0 mg). The 'Non-Responder group' was subdivided into Maintenance (10 mg) and Double dosage group (20 mg). After consecutive 6 months, the response rates of each 10 mg Maintenance groups were compared to those of the other groups, respectively.

Results

Following the first 6 months, the response rate of 10 mg fixed dosage was 74.3%. In the 'Responder group', response rates of 10 mg, 5 mg and Discontinuance groups following 6 months were 52.6%, 53.1%, and 12.5%, respectively. In the 'Non-responder group', response rates of 10 mg and 20 mg groups were 28.6% and 50.0%. Baseline LDL-C levels and body mass index (BMI) of 'Responder group' were significantly lower than those of 'Non-responder group' (P = 0.004, respectively).

Conclusion

Hypercholesterolemia treatment with 10 mg, fixed dosage of atorvastatin was effective in three quarters of the subjects during the first 6-month treatment; however, a significant number of patients with high LDL-C levels and/or BMI require higher starting and maintenance dosage.

Citations

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  • Preparation and Release Behavior of Atorvastatin Calcuim - Encapsulated Polyoxalate Microspheres
    Cheon Jung Lee, Su Young Kim, Hyun Gu Lee, Jaewon Yang, Jin Young Park, Se Rom Cha, Dong-Kwon Lim, Dongwon Lee, Gilson Khang
    Polymer Korea.2014; 38(5): 656.     CrossRef
  • A Retrospective Study on the Efficacy of a Ten-Milligram Dosage of Atorvastatin for Treatment of Hypercholesterolemia in Type 2 Diabetes Mellitus Patients (Korean Diabetes J 2010;34:359-67)
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2011; 35(1): 86.     CrossRef
  • Response: A Retrospective Study on the Efficacy of a Ten-Milligram Dosage of Atorvastatin for Treatment of Hypercholesterolemia in Type 2 Diabetes Mellitus Patients (Korean Diabetes J 2010;34:359-67)
    Dong Kyun Kim, Sa Rah Lee, Min Sik Kim, Suk Hyang Bae, Jin Yeon Hwang, Jung-Min Kim, Sung Hwan Suh, Hye-Jeong Lee, Mi Kyoung Park, Duk Kyu Kim
    Diabetes & Metabolism Journal.2011; 35(1): 88.     CrossRef

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