As in other countries, type 2 diabetes is major health concern in Korea. A dramatic increase in the prevalence of type 2 diabetes and its chronic complications has led to an increase in health costs and economic burdens. Early detection of high risk individuals, hidden diabetic patients, and improvement in the quality of care for the disease are the first steps to mitigate the increase in prevalence. The Committee of Clinical Practice Guidelines of the Korean Diabetes Association revised and updated the '3rd Clinical Practice Guidelines' at the end of 2010. In the guidelines, the committee recommended active screening of high risk individuals for early detection and added the hemoglobin A1c level to the diagnostic criteria for type 2 diabetes based on clinical studies performed in Korea. Furthermore, the committee members emphasized that integrating patient education and self-management is an essential part of care. The drug treatment algorithm based on the degree of hyperglycemia and patient characteristics were also updated.

Citations

Citations to this article as recorded by  

• Paradigm Shift in Management of Hyperglycemia in Patients with Type 2 Diabetes: Glucocentric versus Organ Protection
  Jong Chul Won
  The Journal of Korean Diabetes.2023; 24(2): 59.     CrossRef
• Association of HbA1c with functional outcome by ischemic stroke subtypes and age
  Jihyun Jeong, Jae Kyung Park, Young Ho Koh, Jong-Moo Park, Hee-Joon Bae, Sang-Moon Yun
  Frontiers in Neurology.2023;[Epub]     CrossRef
• Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
  Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sung
  Diabetes & Metabolism Journal.2022; 46(3): 464.     CrossRef
• Correlation between Serum Osmolarity and Creatinine in Health Check-Up Subjects (Examinees) with Diabetes
  Mi-Kyung Park, Geum-Seon Lee, Sun-Hee Kim, Mi-Eun Yun
  The Korean Journal of Community Living Science.2022; 33(2): 237.     CrossRef
• Dietary antioxidant consumption and the risk of type 2 diabetes in South Korean adults: a prospective cohort study based on the Health Examinees study
  Li-Juan Tan, Su Bin Hwang, Shinyoung Jun, Hyojee Joung, Sangah Shin
  BMJ Open.2022; 12(7): e065073.     CrossRef
• Investigating the Effectiveness of Very Low-Calorie Diets and Low-Fat Vegan Diets on Weight and Glycemic Markers in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
  Anjali Kashyap, Alexander Mackay, Ben Carter, Claire L. Fyfe, Alexandra M. Johnstone, Phyo K. Myint
  Nutrients.2022; 14(22): 4870.     CrossRef
• Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
  Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon
  Diabetes & Metabolism Journal.2022; 46(6): 819.     CrossRef
• Mobile Healthcare System Provided by Primary Care Physicians Improves Quality of Diabetes Care
  Tae Jung Oh, Jie-Eun Lee, Seok Kim, Sooyoung Yoo, Hak Chul Jang
  CardioMetabolic Syndrome Journal.2021; 1(1): 88.     CrossRef
• Treatment Patterns of Type 2 Diabetes Assessed Using a Common Data Model Based on Electronic Health Records of 2000–2019
  Kyung Ae Lee, Heung Yong Jin, Yu Ji Kim, Yong-Jin Im, Eun-Young Kim, Tae Sun Park
  Journal of Korean Medical Science.2021;[Epub]     CrossRef
• A Review on Metformin: Clinical Significance and Side Effects
  Mazumder Avijit, Singh Ashini
  Research Journal of Pharmacy and Technology.2021; : 6179.     CrossRef
• Cardiovascular Disease among Patients with Diabetes: The Current Scenario in Saudi Arabia
  Asirvatham Alwin Robert, Mohamed Abdulaziz Al Dawish
  Current Diabetes Reviews.2021; 17(2): 180.     CrossRef
• Association of Cardiometabolic Multimorbidity Pattern with Dietary Factors among Adults in South Korea
  Dawoon Jeong, Jieun Kim, Hansongyi Lee, Do-Yeon Kim, Hyunjung Lim
  Nutrients.2020; 12(9): 2730.     CrossRef
• Comparison of effectiveness and drug cost between dipeptidyl peptidase‐4 inhibitor and biguanide as the first‐line anti‐hyperglycaemic medication among Japanese working generation with type 2 diabetes
  Noriko Ihana‐Sugiyama, Takehiro Sugiyama, Hirokazu Tanaka, Kohjiro Ueki, Yasuki Kobayashi, Mitsuru Ohsugi
  Journal of Evaluation in Clinical Practice.2020; 26(1): 299.     CrossRef
• Exploration of suitable pharmacodynamic parameters for acarbose bioequivalence evaluation: A series of clinical trials with branded acarbose
  Jie Huang, Wen‐yu Liu, Jing‐jing Yu, Jin‐bo Yang, Min Li, Chan Zou, Cheng‐xian Guo, Xiao‐yan Yang, Shuang Yang, Jin‐lian Xie, Zhi‐jun Huang, Hui Chen, Qi Pei, Guo‐ping Yang
  British Journal of Clinical Pharmacology.2020; 86(11): 2225.     CrossRef
• Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults
  So Mi Jemma Cho, Hokyou Lee, Jee-Seon Shim, Hyeon Chang Kim
  Diabetes & Metabolism Journal.2020; 44(5): 711.     CrossRef
• Efficacy and safety of insulin glargine 300 U/mL versus insulin glargine 100 U/mL in Asia Pacific insulin‐naïve people with type 2 diabetes: The EDITION AP randomized controlled trial
  Linong Ji, Eun Seok Kang, XiaoLin Dong, Ling Li, GuoYue Yuan, Shuhua Shang, Elisabeth Niemoeller
  Diabetes, Obesity and Metabolism.2020; 22(4): 612.     CrossRef
• Effect of different dietary patterns on glycemic control in individuals with type 2 diabetes mellitus: A systematic review
  Gabrielli Barbosa de Carvalho, Natalia Lohayne Dias-Vasconcelos, Ramara Kadija Fonseca Santos, Paula Nascimento Brandão-Lima, Danielle Góes da Silva, Liliane Viana Pires
  Critical Reviews in Food Science and Nutrition.2020; 60(12): 1999.     CrossRef
• Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes
  Sang Ouk Chin, In Gyoon Ha, Sang Youl Rhee, Su Jin Jeong, Suk Chon, Sung Hoon Kim, Kyu Jeung Ahn, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Jeong Taek Woo
  International Journal of Endocrinology.2020; 2020: 1.     CrossRef
• Chronic Hyperglycemia before Spinal Cord Injury Increases Inflammatory Reaction and Astrogliosis after Injury: Human and Rat Studies
  Ki-Su Park, Jin Bum Kim, Martin Keung, Ye Jin Seo, Sung Young Seo, Seul Ah Mun, Young-Seok Lee, Dae-Chul Cho, Jeong-Hyun Hwang, Inbo Han, Chi Heon Kim, Kyoung-Tae Kim
  Journal of Neurotrauma.2020; 37(9): 1165.     CrossRef
• National trends in metformin-based combination therapy of oral hypoglycaemic agents for type 2 diabetes mellitus
  Jisu Kim, Susin Park, Hyunsoo Kim, Nam Kyung Je
  European Journal of Clinical Pharmacology.2019; 75(12): 1723.     CrossRef
• Three-Dimensional Paper-Based Microfluidic Analytical Devices Integrated with a Plasma Separation Membrane for the Detection of Biomarkers in Whole Blood
  Chanyong Park, Hong-Rae Kim, Soo-Kyung Kim, In-Kyung Jeong, Jae-Chul Pyun, Sungsu Park
  ACS Applied Materials & Interfaces.2019; 11(40): 36428.     CrossRef
• The Effect of Metformin on Prognosis in Patients With Locally Advanced Gastric Cancer Associated With Type 2 Diabetes Mellitus
  Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Han Hong Lee, Cho Hyun Park
  American Journal of Clinical Oncology.2019; 42(12): 909.     CrossRef
• Discordance in prediction for prognosis of type 2 diabetes after metabolic surgery: comparison of the ABCD, DiaRem, and individualized metabolic surgery models
  Jane Ha, Yeongkeun Kwon, Nam Hoon Kim, Sungsoo Park, Emanuele Lo Menzo, Raul J. Rosenthal
  Annals of Surgical Treatment and Research.2019; 97(6): 309.     CrossRef
• Discrepancies between Glycosylated Hemoglobin and Fasting Plasma Glucose for Diagnosing Impaired Fasting Glucose and Diabetes Mellitus in Korean Youth and Young Adults
  Jieun Lee, Young Ah Lee, Jae Hyun Kim, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
  Diabetes & Metabolism Journal.2019; 43(2): 174.     CrossRef
• 2019 Clinical Practice Guidelines for Type 2 Diabetes Mellitus in Korea
  Mee Kyoung Kim, Seung-Hyun Ko, Bo-Yeon Kim, Eun Seok Kang, Junghyun Noh, Soo-Kyung Kim, Seok-O Park, Kyu Yeon Hur, Suk Chon, Min Kyong Moon, Nan-Hee Kim, Sang Yong Kim, Sang Youl Rhee, Kang-Woo Lee, Jae Hyeon Kim, Eun-Jung Rhee, SungWan Chun, Sung Hoon Yu
  Diabetes & Metabolism Journal.2019; 43(4): 398.     CrossRef
• Lack of Association between Past Helicobacter pylori Infection and Diabetes: A Two-Cohort Study
  Jeung Hui Pyo, Hyuk Lee, Sung Chul Choi, Soo Jin Cho, Yoon-Ho Choi, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Heejin Yoo, Kyunga Kim, Jae J. Kim
  Nutrients.2019; 11(8): 1874.     CrossRef
• Does Korean diet based on brown rice really have the effect on treating chronic diseases and on suspending drug use?
  Su Jin Jung, Baik Hwan Cho, Soo Wan Chae
  Journal of Ethnic Foods.2018;[Epub]     CrossRef
• The effectiveness, reproducibility, and durability of tailored mobile coaching on diabetes management in policyholders: A randomized, controlled, open-label study
  Da Young Lee, Jeongwoon Park, Dooah Choi, Hong-Yup Ahn, Sung-Woo Park, Cheol-Young Park
  Scientific Reports.2018;[Epub]     CrossRef
• Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index
  Kyoung Hwa Ha, Cheol Young Park, In Kyung Jeong, Hyun Jin Kim, Sang-Yong Kim, Won Jun Kim, Ji Sung Yoon, In Joo Kim, Dae Jung Kim, Sungrae Kim
  Diabetes & Metabolism Journal.2018; 42(2): 137.     CrossRef
• Distribution of glycated haemoglobin and its determinants in Korean youth and young adults: a nationwide population-based study
  Ji-Young Seo, Seung-sik Hwang, Jae Hyun Kim, Young Ah Lee, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
  Scientific Reports.2018;[Epub]     CrossRef
• The relationship between age of onset and risk factors including family history and life style in Korean population with type 2 diabetes mellitus
  Jin-Won Noh, Jin Hee Jung, Jeong Eun Park, Jung Hwa Lee, Kang Hee Sim, Jumin Park, Min Hee Kim, Ki-Bong Yoo
  Journal of Physical Therapy Science.2018; 30(2): 201.     CrossRef
• Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
  Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
  Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
• Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data
  Sejeong Park, Sang Youl Rhee, Su Jin Jeong, Kiyoung Kim, Suk Chon, Seung-Young Yu, Jeong-Taek Woo
  Diabetes & Metabolism Journal.2017; 41(5): 393.     CrossRef
• Letter: Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes (Endocrinol Metab2016;31:416-23, Bong-Ki Lee et al.)
  Mee Kyoung Kim
  Endocrinology and Metabolism.2017; 32(1): 140.     CrossRef
• The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose
  Seyoung Kwon, Youngak Na
  The Korean Journal of Clinical Laboratory Science.2017; 49(2): 114.     CrossRef
• Changes in HbA 1c levels and body mass index after successful decompression surgery in patients with type 2 diabetes mellitus and lumbar spinal stenosis: results of a 2-year follow-up study
  Kyoung-Tae Kim, Dae-Chul Cho, Joo-Kyung Sung, Chi Heon Kim, Hyun Kang, Du Hwan Kim
  The Spine Journal.2017; 17(2): 203.     CrossRef
• Validation of a Newly Developed Equation for Estimating Serum Apolipoprotein B: Associations with Cardiovascular Disease Surrogate Markers in Koreans
  Jong-Dai Kim, You-Cheol Hwang, Hong-Yup Ahn, Cheol-Young Park
  Yonsei Medical Journal.2017; 58(5): 975.     CrossRef
• Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
  Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
  The Korean Journal of Internal Medicine.2017; 32(6): 947.     CrossRef
• Diagnostic criteria for diabetes in China: are we pushing too much beyond evidence?
  X Ma, Y-L Zhang, Q Ji, Y Xing, H Pan, S Chen, J-L Tang, S Zhu
  European Journal of Clinical Nutrition.2017; 71(7): 812.     CrossRef
• Patterns, control and complications of diabetes from a hospital based registry established in a low income country
  Jaweed Akhter, Asma Ahmed, Minaz Mawani, Laila Lakhani, Ayaz Kalsekar, Shehla Tabassum, Najmul Islam
  BMC Endocrine Disorders.2017;[Epub]     CrossRef
• Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment
  Yanyun Gu, Xiaokai Wang, Junhua Li, Yifei Zhang, Huanzi Zhong, Ruixin Liu, Dongya Zhang, Qiang Feng, Xiaoyan Xie, Jie Hong, Huahui Ren, Wei Liu, Jing Ma, Qing Su, Hongmei Zhang, Jialin Yang, Xiaoling Wang, Xinjie Zhao, Weiqiong Gu, Yufang Bi, Yongde Peng,
  Nature Communications.2017;[Epub]     CrossRef
• Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association
  Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
  Diabetes & Metabolism Journal.2017; 41(5): 337.     CrossRef
• Regional variations in frequency of glycosylated hemoglobin (HbA1c) monitoring in Korea: A multilevel analysis of nationwide data
  Kyoung-Hun Yoo, Dong-Wook Shin, Mi-Hee Cho, Sang-Hyuck Kim, Hyun-Jung Bahk, Shin-Hye Kim, Su-Min Jeong, Jae-Moon Yun, Jin-Ho Park, Heesun Kim, BeLong Cho
  Diabetes Research and Clinical Practice.2017; 131: 61.     CrossRef
• Fasting plasma glucose concentrations for specified HbA1c goals in Korean populations: data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011)
  Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
  Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
• Metabolic syndrome independently predicts future diabetes in women with a history of gestational diabetes mellitus
  Nam H. Cho, Chang Ho Ahn, Joon Ho Moon, Soo Heon Kwak, Sung Hee Choi, Soo Lim, Kyong Soo Park, Boyd E. Metzger, Hak C. Jang
  Medicine.2016; 95(35): e4582.     CrossRef
• Feasibility of a Patient-Centered, Smartphone-Based, Diabetes Care System: A Pilot Study
  Eun Ky Kim, Soo Heon Kwak, Seungsu Baek, Seung Lyeol Lee, Hak Chul Jang, Kyong Soo Park, Young Min Cho
  Diabetes & Metabolism Journal.2016; 40(3): 192.     CrossRef
• Effectiveness of Web-Based Interventions for Managing Diabetes in Korea
  Jee Young Joo
  CIN: Computers, Informatics, Nursing.2016; 34(12): 587.     CrossRef
• Severe Hypoglycemia and Cardiovascular or All-Cause Mortality in Patients with Type 2 Diabetes
  Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Seawon Hwang, Eun-Jung Yim, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko
  Diabetes & Metabolism Journal.2016; 40(3): 202.     CrossRef
• A Potential Issue with Screening Prediabetes or Diabetes Using Serum Glucose: A Delay in Diagnosis
  Jun Goo Kang, Cheol-Young Park, Sung-Hee Ihm, Sung Woo Park
  Diabetes & Metabolism Journal.2016; 40(5): 414.     CrossRef
• Experiences of Diabetes Education among Educators of Diabetes : a content analysis approach
  Soo Jin Kang, Soo Jung Chang
  Journal of Korean Public Health Nursing.2016; 30(2): 221.     CrossRef
• Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes
  Donghe Li, Sungho Won
  Genomics & Informatics.2016; 14(4): 160.     CrossRef
• A patient-centric approach to optimise insulin therapy in Asia
  Su Yen Goh, Ernesto Ang, Shailendra Bajpai, Chaicharn Deerochanawong, Eun-Gyoung Hong, Zanariah Hussein, Shashank Joshi, Nor Azmi Kamaruddin, Sjoberg Kho, Alice Pik-Shan Kong, Chang Yu Pan, Riccardo Perfetti, Apichati Vichayanrat, Aleksandra Vlajnic, Juli
  Journal of Diabetes and its Complications.2016; 30(6): 973.     CrossRef
• Glycosylated Hemoglobin Threshold for Predicting Diabetes and Prediabetes from the Fifth Korea National Health and Nutrition Examination Survey
  Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Cheol-Young Park, Chang Beom Lee, Sung-Hee Ihm
  Diabetes & Metabolism Journal.2016; 40(2): 167.     CrossRef
• Retrospective Observational Dose-Titration Study of Subjects with Type 2 Diabetes Mellitus with Inadequate Glycemic Control on 15 mg of Pioglitazone
  So Young Ha, Hae Won Jung, Yong Jun Choi, Hyun Kyo Lee, Jong Wook Choi, Ji Hoon Choi, Jung Hyun Noh, Jae Won Hong, Dong-Jun Kim
  The Journal of Korean Diabetes.2016; 17(1): 51.     CrossRef
• Upper-normal waist circumference is a risk marker for metabolic syndrome in normal-weight subjects
  R. Okada, Y. Yasuda, K. Tsushita, K. Wakai, N. Hamajima, S. Matsuo
  Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(1): 67.     CrossRef
• Optimal Glycemic and Hemoglobin A1c Thresholds for Diagnosing Diabetes Based on Prevalence of Retinopathy in an Iranian Population
  Naser Samadi Aidenloo, Alireza Mehdizadeh, Neda Valizadeh, Mohammad Abbaszadeh, Siavash Qarequran, Hamidreza Khalkhali
  Iranian Red Crescent Medical Journal.2016;[Epub]     CrossRef
• Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
  Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
  Medicine.2016; 95(27): e4018.     CrossRef
• Association between estimated blood glucose levels and glycated hemoglobin levels
  Seon-Ah Cha, Seung-Hyun Ko
  The Korean Journal of Internal Medicine.2016; 31(3): 457.     CrossRef
• Uncontrolled diabetes mellitus: Prevalence and risk factors among people with type 2 diabetes mellitus in an Urban District of Karachi, Pakistan
  Fahad Javaid Siddiqui, Bilal Iqbal Avan, Sadia Mahmud, Debra J. Nanan, Abdul Jabbar, Pryseley Nkouibert Assam
  Diabetes Research and Clinical Practice.2015; 107(1): 148.     CrossRef
• Assessment of glycemic control in patients with type 2 diabetes mellitus treated with metformin–sulfonylurea combination: Results of a multicenter, cross‐sectional, observational study in Korea
  Sin Gon Kim, Jong Ryeal Hahm, Duk Kyu Kim, Sung Rae Cho, Dong Seop Choi
  Journal of Diabetes Investigation.2015; 6(3): 317.     CrossRef
• Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
  Jae-Seung Yun, Seung-Hyun Ko
  The Korean Journal of Internal Medicine.2015; 30(1): 6.     CrossRef
• The Correlation between Hemoglobin A1c and Common Carotid Artery Intima Medial Thickness of Both Genders with Less Than 6.5% HbA1c Based on Ultrasound Measurement
  Yeongju Ryu, Youngjin Park, Byeong Jin Ye
  Korean Journal of Health Promotion.2015; 15(2): 47.     CrossRef
• Increased prevalence of albuminuria in individuals with higher range of impaired fasting glucose: the 2011 Korea National Health and Nutrition Examination Survey
  Jong Chul Won, Jae Won Hong, Jung Min Kim, Tae Nyun Kim, Jung Hyun Noh, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
  Journal of Diabetes and its Complications.2015; 29(1): 50.     CrossRef
• The Association between Chronic Kidney Disease and Diabetic Retinopathy: The Korea National Health and Nutrition Examination Survey 2008-2010
  Young-Hoon Park, Jeong Ah Shin, Jae-Hyung Han, Yong-Moon Park, Hyeon Woo Yim, Harald Mischak
  PLOS ONE.2015; 10(4): e0125338.     CrossRef
• Efficacy of a New Medical Information system, Ubiquitous Healthcare Service with Voice Inception Technique in Elderly Diabetic Patients
  Kyoung Min Kim, Kyeong Seon Park, Hyun Ju Lee, Yun Hee Lee, Ji Seon Bae, Young Joon Lee, Sung Hee Choi, Hak Chul Jang, Soo Lim
  Scientific Reports.2015;[Epub]     CrossRef
• Intensive Individualized Reinforcement Education Is Important for the Prevention of Hypoglycemia in Patients with Type 2 Diabetes
  Yun-Mi Yong, Kyung-Mi Shin, Kang-Min Lee, Jae-Young Cho, Sun-Hye Ko, Min-Hyang Yoon, Tae-Won Kim, Jong-Hyun Jeong, Yong-Moon Park, Seung-Hyun Ko, Yu-Bae Ahn
  Diabetes & Metabolism Journal.2015; 39(2): 154.     CrossRef
• The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes: Understanding How Data Can Inform Clinical Practice in Korea
  Seungjoon Oh, Suk Chon, Kyu Jeong Ahn, In-Kyung Jeong, Byung-Joon Kim, Jun Goo Kang
  Diabetes & Metabolism Journal.2015; 39(3): 177.     CrossRef
• Clinical Characteristics of Subjects with Sulfonylurea-Dependent Type 2 Diabetes
  Se Hee Min, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung
  Endocrinology and Metabolism.2015; 30(4): 509.     CrossRef
• Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes
  Jae-Seung Yun, Seung-Hyun Ko, Sun-Hye Ko, Ki-Ho Song, Ki-Dong Yoo, Kun-Ho Yoon, Yong-Moon Park, Yu-Bae Ahn
  Diabetes & Metabolism Journal.2015; 39(6): 498.     CrossRef
• Association between flavonoid intake and diabetes risk among the Koreans
  Jee-Young Yeon, Yun Jung Bae, Eun-Young Kim, Eun-Ju Lee
  Clinica Chimica Acta.2015; 439: 225.     CrossRef
• Association between Self-Reported Smoking and Hemoglobin A1c in a Korean Population without Diabetes: The 2011–2012 Korean National Health and Nutrition Examination Survey
  Jae Won Hong, Cheol Ryong Ku, Jung Hyun Noh, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim, Barbara Fuhrman
  PLOS ONE.2015; 10(5): e0126746.     CrossRef
• Relationship between metabolic syndrome and thyroid nodules in healthy Koreans
  Juyoung Shin, Min-Hee Kim, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
  The Korean Journal of Internal Medicine.2015; 31(1): 98.     CrossRef
• Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome
  Chun-Ja Kim, Hee Sun Kang, Elizabeth A. Schlenk, Sun-Mi Chae
  The Diabetes Educator.2015; 41(2): 203.     CrossRef
• Current Status of Management in Type 2 Diabetes Mellitus at General Hospitals in South Korea
  Jin-Hee Jung, Jung-Hwa Lee, Jin-Won Noh, Jeong-Eun Park, Hee-Sook Kim, Joo-Wha Yoo, Bok-Rye Song, Jeong-rim Lee, Myeong-Hee Hong, Hyang-Mi Jang, Young Na, Hyun-Joo Lee, Jeong-Mi Lee, Yang-Gyo Kang, Sun-Young Kim, Kang-Hee Sim
  Diabetes & Metabolism Journal.2015; 39(4): 307.     CrossRef
• The number of metabolic syndrome components is a good risk indicator for both early- and late-stage kidney damage
  R. Okada, Y. Yasuda, K. Tsushita, K. Wakai, N. Hamajima, S. Matsuo
  Nutrition, Metabolism and Cardiovascular Diseases.2014; 24(3): 277.     CrossRef
• Internet-Based Mentoring Program for Patients with Type 1 Diabetes
  Sun-Hye Ko, Seung-Hyun Ko
  Diabetes & Metabolism Journal.2014; 38(2): 107.     CrossRef
• Association of Vitamin B12Deficiency and Metformin Use in Patients with Type 2 Diabetes
  Sun-Hye Ko, Sun-Hee Ko, Yu-Bae Ahn, Ki-Ho Song, Kyung-Do Han, Yong-Moon Park, Seung-Hyun Ko, Hye-Soo Kim
  Journal of Korean Medical Science.2014; 29(7): 965.     CrossRef
• Plasma Glucose Regulation and Mortality in Korea: A Pooled Analysis of Three Community-Based Cohort Studies
  Nan Hee Kim, Dong-Jun Kim, Seok Won Park, Jee-Young Oh, Joong-Yeol Park, Chol Shin, Hong Kyu Lee, Yongsoo Park
  Diabetes & Metabolism Journal.2014; 38(1): 44.     CrossRef
• The glycemic efficacies of insulin analogue regimens according to baseline glycemic status in Korean patients with type 2 diabetes: sub‐analysis from the A 1 chieve ® study
  Y.‐C. Hwang, J. G. Kang, K. J. Ahn, B. S. Cha, S.‐H. Ihm, S. Lee, M. Kim, B.‐W. Lee
  International Journal of Clinical Practice.2014; 68(11): 1338.     CrossRef
• Higher Prevalence and Awareness, but Lower Control Rate of Hypertension in Patients with Diabetes than General Population: The Fifth Korean National Health and Nutrition Examination Survey in 2011
  Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Nan Hee Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Yong-Moon Park, Bong-Yun Cha
  Diabetes & Metabolism Journal.2014; 38(1): 51.     CrossRef
• Comparison between the Therapeutic Effect of Metformin, Glimepiride and Their Combination as an Add-On Treatment to Insulin Glargine in Uncontrolled Patients with Type 2 Diabetes
  Cheol-Young Park, Jun Goo Kang, Suk Chon, Junghyun Noh, Seung Joon Oh, Chang Beom Lee, Sung Woo Park, T. Mark Doherty
  PLoS ONE.2014; 9(3): e87799.     CrossRef
• Glycaemic and haemoglobin A1c thresholds for detecting diabetic retinopathy: The fifth Korea National Health and Nutrition Examination Survey (2011)
  Yong-Moon Park, Seung-Hyun Ko, Jung-Min Lee, Dae-Jung Kim, Dong-Joon Kim, Kyungdo Han, Julie K. Bower, Yu-Bae Ahn
  Diabetes Research and Clinical Practice.2014; 104(3): 435.     CrossRef
• Development of an HbA1c-Based Conversion Equation for Estimating Glycated Albumin in a Korean Population with a Wide Range of Glucose Intolerance
  Chang Hee Jung, You-Cheol Hwang, Kwang Joon Kim, Bong Soo Cha, Cheol-Young Park, Won Seon Jeon, Jae Hyeon Kim, Sang-Man Jin, Sang Youl Rhee, Jeong-taek Woo, Byung-Wan Lee, Sompop Bencharit
  PLoS ONE.2014; 9(4): e95729.     CrossRef
• Risk of suicidal ideation in diabetes varies by diabetes regimen, diabetes duration, and HbA1c level
  Hoo-Yeon Lee, Myung-Il Hahm, Sang Gyu Lee
  Journal of Psychosomatic Research.2014; 76(4): 275.     CrossRef
• Non-HDL cholesterol is an independent risk factor for aspirin resistance in obese patients with type 2 diabetes
  Jong Dai Kim, Cheol-Young Park, Kue Jeong Ahn, Jae Hyoung Cho, Kyung Mook Choi, Jun Goo Kang, Jae Hyeon Kim, Ki Young Lee, Byung Wan Lee, Ji Oh Mok, Min Kyong Moon, Joong Yeol Park, Sung Woo Park
  Atherosclerosis.2014; 234(1): 146.     CrossRef
• Optimal glycated albumin cutoff value to diagnose diabetes in Korean adults: A retrospective study based on the oral glucose tolerance test
  You-Cheol Hwang, Chang Hee Jung, Hong-Yup Ahn, Won Seon Jeon, Sang-Man Jin, Jeong-taek Woo, Bong Soo Cha, Jae Hyeon Kim, Cheol-Young Park, Byung-Wan Lee
  Clinica Chimica Acta.2014; 437: 1.     CrossRef
• Higher Prevalence of Metformin-Induced Vitamin B12 Deficiency in Sulfonylurea Combination Compared with Insulin Combination in Patients with Type 2 Diabetes: A Cross-Sectional Study
  Donghoon Kang, Jae-Seung Yun, Sun-Hye Ko, Tae-Seok Lim, Yu-Bae Ahn, Yong-Moon Park, Seung-Hyun Ko, Yu Wang
  PLoS ONE.2014; 9(10): e109878.     CrossRef
• The Relationship between BMI and Glycated Albumin to Glycated Hemoglobin (GA/A1c) Ratio According to Glucose Tolerance Status
  Ji Hye Huh, Kwang Joon Kim, Byung-Wan Lee, Dong Wook Kim, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Marta Letizia Hribal
  PLoS ONE.2014; 9(2): e89478.     CrossRef
• Prevalence of Diabetes and Prediabetes according to Fasting Plasma Glucose and HbA1c
  Ja Young Jeon, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Myoung-jin Jang, Yuna Kim, Kyungwon Oh, Dae Jung Kim, Bong-Yun Cha
  Diabetes & Metabolism Journal.2013; 37(5): 349.     CrossRef
• Metformin Based Dual-Combination Therapies in Drug Naïve Type 2 Diabetic Patients
  Dong-Lim Kim
  Diabetes & Metabolism Journal.2013; 37(6): 429.     CrossRef
• Glycemic Effectiveness of Metformin-Based Dual-Combination Therapies with Sulphonylurea, Pioglitazone, or DPP4-Inhibitor in Drug-Naïve Korean Type 2 Diabetic Patients
  Young Ki Lee, Sun Ok Song, Kwang Joon Kim, Yongin Cho, Younjeong Choi, Yujung Yun, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee
  Diabetes & Metabolism Journal.2013; 37(6): 465.     CrossRef
• Long-term changes of the prevalence and control rate of hypertension among Korean adults with diagnosed diabetes: 1998–2008 Korean National Health and Nutrition Examination Survey
  Seung-Hyun Ko, Hyuk-Sang Kwon, Ki-Ho Song, Yu-Bae Ahn, Kun-Ho Yoon, Hyeon Woo Yim, Won-Chul Lee, Yong-Moon Park
  Diabetes Research and Clinical Practice.2012; 97(1): 151.     CrossRef
• Smoking and Type 2 Diabetes Mellitus
  Sang Ah Chang
  Diabetes & Metabolism Journal.2012; 36(6): 399.     CrossRef
• Body Mass Index and Waist Circumference According to Glucose Tolerance Status in Korea: The 2005 Korean Health and Nutrition Examination Survey
  Hye Mi Kang, Dong-Jun Kim
  Journal of Korean Medical Science.2012; 27(5): 518.     CrossRef
• Renal Hyperfiltration in Prediabetes Confirmed by Fasting Plasma Glucose and Hemoglobin A1c
  Rieko Okada, Kenji Wakai, Mariko Naito, Emi Morita, Sayo Kawai, Guang Yin, Noriyo Ozawa, Masatoshi Furuta, Erina Koyama, Rumi Tsuchiya, Noriko Kouno, Nobuyuki Hamajima
  Renal Failure.2012; 34(9): 1084.     CrossRef
• Higher Morning to Evening Ratio in Total Dose of Twice-Daily Biphasic Insulin Analog Might Be Effective in Achieving Glucose Control in Patients with Poorly Controlled Type 2 Diabetes
  Yong-Ho Lee, Byung-Wan Lee, Hea Jin Kwon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
  Diabetes Technology & Therapeutics.2012; 14(6): 508.     CrossRef
• The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone
  Sun Ok Song, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
  Diabetes & Metabolism Journal.2012; 36(5): 371.     CrossRef
• Low Density Lipoprotein Cholesterol Target Goal Attainment Rate and Physician Perceptions about Target Goal Achievement in Korean Patients with Diabetes
  Jenie Yoonoo Hwang, Chang Hee Jung, Woo Je Lee, Cheol Young Park, Sung Rae Kim, Kun-Ho Yoon, Moon Kyu Lee, Sung Woo Park, Joong-Yeol Park
  Diabetes & Metabolism Journal.2011; 35(6): 628.     CrossRef
• Letter: Diabetic Polyneuropathy and Cardiovascular Complications in Type 2 Diabetic Patients (Diabetes Metab J 2011;35:390-6)
  Sun-Hye Ko, Seung-Hyun Ko
  Diabetes & Metabolism Journal.2011; 35(5): 558.     CrossRef

Cardiovascular disease (CVD), a leading cause of death in patients with diabetes mellitus, has several pathogenic mechanisms that are well established. However, the traditional hypoglycemic agents do not have proven positive effects on macrovascular disease. Novel therapeutic agents target the incretin pathway including the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists and the dipeptidyl peptidase-4 inhibitors. The glucose-regulatory actions of these agents function by increasing insulin secretion and suppressing glucagon. They also act to increase weight loss not only by inhibiting gastric emptying, but also by reducing appetite. Although GLP-1 and GLP-1R agonists have demonstrated beneficial effects on myocardium and vascular endothelium including coronary and peripheral mouse vessels, they also have anti-inflammatory and anti-atherogenic actions. These agents also have positive effects on the lipid profile and blood pressure. Although these cardioprotective actions seem to be beyond the effects of glucose control and weight loss, they are mediated through GLP-1R- or GLP-1R-independent actions of cleaved GLP-1 (9-36). Larger randomized controlled trials are necessary to elucidate the clinical promise of these beneficial CVD effects.

Citations

Citations to this article as recorded by  

• Cardioprotective Effects of Glucagon-like Peptide-1 (9-36) Against Oxidative Injury in H9c2 Cardiomyoblasts: Potential Role of the PI3K/Akt/NOS Pathway
  Narawat Nuamnaichati, Warisara Parichatikanond, Supachoke Mangmool
  Journal of Cardiovascular Pharmacology.2022; 79(1): e50.     CrossRef
• Comparisons of pleiotropic effects of SGLT2 inhibition and GLP-1 agonism on cardiac glucose intolerance in heart dysfunction
  Belma Turan, Aysegul Durak, Yusuf Olgar, Erkan Tuncay
  Molecular and Cellular Biochemistry.2022; 477(11): 2609.     CrossRef
• Interrelations of components of metabolic syndrome with the level of the hormones involved in regulation of adipose tissue metabolism
  A. Y. Babenko, G. A. Matveev, T. I. Alekseenko, I. V. Derevitskii, M. A. Kokina, E. V. Shlyakhto
  "Arterial’naya Gipertenziya" ("Arterial Hypertension").2020; 25(6): 639.     CrossRef
• Attenuation of carotid neointimal formation after direct delivery of a recombinant adenovirus expressing glucagon-like peptide-1 in diabetic rats
  Soo Lim, Gha Young Lee, Ho Seon Park, Dong-Hwa Lee, Oh Tae Jung, Kim Kyoung Min, Young-Bum Kim, Hee-Sook Jun, Jang Hak Chul, Kyong Soo Park
  Cardiovascular Research.2017; 113(2): 183.     CrossRef
• Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes
  Cristina Mega, Edite Teixeira-de-Lemos, Rosa Fernandes, Flávio Reis
  Journal of Diabetes Research.2017; 2017: 1.     CrossRef
• Letter: Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients (Diabetes Metab J2015;39:74-81)
  Hannah Seok
  Diabetes & Metabolism Journal.2015; 39(2): 171.     CrossRef
• Diuretic and Natriuretic Effects of Dipeptidyl Peptidase-4 Inhibitor Teneligliptin
  Masao Moroi, Tetsuya Kubota
  Journal of Cardiovascular Pharmacology.2015; 66(2): 159.     CrossRef
• The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors
  Na-Hyung Kim, Taeyang Yu, Dae Ho Lee
  BioMed Research International.2014; 2014: 1.     CrossRef
• Tolerability, effectiveness and predictive parameters for the therapeutic usefulness of exenatide in obese, Korean patients with type 2 diabetes
  Sun Ok Song, Kwang Joon Kim, Byung‐Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
  Journal of Diabetes Investigation.2014; 5(5): 554.     CrossRef
• The endothelium in diabetes: Its role in insulin access and diabetic complications
  Cathryn M. Kolka, Richard N. Bergman
  Reviews in Endocrine and Metabolic Disorders.2013; 14(1): 13.     CrossRef
• Is GPR119 agonism an appropriate treatment modality for the safe amelioration of metabolic diseases?
  Lauren M Cornall, Michael L Mathai, Deanne H Hryciw, Andrew J McAinch
  Expert Opinion on Investigational Drugs.2013; 22(4): 487.     CrossRef
• Effects of GLP-1 on Forearm Vasodilator Function and Glucose Disposal During Hyperinsulinemia in the Metabolic Syndrome
  Manfredi Tesauro, Francesca Schinzari, Angelo Adamo, Valentina Rovella, Francesca Martini, Nadia Mores, Angela Barini, Dario Pitocco, Giovanni Ghirlanda, Davide Lauro, Umberto Campia, Carmine Cardillo
  Diabetes Care.2013; 36(3): 683.     CrossRef
• Effect of a Dipeptidyl Peptidase-IV Inhibitor, Des-Fluoro-Sitagliptin, on Neointimal Formation after Balloon Injury in Rats
  Soo Lim, Sung Hee Choi, Hayley Shin, Bong Jun Cho, Ho Seon Park, Byung Yong Ahn, Seon Mee Kang, Ji Won Yoon, Hak Chul Jang, Young-Bum Kim, Kyong Soo Park, Alice Y. W. Chang
  PLoS ONE.2012; 7(4): e35007.     CrossRef
• Glucagon-like peptide 1 and cardiac cell survival
  Susana Ravassa, Amaia Zudaire, Javier Díez
  Endocrinología y Nutrición (English Edition).2012; 59(9): 561.     CrossRef
• GLP-1 and cardioprotection: from bench to bedside
  S. Ravassa, A. Zudaire, J. Diez
  Cardiovascular Research.2012; 94(2): 316.     CrossRef
• Saxagliptin improves glucose tolerance but not survival in a murine model of dilated cardiomyopathy
  Arpita Kalla Vyas, Lauren B. Aerni-Flessner, Maria A. Payne, Attila Kovacs, Patrick Y. Jay, Paul W. Hruz
  Cardiovascular Endocrinology.2012; 1(4): 74.     CrossRef
• Péptido similar al glucagón tipo 1 y supervivencia de la célula cardiaca
  Susana Ravassa, Amaia Zudaire, Javier Díez
  Endocrinología y Nutrición.2012; 59(9): 561.     CrossRef

The recent epidemic of type 2 diabetes in Asia differs from that reported in other regions of the world in several key areas: it has evolved over a much shorter time, in an earlier stage of life, and in people with lower body mass indices. These phenotypic characteristics of patients strongly suggest that insulin secretory defects may perform a more important function in the development and progression of diabetes. A genetic element clearly underlies β-cell dysfunction and insufficient β-cell mass; however, a number of modifiable factors are also linked to β-cell deterioration, most notably chronic hyperglycemia and elevated free fatty acid (FFA) levels. Neither glucose nor FFAs alone cause clinically meaningful β-cell toxicity, especially in patients with normal or impaired glucose tolerance. Thus the term "glucolipotoxicity" is perhaps more appropriate in describing the phenomenon. Several mechanisms have been proposed to explain glucolipotoxicity-induced β-cell dysfunction and death, but its major factors appear to be depression of key transcription factor gene expression by altered intracellular energy metabolism and oxidative stress. Therefore, stabilization of metabolic changes induced by glucolipotoxicity in β-cells represents a new avenue for the treatment of type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  

• Intravoxel incoherent motion diffusion-weighted imaging of pancreas: Probing evidence of β-cell dysfunction in asymptomatic adults with hyperglycemia in vivo
  Yingying Song, Bo Chen, Kejing Zeng, Kejia Cai, Hui Sun, Deqing Liu, Ping Liu, Gugen Xu, Guihua Jiang
  Magnetic Resonance Imaging.2024; 108: 161.     CrossRef
• PIMT Controls Insulin Synthesis and Secretion through PDX1
  Rahul Sharma, Sujay K. Maity, Partha Chakrabarti, Madhumohan R. Katika, Satyamoorthy Kapettu, Kishore V. L. Parsa, Parimal Misra
  International Journal of Molecular Sciences.2023; 24(9): 8084.     CrossRef
• Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells
  Mohamed Asrih, Rodolphe Dusaulcy, Yvan Gosmain, Jacques Philippe, Emmanuel Somm, François R. Jornayvaz, Baeki E. Kang, Yunju Jo, Min Jeong Choi, Hyon-Seung Yi, Dongryeol Ryu, Karim Gariani
  Molecular and Cellular Endocrinology.2022; 541: 111503.     CrossRef
• Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
  Jasvinder Singh Bhatti, Abhishek Sehrawat, Jayapriya Mishra, Inderpal Singh Sidhu, Umashanker Navik, Naina Khullar, Shashank Kumar, Gurjit Kaur Bhatti, P. Hemachandra Reddy
  Free Radical Biology and Medicine.2022; 184: 114.     CrossRef
• Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
  Jonnell C. Small, Aidan Joblin-Mills, Kaycee Carbone, Maria Kost-Alimova, Kumiko Ayukawa, Carol Khodier, Vlado Dancik, Paul A. Clemons, Andrew B. Munkacsi, Bridget K. Wagner
  ACS Chemical Biology.2022; 17(5): 1131.     CrossRef
• Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
  Svetlana Dinić, Jelena Arambašić Jovanović, Aleksandra Uskoković, Mirjana Mihailović, Nevena Grdović, Anja Tolić, Jovana Rajić, Marija Đorđević, Melita Vidaković
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Targeting pancreatic β cells for diabetes treatment
  Chirag Jain, Ansarullah, Sara Bilekova, Heiko Lickert
  Nature Metabolism.2022; 4(9): 1097.     CrossRef
• The high-fructose intake of dams during pregnancy and lactation exerts sex-specific effects on adult rat offspring metabolism
  Francisca A. Tobar-Bernal, Sergio R. Zamudio, Lucía Quevedo-Corona
  Journal of Developmental Origins of Health and Disease.2021; 12(3): 411.     CrossRef
• Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies
  Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
  International Journal of Molecular Sciences.2021; 22(10): 5303.     CrossRef
• A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives
  Josh Reed, Stephen Bain, Venkateswarlu Kanamarlapudi
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 3567.     CrossRef
• Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2 Diabetes?
  Ana Elena Rodriguez-Rodriguez, Esteban Porrini, Armando Torres
  International Journal of Molecular Sciences.2021; 22(19): 10311.     CrossRef
• Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis
  Piotr Wójcik, Neven Žarković, Agnieszka Gęgotek, Elżbieta Skrzydlewska
  Biomolecules.2020; 10(3): 402.     CrossRef
• Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential
  Maria Karmella Apaya, Tien-Fen Kuo, Meng-Ting Yang, Greta Yang, Chiao-Ling Hsiao, Song-Bin Chang, Yenshou Lin, Wen-Chin Yang
  Pharmacological Research.2020; 156: 104754.     CrossRef
• Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases
  Waihong Chung, Kittichai Promrat, Jack Wands
  World Journal of Hepatology.2020; 12(9): 533.     CrossRef
• Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos
  Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, Willi
  Cell Reports.2019; 28(3): 759.     CrossRef
• Metabolic signatures suggest o-phosphocholine to UDP-N-acetylglucosamine ratio as a potential biomarker for high-glucose and/or palmitate exposure in pancreatic β-cells
  Saleem Yousf, Devika M. Sardesai, Abraham B. Mathew, Rashi Khandelwal, Jhankar D. Acharya, Shilpy Sharma, Jeetender Chugh
  Metabolomics.2019;[Epub]     CrossRef
• Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets
  Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
  Diabetes.2019; 68(10): 1965.     CrossRef
• Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation
  Hyun-Je Kim, Ji Hwan Moon, Hyunwoo Chung, Jun-Seop Shin, Bongi Kim, Jong-Min Kim, Jung-Sik Kim, Il-Hee Yoon, Byoung-Hoon Min, Seong-Jun Kang, Yong-Hee Kim, Kyuri Jo, Joungmin Choi, Heejoon Chae, Won-Woo Lee, Sun Kim, Chung-Gyu Park
  Scientific Reports.2019;[Epub]     CrossRef
• Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action
  Miloš Đorđević, Nevena Grdović, Mirjana Mihailović, Jelena Arambašić Jovanović, Aleksandra Uskoković, Jovana Rajić, Marija Sinadinović, Anja Tolić, Danijela Mišić, Branislav Šiler, Goran Poznanović, Melita Vidaković, Svetlana Dinić
  Journal of Ethnopharmacology.2019; 242: 112043.     CrossRef
• Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis
  Wen Zeng, Jiansong Tang, Haicheng Li, Haixia Xu, Hongyun Lu, Hangya Peng, Chuwen Lin, Rili Gao, Shuo Lin, Keyi Lin, Kunying Liu, Yan Jiang, Jianping Weng, Longyi Zeng
  Cellular Signalling.2018; 47: 65.     CrossRef
• Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity
  Zonghong Li, Hongyang Liu, Zhangjing Niu, Wen Zhong, Miaomiao Xue, Jifeng Wang, Fuquan Yang, Yue Zhou, Yifa Zhou, Tao Xu, Junjie Hou
  Molecular & Cellular Proteomics.2018; 17(11): 2119.     CrossRef
• Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass
  Blandine Laferrère, François Pattou
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia
  Aparecida Gabriela Bexiga Veloso, Nathalia Edviges Alves Lima, Elisabete de Marco Ornelas, Clever Gomes Cardoso, Mara Rubia Marques, Beatriz da Costa Aguiar Alves Reis, Fernando Luiz Affonso Fonseca, Laura Beatriz Mesiano Maifrino
  Medical Molecular Morphology.2018; 51(2): 118.     CrossRef
• Cardiac Glucolipotoxicity and Cardiovascular Outcomes
  Marlon E. Cerf
  Medicina.2018; 54(5): 70.     CrossRef
• High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant
  Jianhui Liu, Kunimasa Yagi, Atsushi Nohara, Daisuke Chujo, Azusa Ohbatake, Aya Fujimoto, Yukiko Miyamoto, Junji Kobayashi, Masakazu Yamagishi
  Journal of Clinical Lipidology.2018; 12(2): 331.     CrossRef
• Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven
  Dulce Morales, Guillermo Ramirez, Armando Herrera-Arellano, Jaime Tortoriello, Miguel Zavala, Alejandro Zamilpa
  Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
• The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response
  Jingqi Fu, Qi Cui, Bei Yang, Yongyong Hou, Huihui Wang, Yuanyuan Xu, Difei Wang, Qiang Zhang, Jingbo Pi
  Food and Chemical Toxicology.2017; 100: 161.     CrossRef
• Phenolic constituents and modulatory effects of Raffia palm leaf ( Raphia hookeri ) extract on carbohydrate hydrolyzing enzymes linked to type-2 diabetes
  Felix A. Dada, Sunday I. Oyeleye, Opeyemi B. Ogunsuyi, Tosin A. Olasehinde, Stephen A. Adefegha, Ganiyu Oboh, Aline A. Boligon
  Journal of Traditional and Complementary Medicine.2017; 7(4): 494.     CrossRef
• A gene-environment interaction analysis of plasma selenium with prevalent and incident diabetes: The Hortega study
  Inmaculada Galan-Chilet, Maria Grau-Perez, Griselda De Marco, Eliseo Guallar, Juan Carlos Martin-Escudero, Alejandro Dominguez-Lucas, Isabel Gonzalez-Manzano, Raul Lopez-Izquierdo, Laisa Socorro Briongos-Figuero, Josep Redon, Felipe Javier Chaves, Maria T
  Redox Biology.2017; 12: 798.     CrossRef
• Differential dose-dependent effects of zinc oxide nanoparticles on oxidative stress-mediated pancreatic β-cell death
  Swati C Asani, Rinku D Umrani, Kishore M Paknikar
  Nanomedicine.2017; 12(7): 745.     CrossRef
• Mild hyperglycemia triggered islet function recovery in streptozotocin‐induced insulin‐deficient diabetic rats
  Yu Cheng, Jing Shen, Weizheng Ren, Haojie Hao, Zongyan Xie, Jiejie Liu, Yiming Mu, Weidong Han
  Journal of Diabetes Investigation.2017; 8(1): 44.     CrossRef
• The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells
  Atsuko Kitahara, Kazuto Takahashi, Naru Morita, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Toshiaki Tanaka, Takuma Kondo, Toshio Hosaka, Hitoshi Ishida
  Marine Drugs.2017; 15(6): 185.     CrossRef
• Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice
  Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, Margit Mahlapuu
  Journal of Endocrinology.2017; 234(1): 15.     CrossRef
• Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
  Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
  Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
• The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
  Ji Sung Yoon, Jun Sung Moon, Yong-Woon Kim, Kyu Chang Won, Hyoung Woo Lee
  Journal of Korean Medical Science.2016; 31(4): 547.     CrossRef
• The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients
  Chenxiao Liu, Xianjin Ke, Ying Wang, Xiu Feng, Qi Li, Ying Zhang, Jian Zhu, Qian Li
  BMC Endocrine Disorders.2016;[Epub]     CrossRef
• Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
  Midhat H. Abdulreda, Rayner Rodriguez-Diaz, Alejandro Caicedo, Per-Olof Berggren
  Cell Metabolism.2016; 23(3): 541.     CrossRef
• Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes
  Purvi C. Trivedi, Jordan J. Bartlett, Lester J. Perez, Keith R. Brunt, Jean Francois Legare, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2016; 1861(12): 1893.     CrossRef
• Diabetes risk prediction model for non‐obese Asian Indians residing in North India using cut‐off values for pancreatic and intra‐abdominal fat volume and liver span
  Shajith Anoop, Anoop Misra, Kalaivani Mani, Ravindra Mohan Pandey, Seema Gulati
  Journal of Diabetes.2016; 8(5): 729.     CrossRef
• Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis
  K. Petropoulou, E. S. Chambers, D. J. Morrison, T. Preston, I. F. Godsland, P. Wilde, A. Narbad, R. Parker, L. Salt, V. J. Morris, C. Domoney, S. J. Persaud, E. Holmes, S. Penson, J. Watson, M. Stocks, M. Buurman, M. Luterbacher, G. Frost
  Nutrition Bulletin.2016; 41(4): 372.     CrossRef
• Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets
  CHENGHU HUANG, LI YUAN, SHUYI CAO
  International Journal of Molecular Medicine.2015; 36(1): 173.     CrossRef
• Mitochondrien als Kraftwerk der β-Zelle
  S. Baltrusch, F. Reinhardt, M. Tiedge
  Der Diabetologe.2015; 11(3): 231.     CrossRef
• Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells
  LiLi Gao, Wei Tang, ZhengZheng Ding, DingYu Wang, XiaoQiang Qi, HuiWen Wu, Jun Guo
  Molecular Medicine.2015; 21(1): 154.     CrossRef
• Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
  Sergio Wehinger, Rina Ortiz, María Inés Díaz, Adam Aguirre, Manuel Valenzuela, Paola Llanos, Christopher Mc Master, Lisette Leyton, Andrew F.G. Quest
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(5): 693.     CrossRef
• Body Fat Patterning, Hepatic Fat and Pancreatic Volume of Non-Obese Asian Indians with Type 2 Diabetes in North India: A Case-Control Study
  Anoop Misra, Shajith Anoop, Seema Gulati, Kalaivani Mani, Surya Prakash Bhatt, Ravindra Mohan Pandey, Anna Alisi
  PLOS ONE.2015; 10(10): e0140447.     CrossRef
• CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells
  Udayakumar Karunakaran, Jun Sung Moon, Hyoung Woo Lee, Kyu Chang Won
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(11): 2414.     CrossRef
• Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1
  Mark F McCarty, James J DiNicolantonio
  Open Heart.2015; 2(1): e000205.     CrossRef
• P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells
  Lingli Zhou, Xiaoling Cai, Xueyao Han, Linong Ji
  Journal of Diabetes Research.2014; 2014: 1.     CrossRef
• ImpairedβCell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia
  Yuhang Ma, Yufan Wang, Qianfang Huang, Qian Ren, Su Chen, Aifang Zhang, Li Zhao, Qin Zhen, Yongde Peng
  Journal of Diabetes Research.2014; 2014: 1.     CrossRef
• Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation
  Ana L. Guadarrama-López, Roxana Valdés-Ramos, Beatríz E. Martínez-Carrillo
  Journal of Immunology Research.2014; 2014: 1.     CrossRef
• A Comparative Study of the Effects of a Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability in Patients with Type 2 Diabetes with Inadequate Glycemic Control on Metformin
  Hun-Sung Kim, Jeong-Ah Shin, Seung-Hwan Lee, Eun-Sook Kim, Jae-Hyoung Cho, Ho-Young Son, Kun-Ho Yoon
  Diabetes Technology & Therapeutics.2013; 15(10): 810.     CrossRef
• Localization and regulation of pancreatic selenoprotein P
  Holger Steinbrenner, Anna-Lena Hotze, Bodo Speckmann, Antonio Pinto, Helmut Sies, Matthias Schott, Margret Ehlers, Werner A Scherbaum, Sven Schinner
  Journal of Molecular Endocrinology.2013; 50(1): 31.     CrossRef
• Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction
  Young Mi Song, Sun Ok Song, Young-Hye You, Kun-Ho Yoon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Ji-Won Kim, Byung-Wan Lee
  Endocrinology.2013; 154(8): 2626.     CrossRef
• miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models
  J.-W. Kim, Y.-H. You, S. Jung, H. Suh-Kim, I.-K. Lee, J.-H. Cho, K.-H. Yoon
  Diabetologia.2013; 56(4): 847.     CrossRef
• Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population
  E. M. Brady, D. R. Webb, D. H. Morris, K. Khunti, D. S. C. Talbot, N. Sattar, M. J. Davies
  Experimental Diabetes Research.2012; 2012: 1.     CrossRef
• Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells
  Yong-Woon Kim, Jun Sung Moon, Ye Jin Seo, So-Young Park, Jong-Yeon Kim, Ji Sung Yoon, In-Kyu Lee, Hyoung Woo Lee, Kyu Chang Won
  Biochemical and Biophysical Research Communications.2012; 420(2): 462.     CrossRef
• Human Monoclonal Antibodies against Glucagon Receptor Improve Glucose Homeostasis by Suppression of Hepatic Glucose Output in Diet-Induced Obese Mice
  Wook-Dong Kim, Yong-ho Lee, Min-Hee Kim, Sun-Young Jung, Woo-Chan Son, Seon-Joo Yoon, Byung-Wan Lee, Nigel Irwin
  PLoS ONE.2012; 7(12): e50954.     CrossRef
• Understanding Pancreas Development for β-Cell Repair and Replacement Therapies
  Aurelia Raducanu, Heiko Lickert
  Current Diabetes Reports.2012; 12(5): 481.     CrossRef

The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors, T1R2 and T1R3. Recent studies have shown that this receptor is also expressed in the extragustatory system, including the gastrointestinal tract, pancreatic β-cells, and glucose-responsive neurons in the brain. In the intestine, the sweet taste receptor regulates secretion of incretin hormones and glucose uptake from the lumen. In β-cells, activation of the sweet taste receptor leads to stimulation of insulin secretion. Collectively, the sweet taste receptor plays an important role in recognition and metabolism of energy sources in the body.

Citations

Citations to this article as recorded by  

• Targeting T2Rs, a feasible approach for natural bitter agents from traditional Chinese medicine modulate ABC transporters to treat respiratory diseases
  Qi Liang, Ruo-Lan Li, Dan-Dan Tang, Ting Zhang, Lian Zhong, Chun-Jie Wu, Wei Peng
  Arabian Journal of Chemistry.2024; 17(1): 105377.     CrossRef
• Impact of dietary sucralose and sucrose-sweetened water intake on lipid and glucose metabolism in male mice
  Xinyi Wu, Le Cui, Haoquan Wang, Jinhong Xu, Zhaozhao Zhong, Xibei Jia, Jiaqi Wang, Huahua Zhang, Yanteng Shi, Yuhang Tang, Qianhui Yang, Qiongdan Liang, Yujing Zhang, Jing Li, Xiaohong Jiang
  European Journal of Nutrition.2023; 62(1): 199.     CrossRef
• How dietary amino acids and high protein diets influence insulin secretion
  Yuuki Yanagisawa
  Physiological Reports.2023;[Epub]     CrossRef
• The elusive cephalic phase insulin response: triggers, mechanisms, and functions
  Wolfgang Langhans, Alan G. Watts, Alan C. Spector
  Physiological Reviews.2023; 103(2): 1423.     CrossRef
• Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
  Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov
  Biomolecules.2023; 13(11): 1618.     CrossRef
• Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease
  Mariah R Stavrou, Sean Souchiart So, Angela M Finch, Sara Ballouz, Nicola J Smith
  Chemical Senses.2023;[Epub]     CrossRef
• Dysgeusia
  Davis C. Thomas, Deepti Chablani, Srishti Parekh, Reshmy Chellam Pichammal, Karpagavalli Shanmugasundaram, Priyanka Kodaganallur Pitchumani
  The Journal of the American Dental Association.2022; 153(3): 251.     CrossRef
• Oral Microbiota-Host Interaction Mediated by Taste Receptors
  Hao Dong, Jiaxin Liu, Jianhui Zhu, Zhiyan Zhou, Marco Tizzano, Xian Peng, Xuedong Zhou, Xin Xu, Xin Zheng
  Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
• New frontiers in the hunger management involving GLP‐1, taste and oestrogen
  Maja Baretić
  Diabetic Medicine.2022;[Epub]     CrossRef
• The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis
  Michelle D. Pang, Gijs H. Goossens, Ellen E. Blaak
  Frontiers in Nutrition.2021;[Epub]     CrossRef
• TAS1R2 sweet taste receptor genetic variation and dietary intake in Korean females
  Jeong-Hwa Choi
  Appetite.2021; 164: 105281.     CrossRef
• Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation
  Elena von Molitor, Katja Riedel, Michael Krohn, Mathias Hafner, Rüdiger Rudolf, Tiziana Cesetti
  Frontiers in Human Neuroscience.2021;[Epub]     CrossRef
• Hazardous Hyperglisemic Effect of Facial Ischemia Following Subarachnoid Hemorrhage: An Experimental Study
  Mehmet Dumlu Aydin, Ozgur Caglar, Mehmet Nuri Kocak, Erdem Karadeniz, Nazan Aydin, Irem Ates, Sevilay Ozmen
  Archives of Neuroscience.2020;[Epub]     CrossRef
• Determinants of Sweetness Preference: A Scoping Review of Human Studies
  Carolina Venditti, Kathy Musa-Veloso, Han Youl Lee, Theresa Poon, Alastair Mak, Maryse Darch, Justine Juana, Dylan Fronda, Daniel Noori, Erika Pateman, Maia Jack
  Nutrients.2020; 12(3): 718.     CrossRef
• Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids
  Vladimir O. Murovets, Ekaterina A. Lukina, Egor A. Sozontov, Julia V. Andreeva, Raisa P. Khropycheva, Vasiliy A. Zolotarev, Keiko Abe
  PLOS ONE.2020; 15(7): e0235913.     CrossRef
• Effect of sucralose and aspartame on glucose metabolism and gut hormones
  Samar Y Ahmad, James K Friel, Dylan S Mackay
  Nutrition Reviews.2020; 78(9): 725.     CrossRef
• Maternal low protein exposure alters glucose tolerance and intestinal nutrient-responsive receptors and transporters expression of rat offspring
  Nan Wang, Bo Lv, Limin Guan, Hu Qiao, Bo Sun, Xiao Luo, Ru Jia, Ke Chen, Jianqun Yan
  Life Sciences.2020; 243: 117216.     CrossRef
• Sugar Reduction in Dairy Food: An Overview with Flavoured Milk as an Example
  Dipendra Kumar Mahato, Russell Keast, Djin Gie Liem, Catherine Georgina Russell, Sara Cicerale, Shirani Gamlath
  Foods.2020; 9(10): 1400.     CrossRef
• Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3
  Juan V. Sanchez-Andres, Willy J. Malaisse, Itaru Kojima
  Pflügers Archiv - European Journal of Physiology.2019; 471(4): 647.     CrossRef
• A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults
  Angélica Y. Gómez-Arauz, Nallely Bueno-Hernández, Leon F. Palomera, Raúl Alcántara-Suárez, Karen L. De León, Lucía A. Méndez-García, Miguel Carrero-Aguirre, Aaron N. Manjarrez-Reyna, Camilo P. Martínez-Reyes, Marcela Esquivel-Velázquez, Alejandra Ruiz-Bar
  Journal of Immunology Research.2019; 2019: 1.     CrossRef
• Sugar reduction without compromising sensory perception. An impossible dream?
  Scott C. Hutchings, Julia Y. Q. Low, Russell S. J. Keast
  Critical Reviews in Food Science and Nutrition.2019; 59(14): 2287.     CrossRef
• Oral and Post‐Oral Actions of Low‐Calorie Sweeteners: A Tale of Contradictions and Controversies
  John I. Glendinning
  Obesity.2018;[Epub]     CrossRef
• Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
  Nicholas M. Dalesio, Sebastian F. Barreto Ortiz, Jennifer L. Pluznick, Dan E. Berkowitz
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons
  Menizibeya O. Welcome, Nikos E. Mastorakis
  NeuroMolecular Medicine.2018; 20(3): 281.     CrossRef
• Anti-diabetic effects of natural products an overview of therapeutic strategies
  Jiyoung Park, Hyeung-Jin Jang
  Molecular & Cellular Toxicology.2017; 13(1): 1.     CrossRef
• Natural sweetener agave inhibits gastric emptying in rats by a cholecystokinin-2- and glucagon like peptide-1 receptor-dependent mechanism
  E. Bihter Gürler, Dilek Özbeyli, Hülya Buzcu, Sezin Bayraktar, İrem Carus, Beyza Dağ, Yasemin Geriş, Seda Jeral, Berrak Ç. Yeğen
  Food & Function.2017; 8(2): 741.     CrossRef
• T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells
  Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M. Rasenick, Takeshi Inagaki, Hiroshi Shibata, Hiroaki Matsunami
  PLOS ONE.2017; 12(5): e0176841.     CrossRef
• Hormonal responses to non-nutritive sweeteners in water and diet soda
  Allison C. Sylvetsky, Rebecca J. Brown, Jenny E. Blau, Mary Walter, Kristina I. Rother
  Nutrition & Metabolism.2016;[Epub]     CrossRef
• Gastrointestinal defense mechanisms
  Hyder Said, Jonathan D. Kaunitz
  Current Opinion in Gastroenterology.2016; 32(6): 461.     CrossRef
• Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells
  Itaru Kojima, Yuko Nakagawa, Kunihisa Hamano, Johan Medina, Longfei Li, Masahiro Nagasawa
  Biological & Pharmaceutical Bulletin.2015; 38(5): 674.     CrossRef
• Impaired Glucose Metabolism in Mice Lacking the Tas1r3 Taste Receptor Gene
  Vladimir O. Murovets, Alexander A. Bachmanov, Vasiliy A. Zolotarev, Hiroaki Matsunami
  PLOS ONE.2015; 10(6): e0130997.     CrossRef
• Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning
  Menizibeya O. Welcome, Nikos E. Mastorakis, Vladimir A. Pereverzev
  Neurology Research International.2015; 2015: 1.     CrossRef
• Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states
  Anya Medina, Yuko Nakagawa, Jinhui Ma, Longfei Li, Kunihisa Hamano, Toshio Akimoto, Yuzo Ninomiya, Itaru Kojima
  Endocrine Journal.2014; 61(8): 797.     CrossRef
• Normal Roles for Dietary Fructose in Carbohydrate Metabolism
  Maren Laughlin
  Nutrients.2014; 6(8): 3117.     CrossRef
• Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3
  Yuko Nakagawa, Yoshiaki Ohtsu, Masahiro Nagasawa, Hiroshi Shibata, Itaru Kojima
  Endocrine Journal.2014; 61(2): 119.     CrossRef
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells
  Yoshiaki Ohtsu, Yuko Nakagawa, Masahiro Nagasawa, Shigeki Takeda, Hirokazu Arakawa, Itaru Kojima
  Molecular and Cellular Endocrinology.2014; 394(1-2): 70.     CrossRef
• Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists
  Itaru Kojima, Yuko Nakagawa, Yoshiaki Ohtsu, Anya Medina, Masahiro Nagasawa
  Endocrinology and Metabolism.2014; 29(1): 12.     CrossRef
• The Role of Sweet Taste in Satiation and Satiety
  Yu Low, Kathleen Lacy, Russell Keast
  Nutrients.2014; 6(9): 3431.     CrossRef
• Insulin release: the receptor hypothesis
  Willy J. Malaisse
  Diabetologia.2014; 57(7): 1287.     CrossRef
• The involvement of the T1R3 receptor protein in the control of glucose metabolism in mice at different levels of glycemia
  V. O. Murovets, A. A. Bachmanov, S. V. Travnikov, A. A. Churikova, V. A. Zolotarev
  Journal of Evolutionary Biochemistry and Physiology.2014; 50(4): 334.     CrossRef
• GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
  Franz M. Matschinsky
  Trends in Pharmacological Sciences.2013; 34(2): 90.     CrossRef
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells
  Yosuke Masubuchi, Yuko Nakagawa, Jinhui Ma, Tsutomu Sasaki, Tadahiro Kitamura, Yoritsuna Yamamoto, Hitoshi Kurose, Itaru Kojima, Hiroshi Shibata, Xing-Ming Shi
  PLoS ONE.2013; 8(1): e54500.     CrossRef
• Goût des aliments et comportement alimentaire
  M. Fantino
  Médecine des Maladies Métaboliques.2012; 6(5): 409.     CrossRef
• The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice
  John I. Glendinning, Jennifer Gillman, Haley Zamer, Robert F. Margolskee, Anthony Sclafani
  Physiology & Behavior.2012; 107(1): 50.     CrossRef
• Repair of diverse diabetic defects of β‐cells in man and mouse by pharmacological glucokinase activation
  Nicolai M. Doliba, Deborah Fenner, Bogumil Zelent, Joseph Bass, Ramakanth Sarabu, Franz M. Matschinsky
  Diabetes, Obesity and Metabolism.2012; 14(s3): 109.     CrossRef

The pancreatic islet β-cell is uniquely specialized to couple its metabolism and rates of insulin secretion with the levels of circulating nutrient fuels, with the mitochondrial playing a central regulatory role in this process. In the β-cell, mitochondrial activation generates an integrated signal reflecting rates of oxidativephosphorylation, Kreb's cycle flux, and anaplerosis that ultimately determines the rate of insulin exocytosis. Mitochondrial activation can be regulated by proton leak and mediated by UCP2, and by alkalinization to utilize the pH gradient to drive substrate and ion transport. Converging lines of evidence support the hypothesis that substrate cycles driven by rates of Kreb's cycle flux and by anaplerosis play an integral role in coupling responsive changes in mitochondrial metabolism with insulin secretion. The components and mechanisms that account for the integrated signal of ATP production, substrate cycling, the regulation of cellular redox state, and the production of other secondary signaling intermediates are operative in both rodent and human islet β-cells.

Citations

Citations to this article as recorded by  

• Nicotinamide Adenine Dinucleotide: The Redox Sensor in Aging-Related Disorders
  Giovanna Schiuma, Djidjell Lara, James Clement, Marco Narducci, Roberta Rizzo
  Antioxidants & Redox Signaling.2024;[Epub]     CrossRef
• ROCK1 regulates insulin secretion from β-cells
  Byung-Jun Sung, Sung-Bin Lim, Won-Mo Yang, Jae Hyeon Kim, Rohit N. Kulkarni, Young-Bum Kim, Moon-Kyu Lee
  Molecular Metabolism.2022; 66: 101625.     CrossRef
• Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
  Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
  Aging and disease.2016; 7(1): 90.     CrossRef
• Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation
  Michael J. MacDonald, Lacmbouh Ade, James M. Ntambi, Israr-Ul H. Ansari, Scott W. Stoker
  Journal of Biological Chemistry.2015; 290(17): 11075.     CrossRef
• Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance inβCell Function and Dysfunction
  Xiaoting Luo, Rongrong Li, Liang-Jun Yan
  Journal of Diabetes Research.2015; 2015: 1.     CrossRef
• Peroxisome Proliferator-activated Receptor γ (PPARγ) and Its Target Genes Are Downstream Effectors of FoxO1 Protein in Islet β-Cells
  Dhananjay Gupta, Averi A. Leahy, Navjot Monga, Mina Peshavaria, Thomas L. Jetton, Jack L. Leahy
  Journal of Biological Chemistry.2013; 288(35): 25440.     CrossRef
• Desnutrin/ATGL Activates PPARδ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells
  Tianyi Tang, Marcia J. Abbott, Maryam Ahmadian, Andressa B. Lopes, Yuhui Wang, Hei Sook Sul
  Cell Metabolism.2013; 18(6): 883.     CrossRef
• Potent humanin analog increases glucose‐stimulated insulin secretion through enhanced metabolism in the β cell
  Regina Kuliawat, Laura Klein, Zhenwei Gong, Marianna Nicoletta‐Gentile, Anjana Nemkal, Lingguang Cui, Claire Bastie, Kai Su, Derek Huffman, Manju Surana, Nir Barzilai, Norman Fleischer, Radhika Muzumdar
  The FASEB Journal.2013; 27(12): 4890.     CrossRef
• Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats
  Shu-Juan Yu, Hong-Chen Liu, Ling-Ling E, Dong-Sheng Wang, Guo-Xiong Zhu
  Experimental Biology and Medicine.2012; 237(4): 395.     CrossRef

Citations

Citations to this article as recorded by  

• Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
  Jeffrey Cummings, Andrew Ortiz, Janelle Castellino, Jefferson Kinney
  European Journal of Neuroscience.2022; 56(9): 5727.     CrossRef
• The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
  Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson
  Scientific Reports.2022;[Epub]     CrossRef
• CYTOCHROMES OF MITOCHONDRIES AND ACTIVITY OF HEME METABOLISM ENZYMES IN THE LIVER UNDER DIFFERENT NUTRIENT REGIMES
  G.P. Kopylchuk, Z.-M. I. Grynenkiv, O.M. Voloshchuk
  Fiziolohichnyĭ zhurnal.2021; 67(2): 37.     CrossRef
• Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
  Mawieh Hamad, Abdul Khader Mohammed, Mahmood Y. Hachim, Debasmita Mukhopadhy, Anila Khalique, Amina Laham, Sarah Dhaiban, Khuloud Bajbouj, Jalal Taneera
  Molecular and Cellular Endocrinology.2021; 538: 111462.     CrossRef
• Food-derived cyanidin-3-O-glucoside alleviates oxidative stress: evidence from the islet cell line and diabetic db/db mice
  Xiang Ye, Wen Chen, Pengcheng Tu, Ruoyi Jia, Yangyang Liu, Yonglu Li, Qiong Tang, Xiaodong Zheng, Qiang Chu
  Food & Function.2021; 12(22): 11599.     CrossRef
• Telmisartan protects against high glucose/high lipid‐induced apoptosis and insulin secretion by reducing the oxidative and ER stress
  Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Han
  Cell Biochemistry and Function.2019; 37(3): 161.     CrossRef
• Ropivacaine regulates the expression and function of heme oxygenase-1
  Xiangbiao Yan, Yu Li, Xuechang Han, Xu Dong, Yajie Zhang, Qunzhi Xing
  Biomedicine & Pharmacotherapy.2018; 103: 284.     CrossRef
• A review on heme oxygenase-1 induction: is it a necessary evil
  Ajaz Ahmad Waza, Zeenat Hamid, Sajad Ali, Shabir Ahmad Bhat, Musadiq Ahmad Bhat
  Inflammation Research.2018; 67(7): 579.     CrossRef
• Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
  Hee Jae Lee, Hye In Seo, Hee Yun Cha, Yun Jung Yang, Soo Hyun Kwon, Soo Jin Yang
  Clinical Nutrition Research.2018; 7(4): 229.     CrossRef
• Social, economic, and policy implications of organ preservation advances
  Alyssa Ward, David K. Klassen, Kate M. Franz, Sebastian Giwa, Jedediah K. Lewis
  Current Opinion in Organ Transplantation.2018; 23(3): 336.     CrossRef
• Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase
  Chunyan Liu, Yanan Hao, Fei Yin, Yonglan Zhang, Jianhui Liu
  Cell Biology International.2017; 41(5): 544.     CrossRef
• Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats
  N. M. Aziz, M. Y. Kamel, R. A. Rifaai
  Endocrine Regulations.2017; 51(1): 20.     CrossRef
• Downregulation of microRNA-155 ameliorates high glucose-induced endothelial injury by inhibiting NF-κB activation and promoting HO-1 and NO production
  Xi Zhang, Xiangyang Liu, Yang Li, Jingbo Lai, Nana Zhang, Jie Ming, Xianjie Ma, Qiuhe Ji, Ying Xing
  Biomedicine & Pharmacotherapy.2017; 88: 1227.     CrossRef
• Sulforaphane Protects against High Cholesterol-Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreaticβ-Cells Function
  Catalina Carrasco-Pozo, Kah Ni Tan, Martin Gotteland, Karin Borges
  Oxidative Medicine and Cellular Longevity.2017; 2017: 1.     CrossRef
• Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines
  Kyril Turpaev, Nils Welsh
  European Journal of Pharmacology.2016; 784: 69.     CrossRef
• Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion
  Han-Hung Huang, Lisa Stehno-Bittel
  Islets.2015; 7(5): e1129097.     CrossRef
• A newly identified polysaccharide from Ganoderma atrum attenuates hyperglycemia and hyperlipidemia
  Kexue Zhu, Shaoping Nie, Chuan Li, Suli Lin, Mengmeng Xing, Wenjuan Li, Deming Gong, Mingyong Xie
  International Journal of Biological Macromolecules.2013; 57: 142.     CrossRef
• Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction
  Young Mi Song, Sun Ok Song, Young-Hye You, Kun-Ho Yoon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Ji-Won Kim, Byung-Wan Lee
  Endocrinology.2013; 154(8): 2626.     CrossRef
• Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice
  Young-Eun Lee, Ji-Won Kim, Eun-Mi Lee, Yu-Bae Ahn, Ki-Ho Song, Kun-Ho Yoon, Hyung-Wook Kim, Cheol-Whee Park, Guolian Li, Zhenqi Liu, Seung-Hyun Ko, Kathrin Maedler
  PLoS ONE.2012; 7(11): e50412.     CrossRef

Citations

Citations to this article as recorded by  

• The antagonistic atorvastatin-glibenclamide interactions suppressed the atorvastatin-induced Bax/cytochrome c/p53 mRNA expressions and increased Rho A mRNA expression in B16f10 melanoma cell culture
  Maryam Malek, Nasim Dana, Ahmad Ghasemi, Maedeh Ghasemi
  Gene Reports.2021; 23: 101156.     CrossRef
• Expression profiles of stress-related genes in islets from donors with progressively impaired glucose metabolism
  Marcus Lundberg, Anton Stenwall, Angie Tegehall, Olle Korsgren, Oskar Skog
  Islets.2018; 10(2): 69.     CrossRef
• Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic Diseases
  Tae Jung, Kyung Choi
  International Journal of Molecular Sciences.2016; 17(2): 192.     CrossRef
• The TRPA1 channel and oral hypoglycemic agents
  Carlos Manlio Diaz-Garcia
  Channels.2013; 7(6): 420.     CrossRef
• Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction
  Young Mi Song, Sun-Ok Song, Yong-Keun Jung, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee
  Autophagy.2012; 8(7): 1085.     CrossRef
• The Duration of Sulfonylurea Treatment Is Associated withβ-Cell Dysfunction in Patients with Type 2 Diabetes Mellitus
  Mi-Seon Shin, Jee Hee Yu, Chang Hee Jung, Jenie Yoonoo Hwang, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park
  Diabetes Technology & Therapeutics.2012; 14(11): 1033.     CrossRef

Citations

Citations to this article as recorded by  

• Bidirectional association between NAFLD and gallstone disease: a systematic review and meta-analysis of observational studies
  Shengying Gu, Shanshan Hu, Shuowen Wang, Chendong Qi, Chenyang Shi, Guorong Fan
  Expert Review of Gastroenterology & Hepatology.2023; 17(3): 283.     CrossRef
• The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease
  Camelia Munteanu, Betty Schwartz
  Antioxidants.2023; 12(4): 903.     CrossRef
• Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease
  Anja Hess, Stefan D Gentile, Amel Ben Saad, Raza‐Ur Rahman, Tim Habboub, Daniel S Pratt, Alan C Mullen
  The EMBO Journal.2023;[Epub]     CrossRef
• Histopathological Examination of the Effects of Tocilizumab and Dexamethasone on the Liver in Rats of Oleic Acid induced Acute Lung Injury
  Funda TERZİ, Hüseyin Serkan EROL
  Balıkesır Health Sciences Journal.2022;[Epub]     CrossRef
• Identifying Lipid Metabolites Influenced by Oleic Acid Administration Using High-Performance Liquid Chromatography–Mass Spectrometry-Based Lipidomics
  Chao Xu, Dan Song, Askild L. Holck, Youyou Zhou, Rong Liu
  ACS Omega.2020; 5(20): 11314.     CrossRef
• Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders
  P. Vineeth Daniel, Prosenjit Mondal
  European Journal of Cell Biology.2020; 99(8): 151128.     CrossRef
• PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation
  Lei Tong, Long Wang, Shuangshuang Yao, Lina Jin, Jian Yang, Yifei Zhang, Guang Ning, Zhiguo Zhang
  Cell Death & Disease.2019;[Epub]     CrossRef
• Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels
  Jianzhong Ye, Longxian Lv, Wenrui Wu, Yating Li, Ding Shi, Daiqiong Fang, Feifei Guo, Huiyong Jiang, Ren Yan, Wanchun Ye, Lanjuan Li
  Frontiers in Microbiology.2018;[Epub]     CrossRef
• Olive oil combined with Lycium barbarum polysaccharides attenuates liver apoptosis and inflammation induced by carbon tetrachloride in rats
  Yun-Yun Chiang, Jane C.-J. Chao
  Journal of Functional Foods.2018; 48: 329.     CrossRef
• Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
  Simon Ducheix, Alexandra Montagner, Arnaud Polizzi, Frédéric Lasserre, Marion Régnier, Alice Marmugi, Fadila Benhamed, Justine Bertrand-Michel, Laila Mselli-Lakhal, Nicolas Loiseau, Pascal G. Martin, Jean-Marc Lobaccaro, Laurent Ferrier, Catherine Postic,
  PLOS ONE.2017; 12(7): e0181393.     CrossRef
• Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β
  Simon Ducheix, Maria Carmela Vegliante, Gaetano Villani, Nicola Napoli, Carlo Sabbà, Antonio Moschetta
  Cellular and Molecular Life Sciences.2016; 73(20): 3809.     CrossRef
• Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
  Young Mi Song, Yong-ho Lee, Ji-Won Kim, Dong-Sik Ham, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee
  Autophagy.2015; 11(1): 46.     CrossRef
• Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease
  Sanja Stojsavljević
  World Journal of Gastroenterology.2014; 20(48): 18070.     CrossRef
• Microglial Cell Activation Increases Saturated and Decreases Monounsaturated Fatty Acid Content, but Both Lipid Species are Proinflammatory
  Emily B. Button, Andrew S. Mitchell, Marcia M. Domingos, Jessica H.‐J. Chung, Ryan M. Bradley, Ashkan Hashemi, Phillip M. Marvyn, Ashley C. Patterson, Ken D. Stark, Joe Quadrilatero, Robin E. Duncan
  Lipids.2014; 49(4): 305.     CrossRef
• Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse
  Jesse D. Riordan, Joseph H. Nadeau
  Mammalian Genome.2014; 25(9-10): 473.     CrossRef
• Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH
  Stephan Laggai, Yvette Simon, Theo Ranssweiler, Alexandra K Kiemer, Sonja M Kessler
  World Journal of Hepatology.2013; 5(10): 558.     CrossRef
• Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction
  Young Mi Song, Sun-Ok Song, Yong-Keun Jung, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee
  Autophagy.2012; 8(7): 1085.     CrossRef

Citations

Citations to this article as recorded by  

• The effect of gestational diabetes mellitus on carotid artery intima-media thickness in and after pregnancy: a systematic review and meta-analysis
  Andrea Sonaglioni, Elisabetta Piergallini, Angelo Naselli, Gian Luigi Nicolosi, Anna Ferrulli, Stefano Bianchi, Michele Lombardo, Giuseppe Ambrosio
  Acta Diabetologica.2023; 61(2): 139.     CrossRef
• Prognostic indicators of persistent carotid intima-media thickness increase in postpartum period in a population of normotensive women with gestational diabetes mellitus
  Andrea Sonaglioni, Gian Luigi Nicolosi, Valentina Esposito, Stefano Bianchi, Michele Lombardo
  European Journal of Obstetrics & Gynecology and Reproductive Biology.2022; 269: 47.     CrossRef
• Pharmacotherapy for gestational diabetes
  Angelo Maria Patti, Rosaria Vincenza Giglio, Kalliopi Pafili, Manfredi Rizzo, Nikolaos Papanas
  Expert Opinion on Pharmacotherapy.2018; 19(13): 1407.     CrossRef
• Women with a history of gestational diabetes on long-term follow up have normal vascular function despite more dysglycemia, dyslipidemia and adiposity
  Olubukola Ajala, Louise A. Jensen, Edmond Ryan, Constance Chik
  Diabetes Research and Clinical Practice.2015; 110(3): 309.     CrossRef
• Gestational Diabetes Mellitus in Korean Women: Similarities and Differences from Other Racial/Ethnic Groups
  Catherine Kim
  Diabetes & Metabolism Journal.2014; 38(1): 1.     CrossRef
• History of Gestational Diabetes Mellitus and Future Risk of Atherosclerosis in Mid‐life: The Coronary Artery Risk Development in Young Adults Study
  Erica P. Gunderson, Vicky Chiang, Mark J. Pletcher, David R. Jacobs, Charles P. Quesenberry, Stephen Sidney, Cora E. Lewis
  Journal of the American Heart Association.2014;[Epub]     CrossRef
• Association of Gestational Diabetes Mellitus (GDM) with subclinical atherosclerosis: a systemic review and meta-analysis
  Jing-Wei Li, Si-Yi He, Peng Liu, Lin Luo, Liang Zhao, Ying-Bin Xiao
  BMC Cardiovascular Disorders.2014;[Epub]     CrossRef
• Cardiovascular Disease Risk in the Offspring of Diabetic Women: The Impact of the Intrauterine Environment
  Laura J. Marco, Kate McCloskey, Peter J. Vuillermin, David Burgner, Joanne Said, Anne-Louise Ponsonby
  Experimental Diabetes Research.2012; 2012: 1.     CrossRef
• The Association between Carotid Atherosclerosis and Glucose
  Bo Kyung Koo
  Diabetes & Metabolism Journal.2011; 35(5): 466.     CrossRef

Citations

Citations to this article as recorded by  

• Impact of diabetes distress on glycemic control and diabetic complications in type 2 diabetes mellitus
  Hye-Sun Park, Yongin Cho, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, Young Ju Suh, Suk Chon, Jeong-Taek Woo, Sei Hyun Baik, Kwan Woo Lee, So Hun Kim
  Scientific Reports.2024;[Epub]     CrossRef
• Clinical and economic impact of changing reimbursement criteria for statin treatment among patients with type 2 diabetes mellitus in South Korea
  Siin Kim, Kyungseon Choi, Ji-yool Kim, Hae Sun Suh
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• The Promising First Cohort Study in Korean Patients with Obesity and Overweight: Gangwon Obesity and Metabolic Syndrome Study
  Eun-Jung Rhee
  Journal of Obesity & Metabolic Syndrome.2022; 31(4): 285.     CrossRef
• Impact of noncommunicable disease conditions and physical burden on intent to leave midwifery in Hungary
  Krisztina Éles Gebriné, Kinga Lampek, Péter Takács, Miklós Zrínyi, Attila Sárváry, Andrea Sárváry
  Kontakt.2021; 23(1): 45.     CrossRef
• Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
  So Young Park, Jieun Kim, Jung Il Son, Sang Youl Rhee, Do-Yeon Kim, Suk Chon, Hyunjung Lim, Jeong-Taek Woo
  Scientific Reports.2021;[Epub]     CrossRef
• Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study (Diabetes Metab J 2021;45:368-78)
  Ja Young Jeon
  Diabetes & Metabolism Journal.2021; 45(4): 613.     CrossRef
• Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study (Diabetes Metab J 2021;45:368-78)
  Kyoung Jin Kim, Jimi Choi, Jae Hyun Bae, Kyeong Jin Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim, Nam Hoon Kim
  Diabetes & Metabolism Journal.2021; 45(4): 617.     CrossRef
• Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes
  Sang Ouk Chin, In Gyoon Ha, Sang Youl Rhee, Su Jin Jeong, Suk Chon, Sung Hoon Kim, Kyu Jeung Ahn, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Jeong Taek Woo
  International Journal of Endocrinology.2020; 2020: 1.     CrossRef
• Perioperative anesthetic management of patients with diabetes mellitus: focused on blood glucose control
  Hyungseok Seo
  Journal of the Korean Medical Association.2020; 63(9): 526.     CrossRef
• Predicting Old-age Mortality Using Principal Component Analysis: Results from a National Panel Survey in Korea
  Jaeyong Shin, Kwang-Soo Lee, Jae-Hyun Kim
  Medicina.2020; 56(7): 360.     CrossRef
• A relationship between endoscopic findings and diabetic regulation, and complications in patients with diabetes mellitus
  Sevki Konur
  Archives of Medical Science – Civilization Diseases.2020; 5(1): 53.     CrossRef
• Randomized control trial comparing the effect of cilostazol and aspirin on changes in carotid intima-medial thickness
  Sangmo Hong, Munsuk Nam, Bertis B. Little, Seihyun Paik, Kwanwoo Lee, Jungtaek Woo, Dooman Kim, Jungoo Kang, Minyoung Chun, Yongsoo Park
  Heart and Vessels.2019; 34(11): 1758.     CrossRef
• Genome‐wide association study identifies new susceptibility loci for diabetic nephropathy in Korean patients with type 2 diabetes mellitus
  Kyung H. Jeong, Jin S. Kim, Jeong‐Taek Woo, Sang Y. Rhee, Yu H. Lee, Yang G. Kim, Ju‐Young Moon, Su K. Kim, Sun W. Kang, Sang H. Lee, Yeong H. Kim
  Clinical Genetics.2019; 96(1): 35.     CrossRef
• Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function
  Da Hea Seo, So Hun Kim, Joon Ho Song, Seongbin Hong, Young Ju Suh, Seong Hee Ahn, Jeong-Taek Woo, Sei Hyun Baik, Yongsoo Park, Kwan Woo Lee, Young Seol Kim, Moonsuk Nam
  Diabetes & Metabolism Journal.2019; 43(6): 840.     CrossRef
• The relationship between demographic and anthropometric characteristics and diabetic complications and number of hospitalizations in hospitalized diabetic patients
  Yusuf Kayar, Mehmet Agin
  Archives of Medical Science – Civilization Diseases.2019; 4(1): 7.     CrossRef
• Importance of family history of diabetes in computing a diabetes risk score in Korean prediabetic population
  Morena Ustulin, Sang Youl Rhee, Suk Chon, Kyu Keung Ahn, Ji Eun Lim, Bermseok Oh, Sung-Hoon Kim, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Young Seol Kim, Jeong-Taek Woo
  Scientific Reports.2018;[Epub]     CrossRef
• Characteristics of frequent emergency department users with type 2 diabetes mellitus in Korea
  Morena Ustulin, Junghoon Woo, Jeong‐taek Woo, Sang Youl Rhee
  Journal of Diabetes Investigation.2018; 9(2): 430.     CrossRef
• Implementation of the Chronic Disease Care System and its association with health care costs and continuity of care in Korean adults with type 2 diabetes mellitus
  Woorim Kim, Yoon Soo Choy, Sang Ah Lee, Eun-Cheol Park
  BMC Health Services Research.2018;[Epub]     CrossRef
• Long‐term effects on glycaemic control and β‐cell preservation of early intensive treatment in patients with newly diagnosed type 2 diabetes: A multicentre randomized trial
  Suk Chon, Sang Youl Rhee, Kyu Jeung Ahn, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Soon Jib Yoo, Gwanpyo Koh, Dae Ho Lee, Young Seol Kim, Jeong‐Taek Woo
  Diabetes, Obesity and Metabolism.2018; 20(5): 1121.     CrossRef
• Cardio-Ankle Vascular Index as a Surrogate Marker of Early Atherosclerotic Cardiovascular Disease in Koreans with Type 2 Diabetes Mellitus
  So Young Park, Sang Ook Chin, Sang Youl Rhee, Seungjoon Oh, Jeong-Taek Woo, Sung Woon Kim, Suk Chon
  Diabetes & Metabolism Journal.2018; 42(4): 285.     CrossRef
• Metformin reduces the risk of cancer in patients with type 2 diabetes
  Hae Jin Kim, SooJin Lee, Ki Hong Chun, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Young Seol Kim, Jeong-Taek Woo, Moon-Suk Nam, Sei Hyun Baik, Kyu Jeung Ahn, Kwan Woo Lee
  Medicine.2018; 97(8): e0036.     CrossRef
• Impact of Socioeconomic Status on Health Behaviors, Metabolic Control, and Chronic Complications in Type 2 Diabetes Mellitus
  So Hun Kim, Seung Youn Lee, Chei Won Kim, Young Ju Suh, Seongbin Hong, Seong Hee Ahn, Da Hae Seo, Moon-Suk Nam, Suk Chon, Jeong-Taek Woo, Sei Hyun Baik, Yongsoo Park, Kwan Woo Lee, Young Seol Kim
  Diabetes & Metabolism Journal.2018; 42(5): 380.     CrossRef
• Failure of monotherapy in clinical practice in patients with type 2 diabetes: The Korean National Diabetes Program
  Ja Young Jeon, Soo Jin Lee, Sieun Lee, Soo Jin Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Young Seol Kim, Jeong Taek Woo, Kyu Jeung Ahn, Moonsuk Nam, Sei Hyun Baik, Yongsoo Park, Kwan‐Woo Lee
  Journal of Diabetes Investigation.2018; 9(5): 1144.     CrossRef
• Prediction of Coronary Heart Disease Risk in Korean Patients with Diabetes Mellitus
  Bo Kyung Koo, Sohee Oh, Yoon Ji Kim, Min Kyong Moon
  Journal of Lipid and Atherosclerosis.2018; 7(2): 110.     CrossRef
• Diagnosis and Management of Diabetic Foot
  Chang Won Lee
  The Journal of Korean Diabetes.2018; 19(3): 168.     CrossRef
• Clinical characteristics and risk factors for retinal diabetic neurodegeneration in type 2 diabetes
  Kiyoung Kim, Eung Suk Kim, Sang Youl Rhee, Suk Chon, Jeong-taek Woo, Seung-Young Yu
  Acta Diabetologica.2017; 54(11): 993.     CrossRef
• Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data
  Sejeong Park, Sang Youl Rhee, Su Jin Jeong, Kiyoung Kim, Suk Chon, Seung-Young Yu, Jeong-Taek Woo
  Diabetes & Metabolism Journal.2017; 41(5): 393.     CrossRef
• Clinical heterogeneity of type 1 diabetes (T1D) found in Asia
  Yongsoo Park, Kupper A. Wintergerst, Zhiguang Zhou
  Diabetes/Metabolism Research and Reviews.2017;[Epub]     CrossRef
• Response: Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data (Diabetes Metab J 2017;41:393-404)
  Sang Youl Rhee, Jeong-Taek Woo
  Diabetes & Metabolism Journal.2017; 41(6): 494.     CrossRef
• Current status of managing diabetes mellitus in Korea
  Kyoung Hwa Ha, Dae Jung Kim
  The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
• Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
  Sang Ouk Chin, Sang Youl Rhee, Suk Chon, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Ki Hong Chun, Jeong-taek Woo, Young Seol Kim
  Diabetes Research and Clinical Practice.2016; 122: 54.     CrossRef
• Relationship between fruit and fish intakes and cardiovascular disease risk factors in Korean women with type 2 diabetes mellitus: Based on the 4th and 5th Korea National Health and Nutrition Examination Surveys
  Ji Soo Oh, Hyesook Kim, Ki Nam Kim, Namsoo Chang
  Journal of Nutrition and Health.2016; 49(5): 304.     CrossRef
• Hypoglycemia and Medical Expenses in Patients with Type 2 Diabetes Mellitus: An Analysis Based on the Korea National Diabetes Program Cohort
  Sang Youl Rhee, Soo Min Hong, Suk Chon, Kyu Jeung Ahn, Sung Hoon Kim, Sei Hyun Baik, Yong Soo Park, Moon Suk Nam, Kwan Woo Lee, Jeong-Taek Woo, Young Seol Kim, Zhengdong Zhang
  PLOS ONE.2016; 11(2): e0148630.     CrossRef
• Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study
  Tae-Seok Lim, Jae-Seung Yun, Seon-Ah Cha, Ki-Ho Song, Ki-Dong Yoo, Yu-Bae Ahn, Yong-Moon Park, Seung-Hyun Ko
  The Korean Journal of Internal Medicine.2016; 31(6): 1110.     CrossRef
• Low Economic Status Is Identified as an Emerging Risk Factor for Diabetes Mellitus in Korean Men Aged 30 to 59 Years in Korean National Health and Nutrition Examination Survey 2008 to 2010
  Bo Kyung Koo, Sang Wan Kim, Ka Hee Yi, Min Kyong Moon
  Diabetes & Metabolism Journal.2015; 39(2): 137.     CrossRef
• Assessment of glycemic control in patients with type 2 diabetes mellitus treated with metformin–sulfonylurea combination: Results of a multicenter, cross‐sectional, observational study in Korea
  Sin Gon Kim, Jong Ryeal Hahm, Duk Kyu Kim, Sung Rae Cho, Dong Seop Choi
  Journal of Diabetes Investigation.2015; 6(3): 317.     CrossRef
• Clinical and Economic Outcomes in Medication-Adherent and -Nonadherent Patients With Type 2 Diabetes Mellitus in the Republic of Korea
  So-Yeon An, Hae Jin Kim, Ki Hong Chun, Tae Ho Kim, Ja Young Jeon, Dae Jung Kim, Seung Jin Han, Young Seol Kim, Jeong Taek Woo, Kyu Jeung Ahn, Yongsoo Park, Moonsuk Nam, Sei Hyun Baik, Kwan-Woo Lee
  Clinical Therapeutics.2014; 36(2): 245.     CrossRef
• Serum Magnesium Level Is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus: The Korea National Diabetes Program Study
  Sae Jeong Yang, Soon Young Hwang, Sei Hyun Baik, Kwan Woo Lee, Moon Suk Nam, Yong Soo Park, Jeong Taek Woo, Young Seol Kim, Sunmin Park, So-Young Park, Chang Hoon Yim, Hyun Koo Yoon, Sung-Hoon Kim
  Journal of Korean Medical Science.2014; 29(1): 84.     CrossRef
• Heart rate variability in children with type 1 diabetes mellitus
  Camila Balsamo Gardim, Bruno Affonso P. de Oliveira, Aline Fernanda B. Bernardo, Rayana Loch Gomes, Francis Lopes Pacagnelli, Roselene Modolo R. Lorençoni, Luiz Carlos M. Vanderlei
  Revista Paulista de Pediatria.2014; 32(2): 279.     CrossRef
• Development of an HbA1c-Based Conversion Equation for Estimating Glycated Albumin in a Korean Population with a Wide Range of Glucose Intolerance
  Chang Hee Jung, You-Cheol Hwang, Kwang Joon Kim, Bong Soo Cha, Cheol-Young Park, Won Seon Jeon, Jae Hyeon Kim, Sang-Man Jin, Sang Youl Rhee, Jeong-taek Woo, Byung-Wan Lee, Sompop Bencharit
  PLoS ONE.2014; 9(4): e95729.     CrossRef
• It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea
  Sang Yong Kim
  Diabetes & Metabolism Journal.2014; 38(3): 194.     CrossRef
• Prevalence and factors associated with diabetic retinopathy in a Korean adult population: The 2008–2009 Korea National Health and Nutrition Examination Survey
  Ju Yean Yang, Na Kyung Kim, Yun Jeong Lee, Jung Hyun Noh, Dae Jung Kim, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
  Diabetes Research and Clinical Practice.2013; 102(3): 218.     CrossRef
• Increasing achievement of the target goals for glycemic, blood pressure and lipid control for adults with diagnosed diabetes in Korea
  Sung Hoon Yu, Jun Goo Kang, Yoo‐Cheol Hwang, Kyu Jeung Ahn, Hyung Joon Yoo, Hong Yup Ahn, Sung Woo Park, Cheol‐Young Park
  Journal of Diabetes Investigation.2013; 4(5): 460.     CrossRef
• Hemoglobin A1c May Be an Inadequate Diagnostic Tool for Diabetes Mellitus in Anemic Subjects
  Jung Il Son, Sang Youl Rhee, Jeong-taek Woo, Jin Kyung Hwang, Sang Ouk Chin, Suk Chon, Seungjoon Oh, Sung Woon Kim, Young Seol Kim
  Diabetes & Metabolism Journal.2013; 37(5): 343.     CrossRef
• Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus
  Hye Jin Yoo, Soon Young Hwang, Ho Cheol Hong, Hae Yoon Choi, Sae Jeong Yang, Kwan Woo Lee, Moon Suk Nam, Yong Soo Park, Jeong Taek Woo, Young Seol Kim, Kyung Mook Choi, Sei Hyun Baik
  Endocrine.2013; 44(3): 680.     CrossRef
• Comparison of Two Creatinine-Based Equations for Predicting Decline in Renal Function in Type 2 Diabetic Patients with Nephropathy in a Korean Population
  Eun Young Lee, Young-Mi Lee, Kyu Hun Choi, Hyun Chul Lee, Byung-Wan Lee, Beom Seok Kim
  International Journal of Endocrinology.2013; 2013: 1.     CrossRef
• Association between Nutrient Intake and Obesity in Type 2 Diabetic Patients from the Korean National Diabetes Program: A Cross-Sectional Study
  So Hun Kim, Seong Bin Hong, Young Ju Suh, Yun Jin Choi, Moonsuk Nam, Hyoung Woo Lee, Ie Byung Park, Suk Chon, Jeong-Taek Woo, Sei Hyun Baik, Yongsoo Park, Dae Jung Kim, Kwan Woo Lee, Young Seol Kim
  Journal of Korean Medical Science.2012; 27(10): 1188.     CrossRef
• C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome
  Kyung Mook Choi, Soon Young Hwang, Ho Cheol Hong, Sae Jeong Yang, Hae Yoon Choi, Hye Jin Yoo, Kwan Woo Lee, Moon Suk Nam, Yong Soo Park, Jeong Taek Woo, Young Seol Kim, Dong Seop Choi, Byung-Soo Youn, Sei Hyun Baik
  Diabetes.2012; 61(11): 2932.     CrossRef
• Direct Medical Costs for Patients with Type 2 Diabetes and Related Complications: A Prospective Cohort Study Based on the Korean National Diabetes Program
  Tae Ho Kim, Ki Hong Chun, Hae Jin Kim, Seung Jin Han, Dae Jung Kim, Jiyeong Kwak, Young Seol Kim, Jeong Taek Woo, Yongsoo Park, Moonsuk Nam, Sei Hyun Baik, Kyu Jeung Ahn, Kwan Woo Lee
  Journal of Korean Medical Science.2012; 27(8): 876.     CrossRef
• Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
  Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi
  Diabetes & Metabolism Journal.2011; 35(6): 571.     CrossRef
• Letter: The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital (Diabetes Metab J 2011;35:543-50)
  Won Jun Kim, Cheol-Young Park
  Diabetes & Metabolism Journal.2011; 35(6): 637.     CrossRef
• Satisfaction with High Deductible Policies among Patients with Diabetes in the Korean General/University Hospital System
  Dae Jung Kim
  Journal of Korean Diabetes.2011; 12(4): 179.     CrossRef

Citations

Citations to this article as recorded by  

• Factors related to the empowerment of patients with diabetes: a cross-sectional study
  Shahla Vaziri Esferjani, Samaneh Sarizadeh, Seyed Mahmoud Latifi, Mostafa Albokordi, Marzieh Araban
  Journal of Public Health.2024; 32(2): 229.     CrossRef
• Predictors of self-care behaviors and glycemic control among patients with type 2 diabetes mellitus
  Towhid Babazadeh, Yosef Lotfi, Soheila Ranjbaran
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Level of physical activity in patients with type 2 diabetes
  Mohammad Amerzadeh, Mahdie Bahrami, Fatemeh Samie, Marzieh Khatooni, Zahra Hosseinkhani, Bahareh Yousefi, Omid Taherkhani
  Journal of Diabetes & Metabolic Disorders.2023;[Epub]     CrossRef
• Determining intention, fast food consumption and their related factors among university students by using a behavior change theory
  Alireza Didarloo, Surur Khalili, Ahmad Ali Aghapour, Fatemeh Moghaddam-Tabrizi, Seyed Mortaza Mousavi
  BMC Public Health.2022;[Epub]     CrossRef
• Self-Care Behaviors in Patients with Hypertension to Prevent Hypertensive Emergencies: a Qualitative Study Based on the Theory of Planned Behavior
  Farnaz Eslamimehr, Zahra Hosseini, Teamur Aghamolaei, Marzieh Nikparvar, Amin Ghanbarnezhad
  Journal of Cardiovascular Emergencies.2022; 8(4): 75.     CrossRef
• Moderate-to-vigorous physical activity changes in a diabetes prevention intervention randomized trial among South Asians with prediabetes – The D-CLIP trial
  Christopher N. Ford, Whitney L. Do, Mary Beth Weber, K.M. Venkat Narayan, Harish Ranjani, R.M Anjana
  Diabetes Research and Clinical Practice.2021; 174: 108727.     CrossRef
• Time-varying association between physical activity and risk of diabetes in the early and late adulthood: A longitudinal study in a West-Asian country
  Parisa Naseri, Parisa Amiri, Hasti Masihay-Akbar, Navideh Sahebi Vaighan, Sajad Ahmadizad, Arash Ghanbarian, Fereidoun Azizi
  Primary Care Diabetes.2021; 15(6): 1026.     CrossRef
• Predicting the Determinants of Nutritional Behaviors among High School Female Students: The Application of Extended Theory of Reasoned Action
  Zahra Baji, Ghodratollah Shakerinejad, Masoumeh Tehrani ‎, Farzaneh Jarvandi, Saeedeh Hajinajaf
  Journal of Education and Community Health.2020; 7(1): 37.     CrossRef
• Predicting Covid-19 Preventive Healthy Behaviors Based on Dysfunctional Attitudes in Five Countries
  Sima Eivazi, Jahangir Karami, Peter John Varey, Sara Eivazi
  Journal of Kermanshah University of Medical Sciences.2020;[Epub]     CrossRef
• ​The Effect of an Educational Intervention Based on Health Belief Model on Nutritional Behaviors in Type 2 Diabetics
  Dadkhah Tehrani. B, Tavakoli. R, Jazayeri. SA
  Military Caring Sciences.2019; 5(4): 303.     CrossRef
• The effect of educational intervention based on BASNEF model on self-medication behavior of type 2 diabetic patients
  AliKhani Jeihooni, Maryam Barati, Amin Kouhpayeh, SeyyedMansour Kashfi, PooyanAfzali Harsini, Milad Rahbar
  Indian Journal of Endocrinology and Metabolism.2019; 23(6): 616.     CrossRef
• Health-Related Quality of Life and its Determinants Amongst Women With Diabetes Mellitus: A Cross-Sectional Analysis
  Alireza Didarloo, Mohammad Alizadeh
  Nursing and Midwifery Studies.2016;[Epub]     CrossRef
• Applying Socioecological Model to Improve Women’s Physical Activity: A Randomized Control Trial
  Hadi Tehrani, Fershteh Majlessi, Davoud Shojaeizadeh, Roya Sadeghi, Marzieh Hasani Kabootarkhani
  Iranian Red Crescent Medical Journal.2016;[Epub]     CrossRef
• Investigating Physical Exercise among Jordanians with Diabetes Mellitus
  Muhammad W. Darawad, Sultan Mosleh, Amani A. Khalil, Mahmoud Maharmeh, Ayman M. Hamdan-Mansour, Osama A. Samarkandi
  Health.2016; 08(02): 181.     CrossRef
• Underdiagnosis of delirium on admission and prediction of patients who will develop delirium during their inpatient stay: a pilot study
  YC Chin, GC Koh, YK Tay, CH Tan, RA Merchant
  Singapore Medical Journal.2016; 57(01): 18.     CrossRef

Citations

Citations to this article as recorded by  

• Assessment of serum and salivary visfatin levels in newly diagnosed patients of type-II DM
  Faith R. Jerusha, Vandana Raghunath
  Journal of Oral and Maxillofacial Pathology.2023; 27(4): 663.     CrossRef
• Evaluation of the serum visfatin eotaxin and fetuin-A levels of patients with type 2 diabetes mellitus
  Hacer KAYHAN KAYA, Abdurrahman ŞERMET, Zafer PEKKOLAY, Ezel TAŞDEMİR, Dilek AYGÜN KEŞİM
  Anatolian Current Medical Journal.2022; 4(1): 113.     CrossRef
• The Association Between Three Adipocytokines (Adiponectin, Resistin and Visfatin) And Thyroid Status in Patients With Type 2 Diabetes Mellitus and Autoimmune Thyroiditis
  Š. Sotak, Z. Schroner, I. Lazúrová, M. Felšőci, I. Jochmanová, D. Petrášová, I. Bertková, M. Mitníková, B. Nováková, H. Wagnerová, O. Bobelová
  Physiological Research.2021; (6): 865.     CrossRef
• Prediction of gestational diabetes mellitus in the first trimester: comparison of maternal fetuin-A, N-terminal proatrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels
  Hatice Kansu-Celik, A. Seval Ozgu-Erdinc, Burcu Kisa, Rahime Bedir Findik, Canan Yilmaz, Yasemin Tasci
  Archives of Endocrinology and Metabolism.2019;[Epub]     CrossRef
• The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies
  F. Roshanzamir, M. Miraghajani, M. H. Rouhani, M. Mansourian, R. Ghiasvand, S. M. Safavi
  Journal of Endocrinological Investigation.2018; 41(1): 33.     CrossRef
• Fetuin-A level in type 2 diabetic patients: relation to microvascular complications
  Nehal H. Al-Said, Fatma M. Taha, Ghada M. Abdel-Aziz, Marwa S. Abdel-Tawab
  The Egyptian Journal of Internal Medicine.2018; 30(3): 121.     CrossRef
• Serum levels of fetuin A are increased in women with gestational diabetes mellitus
  Ozlem Turhan Iyidir, Ceyla Konca Degertekin, Banu Aktas Yilmaz, Alev E. Altinova, Fusun B. Toruner, Nuray Bozkurt, Goksun Ayvaz, Mujde Akturk
  Archives of Gynecology and Obstetrics.2015; 291(4): 933.     CrossRef
• Lower Fetuin-A, Retinol Binding Protein 4 and Several Metabolites after Gastric Bypass Compared to Sleeve Gastrectomy in Patients with Type 2 Diabetes
  Mia Jüllig, Shelley Yip, Aimin Xu, Greg Smith, Martin Middleditch, Michael Booth, Richard Babor, Grant Beban, Rinki Murphy, Pankaj K. Singh
  PLoS ONE.2014; 9(5): e96489.     CrossRef
• Preventive roles of swimming exercise and pioglitazone treatment on hepatic dysfunction in a rat model of metabolic syndrome
  Hussein F. Sakr, Fahaid H. Al-Hashem, Waffaa M. Hassab El-Naby, Mahmoud A. Alkhateeb, Mohamed Samir A. Zaki, Hesham M. El Refaey, Mohamed D. Morsy
  Canadian Journal of Physiology and Pharmacology.2014; 92(2): 162.     CrossRef
• Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy
  Magdalena Olszanecka-Glinianowicz, Aleksander Owczarek, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Tomasz Zdrojewski, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek
  Metabolism.2014; 63(11): 1409.     CrossRef

Citations

Citations to this article as recorded by  

• A Randomized, Two-Treatments, Two-Periods, Crossover, Open label, Laboratory-Blind, Single Dose Bioequivalence Study between Vildagliptin/Metformin 50 mg/1000 mg Film Coated Tablets (Sensityn®) and Galvusmet® 50 mg/1000 mg Film Coated Tablets in healthy a
  J. Shiekmydeen, T. Siddiqi, K. Chakraborty, S. Khalaf, M. Albarazi, I. Eqtefan, J. Sliva
  European Pharmaceutical Journal.2023; 70(2): 1.     CrossRef
• Bioequivalence Studies of New Generic Formulations of Vildagliptin and Fixed-Drug Combination of Vildagliptin and Metformin Versus Respective Originator Products in Healthy Volunteers
  Yvonne Schnaars, Sumedh Gaikwad, Ulrike Gottwald-Hostalek, Ulrike Klingberg, Hari Kiran Chary Vadla, Vamshi Ramana Prathap
  Diabetes Therapy.2022; 13(6): 1215.     CrossRef
• Efficacy and safety of dorzagliatin for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis
  Yunfeng Yu, Xingyu Yang, Keke Tong, Shuang Yin, Gang Hu, Fei Zhang, Pengfei Jiang, Manli Zhou, Weixiong Jian
  Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
• A Single-Center, Observational, Retrospective Cost-Effective Analysis of Treating Inadequately Controlled Type 2 Diabetes Mellitus by Addition of DPP4 Inhibitors Versus Intensified Treatment with Conventional Drugs
  Akshata Kalyani, Sachin Kuchya, >Prashant Punekar
  Journal of Pharmacology and Pharmacotherapeutics.2021; 12(3): 125.     CrossRef
• Comparison of safety and efficacy of glimepiride-metformin and vildagliptin- metformin treatment in newly diagnosed type 2 diabetic patients
  Surendra Kumar
  Indian Journal of Endocrinology and Metabolism.2021; 25(4): 326.     CrossRef
• Comparative clinical study evaluating the effect of adding Vildagliptin versus Glimepiride to ongoing Metformin therapy on diabetic patients with symptomatic coronary artery disease
  Rehab Werida, Mahmoud Kabel, Gamal Omran, Ahmed Shokry, Tarek Mostafa
  Diabetes Research and Clinical Practice.2020; 170: 108473.     CrossRef
• Efficacy of different antidiabetic drugs based on metformin in the treatment of type 2 diabetes mellitus: A network meta‐analysis involving eight eligible randomized‐controlled trials
  Yan Peng, Shu‐Hong Chen, Xiao‐Nan Liu, Qing‐Yun Sun
  Journal of Cellular Physiology.2019; 234(3): 2795.     CrossRef
• A safety and tolerability profile comparison between dipeptidyl peptidase-4 inhibitors and sulfonylureas in diabetic patients: A systematic review and meta-analysis
  Daniela Farah, Graziella Malzoni Leme, Freddy Goldberg Eliaschewitz, Marcelo Cunio Machado Fonseca
  Diabetes Research and Clinical Practice.2019; 149: 47.     CrossRef
• Efficacy and safety of dulaglutide monotherapy compared with glimepiride in East‐Asian patients with type 2 diabetes in a multicentre, double‐blind, randomized, parallel‐arm, active comparator, phase III trial
  Yu Hong Chen, Chien‐Ning Huang, Young Min Cho, Pengfei Li, Liqun Gu, Feng Wang, Jun Yang, Wei Qing Wang
  Diabetes, Obesity and Metabolism.2018; 20(9): 2121.     CrossRef
• Cost effectiveness of vildagliptin versus glimepiride as add-on treatment to metformin for the treatment of diabetes mellitus type 2 patients in Greece
  Hara Kousoulakou, Magdalini Hatzikou, Varvara Baroutsou, John Yfantopoulos
  Cost Effectiveness and Resource Allocation.2017;[Epub]     CrossRef
• The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus
  Gyuri Kim, Sewon Oh, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Moon-Kyu Lee
  Expert Opinion on Pharmacotherapy.2017; 18(12): 1179.     CrossRef
• Predictors of efficacy of GLP-1 agonists and DPP-4 inhibitors: A systematic review
  Helene Bihan, Winda L. Ng, Dianna J. Magliano, Jonathan E. Shaw
  Diabetes Research and Clinical Practice.2016; 121: 27.     CrossRef
• New Oral Diabetes Drugs are more effective than Older Agents: Real or a Fraud?
  Udaya M Kabadi
  Journal of Diabetes, Metabolic Disorders & Control.2016;[Epub]     CrossRef
• Systematic review and meta-analysis of vildagliptin for treatment of type 2 diabetes
  Eleni Bekiari, Chrysoula Rizava, Eleni Athanasiadou, Konstantinos Papatheodorou, Aris Liakos, Thomas Karagiannis, Maria Mainou, Maria Rika, Panagiota Boura, Apostolos Tsapas
  Endocrine.2016; 52(3): 458.     CrossRef
• Sulfonylurea Glimepiride: A Proven Cost Effective, Safe and Reliable War Horse in Combating Hyperglycemia in Type 2 Diabetes
  Udaya M. Kabadi
  Journal of Diabetes Mellitus.2015; 05(04): 211.     CrossRef
• Glycemic effects of vildagliptin and metformin combination therapy in Indian patients with type 2 diabetes: An observational study (印度2型糖尿病患者使用维格列汀与二甲双胍联合治疗对血糖的影响：一项观察性研究)
  Sanjay Chatterjee, Sudip Chatterjee
  Journal of Diabetes.2014; 6(3): 237.     CrossRef
• Head‐to‐head comparison of dipeptidyl peptidase‐IV inhibitors and sulfonylureas – a meta‐analysis from randomized clinical trials
  Yifei Zhang, Jie Hong, Jie Chi, Weiqiong Gu, Guang Ning, Weiqing Wang
  Diabetes/Metabolism Research and Reviews.2014; 30(3): 241.     CrossRef
• Vildagliptin: A Review of Its Use in Type 2 Diabetes Mellitus
  Gillian M. Keating
  Drugs.2014; 74(5): 587.     CrossRef
• Vildagliptin compared to glimepiride on post-prandial lipemia and on insulin resistance in type 2 diabetic patients
  Giuseppe Derosa, Aldo Bonaventura, Lucio Bianchi, Davide Romano, Elena Fogari, Angela D’Angelo, Pamela Maffioli
  Metabolism.2014; 63(7): 957.     CrossRef
• The Placement of DPP-4 Inhibitors in Clinical Practice Recommendations for the Treatment of Types 2 Diabetes
  Jaime A. Davidson
  Endocrine Practice.2013; 19(6): 1050.     CrossRef
• Predictive Clinical Parameters and Glycemic Efficacy of Vildagliptin Treatment in Korean Subjects with Type 2 Diabetes
  Jin-Sun Chang, Juyoung Shin, Hun-Sung Kim, Kyung-Hee Kim, Jeong-Ah Shin, Kun-Ho Yoon, Bong-Yun Cha, Ho-Young Son, Jae-Hyoung Cho
  Diabetes & Metabolism Journal.2013; 37(1): 72.     CrossRef
• The Efficacy of Vildagliptin in Korean Patients with Type 2 Diabetes
  Jun Sung Moon, Kyu Chang Won
  Diabetes & Metabolism Journal.2013; 37(1): 36.     CrossRef
• Effect of Vildagliptin on Glucose and Insulin Concentrations During a 24-Hour Period in Type 2 Diabetes Patients with Different Ranges of Baseline Hemoglobin A1c Levels
  Manuel González-Ortiz, María J. Sánchez-Peña, Luis J. González-Ortiz, José A. Robles-Cervantes, Yessica E. García-Ortega, Esteban A. Gómez-Gaitán, Karina G. Pérez-Rubio, Esperanza Martínez-Abundis
  Diabetes Technology & Therapeutics.2013; 15(7): 564.     CrossRef
• Differential effects of vildagliptin and glimepiride on glucose fluctuations in patients with type 2 diabetes mellitus assessed using continuous glucose monitoring
  Y. L. He, G. Foteinos, S. Neelakantham, D. Mattapalli, K. Kulmatycki, T. Forst, A. Taylor
  Diabetes, Obesity and Metabolism.2013; 15(12): 1111.     CrossRef
• Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus
  Elisa Guarino, Laura Nigi, Aurora Patti, Cecilia Fondelli, Francesco Dotta
  Expert Opinion on Pharmacotherapy.2012; 13(9): 1377.     CrossRef

Citations

Citations to this article as recorded by  

• Evaluation of measured and calculated small dense low-density lipoprotein in capillary blood and association with the metabolic syndrome
  Sara Deza, Inmaculada Colina, Oscar Beloqui, José Ignacio Monreal, Estéfani Martínez-Chávez, Julia Maroto-García, Carmen Mugueta, Alvaro González, Nerea Varo
  Clinica Chimica Acta.2024; 557: 117897.     CrossRef
• Association between measured or calculated small dense low‐density lipoprotein cholesterol and oxidized low‐density lipoprotein in subjects with or without type 2 diabetes mellitus
  Hyun‐Ki Kim, Jinyoung Hong, Sunyoung Ahn, Woochang Lee, Sail Chun, Won‐Ki Min
  Journal of Clinical Laboratory Analysis.2023;[Epub]     CrossRef
• The association of apolipoprotein in the risk of ST-elevation myocardial infarction in patients with documented coronary artery disease
  Astuti Giantini, Nur Gifarani Pratiwi, Renan Sukmawan, Joedo Prihartono, Suzanna Immanuel, Merci Monica Pasaribu, Sri Suryo Adiyanti, Yusuf Bahasoan
  International Journal of Cardiology Cardiovascular Risk and Prevention.2023; 18: 200194.     CrossRef
• Atherogenic Index of Plasma and Its Association with Risk Factors of Coronary Artery Disease and Nutrient Intake in Korean Adult Men: The 2013–2014 KNHANES
  Hye Ran Shin, SuJin Song, Jin Ah Cho, Sun Yung Ly
  Nutrients.2022; 14(5): 1071.     CrossRef
• The Atherogenic Index of Plasma: A Powerful and Reliable Predictor for Coronary Artery Disease in Patients With Type 2 Diabetes
  Kuo Zhou, Zheng Qin, Jinfan Tian, Kongyong Cui, Yunfeng Yan, Shuzheng Lyu
  Angiology.2021; 72(10): 934.     CrossRef
• Direct bilirubin is associated with low-density lipoprotein subfractions and particle size in overweight and centrally obese women
  Y.-J. Kwon, H.-S. Lee, J.-W. Lee
  Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(10): 1021.     CrossRef
• Correlation between Cholesterol, Triglycerides, Calculated, and Measured Lipoproteins: Whether Calculated Small Density Lipoprotein Fraction Predicts Cardiovascular Risks
  Sikandar Hayat Khan, Nadeem Fazal, Athar Abbas Gilani Shah, Syed Mohsin Manzoor, Naveed Asif, Aamir Ijaz, Najmusaqib Khan Niazi, Muhammad Yasir
  Journal of Lipids.2017; 2017: 1.     CrossRef
• Effects of Small Dense LDL in Diabetic Nephropathy in Females with Type 2 Diabetes Mellitus
  Seongyul Ryu, Youngwoo Kim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Ki-Ho Song, Kyung-Jin Yun
  Journal of Lipid and Atherosclerosis.2016; 5(1): 11.     CrossRef
• Prepregnancy Adverse Lipid Profile and Subsequent Risk of Gestational Diabetes
  Emily S. Han, Ronald M. Krauss, Fei Xu, Sneha B. Sridhar, Assiamira Ferrara, Charles P. Quesenberry, Monique M. Hedderson
  The Journal of Clinical Endocrinology & Metabolism.2016; 101(7): 2721.     CrossRef
• Meta-analysis of Atherogenic Index of Plasma and other lipid parameters in relation to risk of type 2 diabetes mellitus
  Xiao-Wei Zhu, Fei-Yan Deng, Shu-Feng Lei
  Primary Care Diabetes.2015; 9(1): 60.     CrossRef
• Higher levels of small dense low‐density lipoprotein (LDL) are associated with cardiac autonomic neuropathy in patients with Type 2 diabetes
  E.‐H. Jang, Y.‐M. Park, J. Hur, M.‐K. Kim, S.‐H. Ko, K.‐H. Baek, K.‐H. Song, K.‐W. Lee, H.‐S. Kwon
  Diabetic Medicine.2013; 30(6): 694.     CrossRef
• Sleep Status and Low-Density Lipoprotein Particle Size in a General Japanese Female Population: The Mima Study
  Kazuhiko Kotani, Kokoro Tsuzaki, Shinji Fujiwara, Naoki Sakane
  Medical Principles and Practice.2013; 22(5): 510.     CrossRef
• Serum small-dense LDL abnormalities in chronic renal disease patients
  M. Chu, A. Y. M. Wang, I. H. S. Chan, S. H. Chui, C. W. K. Lam
  British Journal of Biomedical Science.2012; 69(3): 99.     CrossRef
• Small Dense Low-density Lipoprotein and Cardiovascular Disease
  Sunghwan Suh, Moon-Kyu Lee
  Journal of Lipid and Atherosclerosis.2012; 1(1): 1.     CrossRef