The aim of this study was to compare the fasting serum glucose level with the fasting plasma glucose level for diagnosing hyperglycemic states in real-life clinical situations. Additionally, we investigated a usual delay in sample processing and how such delays can impact the diagnosis of hyperglycemic states. Among 1,254 participants who had normoglycemia or impaired fasting glucose (IFG) assessed by the fasting serum glucose level, 20.9% were newly diagnosed with diabetes based on the plasma fasting glucose level. Of the participants with normoglycemia, 62.1% and 14.2% were newly diagnosed with IFG and diabetes, respectively, according to the plasma fasting glucose level. In our clinical laboratory for performing health examinations, the time delay from blood sampling to glycemic testing averaged 78±52 minutes. These findings show that the ordinary time delay for sample processing of the serum glucose for screening hyperglycemic states may be an important reason for these diagnoses to be underestimated in Korea.

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• Comparing glycemic traits in defining diabetes among rural Chinese older adults
  Pin Wang, Yuanjing Li, Mingqi Wang, Lin Song, Yi Dong, Xiaolei Han, Jaakko Tuomilehto, Yongxiang Wang, Yifeng Du, Chengxuan Qiu, Fredirick Lazaro mashili
  PLOS ONE.2024; 19(1): e0296694.     CrossRef
• Serum glucose, a cost-effective alternate of plasma glucose in diagnosing and monitoring diabetes mellitus
  Vivek Pant, Anders Kallner
  International Journal of Diabetes in Developing Countries.2023; 43(3): 377.     CrossRef
• Hyperglycemia and prematurity: a narrative review
  Dimitrios Angelis, Mambarambath A. Jaleel, Luc P. Brion
  Pediatric Research.2023; 94(3): 892.     CrossRef
• Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
  Kanyin Liane Ong, Lauryn K Stafford, Susan A McLaughlin, Edward J Boyko, Stein Emil Vollset, Amanda E Smith, Bronte E Dalton, Joe Duprey, Jessica A Cruz, Hailey Hagins, Paulina A Lindstedt, Amirali Aali, Yohannes Habtegiorgis Abate, Melsew Dagne Abate, Mo
  The Lancet.2023; 402(10397): 203.     CrossRef
• PM2.5 exposure increases the risk of preterm birth in pre-pregnancy impaired fasting glucose women: A cohort study in a Southern province of China
  Zhijiang Liang, Lina Zhao, Jialing Qiu, Xinhong Zhu, Min Jiang, Guocheng Liu, Qingguo Zhao
  Environmental Research.2022; 204: 112403.     CrossRef
• The impact of maternal prepregnancy impaired fasting glucose on preterm birth and large for gestational age: a large population-based cohort study
  Jie Tang, Xinhong Zhu, Mingzhen Li, Dongming Huang, Qingguo Zhao
  American Journal of Obstetrics and Gynecology.2020; 222(3): 265.e1.     CrossRef
• Utility of point‐of‐care vs reference laboratory testing for the evaluation of glucose levels
  O. M. Andriankaja, F. J. Muñoz‐Torres, J. L. Vergara, C. M. Pérez, K. Joshipura
  Diabetic Medicine.2019; 36(5): 626.     CrossRef
• Pre-analytical factors in blood glucose measurement
  Alpesh Goyal, Yashdeep Gupta
  Diabetes Research and Clinical Practice.2019; 158: 107802.     CrossRef
• Long-term stability of glucose: glycolysis inhibitor vs. gel barrier tubes
  Theresa Winter, Anke Hannemann, Juliane Suchsland, Matthias Nauck, Astrid Petersmann
  Clinical Chemistry and Laboratory Medicine (CCLM).2018; 56(8): 1251.     CrossRef
• Blood Glucose Measurement: Is Serum Equal to Plasma?
  Hye Soon Kim
  Diabetes & Metabolism Journal.2016; 40(5): 365.     CrossRef