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- Epidemiology
- Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study
- Yeli Wang, Woon-Puay Koh, Majken K. Jensen, Jian-Min Yuan, An Pan
- Diabetes Metab J. 2019;43(4):474-486. Published online March 20, 2019
- DOI: https://doi.org/10.4093/dmj.2018.0171
- 4,588 View
- 71 Download
- 9 Web of Science
- 8 Crossref
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Abstract
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Supplementary Material
PubReader Background Fetuin-A is a hepatokine that involved in the pathogenesis of insulin resistance. Previous epidemiological studies have found a positive association between blood fetuin-A and type 2 diabetes mellitus (T2DM) risk among Caucasians and African Americans. We aimed to investigate the prospective relationship between fetuin-A and T2DM in an Asian population for the first time.
Methods A nested case-control study was established within a prospective cohort of Chinese living in Singapore. At blood collection (1999 to 2004), all participants were free of diagnosed T2DM and aged 50 to 79 years. At subsequent follow-up (2006 to 2010), 558 people reported to have T2DM and were classified as incident cases, and 558 controls were randomly chosen from the participants who did not develop T2DM to match with cases on age, sex, dialect group, and date of blood collection. Plasma fetuin-A levels were measured retrospectively in cases and controls using samples collected at baseline. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to examine a potential non-linear association between fetuin-A levels and T2DM risk.
Results Compared with those in the lowest fetuin-A quintile, participants in the highest quintile had a two-fold increased risk of developing T2DM (OR, 2.06; 95% CI, 1.21 to 3.51). A non-linear association was observed (
P nonlinearity=0.005), where the association between fetuin-A levels and T2DM risk plateaued at plasma concentrations around 830 µg/mL.Conclusion There is a positive association between plasma fetuin-A levels and risk of developing T2DM in this Chinese population.
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Citations
Citations to this article as recorded by
- Type 2 diabetes and gut health - Narrative review
Janeline Lunghar, A. Thahira Banu
International Journal of Noncommunicable Diseases.2024; 9(1): 4. CrossRef - The predicted mechanisms and evidence of probiotics on type 2 diabetes mellitus (T2DM)
Ousman Bajinka, Kodzovi Sylvain Dovi, Lucette Simbilyabo, Ishmail Conteh, Yurong Tan
Archives of Physiology and Biochemistry.2023; : 1. CrossRef - Multiplexed measurements of salivary fetuin-A, insulin, and adiponectin as potential non-invasive biomarkers in childhood obesity
Vaithinathan Selvaraju, Jeganathan R. Babu, Thangiah Geetha
Cytokine.2022; 153: 155843. CrossRef - Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus
Margarita Ortiz-Martínez, Mirna González-González, Alexandro J. Martagón, Victoria Hlavinka, Richard C. Willson, Marco Rito-Palomares
Current Diabetes Reports.2022; 22(3): 95. CrossRef - Serum Fetuin-A and Risk of Gestational Diabetes Mellitus: An Observational Study and Mendelian Randomization Analysis
Ping Wu, Yi Wang, Yi Ye, Xue Yang, Qi Lu, Jiaying Yuan, Li Zha, Yan Liu, Xingyue Song, Shijiao Yan, Ying Wen, Xiaorong Qi, Chun-Xia Yang, Yixin Wang, Gang Liu, Chuanzhu Lv, Xiong-Fei Pan, An Pan
The Journal of Clinical Endocrinology & Metabolism.2022; 107(9): e3841. CrossRef - Hepatokines as a Molecular Transducer of Exercise
Dae Yun Seo, Se Hwan Park, Jubert Marquez, Hyo-Bum Kwak, Tae Nyun Kim, Jun Hyun Bae, Jin-Ho Koh, Jin Han
Journal of Clinical Medicine.2021; 10(3): 385. CrossRef - Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress
Shiyao Xue, Hongdong Han, Shunli Rui, Mengliu Yang, Yizhou Huang, Bin Zhan, Shan Geng, Hua Liu, Chen Chen, Gangyi Yang, Ling Li, Colin Murdoch
Oxidative Medicine and Cellular Longevity.2021; 2021: 1. CrossRef - CD44, a Predominant Protein in Methylglyoxal-Induced Secretome of Muscle Cells, is Elevated in Diabetic Plasma
Shakuntala Bai, Arvindkumar H. Chaurasiya, Reema Banarjee, Prachi B. Walke, Faraz Rashid, Ambika G. Unnikrishnan, Mahesh J. Kulkarni
ACS Omega.2020; 5(39): 25016. CrossRef
- Type 2 diabetes and gut health - Narrative review
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